Artigos e Materiais de Revistas Científicas - FM/MPR

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  • article 0 Citação(ões) na Scopus
    Physician's perceptions regarding the pharmaceutical industry: a Brazilian national study
    (2024) GAMEIRO, Giovana Rosa; GAMEIRO, Gustavo Rosa; SILVA, Renan Magalhaes e; GUILLOUX, Aline Gil Alves; CASSENOTE, Alex Jones Flores; SCHEFFER, Mario Cesar
    OBJECTIVE: The objective of this study was to investigate the newly graduated physicians' attitudes and perceptions regarding the medical relationship with the pharmaceutical industry and identify the sociodemographic patterns related to such thinking. METHODS: A structured questionnaire was administered to 4,601 participants selected from a pool of 16,323 physicians who were registered with one of the 27 Regional Medical Councils of Brazil in 2015. Answers were analyzed using two stratification variables: type of medical school (public vs. private) and the sex of the respondents. RESULTS: Out of the participants, 61.8% believed that industry funding could support medical conferences and education, and 48.4% felt that small gifts and conference travel funding were acceptable. Conversely, 64.7% disagreed with industry-sponsored social events. Views on whether pharmaceutical representatives' visits influenced prescriptions were divided. Statistically significant differences were observed between genders and medical school types, with men and private school graduates being more accepting of certain industry interactions. CONCLUSION: The study highlights the nuanced attitudes of new doctors toward industry relationships, indicating the need for clearer ethical guidelines and education in medical schools to align practice with evolving societal values.
  • article 1 Citação(ões) na Scopus
    Maternal depression and child development at 3 years of age: a longitudinal study in a Brazilian child development promotion program
    (2024) SANTOS, Ina S.; BLUMENBERG, Cauane; MUNHOZ, Tiago N.; MATIJASEVICH, Alicia; SALUM, Cristiane; SANTOS JUNIOR, Hernane G.; SANTOS, Leticia Marques dos; CORREIA, Luciano L.; SOUZA, Marta Rovery de; LIRA, Pedro I. C.; BORTOLOTTO, Caroline C.; BARCELOS, Raquel; ALTAFIM, Elisa; CHICARO, Marina Fragata; MACANA, Esmeralda Correa; SILVA, Ronaldo Souza da
    Background: We tested the hypothesis that children of non-depressed mothers perform better in a developmental test at 3 years than children of depressed mothers.Method: Longitudinal analysis from a trial to assess the impact of a child development promotion program in 30 Brazilian municipalities. Mothers and children were appraised at first-year post-partum, 1 and 3 years after enrollment. Child development was assessed through the Ages and Stages Questionnaire (ASQ3) and maternal depression through the Edinburgh Postnatal Depression Scale (EPDS). Crude and adjusted beta coefficients were obtained by linear regression before and after multiple imputation.Results: In total, 2098 mother/child dyads were included and 8.2% of the mothers had persistent depressive symptoms. There was a decrease in ASQ3 as the number of follow-ups with EPDS >= 10 increased (p for trend <0.001). In adjusted analysis, the direction of the association persisted but lost statistical significance. After multiple imputation, children from mothers with EPDS >= 10 in three follow-ups presented a decrease of about 14 points in ASQ3 (adjusted beta coefficient = -13.79; -22.59 to -5.00) (p for trend = 0.001).Conclusions: Identification of women at increased risk of depression should be among the primary health care sector priorities in maternal and child health in Brazil.
  • article
    Homoparenting: challenges for public health
    (2024) GOMES, Romeu; MACHIN, Rosana; NASCIMENTO, Marcos Antonio Ferreira do; COUTO, Marcia Tereza
  • article 1 Citação(ões) na Scopus
    Vitamin D-associated genetic variants in the Brazilian population: Investigating potential instruments for Mendelian randomization
    (2024) SILVERIO, Caroline de Souza; BONILLA, Carolina
    Introduction. Vitamin D is required for bone and mineral metabolism and participates in the regulation of the immune response. It is also linked to several chronic diseases and conditions, usually in populations of European descent. Brazil presents a high prevalence of vitamin D deficiency and insufficiency despite the widespread availability of sunlight in the country. Thus, it is important to investigate the role of vitamin D as a risk factor for disease and to establish causal relationships between vitamin D levels and health -related outcomes in the Brazilian population. Objective. To examine genetic variants identified as determinants of serum vitamin D in genome-wide association studies of European populations and check whether the same associations are present in Brazil. If so, these single nucleotide polymorphisms (SNPs) could be developed locally as proxies to use in genetically informed causal inference methods, such as Mendelian randomization. Materials and methods. We extracted SNPs associated with vitamin D from the genomewide association studies catalog. We did a literature search to select papers ascertaining these variants and vitamin D concentrations in Brazil. Results. GC was the gene with the strongest association with vitamin D levels, in agreement with existing findings in European populations. However, VDR was the most investigated gene, regardless of its non -existing association with vitamin D in the genomewide association studies. Conclusions. More research is needed to validate sound proxies for vitamin D levels in Brazil, for example, prioritizing GC rather than VDR .
