Physical activity, muscle strength, and exercise capacity 3 months after severe sepsis and septic shock

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Arquivos
art_BORGES_Physical_activity_muscle_strength_and_exercise_capacity_3_2015.PDF (1.18 MB)
Citações na Scopus
60
Tipo de produção
article
Data de publicação
2015
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER
Autores
Citação
INTENSIVE CARE MEDICINE, v.41, n.8, p.1433-1444, 2015
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
To quantify the physical activity in daily life (PADL), muscle strength, and exercise capacity in the short and medium term in survivors of severe sepsis and septic shock. Prospective cohort study with a follow-up from hospital admission to 3 months after hospital discharge. Seventy-two patients admitted to the ICU for severe sepsis or septic shock and a control group of healthy sedentary subjects (n = 50) were enrolled. All patients had their PADL quantified by an accelerometer during their hospital stay and 3 months after. Exercise capacity and handgrip and quadriceps muscle strength were also evaluated. During hospitalization, patients spent the majority of their time inactive in a lying or sitting position (90 +/- A 34 % of daily time). Physical inactivity was partially reduced 3 months after (58 +/- A 20 % of daily time). However, the time patients spent walking was only 63 % of the time reported for healthy subjects. Patients also showed lower movement intensity when compared with controls (2.1 +/- A 0.3 vs 2.5 +/- A 0.4 m/s(2)). At hospital discharge, muscle strength and exercise capacity were approximately 54 % of the predicted value, and these parameters showed significant increase in patients 3 months after (70 % of predicted value). Multivariable analysis demonstrated that the use of systemic corticosteroids and hospitalization time negatively influenced quadriceps strength and exercise capacity at the time of hospital discharge. Our results suggest that survivors of sepsis admitted to the ICU have a substantial reduction in physical activity, exercise capacity, and muscle strength compared to healthy subjects that persist even 3 months after hospital discharge.
Palavras-chave
Intensive care unit, Muscle weakness, Physical activity, Recovery of function, Sepsis, Survivors
URI
https://observatorio.fm.usp.br/handle/OPI/11644
Referências
  1. Ali NA, 2008, AM J RESP CRIT CARE, V178, P261, DOI [10.1164/rccm.200712-1829OC, 10.1164/rccm.200712-18290C]
  2. Crapo RO, 2002, AM J RESP CRIT CARE, V166, P111, DOI 10.1164/rccm.166/1/111
  3. Bednarik J, 2005, J NEUROL, V252, P343, DOI 10.1007/s00415-005-0654-x
  4. Black LF, 1999, AM REV RESPIR DIS, V99, P969
  5. BOLTON CF, 1984, J NEUROL NEUROSUR PS, V47, P1223, DOI 10.1136/jnnp.47.11.1223
  6. Borges RC, 2012, COPD, V9, P596, DOI 10.3109/15412555.2012.705364
  7. Bosscha K, 2001, CRIT CARE MED, V29, P1539, DOI 10.1097/00003246-200108000-00007
  8. Brown WJ, 2012, BRIT J SPORT MED, V46, P664, DOI 10.1136/bjsports-2011-090529
  9. Burtin C, 2009, CRIT CARE MED, V37, P2499, DOI 10.1097/CCM.0b013e3181a38937
  10. Callahan Leigh Ann, 2009, Crit Care Med, V37, pS354, DOI 10.1097/CCM.0b013e3181b6e439
  11. Coakley JH, 1998, INTENS CARE MED, V24, P801, DOI 10.1007/s001340050669
  12. De Jonghe B, 2007, CRIT CARE MED, V35, P2007, DOI 10.1097/01.ccm.0000281450.01881.d8
  13. De Jonghe B, 2002, JAMA-J AM MED ASSOC, V288, P2859, DOI 10.1001/jama.288.22.2859
  14. Dellinger RP, 2013, INTENS CARE MED, V39, P165, DOI 10.1007/s00134-012-2769-8
  15. Denehy L, 2012, PHYS THER, V92, P1507, DOI 10.2522/ptj.20110411
  16. Dijkstra B, 2010, AGE AGEING, V39, P259, DOI 10.1093/ageing/afp249
  17. Dijkstra B, 2010, ARCH PHYS MED REHAB, V91, P1272, DOI 10.1016/j.apmr.2010.05.004
