Resistance training downregulates macrophages infiltration in the kidney of 5/6 nephrectomized rats

Página do item simplificado
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMORAES, Milton Rocha
dc.contributor.authorROSA, Thiago Santos
dc.contributor.authorSOUZA, Michel Kendy
dc.contributor.authorNEVES, Rodrigo Vanerson Passos
dc.contributor.authorBACURAU, Reury Frank Pereira
dc.contributor.authorPASSOS, Clevia Santos
dc.contributor.authorCENEDEZE, Marcos Antonio
dc.contributor.authorPASSOS, Michelle Tiveron
dc.contributor.authorMACHADO, Flavia Gomes
dc.contributor.authorPACHECO-SILVA FILHO, Alvaro
dc.contributor.authorCAMARA, Niels Olsen Saraiva
dc.date.accessioned2019-01-17T13:37:02Z
dc.date.available2019-01-17T13:37:02Z
dc.date.issued2018
dc.description.abstractIntroduction: Chronic kidney disease (CKD) is considered a significant world health problem with elevated mortality rates. Patients with CKD are restricted to mild physical activity, present chronic inflammatory state and loss of muscle strength. Currently, the influence of resistance exercise (RE) on the progression of renal disease has not being fully elucidated. Purpose: To evaluate the effects of RE on the progression of CKD in a remnant kidney model (5/6Nx) in rats. Methods: Eight-week-old Wistar rats were submitted to 5/6 nephrectomy and were divided into four groups: Sham sedentary (Sham SD); Sham RE (Sham RE); 5/6Nx SD and 5/6Nx RE. The animals were trained for 8 weeks in a vertical climbing ladder for 3 days per week, on non-consecutive days. Results: As expected, 5/6Nx SD group presented a markedly loss of renal function, increased plasma inflammatory cytokines and increased oxidative stress with a reduced activity of nitric oxide. The higher macrophage infiltration and fibrosis confirmed these conditions. RE attenuated systolic blood pressure and renal function decrease and also improved serum lipid parameters in 5/6 Nx animals. It was evident the increase of muscle strength and mass in the trained groups while the sedentary group showed reduced muscle weight and strength compared to Sham SD. Conclusions: RE implemented following 5/6Nx retard the progression of chronic kidney injury while simultaneously allowed the maintenance of skeletal muscle strength.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.identifier.citationLIFE SCIENCES, v.213, p.190-197, 2018
dc.identifier.doi10.1016/j.lfs.2018.10.037
dc.identifier.eissn1879-0631
dc.identifier.issn0024-3205
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/30077
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDeng
dc.relation.ispartofLife Sciences
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright PERGAMON-ELSEVIER SCIENCE LTDeng
dc.subjectResistance exerciseeng
dc.subjectInflammationeng
dc.subjectMuscle strengtheng
dc.subjectRenal functioneng
dc.subject5/6 nephrectomyeng
dc.subject.otherspontaneously hypertensive-ratseng
dc.subject.otherstage renal-diseaseeng
dc.subject.othernitric-oxideeng
dc.subject.otherexercise intensityeng
dc.subject.othermuscleeng
dc.subject.otherindividualseng
dc.subject.otherpreventioneng
dc.subject.otherstrengtheng
dc.subject.otherlosartaneng
dc.subject.otherreceptoreng
dc.subject.wosMedicine, Research & Experimentaleng
dc.subject.wosPharmacology & Pharmacyeng
