MicroRNAs as Diagnostic and Prognostic Biomarkers in Ischemic Stroke-A Comprehensive Review and Bioinformatic Analysis

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorEYILETEN, Ceren
dc.contributor.authorWICIK, Zofia
dc.contributor.authorROSA, Salvatore De
dc.contributor.authorMIROWSKA-GUZEL, Dagmara
dc.contributor.authorSOPLINSKA, Aleksandra
dc.contributor.authorINDOLFI, Ciro
dc.contributor.authorJASTRZEBSKA-KURKOWSKA, Iwona
dc.contributor.authorCZLONKOWSKA, Anna
dc.contributor.authorPOSTULA, Marek
dc.date.accessioned2019-02-21T17:28:09Z
dc.date.available2019-02-21T17:28:09Z
dc.date.issued2018
dc.description.abstractStroke is the second-most common cause of death worldwide. The pathophysiology of ischemic stroke (IS) is related to inflammation, atherosclerosis, blood coagulation, and platelet activation. MicroRNAs (miRNAs) play important roles in physiological and pathological processes of neurodegenerative diseases and progression of certain neurological diseases, such as IS. Several different miRNAs, and their target genes, are recognized to be involved in the pathophysiology of IS. The capacity of miRNAs to simultaneously regulate several target genes underlies their unique value as diagnostic and prognostic markers in IS. In this review, we focus on the role of miRNAs as diagnostic and prognostic biomarkers in IS. We discuss the most common and reliable detection methods available and promising tests currently under development. We also present original results from bioinformatic analyses of published results, identifying the ten most significant genes (HMGB1, YWHAZ, PIK3R1, STAT3, MAPK1, CBX5, CAPZB, THBS1, TNFRSF10B, RCOR1) associated with inflammation, blood coagulation, and platelet activation and targeted by miRNAs in IS. Additionally, we created miRNA-gene target interaction networks based on Gene Ontology (GO) information derived from publicly available databases. Among our most interesting findings, miR-19a-3p is the most widely modulated miRNA across all selected ontologies and might be proposed as novel biomarker in IS to be tested in future studies.eng
dc.description.indexPubMedeng
dc.description.sponsorshipNational Science Center, Poland [2017/25/N/NZ5/00545]
dc.description.sponsorshipDepartment of Experimental and Clinical Pharmacology, Medical University of Warsaw, Centre for Preclinical Research and Technology CEPT, Warsaw, Poland
dc.identifier.citationCELLS, v.7, n.12, article ID 249, 34p, 2018
dc.identifier.doi10.3390/cells7120249
dc.identifier.issn2073-4409
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/30914
dc.language.isoeng
dc.publisherMDPIeng
dc.relation.ispartofCells
dc.rightsopenAccesseng
dc.rights.holderCopyright MDPIeng
dc.subjectmiRNAeng
dc.subjectbioinformatic analysiseng
dc.subjectischemic strokeeng
dc.subjectmiRNA-gene target interactioneng
dc.subjectnetworkeng
dc.subjectbiomarkereng
dc.subjectdiagnosiseng
dc.subjectprognosiseng
dc.subject.otherc-reactive proteineng
dc.subject.othertranscoronary concentration gradientseng
dc.subject.othertissue factor expressioneng
dc.subject.othercirculating micrornaseng