  • article 0 Citação(ões) na Scopus
    Legal recognition of LGB-parent families and science. An interview with Mar González
    (2024) MACHIN, Rosana; GONZALEZ, Mar
    Mar Gonz & aacute;lez is a psychologist and one of the pioneers in studies on LGB-parent families in Spain. Her research work from the 2000s onwards played an essential role in the parliamentary debate in the country, which culminated in the approval of same -sex marriage in 2005. Spain, a Catholic -majority country that had left the Franco dictatorship three decades earlier, was the third country in the world, after Belgium and Netherlands, to recognize the right of gay and lesbian people to unite. Her studies address unconventional families, family diversity, child and family development, and their relationship with education and health. Our conversation addressed LBG parenthood, the establishment of filiation rights for this social group, studies on these family configurations, and leading LGB parenthood health implications.
  • article 0 Citação(ões) na Scopus
    Lactation induction for transgender women and transfeminine 1 people in health care: a scoping review
    (2024) BERTOLLO, Leandro Pedro Goloni; CAMPOS, Liliana Alice da Silva; SUZUKI, Thaiane Almeida; CHAO, Meily Soares; SANTOS, Vanessa Cunha dos; AMORIM, Ana Paula Andreotti; GERMANI, Ana Claudia Camargo Goncalves
    There are countless proven benefits of breastfeeding, and the demand for such a right in health for transfeminine people is rarely addressed in the literature, reinforcing inequities in health. The article aims to conduct a scoping review of lactation induction for transfeminine people in the health care context. Systematic literature review in six selected databases, looking for articles with terms related to lactation and transfeminine people. Data were extracted and analyzed, summarizing the main results in tables. Three hundred ninety articles were found. After the exclusion of the duplicates there was a selection by title/abstract and a following selection by the full reading of the remaining articles, considering the pre -determined exclusion and inclusion criteria. Twenty-one articles were included, published between 2018 and 2023. Among them, six are case reports with unprecedented information on the topic, and the others are publications in various formats. Lactation induction was achieved in all the case reports. There is a fragile and recent body of evidence affirming the success of lactation induction in transgender women. There is a necessity to support this demand by health professionals and robust studies to optimize necessary interventions.
  • article 0 Citação(ões) na Scopus
    Structural Relationships between Asthma and Dental Caries in Children: A Birth Cohort Study in Southern Brazil
    (2024) AGOSTINI, Bernardo A.; SARKIS-ONOFRE, Rafael; ORTIZ, Fernanda R.; CORREA, Marcos B.; PERES, Marco A.; PERES, Karen G.; SANTOS, Ina S.; MATIJASEVICH, Alicia; BARROS, Fernando C. L. F.; DEMARCO, Flavio F.
    Introduction: There is an inconclusive causal association between asthma symptoms and dental caries in the primary dentition. This study aimed to investigate, using SEM (structural equation modeling), a possible causal relation between asthma and dental caries in the primary dentition. Methods: Using data from the 2004 Pelotas Birth Cohort Study, a sub-sample of 1,303 individuals was selected. Dental caries was clinically evaluated at 5 years old based on decayed, missing, and filled tooth (dmft) index criteria. Asthma-related symptoms (wheezing and shortness of breath) at 1- and 4-year-olds composed a latent variable and were the main exposures to caries occurrence. SEM was used to identify possible direct, indirect, and mediated effects of asthma in primary dentition dental caries. Results: The general prevalence of caries at age 5 was 1.95 (SD: 3.56). When comparing the dmft values for children with asthma symptoms and those without, they presented similar values in both periods where asthma symptoms were evaluated (1- and 4-year-old). SEM analysis showed that asthma was neither directly nor indirectly related to dental caries. Conclusion: Asthma, using a latent variable constructed based on asthma symptoms, showed no causal effect on dental caries occurrence in the primary dentition.
