Livros e Capítulos de Livros - HC/ICHC

URI Permanente para esta coleção

A coleção de Livros e Capítulos de Livros reúne capítulos e resumos de obras produzidas por autores do complexo Hospital das Clínicas - Faculdade de Medicina da Universidade de São Paulo.


Submissões Recentes

Agora exibindo 1 - 20 de 6318
  • bookPart 24 Citação(ões) na Scopus
    Prion disease
    (2018) TAKADA, L. T.; KIM, M.-O.; METCALF, S.; GALA, I. I.; GESCHWIND, M. D.
    Genetic prion diseases (gPrDs) are caused by autosomal-dominant mutations in the prion protein gene (PRNP). Although the first PRNP mutations identified, and most since, are PRNP missense, octapeptide repeat insertions, deletion and nonsense mutations have now also been shown to cause gPrD. Based on clinicopathologic features of familial disease, gPrDs historically have been classified into three forms: familial Jakob–Creutzfeldt disease, Gerstmann–Sträussler–Scheinker disease, and fatal familial insomnia. This classification, however, occurred prior to the identification of PRNP, and although these forms are still recognized, classification now is somewhat more complex. Clinical manifestations, and even pathology, are known to be more heterogeneous and varied than the historic three phenotypic classifications. Most gPrDs either present rapidly with progression of dementia, ataxia, myoclonus, and other motor features leading to death in few months or present more slowly, declining over a few years with mild cognitive impairment, ataxia, or parkinsonism and later dementia; a few very rare mutations, however, present over years to decades with neuropsychiatric disorders and systemic symptoms (gastrointestinal disorders and neuropathy). In this chapter, we review the broad phenotypic spectrum of PRNP mutations causing gPrDs. © 2018 Elsevier B.V.
  • bookPart 0 Citação(ões) na Scopus
    Prolactin-Secreting Pituitary Adenomas: Pathology, Clinical Manifestations, and Diagnosis
    (2019) GLEZER, A.; BRONSTEIN, M. D.
    Hyperprolactinemia is an important cause of hypogonadism in both genders, prolactinoma being its most common pathological cause. The pathophysiology of prolactinomas encompasses several mechanisms involving oncogenes, tumor suppressor genes, and growth factors. Clinical manifestations include menstrual disturbances, galactorrhea, sexual dysfunction, and infertility. Hyperprolactinemia also can be due to physiological (pregnancy and lactation), pharmacological (especially antipsychotics and gastrointestinal medications), and pathological causes as systemic diseases (renal and hepatic failure), endocrine diseases (hypothyroidism, Cushing disease), other pituitary or sellar region tumors causing pituitary stalk disconnection, and conditions leading to intercostal nerve stimulation as thoracic surgery and herpes zoster. Once the abovementioned causes are ruled out, the diagnosis of prolactinoma should be performed by laboratory and image (MRI) evaluation. Usually, serum prolactin levels parallel the tumor size. Laboratory and image pitfalls as macroprolactinemia, hook effect, and pituitary incidentaloma should be considered. Therefore, identifying the correct cause of hyperprolactinemia is crucial for the proper treatment. © 2019, Springer Nature Switzerland AG.
  • bookPart 3 Citação(ões) na Scopus
    Incorporating and Teaching Spirituality into Medical Education: An Overview of the Field and Possible Educational Strategies
    (2019) LUCCHETTI, G.; GONçALVES, L. M.; FERREIRA, A. G. de Carvalho; DAHER, J. C. Jr.; LUCCHETTI, A. L. G.
    Resulting from the increasing scientific evidence on the correlations between spirituality and health (S/H), important institutions such as the World Health Organization, American College of Physicians and Association of American Medical Colleges have already formally recommended the approach of spirituality in clinical practice. In addition, most US and UK medical schools have already included S/H contents in their curriculum, students and medical teachers believe this issue is important to clinical practice and there are several studies showing promising results on the incorporation of S/H courses or strategies to medical students. This chapter will provide a brief panorama on the S/H field, aiming to bring an update overview of the development of the field, the current scientific evidence, the most common educational strategies and initiatives used, the S/H curriculum goals, objectives and general competences. Future challenges of this field are to create an international consensus including the minimum required competences that a medical student should learn concerning S/H, to increase the number of S/H content worldwide and to provide high-quality and continuing training for teachers and students. © 2019, Springer Nature Switzerland AG.
  • bookPart 2 Citação(ões) na Scopus
    Zika Virus Amplification Using Strand Displacement Isothermal Method and Sequencing Using Nanopore Technology
    Development of novel point of care diagnostic methods in order to help in implementing disease control program and identifying the causative agent of an outbreak is crucial. Classical diagnostic techniques, e.g., real-time polymerase chain reaction (PCR), rely on the presence of the nucleic acid sequence of the target in GenBank. In the case of an emerging new strain of a known or novel pathogen, false-negative results will be recorded by PCR. On the other hand, next-generation sequencing technologies allow rapid whole genome sequencing without previous knowledge of the target. One of these methods is the Oxford Nanopore sequencing technique, which utilizes a portable device named MinION and has a short run time. In this protocol, we describe the development of a novel nanopore sequencing protocol by combining random isothermal amplification technology and nanopore sequencing. The established protocol is rapid (<7 h) and sensitive as less than 4% of the sequenced RNA belonged to the target virus, Zika. Interestingly, we have established an offline BLAST search for the data analysis that facilitates the use of the whole protocol at remote settings without the need of an Internet connection. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.