dc.subject.otherpotential biomarkerseng
dc.subject.othersmooth-muscleeng
dc.subject.otherlabel-freeeng
dc.subject.otherserumeng
dc.subject.otherdiseaseeng
dc.subject.otheridentificationeng
dc.subject.wosCell Biologyeng
dc.titleMicroRNAs as Diagnostic and Prognostic Biomarkers in Ischemic Stroke-A Comprehensive Review and Bioinformatic Analysiseng
dc.typearticleeng
dc.type.categoryrevieweng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryPolônia
hcfmusp.affiliation.countryItália
hcfmusp.affiliation.countryisopl
hcfmusp.affiliation.countryisoit
hcfmusp.author.externalEYILETEN, Ceren:Med Univ Warsaw, Dept Expt & Clin Pharmacol, Ctr Preclin Res & Technol CEPT, PL-02097 Warsaw, Poland
hcfmusp.author.externalROSA, Salvatore De:Magna Graecia Univ Catanzaro, Dept Med & Surg Sci, Div Cardiol, I-88100 Catanzaro, Italy
hcfmusp.author.externalMIROWSKA-GUZEL, Dagmara:Med Univ Warsaw, Dept Expt & Clin Pharmacol, Ctr Preclin Res & Technol CEPT, PL-02097 Warsaw, Poland
hcfmusp.author.externalSOPLINSKA, Aleksandra:Med Univ Warsaw, Dept Expt & Clin Pharmacol, Ctr Preclin Res & Technol CEPT, PL-02097 Warsaw, Poland
hcfmusp.author.externalINDOLFI, Ciro:Magna Graecia Univ Catanzaro, Dept Med & Surg Sci, Div Cardiol, I-88100 Catanzaro, Italy; Consiglio Nazl Ric IFC, URT CNR, Dept Med, Viale Europa S-N, I-88100 Catanzaro, Italy
hcfmusp.author.externalJASTRZEBSKA-KURKOWSKA, Iwona:Inst Psychiat & Neurol, Dept Neurol 2, PL-02957 Warsaw, Poland
hcfmusp.author.externalCZLONKOWSKA, Anna:Inst Psychiat & Neurol, Dept Neurol 2, PL-02957 Warsaw, Poland
hcfmusp.author.externalPOSTULA, Marek:Med Univ Warsaw, Dept Expt & Clin Pharmacol, Ctr Preclin Res & Technol CEPT, PL-02097 Warsaw, Poland
hcfmusp.citation.scopus122
hcfmusp.contributor.author-fmusphcZOFIA AGNIESZKA WICIK
hcfmusp.description.articlenumber249
hcfmusp.description.issue12
hcfmusp.description.volume7
hcfmusp.origemWOS
hcfmusp.origem.pubmed30563269
hcfmusp.origem.scopus2-s2.0-85067628500
hcfmusp.origem.wosWOS:000455320700027
hcfmusp.publisher.cityBASELeng
hcfmusp.publisher.countrySWITZERLANDeng
hcfmusp.relation.referenceAgarwal V, 2015, ELIFE, V4, DOI 10.7554/eLife.05005eng
hcfmusp.relation.reference[Anonymous], 2017, EUROPEAN CARDIOVASCUeng
hcfmusp.relation.referenceBader Andreas G., 2012, Frontiers in Genetics, V3, P120, DOI 10.3389/fgene.2012.00120eng
hcfmusp.relation.referenceBam M, 2018, MOL NEUROBIOL, V55, P1419, DOI 10.1007/s12035-016-0347-8eng
hcfmusp.relation.referenceBeal CC, 2010, J NEUROSCI NURS, V42, P80, DOI 10.1097/JNN.0b013e3181ce5c70eng
hcfmusp.relation.referenceBenjamin EJ, 2017, CIRCULATION, V135, pE146, DOI 10.1161/CIR.0000000000000485eng
hcfmusp.relation.referenceBonauer A, 2009, SCIENCE, V324, P1710, DOI 10.1126/science.1174381eng
hcfmusp.relation.referenceBushati N, 2008, CURR OPIN NEUROBIOL, V18, P292, DOI 10.1016/j.conb.2008.07.001eng
hcfmusp.relation.referenceCarino A, 2016, BIOMED RES INT, DOI 10.1155/2016/3968206eng
hcfmusp.relation.referenceCevik O, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0158287eng
hcfmusp.relation.referenceChang TY, 2014, BMC GENOMICS, V15, DOI 10.1186/1471-2164-15-802eng