  • article 2 Citação(ões) na Scopus
    Association between relative age at school and persistence of ADHD in prospective studies: an individual participant data meta-analysis
    (2023) GOSLING, Corentin J.; CAPAROS, Serge; PINABIAUX, Charlotte; SCHWARZER, Guido; RUECKER, Gerta; AGHA, Sharifah S.; ALROUH, Hekmat; AMBLER, Antony; ANDERSON, Peter; ANDIARENA, Ainara; ARNOLD, L. Eugene; ARSENEAULT, Louise; ASHERSON, Philip; BABINSKI, Leslie; BARBATI, Vittoria; BARKLEY, Russell; BARROS, Aluisio J. D.; BELL, Laura J.; BERENGUER, Carmen; BERGEN, Elsje van; BIEDERMAN, Joseph; BIRMAHER, Boris; BOE, Tormod; BOIVIN, Michel; BOOMSMA, Dorret I.; BRANDT, Valerie C.; BRESSAN, Rodrigo A.; BROCKI, Karin C.; BROUGHTON, Thomas R.; BUFFERD, Sara J.; BUSSING, Regina; CAO, Meng; CARTIGNY, Ariane; CASAS, Ana Miranda; CASPI, Avshalom; CASTELLANOS, F. Xavier; CAYE, Arthur; CEDERKVIST, Luise; COLLISHAW, Stephan; COPELAND, William E.; COTE, Sylvana M.; COVENTRY, William L.; DEBES, Nanette M. M. Mol; DENYER, Hayley; DODGE, Kenneth A.; DOGRU, Hicran; EFRON, Daryl; ELLER, Jami; ELMAKSOUD, Marwa Abd; ERCAN, Eyup Sabri; FARAONE, Stephen V.; FENESY, Michelle; FERNANDEZ, Mariana F.; FERNANDEZ-SOMOANO, Ana; FINDLING, Robert L.; FOMBONNE, Eric; FOSSUM, Ingrid N.; FREIRE, Carmen; FRIEDMAN, Naomi P.; FRISTAD, Mary A.; GALERA, Cedric; GARCIA-ARGIBAY, Miguel; GARVAN, Cynthia S.; GONZALEZ, Llucia; GROENMAN, Annabeth P.; GUXENS, Monica; HALPERIN, Jeffrey M.; HAMADEH, Randah R.; HARTMAN, Catharina A.; HILL, Shirley Y.; HINSHAW, Stephen P.; HIPWELL, Alison E.; HOKKANEN, Laura; HOLZ, Nathalie; INIGUEZ, Carmen; JAHRAMI, Haitham A.; JANSEN, Pauline W.; JONSDOTTIR, Lilja K.; JULVEZ, Jordi; KAISER, Anna; KEENAN, Kate; KLEIN, Daniel N.; KLEIN, Rachel G.; KUNTSI, Jonna; LANGFUS, Joshua; LANGLEY, Kate; LANSFORD, Jennifer E.; LANGLEY, Kate; LANSFORD, Jennifer E.; LARSEN, Sally A.; LARSSON, Henrik; LAW, Evelyn; LEE, Steve S.; LERTXUNDI, Nerea; LI, Xiaobo; LI, Yueling; LICHTENSTEIN, Paul; LIU, Jianghong; LUNDERVOLD, Astri J.; LUNDSTROM, Sebastian; MARKS, David J.; MARTIN, Joanna; MASI, Gabriele; MATIJASEVICH, Alicia; MELCHIOR, Maria; MOFFITT, Terrie E.; MONNINGER, Maximilian; MORRISON, Claire L.; MULRANEY, Melissa; MURATORI, Pietro; NGUYEN, Phuc T.; NICHOLSON, Jan M.; OIE, Merete Glenne; O'NEILL, Sarah; O'CONNOR, Cliodhna; ORRI, Massimiliano; PAN, Pedro M.; PASCOE, Leona; PETTIT, Gregory S.; PRICE, Jolie; REBAGLIATO, Marisa; RIANO-GALAN, Isolina; ROHDE, Luis A.; ROISMAN, Glenn I.; ROSA, Maria; ROSENBAUM, Jerrold F.; SALUM, Giovanni A.; SAMMALLAHTI, Sara; SANTOS, Ina S.; SCHIAVONE, Nella S.; SCHMID, Lorrie; SCIBERRAS, Emma; SHAW, Philip; SILK, Tim J.; SIMPSON, Jeffry A.; SKOGLI, Erik W.; STEPP, Stephanie; STRANDBERG-LARSEN, Katrine; SUDRE, Gustavo; SUNYER, Jordi; TANDON, Mini; THAPAR, Anita; THOMSON, Phoebe; THORELL, Lisa B.; TINCHANT, Hannah; TORRENT, Maties; TOVO-RODRIGUES, Luciana; TRIPP, Gail; UKOUMUNNE, Obioha; GOOZEN, Stephanie H. M. Van; VOS, Melissa; WALLEZ, Solene; WANG, Yufeng; WESTERMAIER, Franz G.; WHALEN, Diana J.; YONCHEVA, Yuliya; YOUNGSTROM, Eric A.; SAYAL, Kapil; SOLMI, Marco; DELORME, Richard; CORTESE, Samuele
    Background The youngest children in a school class are more likely than the oldest to be diagnosed with ADHD, but this relative age effect is less frequent in older than in younger school-grade children. However, no study has explored the association between relative age and the persistence of ADHD diagnosis at older ages. We aimed to quantify the association between relative age and persistence of ADHD at older ages. Methods For this meta-analysis, we searched MEDLINE, Embase, CINAHL, PsycINFO, and PubPsych up to April 1, 2022, with terms related to ""cohort"" and ""ADHD"" with no date, publication type, or language restrictions. We gathered individual participant data