Novel role of cholesteryl ester transfer protein (CETP): attenuation of adiposity by enhancing lipolysis and brown adipose tissue activity

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorRAPOSO, Helena F.
dc.contributor.authorFORSYTHE, Patricia
dc.contributor.authorCHAUSSE, Bruno
dc.contributor.authorCASTELLI, Julia Z.
dc.contributor.authorMORAES-VIEIRA, Pedro M.
dc.contributor.authorNUNES, Valeria S.
dc.contributor.authorOLIVEIRA, Helena C. F.
dc.date.accessioned2021-02-18T13:56:55Z
dc.date.available2021-02-18T13:56:55Z
dc.date.issued2021
dc.description.abstractObjective: The systemic function of CETP has been well characterized. CETP plasma activity reduces HDL cholesterol and thus increases the risk of atherosclerosis. Here, we investigated whether CETP expression modulate adiposity. Methods: Body adiposity and energy metabolism related assays and gene/protein expression were compared in CETP transgenic and non-transgenic mice and in hamsters treated with CETP neutralizing antibody. Results: We found that transgenic mice expressing human CETP present less white adipose tissue mass and lower leptinemia than nontransgenic (NTg) littermates. No differences were found in physical activity, food intake, fat fecal excretion, lipogenesis or exogenous lipid accumulation in adipose depots. Nonetheless, adipose lipolysis rates and whole-body energy expenditure were elevated in CETP mice. In accordance, lipolysis-related gene expression and protein content were increased in visceral and brown adipose tissue (BAT). In addition, we verified increased BAT temperature and oxygen consumption. These results were confirmed in two other animal models: 1) hamsters treated with CETP neutralizing antibody and 2) an independent line of transgenic mice expressing simian CETP. Conclusions: These findings reveal a novel anti-adipogenic role for CETP.eng
dc.description.indexMEDLINEeng
dc.identifier.citationMETABOLISM-CLINICAL AND EXPERIMENTAL, v.114, article ID 154429, 14p, 2021
dc.identifier.doi10.1016/j.metabol.2020.154429
dc.identifier.eissn1532-8600
dc.identifier.issn0026-0495
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/39589
dc.language.isoeng
dc.publisherW B SAUNDERS CO-ELSEVIER INCeng
dc.relation.ispartofMetabolism-Clinical and Experimental
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright W B SAUNDERS CO-ELSEVIER INCeng
dc.subjectCETPeng
dc.subjectAdiposityeng
dc.subjectLipolysiseng
dc.subjectOxygen consumptioneng
dc.subjectBrown adipose tissueeng
dc.subject.otherhormone-sensitive lipaseeng
dc.subject.otherdiet-induced obesityeng
dc.subject.othertransgenic miceeng
dc.subject.othergene-expressioneng
dc.subject.othercell-sizeeng
dc.subject.otherhigh-riskeng
dc.subject.otherplasmaeng
dc.subject.otherglucoseeng
dc.subject.otheratherosclerosiseng
dc.subject.othermetabolismeng
dc.subject.wosEndocrinology & Metabolismeng
dc.titleNovel role of cholesteryl ester transfer protein (CETP): attenuation of adiposity by enhancing lipolysis and brown adipose tissue activityeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalRAPOSO, Helena F.:Univ Estadual Campinas, Dept Struct & Funct Biol, Inst Biol, Campinas, SP, Brazil; Univ Estadual Campinas, Obes & Comorbid Res Ctr, Inst Biol, Campinas, SP, Brazil
hcfmusp.author.externalFORSYTHE, Patricia:Univ Estadual Campinas, Dept Struct & Funct Biol, Inst Biol, Campinas, SP, Brazil
hcfmusp.author.externalCHAUSSE, Bruno:Univ Estadual Campinas, Obes & Comorbid Res Ctr, Inst Biol, Campinas, SP, Brazil
hcfmusp.author.externalCASTELLI, Julia Z.:Univ Estadual Campinas, Dept Struct & Funct Biol, Inst Biol, Campinas, SP, Brazil; Univ Estadual Campinas, Obes & Comorbid Res Ctr, Inst Biol, Campinas, SP, Brazil
hcfmusp.author.externalMORAES-VIEIRA, Pedro M.:Univ Estadual Campinas, Obes & Comorbid Res Ctr, Inst Biol, Campinas, SP, Brazil; Univ Estadual Campinas, Lab Immunometab, Dept Genet Evolut Microbiol & Immunol, Inst Biol, Campinas, SP, Brazil; Univ Estadual Campinas, Expt Med Res Cluster EMRC, Campinas, SP, Brazil
hcfmusp.author.externalOLIVEIRA, Helena C. F.:Univ Estadual Campinas, Dept Struct & Funct Biol, Inst Biol, Campinas, SP, Brazil; Univ Estadual Campinas, Obes & Comorbid Res Ctr, Inst Biol, Campinas, SP, Brazil
hcfmusp.citation.scopus8
hcfmusp.contributor.author-fmusphcVALERIA SUTTI NUNES
hcfmusp.description.articlenumber154429
hcfmusp.description.volume114
hcfmusp.origemWOS
hcfmusp.origem.pubmed33166579
hcfmusp.origem.scopus2-s2.0-85096388578
hcfmusp.origem.wosWOS:000599880200018
hcfmusp.publisher.cityPHILADELPHIAeng
hcfmusp.publisher.countryUSAeng
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