Artigos e Materiais de Revistas Científicas - FM/MOG

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A coleção de Artigos e Materiais de Revistas Científicas engloba artigos originais, artigos de revisão, artigos de atualização, artigos técnicos, relatos de experiências, resenhas, ensaios, editoriais, cartas ao editor, debates, notas científicas e técnicas, depoimentos, entrevistas e pontos de vista. Consideram-se como artigos científicos originais os trabalhos redigidos para divulgação de informações e resultados sobre determinada pesquisa científica, publicados em periódico científico após avaliação por outros pesquisadores.


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  • article 0 Citação(ões) na Scopus
    Non-invasive imaging techniques for diagnosis of pelvic deep endometriosis and endometriosis classification systems: an International Consensus Statement
    The International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) and International Deep Endometriosis Analysis (IDEA) group, the European Endometriosis League (EEL), the European Society for Gynaecological Endoscopy (ESGE), ESHRE, the International Society for Gynecologic Endoscopy (ISGE), the American Association of Gynecologic Laparoscopists (AAGL) and the European Society of Urogenital Radiology (ESUR) elected an international, multidisciplinary panel of gynecological surgeons, sonographers, and radiologists, including a steering committee, which searched the literature for relevant articles in order to review the literature and provide evidence-based and clinically relevant statements on the use of imaging techniques for non-invasive diagnosis and classification of pelvic deep endometriosis. Preliminary statements were drafted based on review of the relevant literature. Following two rounds of revisions and voting orchestrated by chairs of the participating societies, consensus statements were finalized. A final version of the document was then resubmitted to the society chairs for approval. Twenty statements were drafted, of which 14 reached strong and three moderate agreement after the first voting round. The remaining three statements were discussed by all members of the steering committee and society chairs and rephrased, followed by an additional round of voting. At the conclusion of the process, 14 statements had strong and five statements moderate agreement, with one statement left in equipoise. This consensus work aims to guide clinicians involved in treating women with suspected endometriosis during patient assessment, counselling, and planning of surgical treatment strategies.
  • article 0 Citação(ões) na Scopus
    Evaluation of HLA-DQ2 and HLA-DQ8 haplotypes in patients with endometriosis, A case-control study
    (2024) ANDRES, Marina P.; PELOGGIA, Alessandra; ABRAO, Henrique M.; MAGALHAES, Thais F.; SIUFI NETO, Joao; ABRAO, Mauricio Simoes
    Objective: To evaluate the relationship between genetic haplotypes associated with celiac disease (Human Leucocyte Antigen [HLA] DQ2 and DQ8) with the diagnosis, clinical presentation, and location of endometriosis in Brazilian women. Method: A retrospective cross-sectional study, was conducted in a Tertiary hospital. Patients: Women aged 18-50 years who underwent HLA-DQ2 and HLA-DQ8 haplotype analysis. Intervention:The patients were divided into endometriosis and control groups and evaluated for symptoms; endometriosis location, American Society for Reproductive Medicine (ASRM) stage, and the presence of anti -tissue transglutaminase IgA (anti-TgA), HLA-DQ2, and HLA-DQ8 markers. Results: A total of 434 consecutive patients with (n = 315) and without (n = 119) endometriosis were included. Pain and infertility were more frequent in the endometriosis group than in the control group. The presence of HLA-DQ2, HLA-DQ8, and anti-TgA was similar between both groups. The presence of HLA-DQ2 and HLA-DQ8 markers did not differ based on age, pain symptoms, ASRM stage, or endometriosis location. Conclusion: Although there are similarities in inflammatory markers and pathophysiology between celiac disease and endometriosis, this study found no significant associations in the presence of HLA-DQ2 or HLA-DQ8 haplotypes and endometriosis.