  18. Eikermann M, 2013, INTENS CARE MED, V39, P2200, DOI 10.1007/s00134-013-3132-4
  19. Eikermann M, 2006, INTENS CARE MED, V32, P251, DOI 10.1007/s00134-005-0029-x
  20. Enright PL, 1998, AM J RESP CRIT CARE, V158, P1384
  21. Fan E, 2014, CRIT CARE MED, V42, P849, DOI 10.1097/CCM.0000000000000040
  22. Fletcher SN, 2003, CRIT CARE MED, V31, P1012, DOI 10.1097/01.CCM.0000053651.38421.D9
  23. Giantomaso T, 2003, CLIN REHABIL, V17, P394, DOI 10.1191/0269215503cr626oa
  24. Guarneri B, 2008, J NEUROL NEUROSUR PS, V79, P838, DOI 10.1136/jnnp.2007.142430
  25. Gunther CM, 2008, J HAND SURG-AM, V33A, P558, DOI 10.1016/j.jhsa.2008.01.008
  26. Hermans G, 2007, AM J RESP CRIT CARE, V175, P480, DOI 10.1164/rccm.200605-665OC
  27. Hernandes NA, 2009, J BRAS PNEUMOL, V35, P949, DOI 10.1590/S1806-37132009001000002
  28. Herridge MS, 2011, NEW ENGL J MED, V364, P1293, DOI 10.1056/NEJMoa1011802
  29. Herridge MS, 2003, NEW ENGL J MED, V348, P683, DOI 10.1056/NEJMoa022450
  30. Heyland DK, 2000, CRIT CARE MED, V28, P3599, DOI 10.1097/00003246-200011000-00006
  31. Hogrel JY, 2007, ARCH PHYS MED REHAB, V88, P1289, DOI 10.1016/j.apmr.2007.07.011
  32. Hough CL, 2009, INTENS CARE MED, V35, P63, DOI 10.1007/s00134-008-1304-4
  33. Khan J, 2008, CRIT CARE CLIN, V24, P165, DOI 10.1016/j.ccc.2007.10.004
  34. Laghi F, 2014, INTENS CARE MED, V40, P1220, DOI 10.1007/s00134-014-3340-6
  35. Langer D, 2009, THORAX, V64, P641, DOI 10.1136/thx.2008.112102
  36. Lareau SC, 1998, HEART LUNG, V27, P159, DOI 10.1016/S0147-9563(98)90003-6
  37. Latronico N, 2011, LANCET NEUROL, V10, P931, DOI 10.1016/S1474-4422(11)70178-8
  38. Latronico Nicola, 2009, Crit Care Med, V37, pS316, DOI 10.1097/CCM.0b013e3181b6f9f3
  39. Moss M, 2014, INTENS CARE MED, V40, P683, DOI 10.1007/s00134-014-3251-6
  40. Neder JA, 1999, BRAZ J MED BIOL RES, V32, P703
  41. PATE RR, 1995, JAMA-J AM MED ASSOC, V273, P402, DOI 10.1001/jama.273.5.402
  42. PERL TM, 1995, JAMA-J AM MED ASSOC, V274, P338, DOI 10.1001/jama.274.4.338
  43. Peterson MJ, 2009, J GERONTOL A-BIOL, V64, P61, DOI 10.1093/gerona/gln001
  44. Pitta F, 2006, EUR RESPIR J, V27, P1040, DOI 10.1183/09031936.06.00064105
  45. Pitta F, 2005, AM J RESP CRIT CARE, V171, P972, DOI 10.1164/rccm.200407-855OC
  46. Pitta F, 2009, RESP MED, V103, P421, DOI 10.1016/j.rmed.2008.09.019
  47. Pitta F, 2006, CHEST, V129, P536, DOI 10.1378/chest.129.3.536
  48. Reid CL, 2004, CLIN NUTR, V23, P273, DOI 10.1016/S0261-5614(03)00129-8
  49. Samitz G, 2011, INT J EPIDEMIOL, V40, P1382, DOI 10.1093/ije/dyr112
  50. SANDERS SH, 1983, PAIN, V15, P399, DOI 10.1016/0304-3959(83)90075-1
  51. Schweickert WD, 2009, LANCET, V373, P1874, DOI 10.1016/S0140-6736(09)60658-9
  52. Schweickert WD, 2007, CHEST, V131, P1541, DOI 10.1378/chest.06-2065
  53. Shephard RJ, 2003, BRIT J SPORT MED, V37, P197, DOI 10.1136/bjsm.37.3.197
  54. Stevens RD, 2007, INTENS CARE MED, V33, P1876, DOI 10.1007/s00134-007-0772-2
  55. Troosters T, 2010, RESP MED, V104, P1005, DOI 10.1016/j.rmed.2010.01.012
  56. Villumsen M, 2014, J AGING PHYS ACTIV, DOI [10.1123/japa.2014-0115, DOI 10.1123/JAPA.2014-0115]
  57. Vorrink SNW, 2011, RESP RES, V12, DOI 10.1186/1465-9921-12-33
  58. Wickerson L, 2013, J CARDIOPULM REHABIL, V33, P106, DOI 10.1097/HCR.0b013e3182839293
  59. Winkelman Chris, 2004, AACN Clin Issues, V15, P74, DOI 10.1097/00044067-200401000-00006
  60. WITT NJ, 1991, CHEST, V99, P176, DOI 10.1378/chest.99.1.176
  61. Wollersheim T, 2014, INTENS CARE MED, V40, P528, DOI 10.1007/s00134-014-3224-9

Coleções
Artigos e Materiais de Revistas Científicas - FM/MFT
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HU
Artigos e Materiais de Revistas Científicas - LIM/20
Artigos e Materiais de Revistas Científicas - LIM/51