MAYSA VIEIRA DE SOUSA
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/18 - Laboratório de Carboidratos e Radioimunoensaios, Hospital das Clínicas, Faculdade de Medicina
LIM/18 - Laboratório de Carboidratos e Radioimunoensaios, Hospital das Clínicas, Faculdade de Medicina
20 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 20
- The ""Football is Medicine"" platformscientific evidence, large-scale implementation of evidence-based concepts and future perspectives(2018) KRUSTRUP, P.; WILLIAMS, C. A.; MOHR, M.; HANSEN, P. R.; HELGE, E. W.; ELBE, A. -M.; SOUSA, M. de; DVORAK, J.; JUNGE, A.; HAMMAMI, A.; HOLTERMANN, A.; LARSEN, M. N.; KIRKENDALL, D.; SCHMIDT, J. F.; ANDERSEN, T. R.; BUONO, P.; RORTH, M.; PARNELL, D.; OTTESEN, L.; BENNIKE, S.; NIELSEN, J. J.; MENDHAM, A. E.; ZAR, A.; UTH, J.; HORNSTRUP, T.; BRASSO, K.; NYBO, L.; KRUSTRUP, B. R.; MEYER, T.; AAGAARD, P.; ANDERSEN, J. L.; HUBBALL, H.; REDDY, P. A.; RYOM, K.; LOBELO, F.; BARENE, S.; HELGE, J. W.; FATOUROS, I. G.; NASSIS, G. P.; XU, J. C.; PETTERSEN, S. A.; CALBET, J. A.; SEABRA, A.; REBELO, A. N.; FIGUEIREDO, P.; POVOAS, S.; CASTAGNA, C.; MILANOVIC, Z.; BANGSBO, J.; RANDERS, M. B.; BRITO, J.
- Highlight article: Dietary protein and exercise for preservation of lean mass and perspectives on type 2 diabetes prevention(2019) SOUSA, Maysa Vieira de; SOARES, Diana Bento da Silva; CARACA, Elaine Reis; CARDOSO, RonaldoSedentary lifestyle and aging favor the increasing prevalence of obesity and type 2 diabetes and their comorbidities. The loss of lean body mass reduces muscle strength, resulting in impaired functional capacity and leading to increased risks of chronic diseases with advancing age. Besides aging, conditions such as inappetence, social isolation, and inadequate dietary intake cause the loss of lean body mass and increased abdominal fatty mass, resulting in sarcopenic obesity and predisposition to type 2 diabetes. Compared to younger people, this condition is more common in the elderly owing to natural changes in body composition associated with aging. Lifestyle changes such as increased physical activity and improved dietary behaviors are effective for preventing the occurrence of comorbidities. Regarding muscle nutrition, besides caloric adequacy, meeting the requirements for the consumption of dietary amino acids and proteins is important for treating sarcopenia and sarcopenic obesity because muscle tissue mainly consists of proteins and is, therefore, the largest reservoir of amino acids in the body. Thus, this review discusses the effects of dietary protein on the preservation of lean body mass, improvements in the functional capacity of muscle tissue, and prevention of chronic diseases such as type 2 diabetes. In addition, we address the effects of regular physical training associated with dietary protein strategies on lean body mass, body fat loss, and muscle strength in the elderly at a risk for type 2 diabetes development. Impact statement Diabetes mellitus is a worldwide health problem associated with obesity and sedentary lifestyle, which predisposes affected individuals to mortality and morbidity. Additionally, aging and unhealthy lifestyle behaviors increase inflammation and insulin resistance, contributing to the reduction of cytokines related to muscle nutrition and the suppression of lipogenesis, resulting in the development of sarcopenic obesity. One strategy for the prevention of T2D is the avoidance of secondary aging by participating in healthy action programs, including exercise and nutritional interventions. This minireview of several studies demonstrates the impact of physical activity and nutritional interventions on gaining or preserving muscle mass and on the functional aspects of muscles with aging. It provides information on the effect of protein, leucine, beta-hydroxy-beta-methylbutyrate (HMB), and creatine supplementation on muscle mass, strength, and volume gain and on the prevention of the progressive decrease in muscle mass with aging in combination with maintaining regular physical activity.