  • article 0 Citação(ões) na Scopus
    Menstrual pattern in polycystic ovary syndrome and hypothalamic-pituitary-ovarian axis immaturity in adolescents: a systematic review and meta-analysis
    (2024) ZUCHELO, Lea T. S.; ALVES, Mayara S.; BARACAT, Edmund C.; SORPRESO, Isabel C. E.; JR, Jose M. Soares
    ObjectiveTo analyze differences in the menstrual pattern, age at menarche, and body mass index (BMI) in adolescents with Hypothalamic-Pituitary-Ovarian (HPO) axis immaturity and Polycystic Ovary Syndrome (PCOS) through a systematic review and meta-analysis.MethodsThe PubMed, EMBASE, Web of Science, Virtual Health Library, Scopus databases were searched using combinations of descriptors. Study quality was assessed using the Newcastle-Ottawa Scale. For data analysis, the results were grouped into PCOS group and NPCOS group (HPO axis immaturity). We performed a meta-analysis of raw data and the inverse variance method, employing the standardized mean difference, of the age at menarche and BMI of adolescents.ResultsParticipants totaled 1,718 from nine selected studies. The meta-analysis showed that the PCOS group had a higher BMI than the NPCOS group (SMD 0.334; CI95% 0.073 - 0.595; p = .012). The degree of heterogeneity of the studies was approximately 40%. No significant difference in age at menarche (SMD - 0.027; CI95% -0.227 - 0.172; p = 0.790) and menstrual patterns was found, but amenorrhea was described only in adolescents with PCOS.ConclusionsThe main characteristic in menstrual pattern that differentiated PCOS patients from girls with HPO axis immaturity was amenorrhea. Also, the BMI of PCOS patients was nearly one third higher than that of adolescents with HPO axis immaturity.
  • article 0 Citação(ões) na Scopus
    FOXO3a deregulation in uterine smooth muscle tumors
    (2024) ALMEIDA, Thais Gomes de; RICCI, Anamaria Ritti; ANJOS, Laura Gonzalez dos; JR, Jose Maria Soares; MACIEL, Gustavo Arantes Rosa; BARACAT, Edmund Chada; CARVALHO, Katia Candido
    Objective: The present study aimed to investigate FOXO3a deregulation in Uterine Smooth Muscle Tumors (USMT) and its potential association with cancer development and prognosis. Methods: The authors analyzed gene and protein expression profiles of FOXO3a in 56 uterine Leiomyosarcomas (LMS), 119 leiomyomas (comprising conventional and unusual leiomyomas), and 20 Myometrium (MM) samples. The authors used techniques such as Immunohistochemistry (IHC), FISH/CISH, and qRT-PCR for the present analyses. Additionally, the authors conducted an in-silico analysis to understand the interaction network involving FOXO3a and its correlated genes. Results: This investigation revealed distinct expression patterns of the FOXO3a gene and protein, including both normal and phosphorylated forms. Expression levels were notably elevated in LMS, and Unusual Leiomyomas (ULM) compared to conventional Leiomyomas (LM) and Myometrium (MM) samples. This upregulation was significantly associated with metastasis and Overall Survival (OS) in LMS patients. Intriguingly, FOXO3a deregulation did not seem to be influenced by EGF/HER-2 signaling, as there were minimal levels of EGF and VEGF expression detected, and HER-2 and EGFR were negative in the analyzed samples. In the examination of miRNAs, the authors observed upregulation of miR-96-5p and miR-155-5p, which are known negative regulators of FOXO3a, in LMS samples. Conversely, the tumor suppressor miR-let7c-5p was downregulated. Conclusions: In summary, the outcomes of the present study suggest that the imbalance in FOXO3a within Uterine Smooth Muscle Tumors might arise from both protein phosphorylation and miRNA activity. FOXO3a could emerge as a promising therapeutic target for individuals with Unusual Leiomyomas and Leiomyosarcomas (ULM and LMS), offering novel directions for treatment strategies.