from prospective cohorts that included at least ten children identified with ADHD before age 10 years. ADHD was defined by either a clinical diagnosis or symptoms exceeding clinical cutoffs. Relative age was recorded as the month of birth in relation to the school-entry cutoff date. Study authors were invited to share raw data or to apply a script to analyse data locally and generate anonymised results. Our outcome was ADHD status at a diagnostic reassessment, conducted at least 4 years after the initial assessment and after age 10 years. No information on sex, gender, or ethnicity was collected. We did a two-stage random-effects individual participant data meta-analysis to assess the association of relative age with persistence of ADHD at follow-up. This study was registered with PROSPERO, CRD42020212650. Findings Of 33 119 studies generated by our search, we identified 130 eligible unique studies and were able to gather individual participant data from 57 prospective studies following up 6504 children with ADHD. After exclusion of 16 studies in regions with a flexible school entry system that did not allow confident linkage of birthdate to relative age, the primary analysis included 41 studies in 15 countries following up 4708 children for a period of 4 to 33 years. We found that younger relative age was not statistically significantly associated with ADHD persistence at follow-up (odds ratio 1 center dot 02, 95% CI 0 center dot 99-1 center dot 06; p=0 center dot 19). We observed statistically significant heterogeneity in our model (Q=75 center dot 82, p=0 center dot 0011, I-2=45%). Participant-level sensitivity analyses showed similar results in cohorts with a robust relative age effect at baseline and when restricting to cohorts involving children with a clinical diagnosis of ADHD or with a follow-up duration of more than 10 years. Interpretation The diagnosis of ADHD in younger children in a class is no more likely to be disconfirmed over time than that of older children in the class. One interpretation is that the relative age effect decreases the likelihood of children of older relative age receiving a diagnosis of ADHD, and another is that assigning a diagnostic label of ADHD leads to unexplored carryover effects of the initial diagnosis that persist over time. Future studies should be conducted to explore these interpretations further.
  • article 1 Citação(ões) na Scopus
    Adolescent Mental Health Before and During COVID-19: Longitudinal Evidence From the 2004 Pelotas Birth Cohort in Brazil
    (2024) MARUYAMA, Jessica Mayumi; TOVO-RODRIGUES, Luciana; SANTOS, Ina S.; MURRAY, Joseph; MATIJASEVICH, Alicia
    Purpose: There is great interest in examining the consequences of the COVID-19 pandemic on adolescent mental health, but most studies were conducted in high-income countries. The identification of overall effects and protective factors is essential to understand the determinants of mental wellbeing in contexts of stress. We aimed to study changes in adolescent mental health during the pandemic and the risk and protective factors associated with these changes in a Brazilian birth cohort. Methods: One thousand nine hundred forty nine adolescents from the 2004 Pelotas Birth Cohort were assessed prepandemic (T1, November 2019 to March 2020, mean age 15.69 years) and midpandemic (T2, August to December 2021, mean age 17.41 years). Mental health was assessed using the Strengths and Difficulties Questionnaire. Prepandemic and pandemic-related predictors were symptoms at T2. Higher emotion regulation levels protected against increases in adolescent mental Discussion: Family-context variables emerged as important risk factors for the deterioration of (c) 2024 Published by Elsevier Inc. on behalf of Society for Adolescent Health and Medicine.
