Artigos e Materiais de Revistas Científicas - HC/InCor

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A coleção de Artigos e Materiais de Revistas Científicas engloba artigos originais, artigos de revisão, artigos de atualização, artigos técnicos, relatos de experiências, resenhas, ensaios, editoriais, cartas ao editor, debates, notas científicas e técnicas, depoimentos, entrevistas e pontos de vista. Consideram-se como artigos científicos originais os trabalhos redigidos para divulgação de informações e resultados sobre determinada pesquisa científica, publicados em periódico científico após avaliação por outros pesquisadores.


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  • article 0 Citação(ões) na Scopus
    Dyslipidemia: A Narrative Review on Pharmacotherapy
    (2024) OLIVEIRA, Lucas Lentini Herling de; ASSIS, Arthur Cicupira Rodrigues de; GIRALDEZ, Viviane Zorzanelli Rocha; SCUDELER, Thiago Luis; SOARES, Paulo Rogerio
    Dyslipidemia plays a fundamental role in the development and progression of atherosclerosis. Current guidelines for treating dyslipidemia focus on low-density lipoprotein-cholesterol (LDL-C). Despite advances in the pharmacotherapy of atherosclerosis, the most successful agents used to treat this disease-statins-remain insufficient in the primary or secondary prevention of acute myocardial infarction. Advancing therapy for hypercholesterolemia with emerging new drugs, either as monotherapy or in combination, is expected to improve cardiovascular outcomes. An emerging field in dyslipidemia pharmacotherapy is research on genetic therapies and genetic modulation. Understanding the genetic mechanisms underlying lipid alterations may lead to the development of personalized treatments that directly target the genetic causes of dyslipidemia. RNA messenger (mRNA)-based therapies are also being explored, offering the ability to modulate gene expression to normalize lipid levels. Furthermore, nanotechnology raises new possibilities in drug delivery for treating dyslipidemia. Controlled-release systems, nanoparticles, and liposomes can enhance the effectiveness and safety of medications by providing more precise and sustained release. This narrative review summarizes current and emerging therapies for the management of patients with dyslipidemia.
  • article
    Right ventricular dysfunction after pericardiectomy for tuberculous constrictive pericarditis: A case report
    (2024) DUARTE, Natania Ferreira; FERREIRA, Stella de Aguiar Trigueirinho; FILHO, Daniel Abdalla Added; VIDAL, Carlos Henrique Lopes; LIMA, Roger Sales; MARTINS, Ana Vitoria Vitoreti; CASTRO, Rafael Oliveira; ASSIS, Arthur Cicupira Rodrigues de; SOARES, Paulo Rogerio; SCUDELER, Thiago Luis
    This case report provides a peculiar case of tuberculous constrictive pericarditis (TCP) who presented with right ventricular dysfunction after pericardiectomy. Right ventricular dysfunction is one of the main postoperative complications after pericardiectomy. Rapid and accurate identification of right ventricular dysfunction confirmed by transthoracic echocardiography (TTE), associated with the rapid initiation of diuretics and inotropic therapy is necessary for the patient's complete recovery.AbstractTCP is a condition characterized by chronic inflammation and fibrosis of the pericardium. Pericardiectomy is the standard treatment for patients with constrictive pericarditis and persistent symptoms. One possible surgical complication is right ventricle (RV) failure. We report a case of a 44-year-old man who developed RV failure after pericardiectomy for TCP. A 41-year-old man with no medical history was referred to our hospital due to progressive dyspnea associated with edema of the lower limbs and significant weight loss (30 kg) over the past 5 months. TTE revealed significant pericardial thickening and mild pericardial effusion with normal RV function. Chest X-ray showed moderate bilateral pleural effusion. The patient underwent pericardiectomy and bilateral pleural drainage. Histopathological examination showed tuberculosis granulomas with caseous necrosis, and antituberculosis medication was initiated. Postoperative TTEs showed normal RV function and mild pericardial thickening. The patient was discharged home after successful postoperative recovery. Three weeks later, the patient was admitted to the emergency department with dyspnea and hypoxemia. TTE revealed RV systolic dysfunction. Chest CT showed a recurrence of moderate pleural effusion, this time loculated, with restrictive atelectasis of the adjacent lung parenchyma. Diuretics and inotropic therapy were initiated, and the patient underwent lung decortication after confirmation of tuberculous empyema. The patient experienced significant clinical improvement. TTE before discharge showed a decreased RV chamber size with improved RV systolic function. The patient was discharged in a stable condition 30 days after admission with a low dose of oral furosemide. Four months after discharge, he remained asymptomatic with good functional status. Pericardiectomy for TCP may carry the risk of developing RV dysfunction. Furthermore, TCP itself may be associated with other complications, such as empyema. We emphasize the importance of conducting a thorough clinical evaluation for patients with TCP, particularly those undergoing pericardiectomy, to mitigate potential adverse outcomes.
  • article 40 Citação(ões) na Scopus
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19
    (2023) PAIRO-CASTINEIRA, Erola; RAWLIK, Konrad; BRETHERICK, Andrew D.; QI, Ting; WU, Yang; NASSIRI, Isar; MCCONKEY, Glenn A.; ZECHNER, Marie; KLARIC, Lucija; GRIFFITHS, Fiona; OOSTHUYZEN, Wilna; KOUSATHANAS, Athanasios; RICHMOND, Anne; MILLAR, Jonathan; RUSSELL, Clark D.; MALINAUSKAS, Tomas; THWAITES, Ryan; MORRICE, Kirstie; KEATING, Sean; MASLOVE, David; NICHOL, Alistair; SEMPLE, Malcolm G.; KNIGHT, Julian; SHANKAR-HARI, Manu; SUMMERS, Charlotte; HINDS, Charles; HORBY, Peter; LING, Lowell; MCAULEY, Danny; MONTGOMERY, Hugh; OPENSHAW, Peter J. M.; BEGG, Colin; WALSH, Timothy; TENESA, Albert; FLORES, Carlos; RIANCHO, Jose A.; ROJAS-MARTINEZ, Augusto; LAPUNZINA, Pablo; YANG, Jian; PONTING, Chris P.; WILSON, James F.; VITART, Veronique; ABEDALTHAGAFI, Malak; LUCHESSI, Andre D.; PARRA, Esteban J.; CRUZ, Raquel; CARRACEDO, Angel; FAWKES, Angie; MURPHY, Lee; ROWAN, Kathy; PEREIRA, Alexandre C.; LAW, Andy; FAIRFAX, Benjamin; HENDRY, Sara Clohisey; BAILLIE, J. Kenneth
    Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown(1) to be highly efficient for discovery of genetic associations(2). Despite the advanced stage of illness at presentation, we have shown that host genetics in patients who are critically ill with COVID-19 can identify immunomodulatory therapies with strong beneficial effects in this group(3). Here we analyse 24,202 cases of COVID-19 with critical illness comprising a combination of microarray genotype and whole-genome sequencing data from cases of critical illness in the international GenOMICC (11,440 cases) study, combined with other studies recruiting hospitalized patients with a strong focus on severe and critical disease: ISARIC4C (676 cases) and the SCOURGE consortium (5,934 cases). To put these results in the context of existing work, we conduct a meta-analysis of the new GenOMICC genome-wide association study (GWAS) results with previously published data. We find 49 genome-wide significant associations, of which 16 have not been reported previously. To investigate the therapeutic implications of these findings, we infer the structural consequences of protein-coding variants, and combine our GWAS results with gene expression data using a monocyte transcriptome-wide association study (TWAS) model, as well as gene and protein expression using Mendelian randomization. We identify potentially druggable targets in multiple systems, including inflammatory signalling (JAK1), monocyte-macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A). An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte-macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).
  • article 0 Citação(ões) na Scopus
    Could there be a slower physiological healing process in vegan individuals?
    (2024) DIAS, Lais Ferreira; ACOSTA-NAVARRO, Julio Cesar; SILVA, Tuane Cassemiro da
    The article ""Comparing Tattoo Removal Responses in Vegan and Omnivore Patients"" by Fusano et al. investigates the clinical outcomes of Q-switched laser tattoo removal in vegans and omnivores. The study reveals that vegans required more laser sessions, exhibited poorer clinical responses, and experienced extended healing periods compared to omnivores. When well-planned vegetarian diets offer numerous health benefits. Unfortunately, the study does not assess the diets of the groups, nor does it address factors like hydration levels and prior skincare regimens, limiting the interpretation of results.
