Hypocaloric high-protein diet improves clinical and biochemical markers in patients with nonalcoholic fatty liver disease (NAFLD)

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorDUARTE, Sebastiao Mauro Bezerra
dc.contributor.authorFAINTUCH, Joel
dc.contributor.authorSTEFANO, Jose Tadeu
dc.contributor.authorOLIVEIRA, Maria Beatriz Sobral de
dc.contributor.authorMAZO, Daniel Ferraz de Campos
dc.contributor.authorRABELO, Fabiola
dc.contributor.authorVANNI, Denise
dc.contributor.authorNOGUEIRA, Monize Aydar
dc.contributor.authorCARRILHO, Flair Jose
dc.contributor.authorOLIVEIRA, Claudia Pinto Marques Souza de
dc.date.accessioned2014-04-28T22:01:27Z
dc.date.available2014-04-28T22:01:27Z
dc.date.issued2014
dc.description.abstractObjective: To investigate the role of hypocaloric high-protein diet, a prospective clinical study was conducted in NAFLD patients. Research methods and procedures: Pre-versus post-interventional data were analyzed in 48 stable NAFLD patients (submitted to a hypocaloric high-protein diet during 75 days. Variables included anthropometrics (body mass index/ BMI and waist circumference/WC), whole-body and segmental bioimpedance analysis and biochemical tests. Diet compliance was assessed by interviews every two weeks. Results: BMI, WC and body fat mass remained relatively stable (-1.3%, -1.8% and -2.5% respectively, no significance). HDL- cholesterol increased (P < 0.05) whereas total, LDL and VLDL cholesterol, triglycerides, aspartate aminotransferase/AST, gamma glutamyltransferase/GGT, alkaline phosphatase/AP, fasting blood glucose and glycated hemoglobin/HbA1c decreased (P < 0.05). When patients were stratified according to increase (22/48, 45.8%) and decrease (21/48, 43.8%) of BMI, association between weight decrease and liver benefit could be elicited in such circumstances for ALT, AP and AST/ALT ratio. No change could be demonstrated in patients who gained weight. Multivariate assessment confirmed that waist circumference, ferritin, triacylglycerol, and markers of glucose homeostasis were the most relevant associated with liver enzymes. Discussion: Ours results are consistent with the literature of calorie restriction in the management of NAFLD. Changes in lifestyle and weight loss are recommended for NAFLD patients. European guidelines also support this recommendation. Conclusion: This is the first study that demonstrated that a high protein, hypocaloric diet were associated with improvement of lipid profile, glucose homeostasis and liver enzymes in NAFLD independent on BMI decrease or body fat mass reduction.
dc.description.indexMEDLINE
dc.identifier.citationNUTRICION HOSPITALARIA, v.29, n.1, p.94-101, 2014
dc.identifier.doi10.3305/nh.2014.29.1.7068
dc.identifier.issn0212-1611
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/5385
dc.language.isoeng
dc.publisherAULA MEDICA EDICIONES
dc.relation.ispartofNutricion Hospitalaria
dc.rightsopenAccess
dc.rights.holderCopyright AULA MEDICA EDICIONES
dc.subjectNAFLD
dc.subjectHypocaloric diet
dc.subjectHyperproteic diet
dc.subjectLiver enzymes
dc.subject.otherinsulin-resistance
dc.subject.otherweight-loss
dc.subject.othermetabolic syndrome
dc.subject.otherobese-patients
dc.subject.othersteatohepatitis
dc.subject.othermanagement
dc.subject.otherglucose
dc.subject.othertransaminases
dc.subject.otherintervention
dc.subject.othercarbohydrate
dc.subject.wosNutrition & Dietetics
dc.titleHypocaloric high-protein diet improves clinical and biochemical markers in patients with nonalcoholic fatty liver disease (NAFLD)
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalVANNI, Denise:Univ Sao Paulo, Sch Med, Dept Gastroenterol, Clin Div,Hepatol Branch LIM 07, BR-05403000 Sao Paulo, Brazil
hcfmusp.citation.scopus32
hcfmusp.contributor.author-fmusphcSEBASTIAO MAURO BEZERRA DUARTE
hcfmusp.contributor.author-fmusphcJOEL FAINTUCH
hcfmusp.contributor.author-fmusphcJOSE TADEU STEFANO
hcfmusp.contributor.author-fmusphcMARIA BEATRIZ SOBRAL DE OLIVEIRA
hcfmusp.contributor.author-fmusphcDANIEL FERRAZ DE CAMPOS MAZO
hcfmusp.contributor.author-fmusphcFABIOLA RABELO
hcfmusp.contributor.author-fmusphcMONIZE AYDAR NOGUEIRA SANTOS
hcfmusp.contributor.author-fmusphcFLAIR JOSE CARRILHO
hcfmusp.contributor.author-fmusphcCLAUDIA PINTO MARQUES SOUZA DE OLIVEIRA
hcfmusp.description.beginpage94
hcfmusp.description.endpage101
hcfmusp.description.issue1
hcfmusp.description.volume29
hcfmusp.origemWOS
hcfmusp.origem.pubmed24483967
hcfmusp.origem.scieloSCIELO:S0212-16112014000100013
hcfmusp.origem.scopus2-s2.0-84896873760
hcfmusp.origem.wosWOS:000331340100013
hcfmusp.publisher.cityMADRID
hcfmusp.publisher.countrySPAIN
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