MARCELLO ANTONIO SIGNORELLI COCUZZA

(Fonte: Lattes)
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Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/55 - Laboratório de Urologia, Hospital das Clínicas, Faculdade de Medicina - Líder

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  • article 8 Citação(ões) na Scopus
    Varicocele-Associated Infertility and the Role of Oxidative Stress on Sperm DNA Fragmentation
    (2021) WOOD, Guilherme Jacom Abdulmassih; CARDOSO, Joao Paulo Greco; PALUELLO, Davi Vischi; NUNES, Thiago Fagundes; COCUZZA, Marcello
    Varicocele has been extensively described and studied as the most important reversible cause of male infertility. Its impact on semen parameters, pregnancy rates, and assisted reproductive outcomes have been associated with multifactorial aspects, most of them converging to increase of reactive oxygen species (ROS). More recently, sperm DNA fragmentation has gained significant attention and potential clinical use, although the body of evidence still needs further evolution. The associations between sperm DNA damage and a variety of disorders, including varicocele itself, share common pathways to ROS increase. This mini-review discusses different aspects related to the etiology of ROS and its relation to varicocele and potential mechanisms of DNA damage.
  • article 267 Citação(ões) na Scopus
    Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility
    (2019) AGARWAL, Ashok; PAREKH, Neel; SELVAM, Manesh Kumar Panner; HENKEL, Ralf; SHAH, Rupin; HOMA, Sheryl T.; RAMASAMY, Ranjith; KO, Edmund; TREMELLEN, Kelton; ESTEVES, Sandro; MAJZOUB, Ahmad; ALVAREZ, Juan G.; GARDNER, David K.; JAYASENA, Channa N.; RAMSAY, Jonathan W.; CHO, Chak-Lam; SALEH, Ramadan; SAKKAS, Denny; HOTALING, James M.; LUNDY, Scott D.; VIJ, Sarah; MARMAR, Joel; GOSALVEZ, Jaime; SABANEGH, Edmund; PARK, Hyun Jun; ZINI, Armand; KAVOUSSI, Parviz; MICIC, Sava; SMITH, Ryan; BUSETTO, Gian Maria; BAKIRCIOGLU, Mustafa Emre; HAIDL, Gerhard; BALERCIA, Giancarlo; PUCHALT, Nicols Garrido; BEN-KHALIFA, Moncef; TADROS, Nicholas; KIRKMAN-BROWNE, Jackson; MOSKOVTSEV, Sergey; HUANG, Xuefeng; BORGES JR., Edson; FRANKEN, Daniel; BAR-CHAMA, Natan; MORIMOTO, Yoshiharu; TOMITA, Kazuhisa; SRINI, Vasan Satya; OMBELET, Willem; BALDI, Elisabetta; MURATORI, Monica; YUMURA, Yasushi; VIGNERA, Sandro La; KOSGI, Raghavender; MARTINEZ, Marlon P.; EVENSON, Donald P.; ZYLBERSZTEJN, Daniel Suslik; ROQUE, Matheus; COCUZZA, Marcello; VIEIRA, Marcelo; BEN-MEIR, Assaf; ORVIETO, Raoul; LEVITAS, Eliahu; WISER, Amir; ARAFA, Mohamed; MALHOTRA, Vineet; PAREKATTIL, Sijo Joseph; ELBARDISI, Haitham; CARVALHO, Luiz; DADA, Rima; SIFER, Christophe; TALWAR, Pankaj; GUDELOGLU, Ahmet; MAHMOUD, Ahmed M. A.; TERRAS, Khaled; YAZBECK, Chadi; NEBOJSA, Bojanic; DURAIRAJANAYAGAM, Damayanthi; MOUNIR, Ajina; KAHN, Linda G.; BASKARAN, Saradha; PAI, Rishma Dhillon; PAOLI, Donatella; LEISEGANG, Kristian; MOEIN, Mohamed-Reza; MALIK, Sonia; YAMAN, Onder; SAMANTA, Luna; BAYANE, Fouad; JINDAL, Sunil K.; KENDIRCI, Muammer; ALTAY, Baris; PEROVIC, Dragoljub; HARLEV, Avi
    Despite advances in the field of male reproductive health, idiopathic male infertility, in which a man has altered semen characteristics without an identifiable cause and there is no female factor infertility, remains a challenging condition to diagnose and manage. Increasing evidence suggests that oxidative stress (OS) plays an independent role in the etiology of male infertility, with 30% to 80% of infertile men having elevated seminal reactive oxygen species levels. OS can negatively affect fertility via a number of pathways, including interference with capacitation and possible damage to sperm membrane and DNA, which may impair the sperm's potential to fertilize an egg and develop into a healthy embryo. Adequate evaluation of male reproductive potential should therefore include an assessment of sperm OS. We propose the term Male Oxidative Stress Infertility, or MOSI, as a novel descriptor for infertile men with abnormal semen characteristics and OS, including many patients who were previously classified as having idiopathic male infertility. Oxidation-reduction potential (ORP) can be a useful clinical biomarker for the classification of MOSI, as it takes into account the levels of both oxidants and reductants (antioxidants). Current treatment protocols for OS, including the use of antioxidants, are not evidence-based and have the potential for complications and increased healthcare-related expenditures. Utilizing an easy, reproducible, and cost-effective test to measure ORP may provide a more targeted, reliable approach for administering antioxidant therapy while minimizing the risk of antioxidant overdose. With the increasing awareness and understanding of MOSI as a distinct male infertility diagnosis, future research endeavors can facilitate the development of evidence-based treatments that target its underlying cause.