  • article 0 Citação(ões) na Scopus
    Smoking cessation decreases arterial blood pressure in hypertensive smokers: A subgroup analysis of the randomized controlled trial GENTSMOKING
    (2024) V, Patricia Gaya; FONSECA, Guilherme Wesley P.; TANJI, Lucas Tsuyoshi; ABE, Tania O.; ALVES, Maria Janieire N. N.; SANTOS, Paulo Caleb Junior de Lima; COLOMBO, Fernanda M. Consolim; SCHOLZ, Jaqueline R.
    INTRODUCTION High blood pressure in hypertensive smokers is affected by nicotine consumption. This study aimed to evaluate the effect of smoking cessation treatments on blood pressure in hypertensive smokers. METHODS A total of 113 hypertensive smokers on antihypertensives during smoking cessation treatment in the randomized controlled trial GENTSMOKING were considered for analysis. At Baseline (T0) and Week 12 (T12), systolic and diastolic blood pressure (SBP and DBP), and heart rate (HR) were measured using a semiautomated digital oscillometric device. Mean arterial pressure (MAP) and delta differences for SBP, DBP, HR, and MAP were calculated. Smoking cessation was confirmed by measuring carbon monoxide (CO) in exhaled air. RESULTS After 12 weeks of treatment, 72 participants ceased smoking (cessation group) and 41 did not (no cessation group). At T0, there was no statistically meaningful difference between groups with respect to age, body mass index, CO, and daily cigarette consumption. At T12, daily cigarette consumption and CO had decreased in both groups (p<0.001). The cessation group showed decreased SBP (131 +/- 2 vs 125 +/- 2 mmHg, p=0.00 4), DBP (79 +/- 1 vs 77 +/- 1 mmHg, p=0.031), MAP (96 +/- 1 vs 93 +/- 1 mmHg, p=0.005), and HR (79 +/- 1 vs 74 +/- 1 beats/min, p=0.001), and increased body weight (77.4 +/- 2.1 vs 79.2 +/- 2.2 kg, p<0.001). No significant differences were seen for these variables in the no cessation group. Decrease in blood pressure was significantly higher among hypertensive participants with SBP >= 130 mmHg: SBP (145 +/- 2 vs 132 +/- 2 mmHg, p<0.001), DBP (85 +/- 2 vs 80 +/- 1 mmHg, p=0.002), MAP (105 +/- 1 vs 97 +/- 1 mmHg, p<0.001), and HR (81 +/- 2 vs 74 +/- 2 beats/min, p=0.002). A positive correlation was found between HR and CO (r=0.34; p=0.001). CONCLUSIONS Smoking cessation treatment reduced blood pressure in hypertensive smokers, allowing them to reach therapeutic targets for hypertension management. Smoking cessation has a positive impact on hypertension treatment; therefore, it should be encouraged in clinical practice.
  • article 2 Citação(ões) na Scopus
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (vol 617, pg 764, 2023)
    (2023) PAIRO-CASTINEIRA, Erola; RAWLIK, Konrad; BRETHERICK, Andrew D.; QI, Ting; WU, Yang; NASSIRI, Isar; MCCONKEY, Glenn A.; ZECHNER, Marie; KLARIC, Lucija; GRIFFITHS, Fiona; OOSTHUYZEN, Wilna; KOUSATHANAS, Athanasios; RICHMOND, Anne; MILLAR, Jonathan; RUSSELL, Clark D.; MALINAUSKAS, Tomas; THWAITES, Ryan; MORRICE, Kirstie; KEATING, Sean; MASLOVE, David; NICHOL, Alistair; SEMPLE, Malcolm G.; KNIGHT, Julian; SHANKAR-HARI, Manu; SUMMERS, Charlotte; HINDS, Charles; HORBY, Peter; LING, Lowell; MCAULEY, Danny; MONTGOMERY, Hugh; OPENSHAW, Peter J. M.; BEGG, Colin; WALSH, Timothy; TENESA, Albert; FLORES, Carlos; RIANCHO, Jose A.; ROJAS-MARTINEZ, Augusto; LAPUNZINA, Pablo; YANG, Jian; PONTING, Chris P.; WILSON, James F.; VITART, Veronique; ABEDALTHAGAFI, Malak; LUCHESSI, Andre D.; PARRA, Esteban J.; CRUZ, Raquel; CARRACEDO, Angel; FAWKES, Angie; MURPHY, Lee; ROWAN, Kathy; PEREIRA, Alexandre C.; LAW, Andy; FAIRFAX, Benjamin; HENDRY, Sara Clohisey; BAILLIE, J. Kenneth
  • article 4 Citação(ões) na Scopus
    Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c
    (2023) ZHOU, Bin; SHEFFER, Kate E.; BENNETT, James E.; GREGG, Edward W.; DANAEI, Goodarz; SINGLETON, Rosie K.; SHAW, Jonathan E.; MISHRA, Anu; LHOSTE, Victor P. F.; CARRILLO-LARCO, Rodrigo M.; KENGNE, Andre P.; PHELPS, Nowell H.; HEAP, Rachel A.; RAYNER, Archie W.; STEVENS, Gretchen A.; PACIOREK, Chris J.; RILEY, Leanne M.; COWAN, Melanie J.; SAVIN, Stefan; HOORN, Stephen Vander; LU, Yuan; PAVKOV, Meda E.; IMPERATORE, Giuseppina; AGUILAR-SALINAS, Carlos A.; AHMAD, Noor Ani; ANJANA, Ranjit Mohan; DAVLETOV, Kairat; FARZADFAR, Farshad; GONZALEZ-VILLALPANDO, Clicerio; KHANG, Young-Ho; KIM, Hyeon Chang; LAATIKAINEN, Tiina; LAXMAIAH, Avula; MBANYA, Jean Claude N.; NARAYAN, K. M. Venkat; RAMACHANDRAN, Ambady; WADE, Alisha N.; ZDROJEWSKI, Tomasz; ABBASI-KANGEVARI, Mohsen; RAHIM, Hanan F. Abdul; ABU-RMEILEH, Niveen M.; ADAMBEKOV, Shalkar; ADAMS, Robert J.; AEKPLAKORN, Wichai; AGDEPPA, Imelda A.; AGHAZADEH-ATTARI, Javad; AGYEMANG, Charles; AHMADI, Ali; AHMADI, Naser; AHMADI, Nastaran; AHMED, Soheir H.; AJLOUNI, Kamel; AL-HINAI, Halima; AL-LAHOU, Badreya; AL-LAWATI, Jawad A.; ASFOOR, Deena Al; QAOUD, Nawal M. Al; ALAROUJ, Monira; ALBUHAIRAN, Fadia; ALDHUKAIR, Shahla; ALDWAIRJI, Maryam A.; ALI, Mohamed M.; ALINEZHAD, Farbod; ALKANDARI, Abdullah; ALOMIRAH, Husam F.; ALY, Eman; AMARAPURKAR, Deepak N.; ANDERSEN, Lars Bo; ANDERSSEN, Sigmund A.; ANDRADE, Dolores S.; ANSARI-MOGHADDAM, Alireza; AOUNALLAH-SKHIRI, Hajer; ARIS, Tahir; ARLAPPA, Nimmathota; ARYAL, Krishna