ANTONIO CARLOS NICODEMO

(Fonte: Lattes)
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Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina - Docente
LIM/46 - Laboratório de Parasitologia Médica, Hospital das Clínicas, Faculdade de Medicina

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Categoria: review × Revista / Livro: American Journal of Tropical Medicine and Hygiene ×

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  • article 5 Citação(ões) na Scopus
    Pathogenesis of Pulmonary Hemorrhagic Syndrome in Human Leptospirosis
    (2021) NICODEMO, Antonio C.; DUARTE-NETO, Amaro Nunes
    Based on a previous study and by incorporating new knowledge, the goal of our study was to understand more fully the pathogenesis of hemorrhagic pneumonia of severe human leptospirosis, highlighting the onset of capillary lesions by Leptospira itself and/or its antigenic/toxic products acting on the endothelium and binding to cadherins. Both events lead to loss of endothelial integrity, alter permeability, cause rupture, and open intercellular junctions, contributing to the hemorrhagic phenomena associated with severe leptospirosis.