  • article 1 Citação(ões) na Scopus
    Perinatal Results and Long-Term Follow-Up of Fetal Cardiac Tumors: A 30-Year Historical Cohort Study
    (2024) CAMARGO, Fabricio Marcondes; BRIZOT, Maria de Lourdes; FRANCISCO, Rossana Pulcineli Vieira; CARVALHO, Werther Brunow de; IKARI, Nana Miura; PERES, Stella Verzinhasse; LOPES, Marco Antonio Borges; LOPES, Lilian Maria
    Background: This was a 30-year retrospective cohort study that approximates closely to the natural history of cardiac tumors diagnosed in the fetus, since there was no case of pregnancy interruption Objective: To assess morbidity and mortality in the perinatal period and at long term in fetuses diagnosed with cardiac tumor. Our secondary objective was to assess the evaluating factors of perinatal and postnatal results. Methods: This was a retrospective cohort study with 74 pregnant women with an echocardiographic diagnosis of fetal cardiac tumor at two referral centers between May 1991 and November 2021. A descriptive analysis was performed, and data were expressed as absolute (n) and relative (%) frequencies, median and interquartile range. Fisher's exact test was used to evaluate the association of echocardiographic characteristics and clinical manifestations with perinatal and postnatal results. Global survival was calculated using the Kaplan-Meier method and the curves were compared by the log-rank test. The time of follow-up, calculated in months, corresponded to the time elapsed from hospital discharge to current status (survived/ censoring or death). The level of significance was set at 5% (p<0.05). Results: Rhabdomyoma is the most common type of cardiac tumor (85%), with a high morbidity (79.3%) and overall mortality of 17.4%. The presence of fetal hydrops was a predictor of death. Conclusion: The presence of fetal hydrops had an impact on mortality, and hence is an important factor in counselling and determining the prognosis. Most deaths occurred before hospital discharge.
  • article 0 Citação(ões) na Scopus
    Association between extrapolated time in range and large for gestational age infants in pregnant women with type 1 diabetes
    (2024) SANTOS, Enio A. M.; ZACCARA, Tatiana A.; PAGANOTI, Cristiane F.; PERES, Stela V.; FRANCISCO, Rossana P. V.; COSTA, Rafaela A.
    Aims: To evaluate the association between extrapolated time in range (eTIR), measured by self-monitoring of blood glucose (SMBG), and large-for-gestational-age (LGA) infants in pregnancies with type 1 diabetes (T1D). Methods: Retrospective cohort analysis including singleton pregnancies with T1D who started antenatal care before 20 gestational weeks and delivered live newborns at a Brazilian hospital between 2010 and 2019, with LGA fetuses as the main outcome. Glycemic records acquired using SMBG were categorized as eTIR, extrapolated time below range (eTBR), and extrapolated time above range (eTAR). Women were divided into two groups (LGA and adequate for gestational age [AGA]) and compared regarding clinical characteristics, obstetric outcomes, and frequencies of eTIR, eTBR, and eTAR. Logistic regression analysis verified the independent predictive variables for LGA infants. Results: Data from 125 pregnancies were analyzed. For the first, second and third trimesters, each 1 % increase in eTIR was associated with a decreased risk of LGA by 2.9 % (OR: 0.971; 95%CI: 0.945-0.998), 2.5 % (OR: 0.975; 95%CI: 0.951-0.999) and 2.3 % (OR: 0.977; 95%CI: 0.955-0.998) and each 1 % increase in eTAR was associated with an increased risk of LGA by 2.7 % (OR: 1.027; 95%CI: 1.005-1.050), 3.9 % (OR: 1.039; 95%CI: 1.014-1.063) and 4.6 % (OR: 1.046; 95%CI: 1.018-1.075), respectively. Conclusion: The concept of TIR can be extrapolated to patients undergoing SMBG to assess the risk of LGA infants in pregnant women with T1D.
  • article 0 Citação(ões) na Scopus
    Advanced glycation end products consumption and the decline of functional capacity in patients with Parkinson's disease: Cross-sectional study
    (2024) ALMEIDA, Jenifer Kristina Alves de; BRECH, Guilherme Carlos; LUNA, Natalia Mariana Silva; IBORRA, Rodrigo Tallada; SOARES-JUNIOR, Jose Maria; BARACAT, Edmund Chada; GREVE, Julia Maria D'Andrea; ALONSO, Angelica Castilho; MACHADO-LIMA, Adriana
    Introduction: Advanced Glycation End-Products (AGEs) are a diverse group of highly reactive molecules that play a vital role in the development of neurodegenerative disorders, such as Parkinson's Disease (PD), leading to a decline in functional and cognitive capacity. The objective of this study was to assess the intake and quantification of AGEs in individuals with PD and to correlate them with their functional and cognitive abilities. Methods: This was a cross-sectional study involving 20 PD patients and 20 non-PD individuals as the Control group (C). The autofluorescence reader was used to evaluate skin AGEs, while food recall was used to quantify AGEs consumed for three different days. The Montreal Cognitive Assessment, Short Physical Performance Battery, and handgrip tests were used. PD patients demonstrated greater impairment in functional capacity compared to the control group. Results: Dominant Handgrip (p = 0.02) and motor performance, in the sit and stand test (p = 0.01) and Short Physical Performance Battery (SPPB) (p = 0.01) were inferior in PD patients than the control group. Although PD patients tended to consume less AGEs than the control group, AGE intake was negatively correlated with handgrip strength in individuals with PD (r = -0.59; p < 0.05). Conclusion: PD patients had lower strength and functional capacity, suggesting that the effects of AGEs might be exacerbated during chronic diseases like Parkinson's.