K.; ASSAH, Felix K.; ASSEMBEKOV, Batyrbek; AUVINEN, Juha; AVDICOVA, Maria; AZAD, Kishwar; AZIMI-NEZHAD, Mohsen; AZIZI, Fereidoun; BACOPOULOU, Flora; BALAKRISHNA, Nagalla; BAMOSHMOOSH, Mohamed; BANACH, Maciej; BANDOSZ, Piotr; BANEGAS, Jose R.; BARBAGALLO, Carlo M.; BARCELO, Alberto; BARETIC, Maja; BARRERA, Lena; BASIT, Abdul; BATIEHA, Anwar M.; BATISTA, Aline P.; BAUR, Louise A.; BELAVENDRA, Antonisamy; ROMDHANE, Habiba Ben; BENET, Mikhail; BERKINBAYEV, Salim; BERNABE-ORTIZ, Antonio; CARRASOLA, Ximena Berrios; BETTIOL, Heloisa; BEYBEY, Augustin F.; BHARGAVA, Santosh K.; LELE, Elysee Claude Bika; BIKBOV, Mukharram M.; BISTA, Bihungum; BJERREGAARD, Peter; BJERTNESS, Espen; BJERTNESS, Marius B.; BJORKELUND, Cecilia; V, Katia Bloch; BLOKSTRA, Anneke; BO, Simona; BOBAK, Martin; BOGGIA, Jose G.; BONACCIO, Marialaura; BONILLA-VARGAS, Alice; BORGHS, Herman; BOVET, Pascal; BRAJKOVICH, Imperia; BRENNER, Hermann; BREWSTER, Lizzy M.; BRIAN, Garry R.; BRICENO, Yajaira; BRITO, Miguel; BUGGE, Anna; BUNTINX, Frank; LEON, Antonio Cabrera de; CAIXETA, Roberta B.; CAN, Gunay; CANDIDO, Ana Paula C.; V, Mario Capanzana; CAPKOVA, Nadezda; CAPUANO, Eduardo; CAPUANO, Rocco; CAPUANO, Vincenzo; CARDOSO, Viviane C.; CARLSSON, Axel C.; CASANUEVA, Felipe F.; CENSI, Laura; CERVANTES-LOAIZA, Marvin; CHAMNAN, Parinya; CHAMUKUTTAN, Snehalatha; CHAN, Queenie; CHARCHAR, Fadi J.; CHATURVEDI, Nish; CHEN, Huashuai; CHERAGHIAN, Bahman; CHIRLAQUE, Maria-Dolores; CHUDEK, Jerzy; CIFKOVA, Renata; CIRILLO, Massimo; CLAESSENS, Frank; COHEN, Emmanuel; CONCIN, Hans; COOPER, Cyrus; COSTANZO, Simona; COWELL, Chris; CRUJEIRAS, Ana B.; CRUZ, Juan J.; V, Felipe Cureau; CUSCHIERI, Sarah; D'ARRIGO, Graziella; D'ORSI, Eleonora; DALLONGEVILLE, Jean; DAMASCENO, Albertino; DASTGIRI, Saeed; CURTIS, Amalia De; GAETANO, Giovanni de; HENAUW, Stefaan De; DEEPA, Mohan; DEGENNARO JR., Vincent; DEMAREST, Stefaan; DENNISON, Elaine; DESCHAMPS, Valerie; DHIMAL, Meghnath; DIKA, Zivka; DJALALINIA, Shirin; DONFRANCESCO, Chiara; DONG, Guanghui; DOROBANTU, Maria; DORR, Marcus; DRAGANO, Nico; DRYGAS, Wojciech; DU, Yong; DUANTE, Charmaine A.; DUBOZ, Priscilla; DUSHPANOVA, Anar; DZIANKOWSKA-ZABORSZCZYK, Elzbieta; EBRAHIMI, Narges; EDDIE, Ricky; EFTEKHAR, Ebrahim; EFTHYMIOU, Vasiliki; EGBAGBE, Eruke E.; EGHTESAD, Sareh; EL-KHATEEB, Mohammad; ATI, Jalila El; ELDEMIRE-SHEARER, Denise; ELOSUA, Roberto; ENANG, Ofem; ERASMUS, Rajiv T.; ERBEL, Raimund; EREM, Cihangir; ERGOR, Gul; ERIKSEN, Louise; ERIKSSON, Johan G.; ESMAEILI, Ali; EVANS, Roger G.; FAKHRADIYEV, Ildar; FALL, Caroline H.; FARAMARZI, Elnaz; FARJAM, Mojtaba; FARZI, Yosef; FATTAHI, Mohammad Reza; FAWWAD, Asher; FELIX-REDONDO, Francisco J.; FERGUSON, Trevor S.; FERNANDEZ-BERGES, Daniel; FERRARI, Marika; FERRECCIO, Catterina; FERREIRA, Haroldo S.; FERRER, Eldridge; FESKENS, Edith J. M.; FLOOD, David; FORSNER, Maria; FOSSE, Sandrine; FOTTRELL, Edward F.; FOUAD, Heba M.; FRANCIS, Damian K.; FRONTERA, Guillermo; FURUSAWA, Takuro; GACIONG, Zbigniew; GARNETT, Sarah P.; GASULL, Magda; GAZZINELLI, Andrea; GEHRING, Ulrike; GHADERI, Ebrahim; GHAMARI, Seyyed-Hadi; GHANBARI, Ali; GHASEMI, Erfan; GHEORGHE-FRONEA, Oana-Florentina; GHIMIRE, Anup; GIALLUISI, Alessandro; GIAMPAOLI, Simona; GIANFAGNA, Francesco; GILL, Tiffany K.; GIRONELLA, Glen; GIWERCMAN, Aleksander; GOLTZMAN, David; GOMULA, Aleksandra; GONCALVES, Helen; GONCALVES, Mauer; GONZALEZ-CHICA, David A.; GONZALEZ-GROSS, Marcela; GONZALEZ-RIVAS, Juan P.; GONZALEZ-VILLALPANDO, Maria-Elena; GONZALEZ, Angel R.; GOTTRAND, Frederic; GRAFNETTER, Dusan; GRODZICKI, Tomasz; GRONTVED, Anders; GUERRERO, Ramiro; GUJRAL, Unjali P.; GUPTA, Rajeev; GUTIERREZ, Laura; GWEE, Xinyi; HAGHSHENAS, Rosa; HAKIMI, Hamid; HAMBLETON, Ian R.; HAMZEH, Behrooz; HANEKOM, Willem A.; HANGE, Dominique; HANTUNEN, Sari; HAO, Jie; KUMAR, Rachakulla Hari; HAROONI, Javad; HASHEMI-SHAHRI, Seyed Mohammad; HATA, Jun; HEIDEMANN, Christin; HENRIQUE, Rafael dos Santos; HERRALA, Sauli; HERZIG, Karl-Heinz; HESHMAT, Ramin; HO, Sai Yin; HOLDSWORTH, Michelle; HOMAYOUNFAR, Reza; HOPMAN, Wilma M.; HORIMOTO, Andrea R. V. R.; HORMIGA, Claudia; HORTA, Bernardo L.; HOUTI, Leila; HOWITT, Christina; HTAY, Thein Thein; HTET, Aung Soe; HTIKE, Maung Maung Than; HUERTA, Jose Maria; HUHTANIEMI, Ilpo Tapani; HUISMAN, Martijn; HUSSEINI, Abdullatif; HUYBRECHTS, Inge; IACOVIELLO, Licia; IAKUPOVA, Ellina M.; IANNONE, Anna G.; WONG, Norazizah Ibrahim; IJOMA, Chinwuba; IRAZOLA, Vilma E.; ISHIDA, Takafumi; ISIGUZO, Godsent C.; ISLAM, Sheikh Mohammed Shariful; ISLEK, Duygu; ITTERMANN, Till; IWASAKI, Masanori; JAASKELAINEN, Tuija; JACOBS, Jeremy M.; JADDOU, Hashem Y.; JADOUL, Michel; JALLOW, Bakary; JAMES, Kenneth; JAMIL, Kazi M.; JANUS, Edward; JARVELIN, Marjo-Riitta; JASIENSKA, Grazyna; JELAKOVIC, Ana; JELAKOVIC, Bojan; JENNINGS, Garry; JHA, Anjani Kumar; JIMENEZ, Ramon O.; JOCKEL, Karl-Heinz; JOKELAINEN, Jari J.; JONAS, Jost B.; JOSHI, Pradeep; JOSIPOVIC, Josipa; JOUKAR, Farahnaz; JOZWIAK, Jacek; KAFATOS, Anthony; KAJANTIE, Eero O.; KALMATAYEVA, Zhanna; KARKI, Khem B.; KATIBEH, Marzieh; KAUHANEN, Jussi; KAZAKBAEVA, Gyulli