dc.titleResistance training downregulates macrophages infiltration in the kidney of 5/6 nephrectomized ratseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalMORAES, Milton Rocha:Univ Catolica Brasilia, Grad Program Phys Educ, QS 07,LT1 S-N Sala 110 Bloco G, BR-71966700 Aguas Claras, DF, Brazil; Univ Fed Sao Paulo, Div Nephrol, Dept Med, Sao Paulo, Brazil
hcfmusp.author.externalROSA, Thiago Santos:Univ Catolica Brasilia, Grad Program Phys Educ, QS 07,LT1 S-N Sala 110 Bloco G, BR-71966700 Aguas Claras, DF, Brazil; Univ Fed Sao Paulo, Program Translat Med, Dept Med, Sao Paulo, Brazil
hcfmusp.author.externalSOUZA, Michel Kendy:Univ Fed Sao Paulo, Div Nephrol, Dept Med, Sao Paulo, Brazil
hcfmusp.author.externalNEVES, Rodrigo Vanerson Passos:Univ Catolica Brasilia, Grad Program Phys Educ, QS 07,LT1 S-N Sala 110 Bloco G, BR-71966700 Aguas Claras, DF, Brazil; Univ Fed Sao Paulo, Program Translat Med, Dept Med, Sao Paulo, Brazil
hcfmusp.author.externalBACURAU, Reury Frank Pereira:Univ Sao Paulo, Sch Arts Sci & Humanities, Sao Paulo, Brazil
hcfmusp.author.externalPASSOS, Clevia Santos:Univ Fed Sao Paulo, Div Nephrol, Dept Med, Sao Paulo, Brazil
hcfmusp.author.externalCENEDEZE, Marcos Antonio:Univ Fed Sao Paulo, Div Nephrol, Dept Med, Sao Paulo, Brazil
hcfmusp.author.externalPASSOS, Michelle Tiveron:Univ Fed Sao Paulo, Div Nephrol, Dept Med, Sao Paulo, Brazil
hcfmusp.author.externalCAMARA, Niels Olsen Saraiva:Univ Fed Sao Paulo, Div Nephrol, Dept Med, Sao Paulo, Brazil; Univ Sao Paulo, Inst Biomed Sci, Sao Paulo, Brazil
hcfmusp.citation.scopus6
hcfmusp.contributor.author-fmusphcFLAVIA GOMES MACHADO
hcfmusp.contributor.author-fmusphcALVARO PACHECO E SILVA FILHO
hcfmusp.description.beginpage190
hcfmusp.description.endpage197
hcfmusp.description.volume213
hcfmusp.origemWOS
hcfmusp.origem.pubmed30352243
hcfmusp.origem.scopus2-s2.0-85055294449
hcfmusp.origem.wosWOS:000448413900024
hcfmusp.publisher.cityOXFORDeng
hcfmusp.publisher.countryENGLANDeng
hcfmusp.relation.referenceArias SCA, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0056215eng
hcfmusp.relation.referenceBergamaschi CT, 1997, MED SCI SPORT EXER, V29, P169, DOI 10.1097/00005768-199702000-00001eng
hcfmusp.relation.referenceBronas UG, 2009, ADV CHRONIC KIDNEY D, V16, P449, DOI 10.1053/j.ackd.2009.07.005eng
hcfmusp.relation.referenceCaso G, 2005, CURR OPIN CLIN NUTR, V8, P73, DOI 10.1097/00075197-200501000-00011eng
hcfmusp.relation.referenceCheema B, 2010, NEPHROLOGY, V15, P454, DOI 10.1111/j.1440-1797.2009.01261.xeng
hcfmusp.relation.referenceCheema BS, 2014, SPORTS MED, V44, P1125, DOI 10.1007/s40279-014-0176-8eng
hcfmusp.relation.referenceCorrea-Costa M, 2012, EUR J PHARMACOL, V689, P233, DOI 10.1016/j.ejphar.2012.05.024eng
hcfmusp.relation.referenceDiment BC, 2015, MED SCI SPORT EXER, V47, P1390, DOI 10.1249/MSS.0000000000000562eng
hcfmusp.relation.referenceDonnelly JE, 2009, MED SCI SPORT EXER, V41, P459, DOI 10.1249/MSS.0b013e3181949333eng
hcfmusp.relation.referenceEghbalzadeh K, 2014, NITRIC OXIDE-BIOL CH, V37, P28, DOI 10.1016/j.niox.2013.12.009eng
hcfmusp.relation.referenceEsfahani PS, 2013, INT J PREVENTIVE MED, V4, pS78eng
hcfmusp.relation.referenceFujihara CK, 2007, AM J PHYSIOL-RENAL, V292, pF1810, DOI 10.1152/ajprenal.00521.2006eng
hcfmusp.relation.referenceGleeson M, 2011, NAT REV IMMUNOL, V11, P607, DOI 10.1038/nri3041eng
hcfmusp.relation.referenceGoncalves ARR, 2004, AM J PHYSIOL-RENAL, V286, pF945, DOI 10.1152/ajprenal.00238.2003eng
hcfmusp.relation.referenceGrimm Jr R. H., 1997, KIDNEY INT S, V63, pS10eng
hcfmusp.relation.referenceJohansen KL, 2006, J AM SOC NEPHROL, V17, P2307, DOI 10.1681/ASN.2006010034eng
