Clinical features of tic-related obsessive-compulsive disorder: results from a large multicenter study

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorALVARENGA, Pedro Gomes de
dc.contributor.authorMATHIS, Maria Alice de
dc.contributor.authorALVES, Anna Claudia Dominguez
dc.contributor.authorROSARIO, Maria Conceicao do
dc.contributor.authorFOSSALUZA, Victor
dc.contributor.authorHOUNIE, Ana Gabriela
dc.contributor.authorMIGUEL, Euripedes Constantino
dc.contributor.authorTORRES, Albina Rodrigues
dc.date.accessioned2013-07-30T15:18:53Z
dc.date.available2013-07-30T15:18:53Z
dc.date.issued2012
dc.description.abstractObjective. To evaluate the clinical features of obsessive-compulsive disorder (OCD) patients with comorbid tic disorders (TD) in a large, multicenter, clinical sample. Method. A cross-sectional study was conducted that included 813 consecutive OCD outpatients from the Brazilian OCD Research Consortium and used several instruments of assessment, including the Yale-Brown Obsessive-Compulsive Scale, the Dimensional Yale-Brown Obsessive-Compulsive Scale, the Yale Global Tic Severity Scale (YGTSS), the USP Sensory Phenomena Scale, and the Structured Clinical Interview for DSM-IV Axis I Disorders. Results. The sample mean current age was 34.9 years old (SE 0.54), and the mean age at obsessive-compulsive symptoms (OCS) onset was 12.8 years old (SE 0.27). Sensory phenomena were reported by 585 individuals (72% of the sample). The general lifetime prevalence of TD was 29.0% (n=236), with 8.9% (n=72) presenting Tourette syndrome, 17.3% (n=5141) chronic motor tic disorder, and 2.8% (n=523) chronic vocal tic disorder. The mean tic severity score, according to the YGTSS, was 27.2 (SE 1.4) in the OCD1TD group. Compared to OCD patients without comorbid TD, those with TD (OCD1TD group, n=236) were more likely to be males (49.2% vs. 38.5%, p<005) and to present sensory phenomena and comorbidity with anxiety disorders in general: separation anxiety disorder, social phobia, specific phobia, generalized anxiety disorder, post-traumatic stress disorder, attention-deficit hyperactivity disorder, impulse control disorders in general, and skin picking. Also, the ""aggressive,"" ""sexual/religious,"" and ""hoarding"" symptom dimensions were more severe in the OCD+TD group. Conclusion. Tic-related OCD may constitute a particular subgroup of the disorder with specific phenotypical characteristics, but its neurobiological underpinnings remain to be fully disentangled.
dc.description.indexMEDLINE
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP, Foundation for the Support of Research in the State of Sao Paulo) [08/57598-7, 2005-55628-8, 06/61459-7]
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ, Brazilian Council for Scientific and Technological Development) [521369/96-7]
dc.identifier.citationCNS SPECTRUMS, v.17, n.2, p.87-93, 2012
dc.identifier.doi10.1017/S1092852912000491
dc.identifier.issn1092-8529
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/1073
dc.language.isoeng
dc.publisherCAMBRIDGE UNIV PRESS
dc.relation.ispartofCNS Spectrums
dc.rightsrestrictedAccess
dc.rights.holderCopyright CAMBRIDGE UNIV PRESS
dc.subjectComorbidity
dc.subjectobsessive-compulsive disorder
dc.subjecttic disorder
dc.subjectTourette syndrome
dc.subject.otherquality-of-life
dc.subject.otherspectrum disorders
dc.subject.othertourettes-syndrome
dc.subject.otherpsychometric-properties
dc.subject.otherrepetitive behaviors
dc.subject.othersymptom dimensions
dc.subject.otherscale
dc.subject.otherepidemiology
dc.subject.otherchildren
dc.subject.otheronset
dc.subject.wosClinical Neurology
dc.subject.wosPsychiatry
dc.titleClinical features of tic-related obsessive-compulsive disorder: results from a large multicenter study
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalROSARIO, Maria Conceicao do:Fed Univ Sao Paulo UNIFESP, Dept Psychiat, Sao Paulo, Brazil
hcfmusp.author.externalFOSSALUZA, Victor:Univ Sao Paulo, Sch Med, Dept Psychiat, BR-05403010 Sao Paulo, Brazil
hcfmusp.author.externalTORRES, Albina Rodrigues:Univ Estadual Paulista, UNESP, Botucatu Med Sch, Dept Neurol Psychol & Psychiat, Botucatu, SP, Brazil
hcfmusp.citation.scopus58
hcfmusp.contributor.author-fmusphcPEDRO GOMES DE ALVARENGA
hcfmusp.contributor.author-fmusphcMARIA ALICE SIMOES DE MATHIS
hcfmusp.contributor.author-fmusphcANNA CLAUDIA DOMINGUEZ ALVES
hcfmusp.contributor.author-fmusphcANA GABRIELA HOUNIE
hcfmusp.contributor.author-fmusphcEURIPEDES CONSTANTINO MIGUEL FILHO
hcfmusp.description.beginpage87
hcfmusp.description.endpage93
hcfmusp.description.issue2
hcfmusp.description.volume17
hcfmusp.lim.ref2012
hcfmusp.origemWOS
hcfmusp.origem.pubmed22789066
hcfmusp.origem.scopus2-s2.0-84869227485
hcfmusp.origem.wosWOS:000305909200004
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
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hcfmusp.remissive.sponsorshipCNPq
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