M.; KAZE, Francois F.; KE, Calvin; KEINANEN-KIUKAANNIEMI, Sirkka; KELISHADI, Roya; KERAMATI, Maryam; KERSTING, Mathilde; KHADER, Yousef Saleh; KHALEDIFAR, Arsalan; KHALILI, Davood; KHEIRI, Bahareh; KHERADMAND, Motahareh; KHOSRAVI, Alireza; KIECHL-KOHLENDORFER, Ursula; KIECHL, Sophia J.; KIECHL, Stefan; KINGSTON, Andrew; KLAKK, Heidi; KLANOVA, Jana; KNOFLACH, Michael; KOLSTEREN, Patrick; KONIG, Jurgen; KORPELAINEN, Raija; KORROVITS, Paul; KOS, Jelena; KOSKINEN, Seppo; KOWLESSUR, Sudhir; KOZIEL, Slawomir; KRIEMLER, Susi; KRISTENSEN, Peter Lund; KROMHOUT, Daan; KUBINOVA, Ruzena; KUJALA, Urho M.; KULIMBET, Mukhtar; KURJATA, Pawel; KYOBUTUNGI, Catherine; Quang Ngoc La; LABADARIOS, Demetre; LACHAT, Carl; LAID, Youcef; LALL, Lachmie; LANKILA, Tiina; LANSKA, Vera; LAPPAS, Georg; LARIJANI, Bagher; LATT, Tint Swe; LAURENZI, Martino; LEHMANN, Nils; LEHTIMAKI, Terho; LEMOGOUM, Daniel; LEUNG, Gabriel M.; LI, Yanping; LIMA-COSTA, M. Fernanda; LIN, Hsien-Ho; LIND, Lars; LISSNER, Lauren; LIU, Xiaotian; LOPEZ-GARCIA, Esther; LOPEZ, Tania; LOZANO, Jose Eugenio; LUKSIENE, Dalia; LUNDQVIST, Annamari; LUNET, Nuno; LUSTIGOVA, Michala; MACHADO-COELHO, George L. L.; MACHADO-RODRIGUES, Aristides M.; MACIA, Enguerran; MACIEIRA, Luisa M.; MADAR, Ahmed A.; MAESTRE, Gladys E.; MAGGI, Stefania; MAGLIANO, Dianna J.; MAGRIPLIS, Emmanuella; MAHASAMPATH, Gowri; MAIRE, Bernard; MAKDISSE, Marcia; MALEKPOUR, Mohammad-Reza; MALEKZADEH, Fatemeh; MALEKZADEH, Reza; RAO, Kodavanti Mallikharjuna; MALYUTINA, Sofia; V, Lynell Maniego; MANIOS, Yannis; MANNIX, Masimango Imani; MANSOUR-GHANAEI, Fariborz; MANZATO, Enzo; MARGOZZINI, Paula; MARINO, Joany; MARQUES, Larissa Pruner; MARTORELL, Reynaldo; MASCARENHAS, Luis P.; MASINAEI, Masoud; MATHIESEN, Ellisiv B.; MATSHA, Tandi E.; POSSO, Anselmo J. Mc Donald; MCFARLANE, Shelly R.; MCGARVEY, Stephen T.; BENCHEKOR, Sounnia Mediene; MEHLIG, Kirsten; MEHRPARVAR, Amir Houshang; MELGAREJO, Jesus D.; MENDEZ, Fabian; MENEZES, Ana Maria B.; MEREKE, Alibek; MESHRAM, Indrapal I.; METO, Diane T.; MINDERICO, Claudia S.; MINI, G. K.; MIQUEL, Juan Francisco; MIRANDA, J. Jaime; MIRJALILI, Mohammad Reza; MODESTI, Pietro A.; MOGHADDAM, Sahar Saeedi; MOHAMED, Mostafa K.; MOHAMMAD, Kazem; MOHAMMADI, Mohammad Reza; MOHAMMADI, Zahra; MOHAMMADIFARD, Noushin; MOHAMMADPOURHODKI, Reza; MOHAN, Viswanathan; YUSOFF, Muhammad Fadhli Mohd; MOHEBBI, Iraj; MOLLER, Niels C.; MOLNAR, Denes; MOMENAN, Amirabbas; MONDO, Charles K.; MENDOZA, Roger A. Montenegro; MONTERRUBIO-FLORES, Eric; MOOSAZADEH, Mahmood; MORADPOUR, Farhad; MOREJON, Alain; MORENO, Luis A.; MORGAN, Karen; MORIN, Suzanne N.; MOSLEM, Alireza; MOSQUERA, Mildrey; MOSSAKOWSKA, Malgorzata; MOSTAFA, Aya; MOSTAFAVI, Seyed-Ali; MOTLAGH, Mohammad Esmaeel; MOTTA, Jorge; MSYAMBOZA, Kelias P.; Thet Thet Mu; MUIESAN, Maria L.; MURSU, Jaakko; MUSA, Kamarul Imran; MUSTAFA, Norlaila; MUYER, Muel Telo M. C.; NABIPOUR, Iraj; NAGEL, Gabriele; NAIDU, Balkish M.; NAJAFI, Farid; NAMESNA, Jana; NANGIA, Vinay B.; NASERI, Take; NEELAPAICHIT, Nareemarn; NEJATIZADEH, Azim; NENKO, Ilona; NERVI, Flavio; Tze Pin Ng; NGUYEN, Chung T.; Quang Ngoc Nguyen; NI, Michael Y.; NIE, Peng; NIETO-MARTINEZ, Ramfis E.; NINOMIYA, Toshiharu; NOALE, Marianna; NOBOA, Oscar A.; NOTO, Davide; NSOUR, Mohannad Al; NUHOGLU, Irfan; O'NEILL, Terence W.; ODILI, Augustine N.; OH, Kyungwon; OHTSUKA, Ryutaro; OMAR, Mohd Azahadi; ONAT, Altan; ONG, Sok King; ONODUGO, Obinna; ORDUNEZ, Pedro; ORNELAS, Rui; ORTIZ, Pedro J.; OSMOND, Clive; OSTOVAR, Afshin; OTERO, Johanna A.; OTTENDAHL, Charlotte B.; OTU, Akaninyene; OWUSU-DABO, Ellis; PALMIERI, Luigi; PAN, Wen-Harn; PANDA-JONAS, Songhomitra; PANZA, Francesco; PAOLI, Mariela; PARK, Suyeon; PARSAEIAN, Mahboubeh; PATEL, Nikhil D.; PECHLANER, Raimund; PECIN, Ivan; PEDRO, Joao M.; PEIXOTO, Sergio Viana; PELTONEN, Markku; PEREIRA, Alexandre C.; PRAZERES, Thaliane Mayara Pessoa dos; PEYKARI, Niloofar; PHALL, Modou Cheyassin; Son Thai Pham; Hiep Hoang Phan; PICHARDO, Rafael N.; PIKHART, Hynek; PILAV, Aida; PILER, Pavel; PITAKAKA, Freda; PIWONSKA, Aleksandra; PIZARRO, Andreia N.; PLANS-RUBIO, Pedro; PLATA, Silvia; PORTA, Miquel; POUDYAL, Anil; POURFARZI, Farhad; POURSHAMS, Akram; POUSTCHI, Hossein; PRADEEPA, Rajendra; PROVIDENCIA, Rui; PUDER, Jardena J.; PUHAKKA, Solie; PUNAB, Margus; QORBANI, Mostafa; QUINTANA, Hedley K.; Tran Quoc Bao; RAHIMIKAZEROONI, Salar; RAITAKARI, Olli; RAMIREZ-ZEA, Manuel; RAMKE, Jacqueline; RAMOS, Rafel; RAMPAL, Lekhraj; RAMPAL, Sanjay; REINA, Daniel A. Rangel; RASHIDI, Mohammad-Mahdi; REDON, Josep; RENNER, Jane D. P.; REUTER, Cezane P.; REVILLA, Luis; REZAEI, Negar; REZAIANZADEH, Abbas; RIGO, Fernando; ROA, Reina G.; ROBINSON, Louise; RODRIGUEZ-ARTALEJO, Fernando; RODRIGUEZ-PEREZ, Maria Del Cristo; RODRIGUEZ-VILLAMIZAR, Laura A.; RODRIGUEZ, Andrea Y.; ROGGENBUCK, Ulla; ROHLOFF, Peter; ROMEO, Elisabetta L.; ROSENGREN, Annika; RUBINSTEIN, Adolfo; RUST, Petra; RUTKOWSKI, Marcin; SABBAGHI, Hamideh; SACHDEV, Harshpal S.; SADJADI, Alireza; SAFARPOUR, Ali Reza; SAFI, Sare; SAFIRI, Saeid; SAGHI, Mohammad Hossien; SAIDI, Olfa; SAKI, Nader; SALAJ, Sanja; SALANAVE, Benoit; SALONEN, Jukka