Antioxidant Properties and Cytoprotective Effect of Pistacia lentiscus L. Seed Oil against 7 beta-Hydroxycholesterol-Induced Toxicity in C2C12 Myoblasts: Reduction in Oxidative Stress, Mitochondrial and Peroxisomal Dysfunctions and Attenuation of Cell Death

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorGHZAIEL, Imen
dc.contributor.authorZARROUK, Amira
dc.contributor.authorNURY, Thomas
dc.contributor.authorLIBERGOLI, Michela
dc.contributor.authorFLORIO, Francesca
dc.contributor.authorHAMMOUDA, Souha
dc.contributor.authorMENETRIER, Franck
dc.contributor.authorAVOSCAN, Laure
dc.contributor.authorYAMMINE, Aline
dc.contributor.authorSAMADI, Mohammad
dc.contributor.authorLATRUFFE, Norbert
dc.contributor.authorBIRESSI, Stefano
dc.contributor.authorLEVY, Debora
dc.contributor.authorBYDLOWSKI, Sergio Paulo
dc.contributor.authorHAMMAMI, Sonia
dc.contributor.authorVEJUX, Anne
dc.contributor.authorHAMMAMI, Mohamed
dc.contributor.authorLIZARD, Gerard
dc.date.accessioned2022-02-24T17:13:25Z
dc.date.available2022-02-24T17:13:25Z
dc.date.issued2021
dc.description.abstractAging is characterized by a progressive increase in oxidative stress, which favors lipid peroxidation and the formation of cholesterol oxide derivatives, including 7 beta-hydroxycholesterol (7 beta-OHC). This oxysterol, which is known to trigger oxidative stress, inflammation, and cell death, could contribute to the aging process and age-related diseases, such as sarcopenia. Identifying molecules or mixtures of molecules preventing the toxicity of 7 beta-OHC is therefore an important issue. This study consists of determining the chemical composition of Tunisian Pistacia lentiscus L. seed oil (PLSO) used in the Tunisian diet and evaluating its ability to counteract the cytotoxic effects induced by 7 beta-OHC in murine C2C12 myoblasts. The effects of 7 beta-OHC (50 mu M; 24 h), associated or not with PLSO, were studied on cell viability, oxidative stress, and on mitochondrial and peroxisomal damages induction. alpha-Tocopherol (400 mu M) was used as the positive control for cytoprotection. Our data show that PLSO is rich in bioactive compounds; it contains polyunsaturated fatty acids, and several nutrients with antioxidant properties: phytosterols, alpha-tocopherol, carotenoids, flavonoids, and phenolic compounds. When associated with PLSO (100 mu g/mL), the 7 beta-OHC-induced cytotoxic effects were strongly attenuated. The cytoprotection was in the range of those observed with alpha-tocopherol. This cytoprotective effect was characterized by prevention of cell death and organelle dysfunction (restoration of cell adhesion, cell viability, and plasma membrane integrity; prevention of mitochondrial and peroxisomal damage) and attenuation of oxidative stress (reduction in reactive oxygen species overproduction in whole cells and at the mitochondrial level; decrease in lipid and protein oxidation products formation; and normalization of antioxidant enzyme activities: glutathione peroxidase (GPx) and superoxide dismutase (SOD)). These results provide evidence that PLSO has similar antioxidant properties than alpha-tocopherol used at high concentration and contains a mixture of molecules capable to attenuate 7 beta-OHC-induced cytotoxic effects in C2C12 myoblasts. These data reinforce the interest in edible oils associated with the Mediterranean diet, such as PLSO, in the prevention of age-related diseases, such as sarcopenia.eng
dc.description.indexPubMedeng
dc.description.sponsorshipUniversite de Bourgogne (Dijon, France)
dc.description.sponsorshipUniversite Tunis El Manar (Tunis, Tunisia)
dc.description.sponsorshipUniversity of Trento (Italy)
dc.description.sponsorshipTelethon and Provincia autonoma di Trento (Italy) [TCP13007]
dc.description.sponsorshipAFM-Telethon (France) [23758]
dc.description.sponsorshipMuscular Dystrophy Association (USA)Muscular Dystrophy Association [874294]
dc.description.sponsorship[LR12ES05]
dc.identifier.citationANTIOXIDANTS, v.10, n.11, article ID 1772, 37p, 2021
dc.identifier.doi10.3390/antiox10111772
dc.identifier.eissn2076-3921
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/44344
dc.language.isoeng
dc.publisherMDPIeng
dc.relation.ispartofAntioxidants
dc.rightsopenAccesseng
dc.rights.holderCopyright MDPIeng
dc.subjectagingeng