hcfmusp.relation.referenceWang YL, 2006, BMC GENOMICS, V7, DOI 10.1186/1471-2164-7-59eng
hcfmusp.relation.referenceWeber M., 2011, CARDIOL RES PRACT, V2011, DOI 10.4061/2011/532915eng
hcfmusp.relation.referenceWu CC, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17030305eng
hcfmusp.relation.referenceWu J, 2017, THROMB HAEMOSTASIS, V117, P992, DOI 10.1160/TH16-08-0606eng
hcfmusp.relation.referenceWu J, 2015, INT J CLIN EXP MED, V8, P21071eng
hcfmusp.relation.referenceYang FH, 2012, J MOL CELL CARDIOL, V52, P761, DOI 10.1016/j.yjmcc.2011.11.013eng
hcfmusp.relation.referenceYang H, 2009, ANGEW CHEM INT EDIT, V48, P8461, DOI 10.1002/anie.200902577eng
hcfmusp.relation.referenceYin KJ, 2013, BRAIN, V136, P1274, DOI 10.1093/brain/awt002eng
hcfmusp.relation.referenceZampetaki A, 2010, CIRC RES, V107, P810, DOI 10.1161/CIRCRESAHA.110.226357eng
hcfmusp.relation.referenceZeng L, 2014, GENE THER, V21, P37, DOI 10.1038/gt.2013.55eng
hcfmusp.relation.referenceZhang XX, 2011, J BIOL CHEM, V286, P1429, DOI 10.1074/jbc.M110.146530eng
hcfmusp.relation.referenceZhou JS, 2014, MOL MED REP, V10, P971, DOI 10.3892/mmr.2014.2245eng
hcfmusp.relation.referenceChen CF, 2005, NUCLEIC ACIDS RES, V33, DOI 10.1093/nar/gni178eng
hcfmusp.relation.referenceChen YJ, 2017, FRONT NEUROL, V8, DOI 10.3389/fneur.2017.00057eng
hcfmusp.relation.referenceChen YS, 2015, J STROKE CEREBROVASC, V24, P2313, DOI 10.1016/j.jstrokecerebrovasdis.2015.06.018eng
hcfmusp.relation.referenceChen ZZ, 2018, CELL PHYSIOL BIOCHEM, V45, P397, DOI 10.1159/000486916eng
hcfmusp.relation.referenceChevillet JR, 2014, P NATL ACAD SCI USA, V111, P14888, DOI 10.1073/pnas.1408301111eng
hcfmusp.relation.referenceChou CH, 2018, NUCLEIC ACIDS RES, V46, pD296, DOI 10.1093/nar/gkx1067eng
hcfmusp.relation.referenceChugh P, 2012, WIRES RNA, V3, P601, DOI 10.1002/wrna.1120eng
hcfmusp.relation.referenceCirillo P, 2005, CARDIOVASC RES, V68, P47, DOI 10.1016/j.cardiores.2005.05.010eng
hcfmusp.relation.referenceCirillo P, 2003, THROMB RES, V112, P51, DOI 10.1016/j.thromres.2003.11.011eng
hcfmusp.relation.referenceCorsten MF, 2010, CIRC-CARDIOVASC GENE, V3, P499, DOI 10.1161/CIRCGENETICS.110.957415eng
hcfmusp.relation.referenceDe Rosa R, 2017, AM J CARDIOL, V120, P15, DOI 10.1016/j.amjcard.2017.03.264eng
hcfmusp.relation.referenceDe Rosa S, 2018, EUR J HEART FAIL, V20, P1000, DOI 10.1002/ejhf.1119eng
hcfmusp.relation.referenceDe Rosa S, 2018, ANN INTERN MED, V168, P343, DOI 10.7326/M17-3033eng
hcfmusp.relation.referenceDe Rosa S, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00002eng
hcfmusp.relation.referenceDe Rosa S, 2015, EXPERIENTIA SUPPL, V106, P139, DOI 10.1007/978-3-0348-0955-9_6eng
hcfmusp.relation.referenceDe Rosa S, 2014, CIRC J, V78, P567, DOI 10.1253/circj.CJ-14-0086eng
hcfmusp.relation.referenceDe Rosa S, 2011, CIRCULATION, V124, P1936, DOI 10.1161/CIRCULATIONAHA.111.037572eng
hcfmusp.relation.referenceDe Rosa S, 2009, J VASC RES, V46, P609, DOI 10.1159/000226229eng
hcfmusp.relation.referenceDervishi I, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-32902-4eng
hcfmusp.relation.referenceDi Ieva A, 2014, NEUROSURGERY, V75, P181, DOI 10.1227/NEU.0000000000000369eng