T.; SALVETTI, Massimo; SANCHEZ-ABANTO, Jose; SANTOS, Diana A.; SANTOS, Lelita C.; SANTOS, Maria Paula; SANTOS, Tamara R.; SARAMIES, Jouko L.; SARDINHA, Luis B.; SARRAFZADEGAN, Nizal; SAUM, Kai-Uwe; SBARAINI, Mariana; SCAZUFCA, Marcia; SCHAAN, Beatriz D.; SCHEIDT-NAVE, Christa; SCHIPF, Sabine; SCHMIDT, Carsten O.; Ben Schottker; SCHRAMM, Sara; SEBERT, Sylvain; SEDAGHATTALAB, Moslem; SEIN, Aye Aye; SEPANLOU, Sadaf G.; SEWPAUL, Ronel; SHAMAH-LEVY, Teresa; SHAMSHIRGARAN, Seyed Morteza; SHARAFKHAH, Maryam; SHARMA, Sanjib K.; SHARMAN, Almaz; SHAYANRAD, Amaneh; SHAYESTEH, Ali Akbar; SHIMIZU-FURUSAWA, Hana; SHIRI, Rahman; SHRESTHA, Namuna; SI-RAMLEE, Khairil; SILVA, Diego Augusto Santos; SIMON, Mary; SIMONS, Judith; SIMONS, Leon A.; SJOSTROM, Michael; SLOWIKOWSKA-HILCZER, Jolanta; SLUSARCZYK, Przemyslaw; SMEETH, Liam; SOBNGWI, Eugene; SODERBERG, Stefan; SOEMANTRI, Agustinus; SOFAT, Reecha; SOLFRIZZI, Vincenzo; SOMI, Mohammad Hossein; SOUMARE, Aicha; SOUSA-POZA, Alfonso; SPARRENBERGER, Karen; STAESSEN, Jan A.; STAVRESKI, Bill; STEENE-JOHANNESSEN, Jostein; STEHLE, Peter; STEIN, Aryeh D.; STESSMAN, Jochanan; STOKWISZEWSKI, Jakub; STRONKS, Karien; SUAREZ-ORTEGON, Milton F.; SUEBSAMRAN, Phalakorn; SUNDSTROM, Johan; SURIYAWONGPAISAL, Paibul; SYLVA, Rene Charles; SZKLO, Moyses; TAMOSIUNAS, Abdonas; TARAWNEH, Mohammed Rasoul; TARQUI-MAMANI, Carolina B.; TAYLOR, Anne; TAYLOR, Julie; TELLO, Tania; THANKAPPAN, K. R.; THEOBALD, Holger; THEODORIDIS, Xenophon; THOMAS, Nihal; THRIFT, Amanda G.; TIMMERMANS, Erik J.; TJANDRARINI, Dwi Hapsari; TOLONEN, Hanna K.; TOLSTRUP, Janne S.; TOMASZEWSKI, Maciej; TOPBAS, Murat; TORRES-COLLADO, Laura; TRAISSAC, Pierre; TRIANTAFYLLOU, Areti; TUITELE, John; TULIAKOVA, Azaliia M.; TULLOCH-REID, Marshall K.; TUOMAINEN, Tomi-Pekka; TZALA, Evangelia; TZOURIO, Christophe; UEDA, Peter; UGEL, Eunice; UKOLI, Flora A. M.; ULMER, Hanno; UUSITALO, Hannu M. T.; VALDIVIA, Gonzalo; BORN, Bert-Jan Van den; HEYDEN, Johan Van der; Hoang Van Minh; ROSSEM, Lenie van; SCHOOR, Natasja M. Van; VALKENGOED, Irene G. M. van; ZUTPHEN, Elisabeth M. van; VANDERSCHUEREN, Dirk; VANUZZO, Diego; VASAN, Senthil K.; VEGA, Tomas; VELASQUEZ-MELENDEZ, Gustavo; VERSTRAETEN, Roosmarijn; VIET, Lucie; VILLALPANDO, Salvador; VIOQUE, Jesus; VIRTANEN, Jyrki K.; VISWANATHAN, Bharathi; VOUTILAINEN, Ari; BEBAKAR, Wan Mohamad Wan; MOHAMUD, Wan Nazaimoon Wan; WANG, Chongjian; WANG, Ningli; WANG, Qian; WANG, Ya Xing; WANG, Ying-Wei; WANNAMETHEE, S. Goya; WEBSTER-KERR, Karen; WEDDERKOPP, Niels; WEI, Wenbin; WESTBURY, Leo D.; WHINCUP, Peter H.; WIDHALM, Kurt; WIDYAHENING, Indah S.; WIECEK, Andrzej; WILKS, Rainford J.; WILLEIT, Johann; WILLEIT, Peter; WILSGAARD, Tom; WOJTYNIAK, Bogdan; WONG, Andrew; WONG, Emily B.; WOODWARD, Mark; WU, Frederick C.; XU, Haiquan; XU, Liang; YAACOB, Nor Azwany; YAN, Li; YAN, Weili; YOOSEFI, Moein; YOSHIHARA, Akihiro; YOUNGER-COLEMAN, Novie O.; YU, Yu-Ling; YU, Yunjiang; YUSOFF, Ahmad Faudzi; ZAINUDDIN, Ahmad A.; ZAMANI, Farhad; ZAMBON, Sabina; ZAMPELAS, Antonis; ZAW, Ko Ko; VRKIC, Tajana Zeljkovic; ZENG, Yi; ZHANG, Zhen-Yu; ZHOLDIN, Bekbolat; ZIMMET, Paul; ZITT, Emanuel; ZOGHLAMI, Nada; CISNEROS, Julio Zuniga; EZZATI, Majid
    Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) are both used to diagnose diabetes, but these measurements can identify different people as having diabetes. We used data from 117 population-based studies and quantified, in different world regions, the prevalence of diagnosed diabetes, and whether those who were previously undiagnosed and detected as having diabetes in survey screening, had elevated FPG, HbA1c or both. We developed prediction equations for estimating the probability that a person without previously diagnosed diabetes, and at a specific level of FPG, had elevated HbA1c, and vice versa. The age-standardized proportion of diabetes that was previously undiagnosed and detected in survey screening ranged from 30% in the high-income western region to 66% in south Asia. Among those with screen-detected diabetes with either test, the age-standardized proportion who had elevated levels of both FPG and HbA1c was 29-39% across regions; the remainder had discordant elevation of FPG or HbA1c. In most low- and middle-income regions, isolated elevated HbA1c was more common than isolated elevated FPG. In these regions, the use of FPG alone may delay diabetes diagnosis and underestimate diabetes prevalence. Our prediction equations help allocate finite resources for measuring HbA1c to reduce the global shortfall in diabetes diagnosis and surveillance. Analysis of HbA1c and FPG levels across 117 population-based studies demonstrates regional variation in prevalence of previously undiagnosed screen-detected diabetes using one or both measures and suggests that use of elevated FPG alone could underestimate diabetes prevalence in low- and middle-income countries.
  • article 0 Citação(ões) na Scopus
    Data-driven models for the prediction of coronary atherosclerotic plaque progression/regression
    (2024) BULANT, Carlos A.; BORONI, Gustavo A.; BASS, Ronald; RABER, Lorenz; LEMOS, Pedro A.; GARCIA-GARCIA, Hector M.; BLANCO, Pablo J.
