JESSICA KAZUMI OKUMA

(Fonte: Lattes)
Índice h a partir de 2011
1
Lattes
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Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
SVANES-62, Hospital Universitário
LIM/16 - Laboratório de Fisiopatologia Renal, Hospital das Clínicas, Faculdade de Medicina

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  • bookPart
    Cricotireoidostomia
    (2017) SOUSA, Braian Lucas Aguiar; OGATA, Fiama Kuroda; OKUMA, Jéssica Kazumi; BRESCIA, Marília D'Elboux Guimarães; TIERNO, Paulo Fernando Guimarães Marzocchi; HOJAIJ, Flávio Carneiro
  • article 17 Citação(ões) na Scopus
    Innate And Adaptive Immunity are Progressively Activated in Parallel with Renal Injury in the 5/6 Renal Ablation Model
    (2017) FANELLI, Camilla; ARIAS, Simone C. A.; MACHADO, Flavia G.; OKUMA, Jessica K.; MALHEIROS, Denise M. A. C.; AZEVEDO, Hatylas; MOREIRA-FILHO, Carlos A.; CAMARA, Niels O. S.; FUJIHARA, Clarice K.; ZATZ, Roberto
    The mechanisms triggering renal inflammation in chronic kidney disease (CKD) are unclear. We performed a detailed analysis of the time course of innate and adaptive immunity activation in the 5/6 renal ablation (Nx) model. Munich-Wistar rats undergoing Nx were studied 15, 60 and 120 days after ablation. Hypertension, albuminuria, creatinine retention, interstitial expansion and infiltration by macrophages and T-lymphocytes were already evident 15 days after Nx. PCR-array was used to screen for altered gene expression, whereas gene and protein expressions of TLR4, CASP1, IL-1 beta and NLRP3 were individually assessed. Tlr4, Tlr5, Lbp, Nlrp3, Casp1, Irf7 and Il1b were already upregulated 15 days after Nx, while activation of Tlr2, Tlr7, Tlr9, Nod2, Tnf and Il6 was seen after 60 days post-ablation. The number of genes related to innate or adaptive immunity grew steadily with time. These observations indicate that parallel activation of innate and adaptive immunity antecedes glomerular injury and involves a growing number of intricate signaling pathways, helping to explain the difficulty in detaining renal injury in Nx as CKD advances, and, stressing the need for early treatment. Additionally, these findings may contribute to the search of therapeutic targets specific for advanced phases of CKD.
  • bookPart
    Cateter venoso central em veia jugular interna
    (2017) OGATA, Fiama Kuroda; OKUMA, Jéssica Kazumi; SOUSA, Braian Lucas Aguiar; BRESCIA, Marília D'Elboux Guimarães; TIERNO, Paulo Fernando Guimarães Marzocchi; HOJAIJ, Flávio Carneiro