  • article 0 Citação(ões) na Scopus
    Neurocognition and brain functional connectivity in a non-clinical population-based sample with psychotic experiences
    (2024) RAGAZZI, Taciana Cristina Carvalho; SHUHAMA, Rosana; SILVA, Pedro Henrique Rodrigues da; CORSI-ZUELLI, Fabiana; LOUREIRO, Camila Marcelino; ROZA, Daiane Leite da; LEONI, Renata Ferranti; MENEZES, Paulo Rossi; DEL-BEN, Cristina Marta
    We characterized the neurocognitive profile of communed-based individuals and unaffected siblings of patients with psychosis from Brazil reporting psychotic experiences (PEs). We also analyzed associations between PEs and the intra and inter-functional connectivity (FC) in the Default Mode Network (DMN), the Fronto-Parietal Network (FPN) and the Salience Network (SN) measured by functional magnetic resonance imaging. The combined sample of communed-based individuals and unaffected siblings of patients with psychosis comprised 417 (neurocognition) and 85 (FC) volunteers who were divided as having low (<75th percentile) and high (>= 75th percentile) PEs (positive, negative, and depressive dimensions) assessed by the Community Assessment of Psychic Experiences. The neurocognitive profile and the estimated current brief intellectual quotient (IQ) were assessed using the digit symbol (processing speed), arithmetic (working memory), block design (visual learning) and information (verbal learning) subtests of Wechsler Adult Intelligence Scale-third edition. Logistic regression models were performed for neurocognitive analysis. For neuroimaging, we used the CONN toolbox to assess FC between the specified regions, and ROI-to-ROI analysis. In the combined sample, high PEs (all dimensions) were related to lower processing speed performance. High negative PEs were related to poor visual learning performance and lower IQ, while high depressive PEs were associated with poor working memory performance. Those with high negative PEs presented FPN hypoconnectivity between the right and left lateral prefrontal cortex. There were no associations between PEs and the DMN and SN FC. Brazilian individuals with high PEs showed neurocognitive impairments like those living in wealthier countries. Hypoconnectivity in the FPN in a community sample with high PEs is coherent with the hypothesis of functional dysconnectivity in schizophrenia.
  • article 0 Citação(ões) na Scopus
    Impairments and related social inequalities among adults: 1 a population-based study in São Paulo city, Brazil
    (2024) CASTRO, Shamyr Sulyvan; BASSICHETTO, Katia Cristina; LIMA, Margareth Guimaraes; CESAR, Chester Luiz Galvao; GOLDBAUM, Moises; BARROS, Marilisa Berti de Azevedo
    The study of the association of social variables with the prevalence of impairments can provide subsidies for more adequate care and health policies for the most needy people by incorporating social aspects. This article aims to estimate the prevalence of diverse types of impairments, the degree of difficulty, limitations, and the need for help they cause and attest whether this prevalence differ by educational attainment in individuals aged 20 years or older. This is a populational cross-sectional study (2015 Health Survey of S & atilde;o Paulo-ISA Capital). Data from 3184 individuals were analyzed via educational attainment as exposure variable and outcome variables related to visual, hearing, intellectual, and mobility impairments. 19.9% of participants had visual, 7.8%, hearing, 2.7%, intellectual, and 7.4%, mobility impairments. Mobility and intellectual impairments limited participants' daily activities the most, 70.3% and 63.3%, respectively; who, thus, needed the most help: 48.9% and 48.5%, respectively. Lower schooling was associated with a higher prevalence of impairments, greater need for help due to visual and intellectual impairments, and greater limitations due to hearing and visual impairments.
  • article 5 Citação(ões) na Scopus
    Conceptual mapping proposed to comprehend the effect of wheelchair mobility on social participation and quality of life: a systematic review
    (2024) FERRETTI, Eliana Chaves; CURI, Haidar Tafner; ANDRADE, Luana Foroni; COOPER, Rory A.; SOAREZ, Patricia Coelho de
    Purpose: To identify and synthesise the available evidence on the effect of mobility on social participation and quality of life (QoL) of wheelchairs (WC) on adults who use WC as their primary means of mobility. Materials and methods: Systematic review undertaken in accordance with the Centre for Reviews and Dissemination Guidelines and registered in the PROSPERO International Prospective Register of Systematic reviews. Nine electronic databases (MEDLINE via PubMed, EMBASE, Cochrane Library, LILACS, CINAHL, PEDro, SCOPUS, Web of Science, and BVS ECOS) were searched with the following PICO eligibility criteria: (P) Population was individuals with mobility limitations that live in their community, aged 18 or older; (I) Intervention was mobility devices, such as manual and powered wheelchairs; (C) Comparators, not applied; (O) Outcome was factors that can be influenced by wheelchair use, such as: social participation, health-related quality of life and QOL. Critical appraisal of methodological quality of studies were undertaken. Results: A total of 18 studies were included. The proportion of studies evaluating the effects of mobility on participation was higher than to mobility on QoL. WC quality, device benefit (ease of repairs and maintenance), confidence using a WC and WC skills were key factors determining participation. The provision of WC according to the eight steps service proposed by the Word Health Organisation contributed to higher levels of physical health, WC satisfaction, hours using the WC and QoL enhancement. Conclusion: Attention should be given to enhance WC service provision (with continuous service support) as well as professional continuing education.