    Coronary artery disease is defined by the existence of atherosclerotic plaque on the arterial wall, which can cause blood flow impairment, or plaque rupture, and ultimately lead to myocardial ischemia. Intravascular ultrasound (IVUS) imaging can provide a detailed characterization of lumen and vessel features, and so plaque burden, in coronary vessels. Prediction of the regions in a vascular segment where plaque burden can either increase (progression) or decrease (regression) following a certain therapy, has remained an elusive major milestone in cardiology. Studies like IBIS-4 showed an association between plaque burden regression and high-intensity rosuvastatin therapy over 13 months. Nevertheless, it has not been possible to predict if a patient would respond in a favorable/adverse fashion to such a treatment. This work aims to (i) Develop a framework that processes lumen and vessel cross-sectional contours and extracts geometric descriptors from baseline and follow-up IVUS pullbacks; and to (ii) Develop, train, and validate a machine learning model based on baseline/follow-up IVUS datasets that predicts future percent of atheroma volume changes in coronary vascular segments using only baseline information, i.e. geometric features and clinical data. This is a post hoc analysis, revisiting the IBIS-4 study. We employed 140 arteries, from 81 patients, for which expert delineation of lumen and vessel contours were available at baseline and 13-month follow-up. Contour data from baseline and follow-up pullbacks were co-registered and then processed to extract several frame-wise features, e.g. areas, plaque burden, eccentricity, etc. Each pullback was divided into regions of interest (ROIs), following different criteria. Frame-wise features were condensed into region-wise markers using tools from statistics, signal processing, and information theory. Finally, a stratified 5-fold cross-validation strategy (20 repetitions) was used to train/validate an XGBoost regression models. A feature selection method before the model training was also applied. When the models were trained/validated on ROI defined by the difference between follow-up and baseline plaque burden, the average accuracy and Mathews correlation coefficient were 0.70 and 0.41 respectively. Using a ROI partition criterion based only on the baseline's plaque burden resulted in averages of 0.60 accuracy and 0.23 Mathews correlation coefficient. An XGBoost model was capable of predicting plaque progression/regression changes in coronary vascular segments of patients treated with rosuvastatin therapy in 13 months. The proposed method, first of its kind, successfully managed to address the problem of stratification of patients at risk of coronary plaque progression, using IVUS images and standard patient clinical data.
  • article 0 Citação(ões) na Scopus
    Early versus delayed coronary angiography in patients with out-of-hospital cardiac arrest and no ST-segment elevation: a systematic review and meta-analysis of randomized controlled trials
    (2024) HAMIDI, Fardin; ANWARI, Elaaha; SPAULDING, Christian; HAUW-BERLEMONT, Caroline; VILFAILLOT, Aurelie; VIANA-TEJEDOR, Ana; KERN, Karl B.; HSU, Chiu-Hsieh; BERGMARK, Brian A.; QAMAR, Arman; BHATT, Deepak L.; FURTADO, Remo H. M.; MYHRE, Peder L.; HENGSTENBERG, Christian; LANG, Irene M.; FREY, Norbert; FREUND, Anne; DESCH, Steffen; THIELE, Holger; PREUSCH, Michael R.; ZELNIKER, Thomas A.
    Background Recent randomized controlled trials did not show benefit of early/immediate coronary angiography (CAG) over a delayed/selective strategy in patients with out-of-hospital cardiac arrest (OHCA) and no ST-segment elevation. However, whether selected subgroups, specifically those with a high pretest probability of coronary artery disease may benefit from early CAG remains unclear. Methods We included all randomized controlled trials that compared a strategy of early/immediate versus delayed/ selective CAG in OHCA patients and no ST elevation and had a follow-up of at least 30 days. The primary outcome of interest was all-cause death. Odds ratios (OR) were calculated and pooled across trials. Interaction testing was used to assess for heterogeneity of treatment effects. Results In total, 1512 patients (67 years, 26% female, 23% prior myocardial infarction) were included from 5 randomized controlled trials. Early/immediate versus delayed/selective CAG was not associated with a statistically significant difference in odds of death (OR 1.12, 95%-CI 0.91-1.38), with similar findings for the composite outcome of all-cause death or neurological deficit (OR 1.10, 95%-CI 0.89- 1.36). There was no effect modification for death by age, presence of a shockable initial cardiac rhythm, history of coronary artery disease, presence of an ischemic event as the presumed cause of arrest, or time to return of spontaneous circulation (all P-interaction > 0.10). However, early/immediate CAG tended to be associated with higher odds of death in women (OR 1.52, 95%- CI 1.00- 2.31, P = 0.050) than in men (OR 1.04, 95%-CI 0.82-1.33, P = 0.74; P-interaction 0.097). Conclusion In OHCA patients without ST-segment elevation, a strategy of early/immediate versus delayed/selective CAG did not reduce all-cause mortality across major subgroups. However, women tended to have higher odds of death with early CAG. [GRAPHICS]
  • article 0 Citação(ões) na Scopus
    The potential for vaccines to aid the treatment of post-TB lung disease
    (2024) SILVA, D. R.; SANTOS, A. P.; VISCA, D.; BOMBARDA, S.; DALCOLMO, M. M. P.; GALVAO, T.; MIRANDA, S. S. de; I, A. A. A. Parente; RABAHI, M. F.; SALES, R. K. B. de; MIGLIORI, G. B.; MELLO, F. C. de Queiroz
  • article 1 Citação(ões) na Scopus
    Perioperative interventions for the prevention of surgical wound infection in adult patients undergoing left ventricular assist devices implantation: A scoping review
    (2024) BRANDA, Sara Michelly Goncalves; URASAKI, Maristela Belletti Mutt; LEMOS, Dayanna Machado Pires; MATOS, Ligia Neres; TAKAHASHI, Mariana; NOGUEIRA, Paula Cristina; GOUVEIA, Vera Lucia Conceicao de
    Background: Surgical wound infection is the most frequent type of care health associated infection. Lack of knowledge about the prevention of surgical wound infection in patients undergoing left ventricular assist device implantation could significantly undermine the potential benefits of surgical intervention. Objectives: This study aimed to map the recommendations for adult patients undergoing left ventricular assist device implantation. Design: This is a scoping review, being registered in the Open Science Framework under DOI .17605/OSF.IO/Q76B3 ( Method: Left ventricular assist device coordinators and nurse specialists in dermatology and stomatherapy conducted a scoping review in Scopus, The Cochrane Database of Systematic Reviews, Cumulative Index to Nursing and Allied Health Literature (CINAHL), limited to the period between 2015 and 2022. The results of this scoping review will be discussed and presented in separate articles. This paper will synthesize research evidence on the perioperative topic. Results: The initial searches resulted in 771 studies. Sixty nine met the eligibility criteria and were included in the scoping review. Eight articles addressing the perioperative topic that answered the question of this article were included. Conclusion: Although this scoping review included heterogeneous, and scarce studies with left ventricular assist device patients. As such, there are many promising future research directions for this topic. Implications for Clinical Practice: Infection surveillance should be an integral part of left ventricular assist device implantation programs in health care institutions. Velvet completely buried in subcutaneous tissues reduces transmission system infection. Triple tunnel method reduces transmission system infection risk.
  • article 0 Citação(ões) na Scopus
    The ESTS-AIR database-initial results of a multi-institutional database on airway surgery
    (2024) SCHWEIGER, Thomas; EVERMANN, Matthias; RENDINA, Erino; MAURIZI, Giulio; VENUTA, Federico; AIGNER, Clemens; SLAMA, Alexis; COLLAUD, Stephane; VERHAGEN, Ad; TIMMAN, Simone; BIBAS, Benoit; CARDOSO, Paulo; PASSANI, Stefano; SALATI, Michele; OPITZ, Isabelle; SZANTO, Zalan; HOETZENECKER, Konrad
    OBJECTIVES Compared to lung resections, airway procedures are relatively rare in thoracic surgery. Despite this, a growing number of dedicated airway centres have formed throughout Europe. These centres are characterized by a close interdisciplinary collaboration and they often act as supra-regional referring centres. To date, most evidence of airway surgery comes from retrospective, single-centre analysis as there is a lack of large-scale, multi-institutional databases.METHODS In 2018, an initiative was formed, which aimed to create an airway database within the framework of the ESTS database (ESTS-AIR). Five dedicated airway centres were asked to test the database in a pilot phase. A 1st descriptive analysis of ESTS-AIR was performed.RESULTS A total of 415 cases were included in the analysis. For adults, the most common indication for airway surgery was post-tracheostomy stenosis and idiopathic subglottic stenosis; in children, most resections/reconstructions had to be performed for post-intubation stenosis. Malignant indications required significantly longer resections [36.0 (21.4-50.6) mm] when compared to benign indications [26.6 (9.4-43.8) mm]. Length of hospital stay was 11.0 (4.1-17.3) days (adults) and 13.4 (7.6-19.6) days (children). Overall, the rates of complications were low with wound infections being reported as the most common morbidity.CONCLUSIONS This evaluation of the 1st cases in the ESTS-AIR database allowed a large-scale analysis of the practice of airway surgery in dedicated European airway centres. It provides proof for the functionality of ESTS-AIR and sets the basis for rolling out the AIR subsection to all centres participating in the ESTS database. Airway surgery is a rare sub-specialty of thoracic surgery and even in high-volume centres, the annual case load is often limited to a hand-full of cases.
