Carbohydrate supplementation delays DNA damage in elite runners during intensive microcycle training

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSOUSA, Maysa Vieira de
dc.contributor.authorMADSEN, Klavs
dc.contributor.authorFUKUI, Rosa
dc.contributor.authorSANTOS, Aritania
dc.contributor.authorSILVA, Maria Elizabeth Rossi da
dc.date.accessioned2013-07-30T17:21:53Z
dc.date.available2013-07-30T17:21:53Z
dc.date.issued2012
dc.description.abstractThe aim of this study was to evaluate the effect of carbohydrate supplementation on free plasma DNA and conventional markers of training and tissue damage in long-distance runners undergoing an overload training program. Twenty-four male runners were randomly assigned to two groups (CHO group and control group). The participants were submitted to an overload training program (days 1-8), followed by a high-intensity intermittent running protocol (10 x 800 m) on day 9. The runners received maltodextrin solution (CHO group) or zero energy placebo solution as the control equivalent before, during, and after this protocol. After 8 days of intensive training, baseline LDH levels remained constant in the CHO group (before: 449.1 +/- 18.2, after: 474.3 +/- 22.8 U/L) and increased in the control group (from 413.5 +/- 23.0 to 501.8 +/- 24.1 U/L, p < 0.05). On day 9, LDH concentrations were lower in the CHO group (509.2 +/- 23.1 U/L) than in the control group (643.3 +/- 32.9 U/L, p < 0.01) post-intermittent running. Carbohydrate ingestion attenuated the increase of free plasma DNA post-intermittent running (48,240.3 +/- 5,431.8 alleles/mL) when compared to the control group (73,751.8 +/- 11,546.6 alleles/mL, p < 0.01). Leukocyte counts were lower in the CHO group than in the control group post-intermittent running (9.1 +/- 0.1 vs. 12.2 +/- 0.7 cells/mu L; p < 0.01) and at 80 min of recovery (10.6 +/- 0.1 vs. 13.9 +/- 1.1 cells/mu L; p < 0.01). Cortisol levels were positively correlated with free plasma DNA, leukocytes, and LDH (all r > 0.4 and p < 0.001). The results showed that ingestion of a carbohydrate beverage resulted in less DNA damage and attenuated the acute post-exercise inflammation response, providing better recovery during intense training.
dc.description.indexMEDLINE
dc.description.sponsorshipState of Sao Paulo Research Foundation (FAPESP), Brazil
dc.description.sponsorshipFAPESP
dc.identifier.citationEUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, v.112, n.2, p.493-500, 2012
dc.identifier.doi10.1007/s00421-011-2000-6
dc.identifier.issn1439-6319
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/1392
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofEuropean Journal of Applied Physiology
dc.rightsrestrictedAccess
dc.rights.holderCopyright SPRINGER
dc.subjectFree plasma DNA
dc.subjectTissue damage
dc.subjectInflammation
dc.subjectOvertraining
dc.subjectIntensive training
dc.subject.otherserum creatine-kinase
dc.subject.otherinduced muscle damage
dc.subject.otherendurance exercise
dc.subject.otherstress hormones
dc.subject.otherovertraining syndrome
dc.subject.otherresistance exercise
dc.subject.othercirculating dna
dc.subject.otherimmune function
dc.subject.othersoccer players
dc.subject.otherrelease
dc.subject.wosPhysiology
dc.subject.wosSport Sciences
dc.titleCarbohydrate supplementation delays DNA damage in elite runners during intensive microcycle training
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryDinamarca
hcfmusp.affiliation.countryisodk
hcfmusp.author.externalMADSEN, Klavs:Aarhus Univ, Dept Sport Sci, Aarhus, Denmark
hcfmusp.citation.scopus15
hcfmusp.contributor.author-fmusphcMAYSA VIEIRA DE SOUSA
hcfmusp.contributor.author-fmusphcROSA TSUNECHIRO FUKUI
hcfmusp.contributor.author-fmusphcARITANIA SOUSA SANTOS
hcfmusp.contributor.author-fmusphcMARIA ELIZABETH ROSSI DA SILVA
hcfmusp.description.beginpage493
hcfmusp.description.endpage500
hcfmusp.description.issue2
hcfmusp.description.volume112
hcfmusp.lim.ref2012
hcfmusp.origemWOS
hcfmusp.origem.pubmed21584681
hcfmusp.origem.scopus2-s2.0-84856557304
hcfmusp.origem.wosWOS:000301567300010
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
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hcfmusp.remissive.sponsorshipFAPESP
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