  • article 0 Citação(ões) na Scopus
    Ethical challenges in global research on health system responses to violence against women: a qualitative study of policy and professional perspectives
    (2024) LEWIS, Natalia V.; KALICHMAN, Beatriz; AZEREDO, Yuri Nishijima; BACCHUS, Loraine J.; D'OLIVEIRA, Ana Flavia
    BackgroundStudying global health problems requires international multidisciplinary teams. Such multidisciplinarity and multiculturalism create challenges in adhering to a set of ethical principles across different country contexts. Our group on health system responses to violence against women (VAW) included two universities in a European high-income country (HIC) and four universities in low-and middle-income countries (LMICs). This study aimed to investigate professional and policy perspectives on the types, causes of, and solutions to ethical challenges specific to the ethics approval stage of the global research projects on health system responses to VAW.MethodsWe used the Network of Ethical Relationships model, framework method, and READ approach to analyse qualitative semi-structured interviews (n = 18) and policy documents (n = 27). In March-July 2021, we recruited a purposive sample of researchers and members of Research Ethics Committees (RECs) from the five partner countries. Interviewees signposted policies and guidelines on research ethics, including VAW.ResultsWe developed three themes with eight subthemes summarising ethical challenges across three contextual factors. The global nature of the group contributed towards power and resource imbalance between HIC and LMICs and differing RECs' rules. Location of the primary studies within health services highlighted differing rules between university RECs and health authorities. There were diverse conceptualisations of VAW and vulnerability of research participants between countries and limited methodological and topic expertise in some LMIC RECs. These factors threatened the timely delivery of studies and had a negative impact on researchers and their relationships with RECs and HIC funders. Most researchers felt frustrated and demotivated by the bureaucratised, uncoordinated, and lengthy approval process. Participants suggested redistributing power and resources between HICs and LMICs, involving LMIC representatives in developing funding agendas, better coordination between RECs and health authorities and capacity strengthening on ethics in VAW research.ConclusionsThe process of ethics approval for global research on health system responses to VAW should be more coordinated across partners, with equal power distribution between HICs and LMICs, researchers and RECs. While some of these objectives can be achieved through education for RECs and researchers, the power imbalance and differing rules should be addressed at the institutional, national, and international levels. Three of the authors were also research participants, which had potential to introduce bias into the findings. However, rigorous reflexivity practices mitigated against this. This insider perspective was also a strength, as it allowed us to access and contribute to more nuanced understandings to enhance the credibility of the findings. It also helped to mitigate against unequal power dynamics.
  • article
    Discussing the relationships between homoparenthood and health 1
    (2024) GOMES, Romeu; MACHIN, Rosana; NASCIMENTO, Marcos Antonio Ferreira do; COUTO, Marcia Tereza
    The present article aims to bridge the gaps or deepen the debate to discuss the relationship between homoparenthood and health. This essay is anchored in specific literature. We seek to work on the following questions throughout the text: (i) How is the central theme of this discussion historically outlined? (ii) How does homoparenthood appear in scientific health production in general? (iii) What sociopolitical dimensions emerge around homoparenthood-health relationships? and (iv) What are the limitations and possibilities for exercising reproductive rights between same -sex couples? Among the conclusions, we underscore the challenge of facing the strangeness of homoparenthood against the idea of the so-called called ""normal"" family based on heteronormative logic. Even in countries with some legal apparatus assuring the rights to homoparental families, their members suffer prejudice, discrimination, and violence.