  • article 0 Citação(ões) na Scopus
    Reduced exercise capacity occurs before intrinsic skeletal muscle dysfunction in experimental rat models of pulmonary hypertension
    (2024) ZHANG, Peng; BOS, Denielli Da Silva Goncalves; VANG, Alexander; FEORD, Julia; MCCULLOUGH, Danielle J.; ZIMMER, Alexsandra; D'SILVA, Natalie; CLEMENTS, Richard T.; CHOUDHARY, Gaurav
    Reduced exercise capacity in pulmonary hypertension (PH) significantly impacts quality of life. However, the cause of reduced exercise capacity in PH remains unclear. The objective of this study was to investigate whether intrinsic skeletal muscle changes are causative in reduced exercise capacity in PH using preclinical PH rat models with different PH severity. PH was induced in adult Sprague-Dawley (SD) or Fischer (CDF) rats with one dose of SU5416 (20 mg/kg) injection, followed by 3 weeks of hypoxia and additional 0-4 weeks of normoxia exposure. Control s rats were injected with vehicle and housed in normoxia. Echocardiography was performed to assess cardiac function. Exercise capacity was assessed by VO2 max. Skeletal muscle structural changes (atrophy, fiber type switching, and capillary density), mitochondrial function, isometric force, and fatigue profile were assessed. In SD rats, right ventricular systolic dysfunction is associated with reduced exercise capacity in PH rats at 7-week timepoint in comparison to control rats, while no changes were observed in skeletal muscle structure, mitochondrial function, isometric force, or fatigue profile. CDF rats at 4-week timepoint developed a more severe PH and, in addition to right ventricular dysfunction, the reduced exercise capacity in these rats is associated with skeletal muscle atrophy; however, mitochondrial function, isometric force, and fatigue profile in skeletal muscle remain unchanged. Our data suggest that cardiopulmonary impairments in PH are the primary cause of reduced exercise capacity, which occurs before intrinsic skeletal muscle dysfunction.
  • article 0 Citação(ões) na Scopus
    Rationale and design of the CONFIRM2 (Quantitative COroNary CT Angiography Evaluation For Evaluation of Clinical Outcomes: An InteRnational, Multicenter Registry) study
    (2024) ROSENDAEL, Alexander R. van; CRABTREE, Tami; BAX, Jeroen J.; NAKANISHI, Rine; MUSHTAQ, Saima; PONTONE, Gianluca; ANDREINI, Daniele; BUECHEL, Ronny R.; GRANI, Christoph; FEUCHTNER, Gudrun; PATEL, Toral R.; CHOI, Andrew D.; AL-MALLAH, Mouaz; NABI, Faisal; KARLSBERG, Ronald P.; ROCHITTE, Carlos E.; ALASNAG, Mirvat; HAMDAN, Ashraf; CADEMARTIRI, Filippo; MARQUES, Hugo; KALRA, Dinesh; GERMAN, David M.; GUPTA, Himanshu; HADAMITZKY, Martin; DEAN, Roderick C.; KHALIQUE, Omar; KNAAPEN, Paul; HOFFMANN, Udo; EARLS, James; MIN, James K.; DANAD, Ibrahim
    Background: In the last 15 years, large registries and several randomized clinical trials have demonstrated the diagnostic and prognostic value of coronary computed tomography angiography (CCTA). Advances in CT scanner technology and developments of analytic tools now enable accurate quantification of coronary artery disease (CAD), including total coronary plaque volume and low attenuation plaque volume. The primary aim of CONFIRM2, (Quantitative COroNary CT Angiography Evaluation For Evaluation of Clinical Outcomes: An InteRnational, Multicenter Registry) is to perform comprehensive quantification of CCTA findings, including coronary, non-coronary cardiac, non-cardiac vascular, non-cardiac findings, and relate them to clinical variables and cardiovascular clinical outcomes. Design: CONFIRM2 is a multicenter, international observational cohort study designed to evaluate multidimensional associations between quantitative phenotype of cardiovascular disease and future adverse clinical outcomes in subjects undergoing clinically indicated CCTA. The targeted population is heterogenous and includes patients undergoing CCTA for atherosclerotic evaluation, valvular heart disease, congenital heart disease or preprocedural evaluation. Automated software will be utilized for quantification of coronary plaque, stenosis, vascular morphology and cardiac structures for rapid and reproducible tissue characterization. Up to 30,000 patients will be included from up to 50 international multi-continental clinical CCTA sites and followed for 3-4 years. Summary: CONFIRM2 is one of the largest CCTA studies to establish the clinical value of a multiparametric approach to quantify the phenotype of cardiovascular disease by CCTA using automated imaging solutions.
  • article 0 Citação(ões) na Scopus
    Guide catheter extension use are associated with higher procedural success in chronic total occlusion percutaneous coronary interventions
    (2024) FILHO, Evandro M.; ARAUJO, Gustavo N.; MACHADO, Guilherme P.; PADILLA, Lucio; PAULA, Joao E. T. de; BOTELHO, Antonio C.; CAMPOS, Carlos M.; QUESADA, Franklin L. H.; ALCANTARA, Marco; SANTIAGO, Ricardo; SANTOS, Felix D. de los; OLIVEIRA, Marcos D.; RIBEIRO, Marcelo H.; PEREZ, Luiz; PINTO, Mauro E.; CORTES, Leandro A.; PICCARO, Pedro; BRILAKIS, Emmanouil S.; QUADROS, Alexandre S.
    Background: Guide catheter extensions (GCEs) increase support and facilitate equipment delivery, but aggressive instrumentation may be associated with a higher risk of complications. Aim: Our aim was to assess the impact of GCEs on procedural success and complications in patients submitted to chronic total occlusion (CTO) percutaneous coronary intervention (PCI). Methods: We analyzed data from the multicenter LATAM CTO Registry. Procedural success was defined as <30% residual stenosis and TIMI 3 distal flow. Major adverse cardiac and cerebrovascular events (MACCE) was defined as the composite of all-cause death, myocardial infarction, target vessel revascularization, and stroke. Propensity score matching (PSM) was used to compare outcomes with and without GCE use. Results: From August 2010 to August 2021, 3049 patients were included. GCEs were used in 438 patients (14.5%). In unadjusted analysis, patients in the GCE group were older and had more comorbidities. The median J-CTO score and its components were higher in the GCE group. After PSM, procedural success was higher with GCE use (87.7% vs. 80.5%, p = 0.007). The incidence of coronary perforation (odds ratio [OR]: 1.46, 95% confidence interval [CI]: 0.78-2.71, p = 0.230), bleeding (OR: 1.99, 95% CI: 0.41-2.41, p = 0.986), in-hospital death (OR: 1.39, 95% CI: 0.54-3.62, p = 0.495) and MACCE (OR: 1.07, 95% CI: 0.52-2.19, p = 0.850) were similar in both groups. Conclusion: In a contemporary, multicenter cohort of patients undergoing CTO PCI, GCEs were used in older patients, with more comorbidities and complex anatomy. After PSM, GCE use was associated with higher procedural success, and similar incidence of adverse outcomes.