  • bookPart 3 Citação(ões) na Scopus
    Computational Intelligence: A Step Forward in Cancer Biomarker Discovery and Therapeutic Target Prediction
    Computational intelligence (CI) is one of the most popular and advanced fields that mimics human intelligence and transforms numerous aspects of the healthcare industry. For the past two decades, CI has grown extensively and reached a new height in clinical research on cancer. The subfields of artificial intelligence, like deep learning and machine learning, are also applied to tackle various scientific problems. Cancer is one of the most aggressive and dreaded diseases, which every year costs more than 10 million lives globally, and it is expected that these tolls may reach 16.4 million by 2040. Hence, meticulous prognosis and early diagnosis of this disease are very significant to increase the chance of patient survival. In recent years, breakthroughs in various AI-based stratagems for precision oncology, digital pathology, and next-generation sequencing (NSG) are driving the need for new prognostic and predictive assays that facilitate the stratification and selection of patients for treatment. This chapter briefly includes the applications of CI and its subfields in cancer biomarkers and therapeutic target prediction. However, we explore how these applications have assisted in solving biomedical problems with unprecedented accuracy and deep learning. We also demonstrated how these data could be run on natural and mathematical algorithms to derive a classification of cancer genomes, identify potential biomarkers, therapeutic targets, drugs, and draw scientifically sound conclusions based on them. By providing a fresh viewpoint on how computational tools might aid enhance cancer detection, this chapter can help make significant advances in the medical disciplines and scientific community. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd 2022.
  • bookPart 0 Citação(ões) na Scopus
    Intrastromal Rings and Phakic Lenses
    (2022) MARTINES, E.; MARTINES, C. Minelli; PAULA, T. A. A.
    Keratoconus (KC) is an ectatic disease with coniform corneal deformation and irregular myopic astigmatism, causing the perception of distorted images, which affects approximately 1 in 2000 people. Treatment for this condition includes three points: stopping progression, improving corneal curvature, and minimizing residual refractive error. It is fundamental to individualize each case and make a meticulous evaluation to better understand the components that affect the patient’s vision, carefully evaluating the VA with and without correction and the visual quality of the patients as KC courses with high-order aberrations. It is also necessary to follow the sequence of treatment from less invasive to more invasive methods. Anterior and posterior chamber pIOL implantation is a viable and safe alternative for the correction of high ametropias after ICRS in patients with corneal ectatic disease. However, we must remember that the vast majority of studies in literature are case reports or case series. Therefore, more studies are required to determine which procedure is more indicated in each situation. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.
  • bookPart 0 Citação(ões) na Scopus
    Cerebellar Transcranial Magnetic Stimulation in Cerebellar Ataxias
    (2023) FRANçA, C.; CURY, R. G.
    Treatment options for autosomal dominant cerebellar ataxias are still scarce. Transcranial magnetic stimulation (TMS), a neuromodulation technique currently used for the treatment of depression, pain, vascular motor deficit, and posttraumatic stress disorder, can be a symptomatic treatment for ataxic patients. In this chapter, we reviewed current medical literature for the use of cerebellar TMS in spinocerebellar ataxias. Ten articles, including 170 ataxic patients, reported ataxia improvement after cerebellar TMS, with variable, but overall small effect sizes. This procedure appears to be safe since no severe side effect was reported. Additionally, cerebellar TMS can increase cerebellar blood flow, decrease oxidative stress, and decrease inhibition of the cerebellum over the contralateral motor cortex. However optimistic, these results still need to be better investigated in larger, longer, and more homogeneous trials. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.
  • bookPart
    Cirurgia metabólica no paciente diabético e doenças cardiovasculares
    (2023) LIBANORI, Hilton Telles; MARSON, Allan Garms
  • bookPart
    Toxina botulínica nos espasmos e no tratamento da dor neuropática
    (2023) MACHADO, Felipe Chiodini; WEDEMANN, Sylvia Regina Rodrigues
  • bookPart
    Diabetes tipo 1 e doença cardiovascular
    (2023) GOMES, Karla Fabiana Brasil; SILVA, Giordana Maluf da; SANTOS, Rosa Ferreira dos; SILVA, Maria Elizabeth Rossi da
  • bookPart
    Neuropatia periférica induzida pela quimioterapia
    (2023) D´ALESSANDRO, Eduardo Guilherme; PINHEIRO, Helio Widson Alves
  • bookPart
    Tratamento clínico convencional na doença de Crohn
    (2015) DAMIãO, Adérson Omar Mourão Cintra; FEITOSA, Flávio; MILANI, Luciane Reis
  • bookPart
    Etiologia da dor neuropática
    (2023) JúNIOR, José Oswaldo de Oliveira Oliveira; MORAIS, Marcus Vinicius de
  • bookPart
    Diagnóstico histopatológico na doença inflamatória intestinal
    (2015) KISHI, Humberto Setsuo; IBRAHIM, Roberto El
  • bookPart
    Câncer colorretal na doença inflamatória intestinal
    (2015) SOBRADO, Carlos Walter; COTTI, Guilherme Cutait de Castro
  • bookPart
    Tratamento cirúrgico na retocolite ulcerativa
    (2015) TEIXEIRA, Magaly Gemio
  • bookPart
    Epidemiologia na doença inflamatória intestinal
    (2015) LEITE, André Zonetti de Arruda; ANDRADE, Guilherme Marques
  • bookPart
    Manifestações dermatológicas na doença inflamatória intestinal
    (2015) ROMITI, Ricardo; CéSAR, Sabrina Sisto Alessi
  • bookPart
    Curso experimental de medicina: minha visão
    (2023) CESCATO, Valter Angelo Sperling
  • bookPart
    Manifestações tromboembólicas na doença inflamatória intestinal
    (2015) D´AMICO, Elbio Antonio; VALIM, Audrey Krüse Zeinad; JUNQUEIRA, Patrícia Lima