JOAO CARLOS NAKAMOTO
Projetos de Pesquisa
Unidades Organizacionais
LIM/41 - Laboratório de Investigação Médica do Sistema Músculoesquelético, Hospital das Clínicas, Faculdade de Medicina
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
- Evaluation of the Use of Nerve Allograft Preserved in Glycerol(2021) NAKAMOTO, Joao Carlos; WATAYA, Erick Yoshio; NAKAMOTO, Hugo Alberto; SANTOS, Gustavo Bispo; RIBARIC, Ivan; HERRERA, Ana K. A.; FARIA, Jose C. M.Background: We aimed to evaluate the use of nerve allograft preserved in glycerol. We compared the efficiency of glycerol-preserved allografts with autogenous nerve grafting, cryopreserved grafts, and detergent-processed grafts in the axonal regeneration. Secondarily, we evaluated the effectiveness of each preservation method in maintaining the extracellular matrix free of cellular components. Methods: This was a prospective experimental, longitudinal, unblinded, nonrandomized, controlled animal model study. Three different allograft preservation techniques for the repair of sciatic nerve injuries were compared, including cold preservation, glycerol preservation, and detergent preservation. Functional assessment was performed, and histomorphometric analyses were further performed, which enabled the allograft structure evaluation and an estimation of the nerve regeneration efficacy based on the myelinated axons count and on their diameters. Results: After the 14(th) week, all groups were already balanced and similar (P = 0.265): all groups present near-zero SFIs, thus confirming their efficiency in promoting nerve regeneration. In the histomorphometric evaluations, all groups were equivalent, presenting a similar efficiency in nerve regeneration (P = 0.716 and P = 0.577, respectively). Similarly, histomorphometric evaluations showed a reduction in the number of axons and in their diameters, but none of them effectively eliminated all cellular debris. Comparing the groups with each other, the groups preserved in glycerol and detergent solution were similar, both presenting better results than the cooled group. Conclusion: By evaluating the presence of cell debris after the treatment using glycerol, it was found to be similar to the treatment using detergent and significantly better than the cold-preservation treatment.
bookPart Anatomia cirúrgica das mãos(2015) NAKAMOTO, Hugo Alberto; NAKAMOTO, João Carlos; MUNHOZ, Alexandre Mendonça- TREATMENT OF SCHAPHOID NONUNION WITH VOLAR LOCKED PLATE(2019) BURGOS, Felipe Hellmeister; NAKAMOTO, Joao Carlos; NAKAMOTO, Hugo Alberto; IWASE, Fernanda do Carmo; MATTAR JUNIOR, RamesObjective: To assess and compare radiographic, tomographic and functional pre and postoperative parameters of patients submitted to treatment of nonunion of the scaphoid waist with locked plate for scaphoid. Methods: This is a case series of scaphoid waist nonunion, operated from March 2017 to March 2018 at the Institute of Orthopedics and Traumatology of HCFMUSP, using the technique of Fisk-Fernandez and osteosynthesis with locked plate for scaphoid APTUS (R) Hand from Medartis. The patients were submitted to radiographs, computed tomography and functional evaluation by the occupational therapy team in the pre and postoperative periods. Results: There was consolidation of the scaphoid waist nonunion in all cases, improvement in the parameters of carpal alignment in the imaging examinations, but functionally we observed reduction of the range of motion and grip strength in relation to the contralateral limb. Conclusions: The treatment of the scaphoid waist nonunion with locked plate was effective, with a high index of consolidation and improvement of the carpal alignment in the imaging tests, although with a reduction in the range of motion and grip strength in relation to the contralateral limb when evaluated with 12 weeks postoperatively.
- Reconstrução tardia na mão traumatizada com perda de múltiplos dedos(2017) TAKEMURA, RENAN LYUJI; NAKAMOTO, HUGO ALBERTO; IWASE, FERNANDA DO CARMO; NAKAMOTO, JOÃO CARLOS; VERONESI, BRUNO AZEVEDO; WEI, TENG HSIANGABSTRACT Mutilating hand injuries are a challenge to both the hand surgeon and the patient. The surgeon must make decisions ranging from the initial debridement to which fingers and joints will be preserved and the appropriate use of the parts to be removed. Late reconstruction constitutes the second part of this difficult task. The difficulty attributed to the characteristics of each lesion, the large number of treatment possibilities, and the different levels of complexity must be adapted to the personal needs and motivation of each patient. This case report describes a late hand reconstruction with index and middle finger loss, using metacarpophalangeal joint transplantation of the index finger to gain the proximal interphalangeal function of the middle finger.
bookPart Traumatismo das mãos e lesões nervosas(2015) NAKAMOTO, Hugo Alberto; NAKAMOTO, João Carlos; TUMA JR., PaulobookPart Lesão dos tendões extensores(2021) NAKAMOTO, João Carlos; PAULOS, Renata Gregório