  • article
    Scintigraphic and Echocardiographic Study of Patients with Pathogenic or Probably Pathogenic Variants of the TTR Gene without Overt Cardiac Involvement
    (2024) SILVA, Tonnison de Oliveira; DARZE, Eduardo Sahade; COSTA, Marcela Machado; JR, Luiz Jose; XIMENES, Antonio A. B.; FERNANDES, Fabio; ROCHA, Mario de Seixas; NOYA-RABELO, Marcia M.; RITT, Luiz Eduardo Fonteles
    Background: Transthyretin amyloidosis (ATTR) is an infiltrative disease caused by abnormal protein deposition mainly in the heart and peripheral nervous system. When it affects the heart, the disease presents as restrictive cardiomyopathy; when it affects the peripheral and autonomic nervous system, it manifests as polyneuropathy, and is called familial amyloid polyneuropathy (FAP). There are two ATTR subtypes: wild-type ATTR, where there is no mutation, and mutant ATTR (ATTRm), which is characterized by a mutation in the gene encoding the transthyretin protein (TTR). In both subtypes, cardiac involvement is the major marker of poor prognosis. Objectives: To assess the prevalence of subclinical cardiac involvement in a sample of patients with TTR gene mutation by using pyrophosphate scintigraphy and strain echocardiography; to compare scintigraphy and strain findings; to evaluate the association between neurological manifestations (FAP) and subclinical cardiac involvement; and to analyze whether there is an association between any specific mutation and cardiac involvement. Methods: This is a cross-sectional study with carriers of the TTR gene mutation, without cardiovascular symptoms or changes in electrocardiographic or conventional echocardiographic parameters. All patients underwent pyrophosphate scintigraphy and strain echocardiography. Subclinical cardiac involvement was defined as a Perugini score >= 2, heart-to-contralateral lung (H/CL) ratio >= 1.5 at 1 h, H/CL >= 1.3 at 3 h, or global longitudinal strain (GLS) <= -17%. Descriptive and analytical analyses were performed and Fisher's exact test and Mann-Whitney test were applied. A value of p < 0.05 was considered significant. Results: The 23 patients evaluated had a median age of 51 years (IQR 37-57 years), 15 (65.2%) were female, 12 (52.2%) were Pardo, nine (39.1%) had systemic arterial hypertension, and nine (39.1%) had a previous diagnosis of FAP. Of the nine patients with FAP, 8 (34.8%) were on tafamidis. The associated mutations were Val142IIe, Val50Met, and IIe127Val. The median GLS in the sample was -19% (-16% to -20%). Of the 23 patients, nine (39.1%; 95% CI = 29-49%) met criteria for cardiac involvement, six (26%) by the GLS-based criteria only. There was no association between having FAP and being an asymptomatic carrier, as assessed by strain echocardiography and pyrophosphate scintigraphy (p = 0.19). The prevalence of systemic arterial hypertension, diabetes mellitus, dyslipidemia, smoking, and reduced GLS did not differ between groups. Septal e' wave velocity was the only variable that significantly differed between individuals with and without reduced GLS, with an area under the ROC curve of 0.80 (95% CI = 0.61-0.98, p = 0.027). The best diagnostic accuracy was achieved with a septal e' velocity <= 8.5 cm/s. There was no association between mutation type and preclinical cardiac involvement, nor between tafamidis use and lower degree of cardiac involvement (37.5% versus 40.0%, p = 0.90). Conclusion: Subclinical cardiac involvement was common in a sample of TTR mutation carriers without cardiac involvement. Reduced left ventricular GLS was the most frequent finding. There was no association between the presence of amyloid polyneuropathy and subclinical cardiac involvement. Type of mutation was not associated with early cardiac involvement. In this sample, the use of tafamidis 20 mg/day was not associated with a lower prevalence of subclinical cardiac involvement.
  • article 0 Citação(ões) na Scopus
    Randomized controlled trials: advantages and pitfalls when studying causality
    (2024) CARUSO, Diego; FERREIRA, Juliana C.
  • article 1 Citação(ões) na Scopus
    Social determinants of respiratory health from birth: still of concern in the 21st century?
    (2024) BUSH, Andrew; BYRNES, Catherine A.; CHAN, Kate C.; CHANG, Anne B.; FERREIRA, Juliana C.; HOLDEN, Karl A.; LOVINSKY-DESIR, Stephanie; REDDING, Gregory; SINGH, Varinder; SINHA, Ian P.; ZAR, Heather J.
    Respiratory symptoms are ubiquitous in children and, even though they may be the harbinger of poor longterm outcomes, are often trivialised. Adverse exposures pre -conception, antenatally and in early childhood have lifetime impacts on respiratory health. For the most part, lung function tracks from the pre-school years at least into late middle age, and airflow obstruction is associated not merely with poor respiratory outcomes but also early all -cause morbidity and mortality. Much would be preventable if social determinants of adverse outcomes were to be addressed. This review presents the perspectives of paediatricians from many different contexts, both high and low income, including Europe, the Americas, Australasia, India, Africa and China. It should be noted that there are islands of poverty within even the highest income settings and, conversely, opulent areas in even the most deprived countries. The heaviest burden of any adverse effects falls on those of the lowest socioeconomic status. Themes include passive exposure to tobacco smoke and indoor and outdoor pollution, across the entire developmental course, and lack of access even to simple affordable medications, let alone the new biologicals. Commonly, disease outcomes are worse in resource -poor areas. Both within and between countries there are avoidable gross disparities in outcomes. Climate change is also bearing down hardest on the poorest children. This review highlights the need for vigorous advocacy for children to improve lifelong health. It also highlights that there are ongoing culturally sensitive interventions to address social determinants of disease which are already benefiting children.
  • article 1 Citação(ões) na Scopus
    Geographic disparity of pathophysiological coronary artery disease characteristics: Insights from ASET trials
    (2024) KOTOKU, Nozomi; NINOMIYA, Kai; MASUDA, Shinichiro; TSAI, Tsung Ying; REVAIAH, Pruthvi C.; GARG, Scot; KAGEYAMA, Shigetaka; TU, Shengxian; KOZUMA, Ken; KAWASHIMA, Hideyuki; ISHIBASHI, Yuki; NAKAZAWA, Gaku; TAKAHASHI, Kuniaki; OKAMURA, Takayuki; MIYAZAKI, Yosuke; TATEISHI, Hiroki; NAKAMURA, Masato; KOGAME, Norihiro; ASANO, Taku; NAKATANI, Shimpei; MORINO, Yoshihiro; ISHIDA, Masaru; KATAGIRI, Yuki; MARTINO, Fernando De; TINOCO, Joao; GUIMARAES, Patricia O.; TANABE, Kengo; OZAKI, Yukio; MURAMATSU, Takashi; LEMOS, Pedro A.; ONUMA, Yoshinobu; SERRUYS, Patrick W.
    Background: The geographical disparity in the pathophysiological pattern of coronary artery disease (CAD) among patients undergoing percutaneous coronary intervention (PCI) is unknown. Objectives: To elucidate the geographical variance in the pathophysiological characteristics of CAD. Methods: Physiological indices derived from angiography-based fractional flow reserve pullbacks from patients with chronic coronary syndrome enrolled in the ASET Japan (n = 206) and ASET Brazil (n = 201) studies, which shared the same eligibility criteria, were analysed. The pathophysiological patterns of CAD were characterised using Murray law -based quantitative flow ratio (mu QFR)-derived indices acquired from pre-PCI angiograms. The diffuseness of CAD was defined by the mu QFR pullback pressure gradient index. Results: Significant functional stenoses pre-PCI (mu QFR <= 0.80) were more frequent in ASET Japan compared to ASET Brazil (89.9% vs. 67.5%, p < 0.001), as were rates of a post-PCI mu QFR <0.91 (22.1% vs. 12.9%, p = 0.013). In the multivariable analysis, pre -procedural mu QFR and diffuse disease were independent factors for predicting a post-PCI mu QFR <0.91, which contributed to the different rates of post-PCI mu QFR >= 0.91 between the studies. Among vessels with a post-PCI mu QFR <0.91, a consistent diffuse pattern of CAD pre- and post-PCI occurred in 78.3% and 76.7% of patients in ASET Japan and Brazil, respectively; only 6.3% (Japan) and 10.0% (Brazil) of vessels had a major residual gradient. Independent risk factors for diffuse disease were diabetes mellitus in ASET Japan, and age and male gender in Brazil. Conclusions: There was geographic disparity in pre -procedural angiography-based pathophysiological characteristics. The combined pre -procedural physiological assessment of vessel mu QFR and diffuseness of CAD may potentially identify patients who will benefit most from PCI.
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    Neurochagas in post-heart transplant: clinical and epidemiological analysis of this entity based on a series of cases
    (2024) ROMERO, Cristhian Espinoza; MARCHI, Daniel Catto De; MARCONDES-BRAGA, Fabiana G.; MANGINI, Sandrigo; AVILA, Monica Samuel; BACAL, Fernando