Lack of evidence to support the association of a single IL28B genotype SNP rs12979860 with the HTLV-1 clinical outcomes and proviral load

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSANABANI, Sabri Saeed
dc.contributor.authorNUKUI, Youko
dc.contributor.authorPEREIRA, Juliana
dc.contributor.authorCOSTA, Antonio Charlys da
dc.contributor.authorOLIVEIRA, Ana Carolina Soares de
dc.contributor.authorPESSOA, Rodrigo
dc.contributor.authorLEAL, Fabio Eudes
dc.contributor.authorSEGURADO, Aluisio C.
dc.contributor.authorKALLAS, Esper Georges
dc.contributor.authorSABINO, Ester Cerdeira
dc.date.accessioned2013-07-30T15:07:47Z
dc.date.available2013-07-30T15:07:47Z
dc.date.issued2012
dc.description.abstractBackground: The Interleukin 28B (IL28B) rs12979860 polymorphisms was recently reported to be associated with the human T-cell leukemia virus type 1 (HTLV-1) proviral load (PvL) and the development of the HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Methods: In an attempt to examine this hypothesis, we assessed the association of the rs12979860 genotypes with HTLV-1 PvL levels and clinical status in 112 unrelated Brazilian subjects (81 HTLV-1 asymptomatic carriers, 24 individuals with HAM/TSP and 7 with Adult T cell Leukemia/Lymphoma (ATLL)). Results: All 112 samples were successfully genotyped and their PvLs compared. Neither the homozygote TT nor the heterozygote CT mutations nor the combination genotypes (TT/CT) were associated with a greater PvL. We also observed no significant difference in allele distribution between asymptomatic carriers and patients with HTLV-1 associated HAM/TSP. Conclusions: Our study failed to support the previously reported positive association between the IL28B rs12979860 polymorphisms and an increased risk of developing HAM/TSP in the Brazilian population.
dc.description.indexMEDLINE
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP) [2010/08550-1, 2011/12297-2]
dc.identifier.citationBMC INFECTIOUS DISEASES, v.12, article ID 374, 6p, 2012
dc.identifier.doi10.1186/1471-2334-12-374
dc.identifier.issn1471-2334
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/729
dc.language.isoeng
dc.publisherBIOMED CENTRAL LTD
dc.relation.ispartofBMC Infectious Diseases
dc.rightsopenAccess
dc.rights.holderCopyright BIOMED CENTRAL LTD
dc.subjectHTLV-1
dc.subjectILB 28 polymorphisms
dc.subjectHAM/TSP
dc.subjectProviral load
dc.subject.othert-cell leukemia
dc.subject.othervirus type-i
dc.subject.otherchronic hepatitis-c
dc.subject.othergenome-wide association
dc.subject.othertumor-necrosis-factor
dc.subject.othergenetic-variation
dc.subject.otherinterleukin-10 promoter
dc.subject.otherspastic paraparesis
dc.subject.otherhiv-infection
dc.subject.otherpolymorphism
dc.subject.wosInfectious Diseases
dc.titleLack of evidence to support the association of a single IL28B genotype SNP rs12979860 with the HTLV-1 clinical outcomes and proviral load
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalNUKUI, Youko:Univ Sao Paulo, Dept Hematol, Sao Paulo, Brazil
hcfmusp.author.externalPESSOA, Rodrigo:Univ Sao Paulo, Clin Lab, Dept Pathol, LIM 03,HC,Sch Med, Sao Paulo, Brazil
hcfmusp.citation.scopus13
hcfmusp.contributor.author-fmusphcSABRI SAEED MOHAMMED ALSANABANI
hcfmusp.contributor.author-fmusphcJULIANA PEREIRA
hcfmusp.contributor.author-fmusphcANTONIO CHARLYS DA COSTA
hcfmusp.contributor.author-fmusphcANA CAROLINA SOARES DE OLIVEIRA
hcfmusp.contributor.author-fmusphcFABIO EUDES LEAL
hcfmusp.contributor.author-fmusphcALUISIO AUGUSTO COTRIM SEGURADO
hcfmusp.contributor.author-fmusphcESPER GEORGES KALLAS
hcfmusp.contributor.author-fmusphcESTER CERDEIRA SABINO
hcfmusp.description.articlenumber374
hcfmusp.description.volume2012
hcfmusp.lim.ref2012
hcfmusp.origemWOS
hcfmusp.origem.pubmed23259930
hcfmusp.origem.scopus2-s2.0-84872566566
hcfmusp.origem.wosWOS:000314097700001
hcfmusp.publisher.cityLONDON
hcfmusp.publisher.countryENGLAND
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