  • article 1 Citação(ões) na Scopus
    Anthropometric, Metabolic, and Endocrine Parameters as Predictors of Estimated Average Glucose and Other Biomarkers of Dysglycemia in Women with Different Phenotypes of Polycystic Ovary Syndrome
    (2024) MEDEIROS, Sebastiao Freitas de; MEDEIROS, Ana Lin Winck Yamamoto de; MEDEIROS, Matheus Antonio Souto de; CARVALHO, Anna Bethany da Silva; YAMAMOTO, Marcia W.; SOARES, Jose M.; BARACAT, Edmund C.
    The aim of the study was to evaluate the efficacy of anthropometric, metabolic, and endocrine abnormalities as predictors of estimated average glucose and other biomarkers of dysglycemia in women with different phenotypes of polycystic ovary syndrome (PCOS). This cross-sectional study included 648 women with PCOS and 330 controls. A single protocol of investigation was applied for all subjects. PCOS women were divided by phenotypes according to the Rotterdam criteria. Biomarkers of dysglycemia were considered dependent variables and anthropometric, lipid, and hormone alterations as independent variables using univariate and multivariate logistic regressions. Univariate logistic regression analysis, controlled for age and BMI, showed that many biomarkers of dysglycemia could be predicted by anthropometric, lipid, and endocrine variables. Multivariate logistic models showed that in non-PCOS women estimated average glucose (eAG) was predicted by lower TSH levels (OR=0.39; p=0.045); fasting glucose was predicted by increased T (OR=2.3). For PCOS, phenotype A, eAG was predicted by decreased HDL-C (OR=0.17, p=0.023) and high levels of free estradiol (OR=7.1, p<0.001). Otherwise, in PCOS, phenotype D, eAG was predicted by higher levels of HDL-C. The current study demonstrated that eAG was poorly predicted by anthropometric, lipid, and hormone parameters. Nevertheless, without adding significant benefits, it was comparable with other established markers of dysglycemia in women with different PCOS phenotypes.
  • article 0 Citação(ões) na Scopus
    Antioxidant Actions of Melatonin: A Systematic Review of Animal Studies
    (2024) MONTEIRO, Karla Krislane Alves Costa; SHIROMA, Marcos Eiji; DAMOUS, Luciana Lamarao; SIMOES, Manuel de Jesus; SIMOES, Ricardo dos Santos; CIPOLLA-NETO, Jose; BARACAT, Edmund Chada; SOARES-JR., Jose Maria
    Melatonin is an indoleamine with crucial antioxidant properties that are used to combat inflammatory and neoplastic processes, as well as control transplants. However, the clinical applications of melatonin have not yet been fully consolidated in the literature and require in-depth analysis. Objectives: This study reviewed the literature on the antioxidant properties of melatonin in rat models. Methods: We followed the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses and used the PubMed, LILACS, and Cochrane databases, Google Scholar, and article references, irrespective of publication time. Results: Ten articles involving 485 rats were selected, and the effects of melatonin on antioxidant markers were investigated. Melatonin increased superoxide dismutase in nine studies, glutathione peroxidase in seven studies, and catalase in five studies. In contrast, melatonin reduced glutathione in three studies and malonaldehyde in seven of eight studies. Conclusion: Our findings suggest that melatonin effectively reduces oxidative stress.
  • article 0 Citação(ões) na Scopus
    Melatonin, menopause, and thyroid function in gynecologic endocrinology: what is the role?