dc.subject7 beta-hydroxycholesteroleng
dc.subjectmitochondriaeng
dc.subjectoxidative stresseng
dc.subjectperoxisomeeng
dc.subject<p>Pistacia lentiscus L.& nbspeng
dc.subjectseed oil</p>eng
dc.subjectseed oileng
dc.subjectsarcopeniaeng
dc.subject.otherfatty-acid-compositioneng
dc.subject.otherskeletal-muscle cellseng
dc.subject.otherbeta-sitosteroleng
dc.subject.othercholesterol homeostasiseng
dc.subject.otherdocosahexaenoic acideng
dc.subject.otherlipid-peroxidationeng
dc.subject.otheralpha-tocopheroleng
dc.subject.otherreactive oxygeneng
dc.subject.otherfruit oileng
dc.subject.otheroxysterolseng
dc.subject.wosBiochemistry & Molecular Biologyeng
dc.subject.wosChemistry, Medicinaleng
dc.subject.wosFood Science & Technologyeng
dc.titleAntioxidant Properties and Cytoprotective Effect of Pistacia lentiscus L. Seed Oil against 7 beta-Hydroxycholesterol-Induced Toxicity in C2C12 Myoblasts: Reduction in Oxidative Stress, Mitochondrial and Peroxisomal Dysfunctions and Attenuation of Cell Deatheng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryTunísia
hcfmusp.affiliation.countryFrança
hcfmusp.affiliation.countryItália
hcfmusp.affiliation.countryisotn
hcfmusp.affiliation.countryisofr
hcfmusp.affiliation.countryisoit
hcfmusp.author.externalGHZAIEL, Imen:Univ Bourgogne Franche Comte, Team Biochem Peroxisome Inflammat & Lipid Metab E, INSERM, F-21000 Dijon, France; Univ Monastir, Fac Med, Lab NAFS Nutr Funct Food & Vasc Hlth, LR12ES05, Monastir 5000, Tunisia; Univ Tunis El Manar, Fac Sci Tunis, Tunis 2092, Tunisia
hcfmusp.author.externalZARROUK, Amira:Univ Monastir, Fac Med, Lab NAFS Nutr Funct Food & Vasc Hlth, LR12ES05, Monastir 5000, Tunisia; Univ Sousse, Fac Med, Sousse 4000, Tunisia
hcfmusp.author.externalNURY, Thomas:Univ Bourgogne Franche Comte, Team Biochem Peroxisome Inflammat & Lipid Metab E, INSERM, F-21000 Dijon, France
hcfmusp.author.externalLIBERGOLI, Michela:Univ Trento, Dept Cellular Computat & Integrat Biol CIBio, I-38123 Trento, Italy; Univ Trento, Dulbecco Telethon Inst, I-38123 Trento, Italy
hcfmusp.author.externalFLORIO, Francesca:Univ Trento, Dept Cellular Computat & Integrat Biol CIBio, I-38123 Trento, Italy; Univ Trento, Dulbecco Telethon Inst, I-38123 Trento, Italy
hcfmusp.author.externalHAMMOUDA, Souha:Univ Monastir, Fac Med, Lab NAFS Nutr Funct Food & Vasc Hlth, LR12ES05, Monastir 5000, Tunisia
hcfmusp.author.externalMENETRIER, Franck:Univ Bourgogne Franche Comte, INRAE, CNRS, AgroSup Dijon,Ctr Sci Gout & Alimentat, F-21065 Dijon, France
hcfmusp.author.externalAVOSCAN, Laure:Univ Bourgogne Franche Comte, Plateforme DimaCell, INRAE, Agroecol,AgroSup Dijon,CNRS, F-21000 Dijon, France
hcfmusp.author.externalYAMMINE, Aline:Univ Bourgogne Franche Comte, Team Biochem Peroxisome Inflammat & Lipid Metab E, INSERM, F-21000 Dijon, France
hcfmusp.author.externalSAMADI, Mohammad:Univ Lorraine, LCPMC A2, ICPM, Dept Chem, Metz Technopole, F-57070 Metz, France
hcfmusp.author.externalLATRUFFE, Norbert:Univ Bourgogne Franche Comte, Team Biochem Peroxisome Inflammat & Lipid Metab E, INSERM, F-21000 Dijon, France
hcfmusp.author.externalBIRESSI, Stefano:Univ Trento, Dept Cellular Computat & Integrat Biol CIBio, I-38123 Trento, Italy; Univ Trento, Dulbecco Telethon Inst, I-38123 Trento, Italy
hcfmusp.author.externalHAMMAMI, Sonia:Univ Monastir, Fac Med, Lab NAFS Nutr Funct Food & Vasc Hlth, LR12ES05, Monastir 5000, Tunisia
hcfmusp.author.externalVEJUX, Anne:Univ Bourgogne Franche Comte, Team Biochem Peroxisome Inflammat & Lipid Metab E, INSERM, F-21000 Dijon, France
hcfmusp.author.externalHAMMAMI, Mohamed:Univ Monastir, Fac Med, Lab NAFS Nutr Funct Food & Vasc Hlth, LR12ES05, Monastir 5000, Tunisia
hcfmusp.author.externalLIZARD, Gerard:Univ Bourgogne Franche Comte, Team Biochem Peroxisome Inflammat & Lipid Metab E, INSERM, F-21000 Dijon, France
hcfmusp.citation.scopus15
hcfmusp.contributor.author-fmusphcDEBORA LEVY
hcfmusp.contributor.author-fmusphcSERGIO PAULO BYDLOWSKI
hcfmusp.description.articlenumber1772
hcfmusp.description.issue11
hcfmusp.description.volume10
hcfmusp.origemWOS
hcfmusp.origem.pubmed34829643
hcfmusp.origem.scopus2-s2.0-85118718402
hcfmusp.origem.wosWOS:000725014100001
hcfmusp.publisher.cityBASELeng
hcfmusp.publisher.countrySWITZERLANDeng
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