- Positive effects of football on fitness, lipid profile, and insulin resistance in Brazilian patients with type 2 diabetes(2014) SOUSA, M. V. de; FUKUI, R.; KRUSTRUP, P.; PEREIRA, R. M. R.; SILVA, P. R. S.; RODRIGUES, A. C.; ANDRADE, J. L. de; HERNANDEZ, A. J.; SILVA, M. E. R. daWe evaluated the effects of recreational football training combined with calorie-restricted diet (football+diet) vs calorie-restricted diet alone (diet) on aerobic fitness, lipid profile, and insulin resistance indicators in type 2 diabetes (T2D) patients. Forty-four T2D patients aged 48-68 years (27 females, 17 males) were randomly allocated to the football+diet group (FDG; n=22) or to the diet group (DG; n=22), of whom 19 FDG and 15 DG subjects completed the study. The football training was performed for 3x40min/week for 12 weeks. Dual-energy X-ray absorptiometry scanning, treadmill testing, and fasting blood samplings were performed pre and post-intervention. After 12 weeks, maximal oxygen uptake (VO2max) was elevated (P<0.05) by 10 +/- 4% in FDG but not in DG (-3 +/- 4%, P<0.05). After 12 weeks, reductions in blood triglycerides (0.4 +/- 0.1mmol/L), total cholesterol (0.6 +/- 0.2mmol/L), low-density lipoprotein, and very low-density lipoprotein levels were observed only in FDG. Fat mass decreased (P<0.05) by 3.4 +/- 0.4kg in FDG and 3.7 +/- 0.4kg in DG. The lower (P<0.05) glucagon and homeostatic model assessment of insulin resistance indicated an improvement in insulin sensitivity in FDG. In conclusion, football combined with restricted diet was effective in enhancing VO2max, reducing total cholesterol and triglycerides, and increasing insulin sensitivity, potentially providing better tools for the prevention of T2D complications than diet alone.
- Relationship between body mass index with dietary fiber intake and skinfolds-differences among bodybuilders who train during morning and nocturne period(2012) MONTEIRO, J. C. V.; PIMENTEL, G. D.; SOUSA, M. V.Background: The prevalence of overweight individuals has increased in recent years. Moreover, the importance of a healthy diet is associated with the practice of physical activity and attempt to verify the achievement of physical exercise influences on food choice. However, it relationship between food intake and physical activity have not been studied. Aim: To evaluate if the period in which the trainings are conducted, morning and nocturne, interfere qualitatively and quantitatively in food consumption as well as verify possible associations between anthropometric profiles and dietary habits. Methods: We collected data from 33 adult volunteers, between men and women, practitioners of bodybuilding. Results: A total of 33 volunteers were interviewed (18 (54.5%) were men and 15 (45.5%) were women). Regarding anthropometric data, it turns out that that the volunteers of the two periods had similar characteristics, differentiating only weight. The consumption of nutritional supplements was observed in 30.77% of the practitioners in the morning period vs. 35% for the nocturne. Considering macronutrient intake, there was a significant difference in the consumption of protein between the periods. The consumption during nocturne period was greater (126 +/- 5% of the daily requirement) than the morning period (115.7 +/- 2%). As for micro-nutrients, calcium intake was greater among men when compared to women. There was a positive correlation between the BMI, and arm circumference for practitioners of the morning period. Conclusion: This study show that the practitioners who train in the morning have quietly better eating habits than those in the nocturne period, however both are inappropriate.
- Skeletal muscle gene expression in older adults with type 2 diabetes mellitus undergoing calorie-restricted diet and recreational sports training - a randomized clinical trial(2022) SOARES, Diana Bento da Silva; SHINJO, Samuel Katsuyuki; SANTOS, Aritania Sousa; JESUS, Joyce de Cassia Rosa de; SCHENK, Simon; CASTRO, Gabriela Salim de; ZANOTELI, Edmar; KRUSTRUP, Peter; SILVA, Maria Elizabeth Rossi da; SOUSA, Maysa Vieira deAims: This study aimed to evaluate the impact of a 12-week calorie-restricted diet and recreational sports training on gene expressions IL-15, ATROGIN-1 and MURF-1 in skeletal muscle of T2D patients. Methods: Older adults with T2D (n = 39, 60 +/- 6.0 years, BMI 33.5 +/- 0.6 kg/m(2)) were randomly allocated to Diet+Soccer (DS), Diet+Running (DR) or Diet (D). The training sessions were moderate-to-high-intensity and performed 3 x 40 min/week for 12-weeks. Gene expression from vastus lateralis muscle obtained by qRT-PCR, dual-energy X-ray and fasting blood testing measurements were performed before and after 12-weeks. Statistical analysis adopted were two-way ANOVA and Paired t-test for gene expression, and RM-ANOVA test for the remainder variables. Results: Total body weight was reduced in similar to 4 kg representing body fat mass in all groups after 12-weeks (P < 0.05). HbA1c values decreased in all groups post-intervention. Lipids profile improved in the training groups (P < 0.05) after 12-weeks. ATROGIN-1 and MURF-1 mRNA reduced in the DS (1.084 +/- 0.14 vs. 0.754 +/- 1.14 and 1.175 +/- 0.34 vs. 0.693 +/- 0.12, respectively; P < 0.05), while IL-15 mRNA increased in the DR (1.056 +/- 0.12 vs. 1.308 +/- 0.13; P < 0.05) after 12-weeks intervention. Conclusion: Recreational training with a moderate calorie-restricted diet can downregulates the expression of atrophy-associated myokines and increases the expression of anti-inflammatory gene IL-15.
