Livros e Capítulos de Livros - LIM/19
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A coleção de Livros e Capítulos de Livros reúne capítulos e resumos de obras produzidas por autores do sistema FMUSP-HC que inclui a Faculdade de Medicina da Universidade de São Paulo (FMUSP), o Hospital das Clínicas da FMUSP e demais institutos associados.
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- Rheumatic fever: From pathogenesis to vaccine perspectives(2023) GUILHERME, L.; BRANCO, C. E.; BARROS, S. F. De; KALIL, J.Rheumatic fever (RF) is considered a model of autoimmune disease due to untreated throat infection by S. pyogenes that affects children and teenagers. The autoimmune process is believed to be the basis of all of the clinical manifestations; for instance, arthritis by immune complex deposition, chorea by antibody binding to neuronal cells, skin and subcutaneous manifestations that are mediated by a delayed hypersensitivity reaction, and carditis that is caused by cross-reactive antibodies and T cells. This chapter presents an overview of the mechanisms leading to the tissue lesions, treatment, and future possibilities of a vaccine against S. pyogenes. © 2023 Elsevier Inc. All rights reserved.
bookPart Acompanhamento da criança e do adolescente submetidos a transplante renal(2023) RODRIGUES, Helcio; METRAN, Camila Cardoso; WATANABE, Andreia- Endothelium-Dependent Vasodilation: Nitric Oxide and Other Mediators(2018) LAURINDO, F. R. M.; LIBERMAN, M.; FERNANDES, D. C.; LEITE, P. F.Vasodilation is the archetypal function of the endothelial cell and the discovery of paracrine-dependent vasorelaxation by endothelium-derived production of the gaseous mediator nitric oxide (NO) was revolutionary. NO mediates its regulatory vasorelaxing effects through guanilyl cyclase activation. Also, thiol S-nitrosation by NO is increasingly evident as an effector mechanism. Another important NO-related chemistry is its reaction with superoxide radicals, yielding peroxynitrite and related oxidant and nitrating species associated with toxic effects. Nitrogen oxides are storage forms of NO which can exert vasodilation in the presence of hemeproteins. NO generation is mediated by NO synthase enzymes (endothelial, neuronal, and inducible isoforms), which depict complex regulation dependent on cofactors. The absence of such cofactors can uncouple NO generation from electron transfer, generating superoxide. The endothelium additional promotes vasodilation, mainly of small resistance arteries, through endothelium-derived hyperpolarizing factor(s) such as hydrogen peroxide, epoximetabolites of arachidonic acid, and gap junctions. Hydrogen sulfide is a novel gaseous endothelium-derived vasodilator. Together, these mechanisms compose an integrative platform providing an endothelium-associated dilator tone. © 2018 Elsevier Inc. All rights reserved.
- Endothelium in Atherosclerosis: Plaque Formation and Its Complications(2018) LUZ, P. L. da; CHAGAS, A. C. P.; DOURADO, P. M. M.; LAURINDO, F. R. M.Atherosclerosis refers to the slow process of plaque formation on the walls of the arteries and includes the deposit of fat and cellular debris in the inner wall of the arteries, inflammation, proliferative responses and apoptosis. Arteries become progressively thickened and often calcified. Typically, the atherosclerotic process begins in the first decades of life and progresses slowly. Aging and genetic susceptibility play a preponderant role in the evolution of atherosclerosis. The pathophysiological understanding of atherosclerosis has gone through several stages. Today, it is understood as an inflammatory/proliferative disease. Endothelial dysfunction plays a central role in the formation of atherosclerotic plaque, in its progression, and in complications. Therefore, the main objective of this chapter is to offer an integrated review of the main factors that participate in the formation of the atherosclerotic plaque with specific focus on the endothelium. © 2018 Elsevier Inc. All rights reserved.
bookPart 0 Citação(ões) na Scopus Occupational allergy in elite runners(2014) TEIXEIRA, R. N.; ROMANHOLO, B. S.; AGONDI, R. C.; PINTO, A. F.; MARTINS, M. de Arruda; CARVALHO, C. R. F.Background: The prevalence of allergy, asthma and airwayinflammation and hyperresponsiveness in elite athletes has increased overthe years and appears to vary between sport modalities. Although allergicand respiratory diseases have been extensively studied in enduranceathletes, especially swimmers and winter sports athletes, the prevalencein elite runners remains unknown.Objective: The aims of this study were to screen allergy symptoms inelite runners and to evaluate the airway responsiveness and airwayinflammatory cells in these athletes.Methods: One hundred and thirty elite runners were invited tocomplete the Allergy Questionnaire for Athletes (AQUA©), a validatedquestionnaire to screen allergy in athletes, in addition to answeringquestions related to training history, running distance per week and bestrace time in a marathon or half-marathon. A subgroup of 36 nonasthmaticathletes also performed the methacholine challenge test,sputum induction and cardiopulmonary exercise testing. Airwayinflammation was quantified via cellular airway infiltration.Results: The presence of allergy was based on the AQUA© totalscore, and athletes were classified as either AQUA+ or AQUA- (a score=5 or <5, respectively). Sixty-one athletes (60%) reported allergysymptoms, and no significant differences between the groups (AQUA+and AQUA-) were observed regarding gender, age, running experience,weekly training volume or best performance time in a half-marathon ormarathon (p>0.05). Most athletes presented airway inflammation witheosinophilic predominance (23.6%); however, only 8.3% of the eliterunners had a positive response to methacoline challenge.Conclusions: Our study demonstrated that elite runners have a highprevalence of allergy and eosinophilic airway inflammation withoutevidence of airway hyperresponsiveness; this finding was independent ofgender, age, quantity of training and performance. © 2014 Nova Science Publishers, Inc. All rights reserved.- Rheumatic Fever: How Streptococcal Throat Infection Triggers an Autoimmune Disease(2015) GUILHERME, L.; KALIL, J.Molecular mimicry between streptococcal and human proteins has been proposed as the triggering factor leading to autoimmunity in rheumatic fever (RF) and rheumatic heart disease (RHD). Punctual genetic polymorphisms related to both innate and adaptive immune responses are involved in the development of RF/RHD. Some adhesion molecules and chemokines facilitate the monocytes and macrophages and T and B cell infiltration to the heart-tissue. Here we presented data on molecular mimicry mediated by B and T cell responses of peripheral blood and T cell clones infiltrating heart lesions from RHD patients against streptococcal antigens and human tissue proteins. The molecular analysis of T cell recognition is assessed by the definition of heart-cross reactive antigens. Degenerate patterns of T cell receptor (TCR) recognition in which intralesional T cell clones presenting the same TCR-BVJB and AVJB and recognized different antigens are described. The production of inflammatory cytokines such as TNFa, IL-2, IL-17, IL-23 and IFNg from peripheral and heart-infiltrating mononuclear cells, suggested that Th-1 and Th-17 type cytokines are the mediators of RHD heart lesions. All the results presented here delineate the mechanisms involved in RF/RHD and can certainly be a model for other autoimmune diseases. © 2015 Elsevier B.V. All rights reserved.
