Pathogenesis of Pulmonary Hemorrhagic Syndrome in Human Leptospirosis
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Citações na Scopus
5
Tipo de produção
article
Data de publicação
2021
Título da Revista
ISSN da Revista
Título do Volume
Editora
AMER SOC TROP MED & HYGIENE
Citação
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, v.104, n.6, p.1970-1972, 2021
Resumo
Based on a previous study and by incorporating new knowledge, the goal of our study was to understand more fully the pathogenesis of hemorrhagic pneumonia of severe human leptospirosis, highlighting the onset of capillary lesions by Leptospira itself and/or its antigenic/toxic products acting on the endothelium and binding to cadherins. Both events lead to loss of endothelial integrity, alter permeability, cause rupture, and open intercellular junctions, contributing to the hemorrhagic phenomena associated with severe leptospirosis.
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Referências
- Bernardi FD, 2012, HUM PATHOL, V43, P1601, DOI 10.1016/j.humpath.2011.11.017
- De Brito T, 2018, REV INST MED TROP SP, V60, DOI [10.1590/S1678-9946201860023, 10.1590/s1678-9946201860023]
- Evangelista K, 2014, PLOS NEGLECT TROP D, V8, DOI 10.1371/journal.pntd.0002672
- Evangelista KV, 2010, FUTURE MICROBIOL, V5, P1413, DOI 10.2217/FMB.10.102
- Fraga TR, 2016, FRONT IMMUNOL, V7, DOI 10.3389/fimmu.2016.00623
- Kochi LT, 2019, VIRULENCE, V10, P734, DOI 10.1080/21505594.2019.1650613
- Miyahara S, 2014, INT J EXP PATHOL, V95, P271, DOI 10.1111/iep.12085
- Nicodemo AC, 1997, AM J TROP MED HYG, V56, P181, DOI 10.4269/ajtmh.1997.56.181
- Sato H, 2017, PLOS NEGLECT TROP D, V11, DOI 10.1371/journal.pntd.0005830
- Smith S, 2019, PLOS NEGLECT TROP D, V13, DOI 10.1371/journal.pntd.0007929
- Vieira ML, 2014, FEMS MICROBIOL LETT, V352, P129, DOI 10.1111/1574-6968.12349