- Effect of sprint and strength training on glucoregulatory hormones: Effect of advanced age(2017) SELLAMI, Maha; ABDERRAHMAN, Abderraouf Ben; KEBSI, Wiem; SOUSA, Maysa Vieira De; ZOUHAL, HassaneThe aim of this study was to examine the effect of high-intensity sprint and strength training (HISST) on glucoregulatory hormones in young (20 years) and middle-aged (40 years) men. Thirty-six moderately trained men participated as volunteers in this study. After medical examination, eligible subjects were randomly assigned to one of four groups according to their age: a young training group (21.3 +/- 1.3 yrs, YT, n = 9), a young control group (21.4 +/- 1.7 yrs, YC, n = 9), a middle-aged training group (40.7 +/- 1.8 yrs, AT, n = 9), and a middle-aged control group (40.5 +/- 1.8 yrs, AC, n = 9). YT and AT participated in HISST for 13 weeks. Before and after HISST, all participants performed the Wingate Anaerobic Test (WAnT). Blood samples were collected at rest, after warm-up (50% VO2max), immediately post-WAnT, and 10 min post-WAnT. Before HISST, we observed significantly higher (P < 0.05) glucose concentrations in AT (5.86 +/- 0.32 mmol. L-1) compared to YT (4.24 +/- 0.79 mmol. L-1) at rest, and in response to WAnT (6.56 +/- 0.63 mmol. L-1 vs. 5.33 +/- 0.81 mmol. L-1). Cortisol levels were significantly higher (P< 0.05) in AT than in YT in response to WAnT (468 +/- 99.50 ng. mL(-1) vs. 382 +/- 64.34 ng. mL(-1)). Catecholamine levels measured at rest and in response to WAnT rose in a similar fashion. After HISST, this ""age effect'' disappeared at rest and in response to exercise in the trained groups (YT and AT). Changes in hormone concentrations with intense training are due to adaptive changes in various tissues, especially in the skeletal muscle and liver in trained subjects. HISST may, at least in part, counteract the negative ""age effect'' on glucose metabolism.
- Plyometric exercise combined with high-intensity interval training improves metabolic abnormalities in young obese females more so than interval training alone(2016) RACIL, Ghazi; ZOUHAL, Hassane; ELMONTASSAR, Wassim; ABDERRAHMANE, Abderraouf Ben; SOUSA, Maysa Vieira De; CHAMARI, Karim; AMRI, Mohamed; COQUART, Jeremy B.The aim of this study was to compare the effects of 12 weeks of high-intensity interval training (HIIT) with the effects of 12 weeks of plyometric exercise combined with HIIT (P+HIIT) on anthropometric, biochemical, and physical fitness data in young obese females. Sixty-eight participants (age, 16.6 +/- 1.3 y; body mass, 82.8 +/- 5.0 kg; body fat, 39.4% +/- 3.3%; body mass index z score, 2.9 +/- 0.4) were assigned to 1 of 3 groups: HIIT (2 blocks per session of 6-8 bouts of 30-s runs at 100% velocity at peak oxygen uptake, with 30-s active recovery between bouts at 50% velocity at peak oxygen uptake (n = 23)); P+HIIT (2 blocks per session of 3 different 15-s plyometric exercises with 15-s passive recoveries, totaling 2 min for each plyometric exercise + the same HIIT program (n = 26)); or control (no exercise (n = 19)). Anthropometric (body mass, body mass index z score, body fat, lean body mass, and waist circumference), biochemical (plasma glucose, insulin, leptin and adiponectin concentrations, leptin/adiponectin ratio, and homeostasis model assessment of insulin resistance (HOMA-IR)), physical fitness (peak oxygen uptake, velocity at peak oxygen uptake, squat jump, and countermovement jump performances), and energy intake data were collected. Both training programs improved the anthropometric, biochemical, and physical fitness variables. However, the P+HIIT program induced greater improvements than did the HIIT program in lean body mass (+3.0% +/- 1.7%), plasma glucose and leptin concentrations (-11.0% +/- 4.7% and -23.8% +/- 5.8%, respectively), plasma leptin/adiponectin ratio (-40.9% +/- 10.9%), HOMA-IR (-37.3% +/- 6.2%), and squat jump performance (22.2% +/- 7.5%). Taken together, these findings suggest that adding plyometric exercises to a HIIT program may be more beneficial than HIIT alone in obese female adolescents.