- Massive bee envenomation(2017) FAN, H. W.; KALIL, J.
- Rheumatic Fever and Rheumatic Heart Disease(2017) GUILHERME, L.; SAMPAIO, R. O.; BARROS, S. Freschi de; KöHLER, K. F.; SPINA, G. S.; TARASOUTCHI, F.; KALIL, J.Rheumatic fever (RF) is the prototype of postinfectious autoimmune diseases. Similarities of structure and/or spatial conformation between Streptococcus pyogenes and human tissue proteins lead to autoimmune reactions due to molecular mimicry. The activation of T and B lymphocytes involves several genetically controlled molecules that act in both the innate and adaptive immune response. In this chapter, we describe the strains of bacteria that are more commonly involved in the development of RF worldwide as well as the genetic predisposition of diverse ethnic groups. The disease manifests in susceptible children and teenagers, usually starting as polyarthritis or Sydenham's chorea. This condition generally occurs several months after streptococcal infection. Erythema marginatum and subcutaneous nodules are rare cutaneous manifestation, and carditis is the most serious sequelae and can lead to severe valve damage and rheumatic heart disease (RHD). The immune mechanisms that lead to the diverse manifestations mentioned above are discussed. The diagnosis and treatment, particularly the revision of Jones Criteria in the era of Doppler echocardiography, as well as the perspective of vaccine development, are also presented. © 2017 Elsevier Inc. All rights reserved.
- Rheumatic fever and rheumatic heart disease(2019) GUILHERME, L.; KALIL, J.Rheumatic heart disease is a sequel of rheumatic fever that follows an untreated group A streptococcal infection of young susceptible individuals. The disease is mediated by inflammatory and autoimmune reactions. Several genes related to both innate and adaptive immune responses are involved. Human leukocytes antigens class II alleles have been associated with the disease. Both cellular and humoral immune responses are involved with the autoimmune reactions, and Th1 and Th17 inflammatory cytokines are the mediators of rheumatic heart lesions. Although humans are unique hosts for Streptococcus pyogenes infections, several studies have been done to find a suitable animal model and numerous different species (mice, rats, hamsters, rabbits, and primates). The in vitro analysis of tissue-infiltrating T cells showed their ability of recognizing several streptococcal-M protein peptides and self-antigens by molecular mimicry mechanism and demonstrated the involvement of CD4+ T cells in the pathogenesis of the disease. © 2020 Elsevier Inc. All rights reserved.
bookPart Testes de função pulmonar e nasofibrolaringoscopia(2022) AGONDI, Rosana Câmara; TAKEJIMA, Priscila; SILVA, Ari de PaulabookPart Angioedema(2022) MOTTA, Antônio Abílio; AGONDI, Rosana CâmarabookPart Urticárias agudas e crônicas(2022) AGONDI, Rosana Câmara; LOPES, Mariele Morandin; MOTTA, Antônio AbíliobookPart Tosse crônica(2022) AGONDI, Rosana CâmarabookPart Imunobiológicos(2022) AGONDI, Rosana Câmara; GIAVINA-BIANCHI, Pedro; KALIL, JorgebookPart Reações adversas às vacinas(2022) MARINHO, Ana Karolina Barreto Berseli; LIMA, Karine de Amicis; KALIL, JorgebookPart Laboratório em alergia(2022) KOKRON, Cristina Maria; SANTOS, Keity SouzabookPart Imunizações em imunocomprometidos(2022) MARINHO, Ana Karolina Barreto Berseli; KOKRON, Cristina Maria; KALIL, JorgebookPart Medicina de precisão em alergia(2022) SANTOS, Keity Souza; LIMA, Karine de Amicis; CASTRO, Fábio Fernandes Morato; KALIL, JorgebookPart Asma(2022) AGONDI, Rosana Câmara; TAKEJIMA, Priscila; GIAVINA-BIANCHI, PedrobookPart Doenças autoinflamatórias(2022) MENDONçA, Leonardo Oliveira; GATTORNO, Marco; PRADO, Alex Isidoro Ferreira; BARROS, Myrthes Anna Maragna Toledo; KALIL, Jorge
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