    (2024) JR, Jose Maria Soares; DETANAC, Dzemail; SENGUL, Ilker; DUGALIC, Stefan; SENGUL, Demet; DETANAC, Dzenana
  • article 0 Citação(ões) na Scopus
    An overview of systematic reviews of medicinal plants and herbal formulations for the treatment of climacteric symptoms
    (2024) PORTELLA, Caio Fabio Schlechta; SILVA, Igor De Azevedo; SIMOES, Ricardo Santos; GHELMAN, Ricardo; BARACAT, Edmund Chada; SOARES JUNIOR, Jose Maria; SORPRESO, Isabel Cristina Esposito
    Introduction: Climacteric syndrome, marking the end of a woman's reproductive years, is accompanied by a host of physical and emotional symptoms that significantly impact her quality of life. There is a growing demand for safe and effective complementary treatments due necessity of another treatment options to meet clinical needs and women's choice. This has led to a surge of interest in medicinal plants and herbal formulations, with traditional uses across cultures and emerging scientific evidence suggesting potential benefits. Methods: A systematic overview was conducted in 2022 across five electronic databases, adhering to the standards and PRISMA guidelines. Eligibility evaluation and methodological quality assessment of studies were performed by independent reviewers using the AMSTAR2 tool. Results: The review identified 51 medicinal plants and herbal formulations in 57 systematic reviews. Soy isoflavones, red clover extract, Hypericum perforatum preparations, black cohosh extract, and Chinese herbal medicine formulations demonstrated potential efficacy in managing climacteric symptoms. Discussion/Conclusions: This study underscores the potential of medicinal plants and herbal formulations in managing climacteric syndrome symptoms. Notably, soy isoflavones, red clover extract, and black cohosh extract exhibited promising results. However, the current evidence base is variable, underlining the need for rigorous, well-designed research to substantiate these findings. Additionally, the intriguing results related to the reduction of sexual symptoms by Maca and Tribulus terrestris, and the potential therapeutic benefits of botanicals such as evening primrose, fenugreek, vitex, and cannabis, call for deeper investigation. This comprehensive overview serves to guide future research directions and inform clinical practice in this burgeoning field.
  • article 0 Citação(ões) na Scopus
    Biological action of melatonin on target receptors in breast cancer
    (2024) PARDI, Paulo Celso; TURRI, Jose Antonio Orellana; BAYER, Luiza Helena Costa Moreira; NOBREGA, Gabriela Bezerra; FILASSI, Jose Roberto; SIMOES, Ricardo dos Santos; MOTA, Bruna Salani; SORPRESO, Isabel Cristina Esposito; BARACAT, Edmund Chada; SOARES JUNIOR, Jose Maria
  • article 0 Citação(ões) na Scopus
    Giant uterine tumor and miscarriage: how to proceed?
    Expanding uterine masses can be the cause of pregnancy loss and add technical difficulties to uterus evacuation due to the intense anatomical distortion of the endocervical canal and uterine cavity. The literature is scarce in the peculiarities of the management of missed abortions in uterus with important distorted anatomies. We report a case of a primigravida patient who presented a rapid and expressive increase of abdominal volume due to a giant uterine mass, evolving to miscarriage. Ultrasound can be a useful tool, allowing visualization of the endocervical path and uterine cavity, helping to perform uterine evacuation in the presence of anatomical distortion without compromising the reproductive future. To the best of our knowledge, no such case has been previously reported.
  • article 0 Citação(ões) na Scopus
    Not as easy as it seems: indocyanine green tracking and anatomical variations of sentinel lymph node locations
    (2024) FERNANDES, Rodrigo Pinto; ABU-RUSTUM, Nadeem R.; ANTON, Cristina; CARVALHO, Jesus Paula
  • article 0 Citação(ões) na Scopus
    A randomized clinical trial comparing internal and external pessaries in the treatment of pelvic organ prolapse in postmenopausal women: A pilot study
    (2024) HOSOUME, Renato Sugahara; PETERSON, Thais Villela; JR, Jose Maria Soares; BARACAT, Edmund Chada; HADDAD, Jorge Milhem
    Introduction and hypothesis: Internal vaginal pessary is among the leading treatments for pelvic organ prolapse (POP); however, it has a high adverse event rate. An external pessary was recently developed as an alternative. The study's objective was to compare the efficacy of external and internal pessaries in treating POP in postmenopausal women. Methods: This parallel randomized (1:1 ratio) open-blind study included 40 symptomatic women with stage 2 or 3 POP. They were randomized into two groups: group 1 (internal pessary) and group 2 (external pessary) (n = 20 in each); and evaluated at the start of and 3 months after the treatment. Statistical analysis was performed to compare the results within and between the groups before and after the 3-month treatment. Results: The groups were homogeneous, except for the variables previous pregnancies (p = 0.030) and POP-Q score of apical prolapse (p = 0.023) whose values were higher in group 2. A significant improvement in quality of life was observed in both groups after 3 months of follow-up; however, internal pessaries were found to be more effective (p < 0.001). In group 1 there were differences between the initial and final POP-Q scores of anterior (0.004) and apical prolapse (p = 0.005). The complication rate associated with internal pessary use was high (p = 0.044). Conclusions: The present data suggested that external pessaries have a similar effect to internal ones for the treatment of POP and improvement of the quality of life of postmenopausal women.
