Systemic Chemotherapy Interferes in Homocysteine Metabolism in Breast Cancer Patients

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorYAMASHITA, Eliana K.
dc.contributor.authorTEIXEIRA, Bianca M.
dc.contributor.authorYOSHIHARA, Renata N.
dc.contributor.authorKUNIYOSHI, Renata K.
dc.contributor.authorALVES, Beatriz C. A.
dc.contributor.authorGEHRKE, Flavia S.
dc.contributor.authorVILAS-BOAS, Viviane A.
dc.contributor.authorCORREIA, Joao A.
dc.contributor.authorAZZALIS, Ligia A.
dc.contributor.authorJUNQUEIRA, Virginia B. C.
dc.contributor.authorPEREIRA, Edimar Cristiano
dc.contributor.authorFONSECA, Fernando L. A.
dc.date.accessioned2014-09-30T14:46:31Z
dc.date.available2014-09-30T14:46:31Z
dc.date.issued2014
dc.description.abstractBackground Hyperhomocysteinemia in breast cancer (BC) patients can be a risk factor for thromboembolic events. This study aimed to evaluate homocysteine and its cofators (folic acid and vitamin B12) concentrations and platelet count at diagnosis of BC, 3 and 6 months after the beginning of chemotherapy treatment and to correlate them with clinical data. Methods Thirty-five BC patients were included; blood samples were obtained by venipuncture. Plasmatic Hcy and cofactors concentrations were measured by competitive chemiluminescent enzyme immunoassay method. Platelet count was done using an automated analyzer. Statistical analysis was performed using the software SPSS. Results During chemotherapy, homocysteine (P = 0.032) and vitamin B12 (P < 0.001) concentrations increased, while folate and platelets decreased (P < 0.001). Among the clinical data, the menopausal status showed significant positive correlation (P = 0.022) with homocysteine concentration increase. Conclusions Evaluation of homocysteine concentrations during chemotherapy is extremely important because their levels increase during chemotherapy treatment, thus increasing the risk of thromboembolism development.
dc.description.indexMEDLINE
dc.description.sponsorshipFAPESP [2009/54343-0 2009/54342-4]
dc.identifier.citationJOURNAL OF CLINICAL LABORATORY ANALYSIS, v.28, n.2, p.157-162, 2014
dc.identifier.doi10.1002/jcla.21660
dc.identifier.eissn1098-2825
dc.identifier.issn0887-8013
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/7732
dc.language.isoeng
dc.publisherJOHN WILEY & SONS INC
dc.relation.ispartofJournal of Clinical Laboratory Analysis
dc.rightsrestrictedAccess
dc.rights.holderCopyright JOHN WILEY & SONS INC
dc.subjecthomocysteine
dc.subjectfolic acid
dc.subjectvitamin B 12
dc.subjectbreast neoplasms
dc.subjectchemotherapy and thromboembolism
dc.subject.othercirculating tumor-cells
dc.subject.othervenous thromboembolism
dc.subject.otherperipheral-blood
dc.subject.otheradjuvant therapy
dc.subject.otherthrombosis
dc.subject.otherrisk
dc.subject.wosMedical Laboratory Technology
dc.titleSystemic Chemotherapy Interferes in Homocysteine Metabolism in Breast Cancer Patients
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalYAMASHITA, Eliana K.:ABC, Sch Med, Dept Hematol & Oncol, Santo Andre, SP, Brazil
hcfmusp.author.externalTEIXEIRA, Bianca M.:ABC, Sch Med, Dept Hematol & Oncol, Santo Andre, SP, Brazil
hcfmusp.author.externalYOSHIHARA, Renata N.:ABC, Sch Med, Dept Hematol & Oncol, Santo Andre, SP, Brazil
hcfmusp.author.externalALVES, Beatriz C. A.:ABC, Sch Med, Dept Hematol & Oncol, Santo Andre, SP, Brazil
hcfmusp.author.externalGEHRKE, Flavia S.:ABC, Sch Med, Dept Hematol & Oncol, Santo Andre, SP, Brazil
hcfmusp.author.externalVILAS-BOAS, Viviane A.:ABC, Sch Med, Dept Hematol & Oncol, Santo Andre, SP, Brazil
hcfmusp.author.externalCORREIA, Joao A.:ABC, Sch Med, Dept Hematol & Oncol, Santo Andre, SP, Brazil
hcfmusp.author.externalAZZALIS, Ligia A.:Univ Fed Sao Paulo, Dept Biol Sci, BR-09972270 Diadema, SP, Brazil
hcfmusp.author.externalJUNQUEIRA, Virginia B. C.:Univ Fed Sao Paulo, Dept Biol Sci, BR-09972270 Diadema, SP, Brazil
hcfmusp.author.externalPEREIRA, Edimar Cristiano:Univ Fed Sao Paulo, Dept Biol Sci, BR-09972270 Diadema, SP, Brazil
hcfmusp.author.externalFONSECA, Fernando L. A.:ABC, Sch Med, Dept Hematol & Oncol, Santo Andre, SP, Brazil; Univ Fed Sao Paulo, Dept Biol Sci, BR-09972270 Diadema, SP, Brazil
hcfmusp.citation.scopus18
hcfmusp.contributor.author-fmusphcRENATA KELLY KUNIYOSHI
hcfmusp.description.beginpage157
hcfmusp.description.endpage162
hcfmusp.description.issue2
hcfmusp.description.volume28
hcfmusp.origemWOS
hcfmusp.origem.pubmed24395112
hcfmusp.origem.scopus2-s2.0-84896105774
hcfmusp.origem.wosWOS:000332840500013
hcfmusp.publisher.cityHOBOKEN
hcfmusp.publisher.countryUSA
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hcfmusp.remissive.sponsorshipFAPESP
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