Is Gilbert Syndrome a new risk factor for breast cancer?
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Citações na Scopus
4
Tipo de produção
article
Data de publicação
2011
Título da Revista
ISSN da Revista
Título do Volume
Editora
CHURCHILL LIVINGSTONE
Autores
BUGANO, Diogo Diniz Gomes
FRANCISCO, Alice Aparecida Rodrigues Ferreira
Citação
MEDICAL HYPOTHESES, v.77, n.2, p.162-164, 2011
Resumo
Patients with Gilbert Syndrome have an impaired function of the enzyme UGT1A1, responsible for the degradation of 4-OH-estrogens. These elements are produced by the degradation of estrogens and are well-known carcinogens. In theory, patients with Gilbert Syndrome accumulate 4-OH-estrogens and, therefore, might have a higher risk for breast cancer, especially when exposed to higher levels of estrogens. If this theory is true, a new risk group for breast cancer would be described, producing new insights in breast carcinogenesis.
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Referências
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