  • article 0 Citação(ões) na Scopus
    Immune checkpoint inhibitors: here to stay
    (2023) CARVALHO, Filomena Marino; DIZ, Maria Del Pilar Estevez; CARVALHO, Jesus Paula
  • article 0 Citação(ões) na Scopus
    MicroRNA-210-3p Regulates Endometriotic Lesion Development by Targeting IGFBP3 in Baboons and Women with Endometriosis (vol 30, pg 2932, 2023)
    (2024) KAI, Kentaro; JOSHI, Niraj R.; BURNS, Gregory W.; HRBEK, Samantha M.; VEGTER, Erin L.; OCHOA-BERNAL, Maria Ariadna; SONG, Yong; MOLDOVAN, Genna E.; SEMPERE, Lorenzo F.; MIYADAHIRA, Eduardo H.; SERAFINI, Paulo C.; FAZLEABAS, Asgerally T.
  • article 1 Citação(ões) na Scopus
    A closer look at heterotopic sites of pleomorphic adenoma, particularly in women: fide, sed cui vide?
    (2024) SENGUL, Ilker; SENGUL, Demet; JUNIOR, Jose Maria Soares
  • article 0 Citação(ões) na Scopus
    Low back pain, pelvic pain, and associated factors in type 1 diabetic pregnant women
    (2024) BATISTA, Patricia Andrade; OLIVEIRA, Claudia de; COSTA, Rafaela Alkmin da; FRANCISCO, Rossana Pulcineli Vieira; CABAR, Fabio Roberto
    Introduction: Pregnancy and diabetes mellitus promote several musculoskeletal changes predisposing this population to complaints of Lower Back (LB) and Pelvic Pain (PP). Objective: To assess the frequency of LB and PP and associated factors in type 1 Diabetic (DM1) pregnant women. Method: An observational analytical cross-sectional study. Thirty-six pregnant women with DM1 were evaluated through a postural assessment with a focus on pelvic positioning and what patients reported. The associated factors were assessed using the State-Trait Anxiety Inventory (STAI), the International Consultation on Incontinence Questionnaire Short Form (ICIQ-SF), and the Female Sexual Function Index (FSFI). Results: The frequency of LB and PP was 55.6 % and 30.6 %, respectively. The presence of anxiety was not associated with a higher prevalence of pain. The incidence of sexual dysfunctions was higher in the GD. DM1 duration had a mean of 14.9 years (+/- 8.2 SD) in the GD and 9.0 years (+/- 6.9 SD) in the GSD, which was statistically significant (p <= 0.050). In the multiple binary regression analysis for the occurrence of pain, the independent factor was DM1 duration >= 17 years (OR = 11.2; 95 % CI = 1.02-124.75). The association between DM1 duration >= 17 years and being overweight showed a probability of 95 % for the studied population in the analysis of the probabilities of occurrence of the pain event. Conclusion: There was a high frequency of LB and PP related to pregnancy in DM1 pregnant women in the second trimester of pregnancy. The incidence of sexual dysfunction and DM1 duration >= 17 years increases the chance that DM1 pregnant women will experience pain. There was no association between anxiety. urinary incontinence and pain in DM1 pregnant women.
  • article 0 Citação(ões) na Scopus
    Autologous heterotopic fresh ovarian graft: technique description
    (2023) BERTOLAZZI, Marilia Albanezi; FERNANDES, Rodrigo Pinto; GENTA, Maria Luiza Nogueira Dias; BARACAT, Edmund Chada; CARVALHO, Jesus Paula