hcfmusp.relation.referenceDiamanti D, 2013, J HUNTINGTONS DIS, V2, P185, DOI 10.3233/JHD-120042eng
hcfmusp.relation.referenceDoebele C, 2010, BLOOD, V115, P4944, DOI 10.1182/blood-2010-01-264812eng
hcfmusp.relation.referenceDong HF, 2012, ANAL CHEM, V84, P8670, DOI 10.1021/ac301860veng
hcfmusp.relation.referenceDurinck S, 2009, NAT PROTOC, V4, P1184, DOI 10.1038/nprot.2009.97eng
hcfmusp.relation.referenceEminaga Seda, 2013, Curr Protoc Mol Biol, VChapter 4, DOI 10.1002/0471142727.mb0417s103eng
hcfmusp.relation.referenceFerraro D, 2016, SCI REP-UK, V6, DOI 10.1038/srep25540eng
hcfmusp.relation.referenceFichtlscherer S, 2010, CIRC RES, V107, P677, DOI 10.1161/CIRCRESAHA.109.215566eng
hcfmusp.relation.referenceGan CS, 2012, GENET MOL RES, V11, P147, DOI 10.4238/2012.January.27.1eng
hcfmusp.relation.referenceGao JB, 2015, CLIN CHIM ACTA, V450, P176, DOI 10.1016/j.cca.2015.08.014eng
hcfmusp.relation.referenceGareri C, 2016, CIRC RES, V118, P1170, DOI 10.1161/CIRCRESAHA.115.308237eng
hcfmusp.relation.referenceGong Z, 2016, J NEUROL SCI, V361, P150, DOI 10.1016/j.jns.2015.12.047eng
hcfmusp.relation.referenceHe WZ, 2016, J STROKE CEREBROVASC, V25, P1753, DOI 10.1016/j.jstrokecerebrovasdis.2016.03.023eng
hcfmusp.relation.referenceHuang SL, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0163951eng
hcfmusp.relation.referenceJaguszewski M, 2014, EUR HEART J, V35, P999, DOI 10.1093/eurheartj/eht392eng
hcfmusp.relation.referenceJanssen HLA, 2013, NEW ENGL J MED, V368, P1685, DOI 10.1056/NEJMoa1209026eng
hcfmusp.relation.referenceJi QH, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0163645eng
hcfmusp.relation.referenceJia LH, 2015, CELL BIOCHEM FUNCT, V33, P314, DOI 10.1002/cbf.3116eng
hcfmusp.relation.referenceJickling GC, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0099283eng
hcfmusp.relation.referenceJin FQ, 2017, NEUROL SCI, V38, P2015, DOI 10.1007/s10072-017-3071-xeng
hcfmusp.relation.referenceKang K, 2012, J ANIM SCI BIOTECHNO, V3, DOI 10.1186/2049-1891-3-4eng
hcfmusp.relation.referenceLee HJ, 2013, EXP BIOL MED, V238, P339, DOI 10.1258/ebm.2012.012251eng
hcfmusp.relation.referenceLeung LY, 2014, CLIN CHIM ACTA, V433, P139, DOI 10.1016/j.cca.2014.03.007eng
hcfmusp.relation.referenceLi PF, 2015, CELL MOL NEUROBIOL, V35, P433, DOI 10.1007/s10571-014-0139-5eng
hcfmusp.relation.referenceLi YH, 2016, ANN TRANSL MED, V4, DOI 10.21037/atm.2016.03.12eng
hcfmusp.relation.referenceLiang ZX, 2016, PROG NEUROBIOL, V137, P1, DOI 10.1016/j.pneurobio.2015.11.001eng
hcfmusp.relation.referenceLiu LF, 2012, J GERIATR CARDIOL, V9, P28, DOI 10.3724/SP.J.1263.2012.00028eng
hcfmusp.relation.referenceLiu XS, 2013, J BIOL CHEM, V288, P12478, DOI 10.1074/jbc.M112.449025eng
hcfmusp.relation.referenceLiu YP, 2015, J CLIN NEUROSCI, V22, P291, DOI 10.1016/j.jocn.2014.05.042eng
hcfmusp.relation.referenceLong GW, 2013, BMC NEUROL, V13, DOI 10.1186/1471-2377-13-178eng
hcfmusp.relation.referenceLuengo-Fernandez R, 2013, NEUROLOGY, V81, P1588, DOI 10.1212/WNL.0b013e3182a9f45feng
hcfmusp.relation.referenceMick E, 2017, STROKE, V48, P828, DOI 10.1161/STROKEAHA.116.015140eng
