The Role of Reflectance Confocal Microscopy in the Evaluation of Pigmented Oral Lesions and Their Relationship With Histopathological Aspects

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLUPPI, Juliana Bronzato
dc.contributor.authorSOUZA, Renata Pereira de
dc.contributor.authorFLOREZI, Giovanna Piacenza
dc.contributor.authorNICO, Marcello Menta Simonsen
dc.contributor.authorLOURENCO, Silvia Vanessa
dc.date.accessioned2022-12-21T13:21:17Z
dc.date.available2022-12-21T13:21:17Z
dc.date.issued2022
dc.description.abstractOral pigmentations are a heterogeneous group and can be the result of physiological activity of oral mucosal melanocytes, secondary to exogenous causes, associated with systemic or local diseases, or due to proliferative activity of melanocytes. Their diagnosis is critical because these lesions can be markers of internal diseases or, in the case of melanocytic proliferative processes, they may represent a malignant neoplasm. In the past decade, the use of reflectance confocal microscopy, a noninvasive imaging tool, has aided the analysis of such lesions, but the establishment of firm criteria in their evaluation is still lacking. This study evaluated a series of 19 cases of pigmented oral lesions and correlated the reflectance confocal microscopy findings with histopathological classical criteria. We found 13 cases of melanotic macule, 1 of them associated with Peutz-Jeghers syndrome and 2 with Laugier-Hunzinker syndrome; 1 melanocytic nevus; 2 lentigo maligna; 2 pigmented actinic cheilitis; and 1 case of postinflammatory pigmentation secondary to a lupus erythematosus oral discoid lesion. The main difference between benign and malignant lesions was the presence of atypical proliferation in lentigo maligna. Langerhans cells with thick dendritic processes, which may be present in other benign and inflammatory pigmentations is one of the main reasons for diagnostic pitfalls.eng
dc.description.indexMEDLINEeng
dc.identifier.citationAMERICAN JOURNAL OF DERMATOPATHOLOGY, v.44, n.9, p.658-663, 2022
dc.identifier.doi10.1097/DAD.0000000000002220
dc.identifier.eissn1533-0311
dc.identifier.issn0193-1091
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/50497
dc.language.isoeng
dc.publisherLIPPINCOTT WILLIAMS & WILKINSeng
dc.relation.ispartofAmerican Journal of Dermatopathology
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright LIPPINCOTT WILLIAMS & WILKINSeng
dc.subjectoral mucosal melanosiseng
dc.subjectreflectance confocal microscopyeng
dc.subjectlentigo malignaeng
dc.subject.othermucosal melanomaeng
dc.subject.otherdiagnosiseng
dc.subject.othermaculeseng
dc.subject.otherneckeng
dc.subject.otherheadeng
dc.subject.otherlipeng
dc.subject.wosDermatologyeng
dc.titleThe Role of Reflectance Confocal Microscopy in the Evaluation of Pigmented Oral Lesions and Their Relationship With Histopathological Aspectseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalSOUZA, Renata Pereira de:Univ Sao Paulo, Dent Sch, Dept Stomatol, Av Prof Lineu Prestes 2227, BR-05508000 Sao Paulo, SP, Brazil
hcfmusp.author.externalFLOREZI, Giovanna Piacenza:Univ Sao Paulo, Dent Sch, Dept Stomatol, Av Prof Lineu Prestes 2227, BR-05508000 Sao Paulo, SP, Brazil
hcfmusp.author.externalLOURENCO, Silvia Vanessa:Univ Sao Paulo, Dent Sch, Dept Stomatol, Av Prof Lineu Prestes 2227, BR-05508000 Sao Paulo, SP, Brazil
hcfmusp.citation.scopus3
hcfmusp.contributor.author-fmusphcJULIANA BRONZATO LUPPI
hcfmusp.contributor.author-fmusphcMARCELLO MENTA SIMONSEN NICO
hcfmusp.description.beginpage658
hcfmusp.description.endpage663
hcfmusp.description.issue9
hcfmusp.description.volume44
hcfmusp.origemWOS
hcfmusp.origem.pubmed35503878
hcfmusp.origem.scopus2-s2.0-85136319399
hcfmusp.origem.wosWOS:000841530800009
hcfmusp.publisher.cityPHILADELPHIAeng
hcfmusp.publisher.countryUSAeng
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hcfmusp.scopus.lastupdate2024-05-17
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Artigos e Materiais de Revistas Científicas - FM/MDT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/06