hcfmusp.relation.referenceJohansen KL, 2012, AM J KIDNEY DIS, V59, P126, DOI 10.1053/j.ajkd.2011.10.008eng
hcfmusp.relation.referenceJoles JA, 2013, CLIN EXP PHARMACOL P, V40, P600, DOI 10.1111/1440-1681.12140eng
hcfmusp.relation.referenceKosmadakis GC, 2010, NEPHRON CLIN PRACT, V115, pE7, DOI 10.1159/000286344eng
hcfmusp.relation.referenceLee JongUn, 2016, Chonnam Med J, V52, P81, DOI 10.4068/cmj.2016.52.2.81eng
hcfmusp.relation.referenceLewis D, 2010, J REN CARE, V36, P27, DOI 10.1111/j.1755-6686.2010.00173.xeng
hcfmusp.relation.referenceLuiz RD, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0055363eng
hcfmusp.relation.referenceMak RH, 2011, J CACHEXIA SARCOPENI, V2, P9, DOI 10.1007/s13539-011-0019-5eng
hcfmusp.relation.referenceMolsted S, 2014, BIOMED RES INT, DOI 10.1155/2014/176190eng
hcfmusp.relation.referenceMOORHEAD JF, 1982, LANCET, V2, P1309eng
hcfmusp.relation.referenceMoraes MR, 2012, J HUM HYPERTENS, V26, P533, DOI 10.1038/jhh.2011.67eng
hcfmusp.relation.referenceNeves R., 2016, ARQ BRAS CARDIOL, V106eng
hcfmusp.relation.referenceOda H, 1998, NEPHROL DIAL TRANSPL, V13, P45, DOI 10.1093/ndt/13.suppl_1.45eng
hcfmusp.relation.referencePassos CS, 2012, CAN J PHYSIOL PHARM, V90, P201, DOI [10.1139/Y11-120, 10.1139/y11-120]eng
hcfmusp.relation.referencePassos MT, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0123753eng
hcfmusp.relation.referenceNeves RVP, 2016, ARQ BRAS CARDIOL, V106, P201, DOI 10.5935/abc.20160019eng
hcfmusp.relation.referencePedersen BK, 2008, PHYSIOL REV, V88, P1379, DOI 10.1152/physrev.90100.2007eng
hcfmusp.relation.referencePeng CC, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0037388eng
hcfmusp.relation.referenceMiyagi MYS, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0108543eng
hcfmusp.relation.referenceSantana HAP, 2013, AGING CLIN EXP RES, V25, P43, DOI 10.1007/s40520-013-0017-xeng
hcfmusp.relation.referenceSasaki M, 2011, ACTA MED OKAYAMA, V65, P81eng
hcfmusp.relation.referenceCorrea CS, 2015, J SPORT MED PHYS FIT, V55, P1037eng
hcfmusp.relation.referenceSouza MK, 2018, LIFE SCI, V206, P93, DOI 10.1016/j.lfs.2018.05.034eng
hcfmusp.relation.referenceStride M, 2011, BRIT J HOSP MED, V72, P200, DOI 10.12968/hmed.2011.72.4.200eng
hcfmusp.relation.referenceTremblay AJ, 2004, ATHEROSCLEROSIS, V172, P367, DOI 10.1016/j.atherosclerosis.2003.11.011eng
hcfmusp.relation.referenceWalsh NP, 2011, EXERC IMMUNOL REV, V17, P6eng
hcfmusp.relation.referenceWatson EL, 2015, AM J KIDNEY DIS, V66, P249, DOI 10.1053/j.ajkd.2014.10.019eng
hcfmusp.relation.referenceWilkinson TJ, 2016, SCAND J MED SCI SPOR, V26, P985, DOI 10.1111/sms.12714eng
hcfmusp.relation.referenceXie FY, 2017, ENDOCR J, V64, P685, DOI 10.1507/endocrj.EJ17-0012eng
hcfmusp.relation.referenceY. Ishikawa, 2012, EXP DIABETES RES, V2012eng
hcfmusp.scopus.lastupdate2024-05-10
relation.isAuthorOfPublicationdeafa5fe-63d9-46d8-890d-c3fea758824b
relation.isAuthorOfPublicationc717779e-613a-4cc1-9b3e-8b276ace2bac
relation.isAuthorOfPublication.latestForDiscoverydeafa5fe-63d9-46d8-890d-c3fea758824b
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
art_MORAES_Resistance_training_downregulates_macrophages_infiltration_in_the_kidney_2018.PDF
Tamanho:
1.19 MB
Formato:
Adobe Portable Document Format
Descrição:
publishedVersion (English)
Baixar
Coleções
Artigos e Materiais de Revistas Científicas - FM/Outros
Artigos e Materiais de Revistas Científicas - ODS/03