hcfmusp.relation.referenceMiller JA, 2008, J NEUROSCI, V28, P1410, DOI 10.1523/JNEUROSCI.4098-07.2008eng
hcfmusp.relation.referenceMoldovan L, 2014, J CELL MOL MED, V18, P371, DOI 10.1111/jcmm.12236eng
hcfmusp.relation.referenceNelson PT, 2008, BRAIN PATHOL, V18, P130, DOI 10.1111/j.1750-3639.2007.00120.xeng
hcfmusp.relation.referenceOuyang YB, 2014, NEUROCHEM INT, V77, P2, DOI 10.1016/j.neuint.2013.12.006eng
hcfmusp.relation.referenceOuyang YB, 2014, NEUROSCI LETT, V565, P53, DOI 10.1016/j.neulet.2013.11.015eng
hcfmusp.relation.referencePanda AC, 2017, NUCLEIC ACIDS RES, V45, P4021, DOI 10.1093/nar/gkw1201eng
hcfmusp.relation.referencePeng GP, 2015, TRANSL STROKE RES, V6, P437, DOI 10.1007/s12975-015-0422-xeng
hcfmusp.relation.referencePolimeni A, 2013, TRENDS CARDIOVAS MED, V23, P9, DOI 10.1016/j.tcm.2012.08.004eng
hcfmusp.relation.referencePordzik J, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00074eng
hcfmusp.relation.referenceRidker PM, 2017, NEW ENGL J MED, V377, P1119, DOI 10.1056/NEJMoa1707914eng
hcfmusp.relation.referenceRoy S, 2011, LAB CHIP, V11, P1886, DOI 10.1039/c0lc00638feng
hcfmusp.relation.referenceSepramaniam S, 2014, INT J MOL SCI, V15, P1418, DOI 10.3390/ijms15011418eng
hcfmusp.relation.referenceShannon P, 2003, GENOME RES, V13, P2498, DOI 10.1101/gr.1239303eng
hcfmusp.relation.referenceSingh V, 2016, ANTIOXID REDOX SIGN, V24, P635, DOI 10.1089/ars.2015.6397eng
hcfmusp.relation.referenceSluijter JPG, 2013, CIRC-CARDIOVASC GENE, V6, P441, DOI 10.1161/CIRCGENETICS.113.000344eng
hcfmusp.relation.referenceSorrentino S, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-017-19136-6eng
hcfmusp.relation.referenceSpinetti G, 2013, CIRC RES, V112, DOI 10.1161/CIRCRESAHA.111.300418eng
hcfmusp.relation.referenceStreit S, 2009, NAT PROTOC, V4, P37, DOI 10.1038/nprot.2008.216eng
hcfmusp.relation.referenceSun J, 2016, J MOL NEUROSCI, V59, P90, DOI 10.1007/s12031-016-0717-8eng
hcfmusp.relation.referenceSzklarczyk D, 2017, NUCLEIC ACIDS RES, V45, pD362, DOI 10.1093/nar/gkw937eng
hcfmusp.relation.referenceTan KS, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0007689eng
hcfmusp.relation.referenceTian CO, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0166688eng
hcfmusp.relation.referenceTiedt S, 2017, CIRC RES, V121, P970, DOI 10.1161/CIRCRESAHA.117.311572eng
hcfmusp.relation.referenceTijsen AJ, 2010, CIRC RES, V106, P1035, DOI 10.1161/CIRCRESAHA.110.218297eng
hcfmusp.relation.referenceTran HV, 2013, BIOSENS BIOELECTRON, V49, P164, DOI 10.1016/j.bios.2013.05.007eng
hcfmusp.relation.referenceTsai PC, 2013, J VASC RES, V50, P346, DOI 10.1159/000351767eng
hcfmusp.relation.referenceVarallyay E, 2008, NAT PROTOC, V3, P190, DOI 10.1038/nprot.2007.528eng
hcfmusp.relation.referenceWang Hao, 2018, Oncotarget, V9, P5600, DOI 10.18632/oncotarget.23789eng
hcfmusp.relation.referenceWang WH, 2014, J STROKE CEREBROVASC, V23, P2607, DOI 10.1016/j.jstrokecerebrovasdis.2014.06.002eng
hcfmusp.relation.referenceWang Y, 2014, BMC NEUROL, V14, DOI 10.1186/1471-2377-14-77eng
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