- Carbohydrate beverages attenuate bone resorption markers in elite runners(2014) SOUSA, Maysa Vieira de; PEREIRA, Rosa Maria R.; FUKUI, Rosa; CAPARBO, Valeria Falco; SILVA, Maria Elizabeth Rossi daObjective. We evaluated the effects of carbohydrate (CHO) supplementation on markers of bone turnover in elite runners. Design. Twenty-four male runners were randomly assigned to two groups - a CHO and a control (CON) group - using a double-blind design. The participants were submitted to an overload training program (days 1-8), followed by a high-intensity intermittent running protocol (10 x 800 m) on day 9. They received a maltodextrin solution (CHO group) or a placebo solution as the CON equivalent, before, during, and after these protocols. Results. After 8 days of intensive training, baseline levels of osteocalcin (OC) decreased in both CHO and CON groups (before: 28.8 +/- 3.6 and 26.6 +/- 2.4 ng/ml, after: 24.8 +/- 3.0 and 21.9 +/- 1.6 ng/ml, respectively, p < 0.01). On day 9, at 80 min of the recovery period, carboxy-terminal of telopeptide type I collagen (CTX) serum concentration was suppressed in the CHO group (0.3 +/- 0.1 ng/ml) vs. 0.6 +/- 0.0 ng/ml for the CON group (p < 0.01). CHO supplementation was effective in decreasing CTX levels from baseline to recovery (0.5 +/- 0.1 ng/mL to 0.3 +/- 0.1 ng/mL, p < 0.001), while an increase from 0.4 +/- 0.0 ng/mL to 0.6 +/- 0.0 ng/mL (p < 0.001) was observed in the CON group. Conclusion. CHO beverage ingestion attenuated the exercise-induced increase in CTX concentration, suggesting that CHO supplementation is a potential strategy to prevent bone damage in athletes.
- Combination of recreational soccer and caloric restricted diet reduces markers of protein catabolism and cardiovascular risk in patients with type 2 diabetes(2017) SOUSA, M. Vieira De; FUKUI, R.; KRUSTRUP, P.; DAGOGO-JACK, S.; SILVA, M. E. Rossi DaModerate calorie-restricted diets and exercise training prevent loss of lean mass and cardiovascular risk. Because adherence to routine exercise recommendation is generally poor, we utilized recreational soccer training as a novel therapeutic exercise intervention in type 2 diabetes (T2D) patients. We compared the effects of acute and chronic soccer training plus calorie-restricted diet on protein catabolism and cardiovascular risk markers in T2D. Fifty-one T2D patients (61.1 +/- 6.4 years, 29 females: 22 males) were randomly allocated to the soccer+diet-group (SDG) or to the dietgroup (DG). The 40-min soccer sessions were held 3 times per week for 12 weeks. Nineteen participants attended 100% of scheduled soccer sessions, and none suffered any injuries. The SDG group showed higher levels of growth hormone (GH), free fatty acids and ammonia compared with DG. After 12 weeks, insulin-like growth factor binding protein (IGFPB)-3 and glucose levels were lower in SDG, whereas insulin-like growth factor (IGF)-1/ IGFBP-3 ratio increased in both groups. After the last training session, an increase in IGF-1/IGFBP-3 and attenuation in ammonia levels were suggestive of lower muscle protein catabolism. Recreational soccer training was popular and safe, and was associated with decreased plasma glucose and IGFBP-3 levels, decreased ammoniagenesis, and increased lipolytic activity and IGF-1/IGFBP-3 ratio, all indicative of attenuated catabolism.
- Executive summary: Elite women's football-Performance, recovery, diet, and health(2022) MOHR, Magni; BRITO, Joao; SOUSA, Maysa de; PETTERSEN, Svein ArneThe present special issue of Scandinavian Journal of Medicine & Science in Sports focuses on performance, recovery, diet, and health in elite women's football. Beside this summary, an editorial, topic reviews, and original articles written by several of the most published authors in football research are presented. It is, for example, highlighted that there is a great gender inequality in football research in favor of men, especially within elite football populations. Therefore, the broad-spectrum content of the special issue with focus on several performance areas in women's football, recovery strategies, nutrition, and psychological factors is highly warranted. Several of the topics examined and data presented are examined for the first on elite women's football, and therefore, we hope that this special issue will contribute to gender balance the research and emphasis on football in both genders.