  • article 0 Citação(ões) na Scopus
    Discussing the relationships between homoparenthood and health
    (2024) GOMES, Romeu; MACHIN, Rosana; NASCIMENTO, Marcos Antonio Ferreira do; COUTO, Marcia Tereza
    The present article aims to bridge the gaps or deepen the debate to discuss the relationship between homoparenthood and health. This essay is anchored in specific literature. We seek to work on the following questions throughout the text: (i) How is the central theme of this discussion historically outlined? (ii) How does homoparenthood appear in scientific health production in general? (iii) What sociopolitical dimensions emerge around homoparenthood-health relationships? and (iv) What are the limitations and possibilities for exercising reproductive rights between same-sex couples? Among the conclusions, we underscore the challenge of facing the strangeness of homoparenthood against the idea of the so-called called ""normal"" family based on heteronormative logic. Even in countries with some legal apparatus assuring the rights to homoparental families, their members suffer prejudice, discrimination, and violence.
  • article 2 Citação(ões) na Scopus
    The reproductive silk route: transnational mobility of oocytes from Europe to Brazil
    (2024) MACHIN, Rosana; PLAZA, Consuelo Alvarez; HERNANDEZ, Marc Abraham Puig
    Assisted human reproduction has been deterritorialised into reproductive connectivity networks capable of adapting to contradictory laws, technological development and the mobility of people, reproductive substances, knowledge and capital. We reflect on the reproductive market and the dynamic capacity of cross-border reproductive care (CBRC), thanks to oocyte vitrification for egg donation, and on the legislative gaps that favour these flows. The purpose of the present study is to show the reproductive flows of oocytes from Europe to Brazil, which seem to have erratic route changes, leaving Spain and passing through other European countries, where they are stored, before arriving in Brazil. We carried out a qualitative study, based on documentary analysis of Brazilian Ministry of Health records on oocyte importation, the EU Coding Platform (System for Tissues and Cells), 10 in-depth interviews with key informants and legislative analysis on reproductive technologies in Spain, Brazil, Slovakia and Italy. This flow of oocytes underscores the flexibility and adaptability of transnational reproductive care.
  • article 3 Citação(ões) na Scopus
    Short-term associations between fine particulate air pollution and cardiovascular and respiratory mortality in 337 cities in Latin America
    (2024) GOUVEIA, Nelson; RODRIGUEZ-HERNANDEZ, Jordan L.; KEPHART, Josiah L.; ORTIGOZA, Ana; BETANCOURT, Ricardo Morales; SANGRADOR, Jose Luis Texcalac; RODRIGUEZ, Daniel A.; ROUX, Ana V. Diez; SANCHEZ, Brisa; YAMADA, Goro
    Ambient air pollution is a health concern in Latin America given its large urban population exposed to levels above recommended guidelines. Yet no studies have examined the mortality impact of air pollutants in the region across a wide range of cities. We assessed whether short-term levels of fine particulate matter (PM2.5) from modeled estimates, are associated with cardiovascular and respiratory mortality among adults in 337 cities from 9 Latin American countries. We compiled mortality, PM2.5 and temperature data for the period 2009-2015. For each city, we evaluated the association between monthly changes in PM2.5 and cardiovascular and respiratory mortality for sex and age subgroups using Poisson models, adjusted for seasonality, long-term trend, and temperature. To accommodate possibly different associations of mortality with PM2.5 by age, we included interaction terms between changes in PM2.5 and age in the models. We combined the city -specific estimates using a random effects meta -regression to obtain mortality relative risks for each sex and age group. We analyzed 3,026,861 and 1,222,623 cardiovascular and respiratory deaths, respectively, from a study population that represents 41 % of the total population of Latin America. We observed that a 10 mu g/m3 increase in monthly PM2.5 is associated with an increase of 1.3 % (95 % confidence interval [CI], 0.4 to 2.2) in cardiovascular mortality and a 0.9 % increase (95 % CI -0.6 to 2.4) in respiratory mortality. Increases in mortality risk ranged between -0.5 % to 3.0 % across 6 sex -age groups, were larger in men, and demonstrated stronger associations with cardiovascular mortality as age increased. Socioeconomic, environmental and health contexts in Latin America are different than those present in higher income cities from which most evidence on air pollution impacts is drawn. Locally generated evidence constitutes a powerful instrument to engage civil society and help drive actions to mitigate and control ambient air pollution.
