Development of a platform for the production of multiple modal chelating and imaging agents using desferrioxamine and bovine albumin as a model

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art_CORREIA_Development_of_a_platform_for_the_production_of_2021.PDF (1.01 MB)
Citações na Scopus
0
Tipo de produção
article
Data de publicação
2021
DOI
Scopus
Web of Science
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER INTERNATIONAL PUBLISHING AG
Autores
CORREIA, Lucas Antonio Arias
GARCIA, Rodrigo Santos
COLNAGO, Luiz Alberto
ESPOSITO, Breno Pannia
Citação
CHEMICAL PAPERS, v.75, n.3, p.1157-1163, 2021
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The linker p-SCN-Bz-desferrioxamine was used as a conjugating agent to bovine serum albumin. The conjugate (BSA-DFO) did not display relevant structural alterations in comparison with the native protein. BSA-DFO was able to bind iron in a high affinity, antioxidant form similar to the native siderophore desferrioxamine. The gadolinium complex of BSA-DFO displayed 7-10 times higher relaxivities compared to the low molecular weight complex. Preparation of the radiotracers(68)Ga(BSA-DFO) and(89)Zr(BSA-DFO) in high radiochemical yields was accomplished quickly in mild conditions. These results indicate that BSA-DFO might be useful as an alternative treatment for iron overload disorders, and as a platform for the production of radiotracers or contrast agents for magnetic resonance imaging.
Palavras-chave
Desferrioxamine, Albumin, Iron, Gadolinium, Gallium-68, Zirconium-89
URI
https://observatorio.fm.usp.br/handle/OPI/40038
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Coleções
Artigos e Materiais de Revistas Científicas - FM/Outros
Artigos e Materiais de Revistas Científicas - FM/MDR
Artigos e Materiais de Revistas Científicas - HC/InRad
Artigos e Materiais de Revistas Científicas - LIM/43