  • article 0 Citação(ões) na Scopus
    Detection of Internal Transcribed Spacer 1 and hsp70 Genetic Markers Using Restriction Fragment Length Polymorphisms and Sequencing in Identification of Leishmania Species Causing Tegumentary Leishmaniasis in Brazil
    (2024) DELPRETE, Jaqueline Alves; ALMEIDA, Livia Vieira de; BARROS, Alessandra Moraes; SOLER, Rita de Cassia; BITTENCOURT, Amanda Azevedo; LUNA, Expedito Jose de Albuquerque; LINDOSO, Jose Angelo Lauletta; BRAZ, Lucia Maria Almeida
    The identification of Leishmania species that cause tegumentary leishmaniasis (TL) is important for taxonomic and prognostic purposes. Molecular analysis using different Leishmania genomic targets is the most useful method for identifying Leishmania species. Therefore, we evaluated the performance of ribosomal RNA internal transcribed spacer 1 (ITS1) and heat shock protein (hsp70) genetic markers by polymerase chain reaction (PCR), followed by restriction fragment length polymorphism analysis (RFLP) and sequencing, for identification of Leishmania species. Samples from 84 Brazilian patients were amplified. Internal transcribed spacer 1 PCR followed by RFLP (HaeIII) [ITS1-RFLP (HaeIII)] identified 46.4% (39/84) of the samples as compatible with the Viannia subgenus. Internal transcribed spacer 1 PCR followed by sequencing (ITS1-sequencing) identified Leishmania (Viannia) braziliensis in 91.7% (77/84) of the TL samples, Leishmania (Leishmania) amazonensis in 3.6% (3/84), L. (V.) guyanensis in 2.4% (2/84), and L. (L.) infantum in 1.2% (1/84). One of the samples showed the same proportion of similarity with L. (V.) guyanensis and L. (V.) panamensis. hsp70 nested PCR followed by RFLP (HaeIII) [nested hsp70-RFLP (HaeIII)] identified 91.7% (77/84) of the samples as compatible with L. (V.) braziliensis/L. (V.) naiffi, 3.6% (3/84) with L. (L.) amazonensis, 1.2% (1/84) with L. (L.) infantum, and 3.6% (3/84) with L. (V.) guyanensis. hsp70 PCR followed by sequencing (hsp70-sequencing) identified L. (V.) braziliensis in 91.7% (77/84) of the TL samples, L. (L.) amazonensis in 3.6% (3/84), L. (V.) guyanensis in 3.6% (3/84), and L. (L.) infantum in 1.2% (1/84). Our findings clearly showed that nested hsp70-RFLP (HaeIII) is better than ITS1-RFLP (HaeIII) and that ITS1 or hsp70 PCR followed by sequencing was adequate for identifying Leishmania species. We also found that Leishmania (Viannia) braziliensis is the most common species causing TL in Brazil. Therefore, sequencing multiple target genes such as ITS1 and hsp 70 is more accurate than RFLP for identifying Leishmania species.
  • article 0 Citação(ões) na Scopus
    GOVERNANÇA E COORDENAÇÃO NO SUS: Aprendendo com a pandemia de Covid-19
    (2023) COELHO, VERA SCHATTAN P.; BLOOM, GERRY; PAES-SOUSA, RÔMULO; FIORE, DANILO CESAR; VIANA, ANA LUIZA; IBAÑEZ, NELSON; ARBIX, GLAUCO; MELLO, GUILHERME; CERON, MARIANE
    ABSTRACT For plural health systems, promoting coordination between multiple sectors and governments levels is a permanent challenge. This study explores how the SUS dealt with this challenge during the Covid-19 pandemic, identifying proactive subnational actors, cross-sector cooperation and digital health as innovations that enhanced this coordination. Their emergence, the possibilities they represent for improving the SUS and how they can be sustained are discussed.
  • article 0 Citação(ões) na Scopus
    Risk and protective factors for the development of stress in the Federal Highway Police
    (2023) OLIVEIRA, Léa Pintor de Arruda; OLIVEIRA, Lucio Garcia de; CARVALHO, Heráclito Barbosa de
    Abstract Objective The present study aimed to identify the risk and protective factors for the development of stress in a random and stratified sample of Brazilian federal highway police officers in the state of São Paulo (N = 202). Method The instruments used were a General Questionnaire (sociodemographic and occupational variables) and Lipp’s Stress Symptom Inventory for Adults. The prevalence ratio was used as a measure of association and the independent variables were organized into 8 models and inserted into a logistic regression model. Results A stress prevalence of 43.1% (95% CI = 36.2–50.0) was found, with most of the sample in the resistance phase (82.7%). The factors related to stress were leisure, educational level, degree of job satisfaction, low remuneration, suicidal ideations, insomnia, lack of training, and work-family conflict. Conclusion The results can influence actions aimed at controlling stress.