ARIELLA FORNACHARI RIBEIRO BELAN
Projetos de Pesquisa
Unidades Organizacionais
LIM/27 - Laboratório de Neurociências, Hospital das Clínicas, Faculdade de Medicina
14 resultados
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Agora exibindo 1 - 10 de 14
- Cognitive-communication disorder following right hemisphere damage: Narrative production(2022) RODRIGUEZ, E.; BELAN, A. F. R.; RADANOVIC, M.Background: Cognitive-communication disorder (CCD) results from the association of language and cognition impairment that may follow right hemisphere (RH) damage and impair the quality of life of affected persons. Objective: We studied a set of 1,625 narratives produced by a cohort of 125 individuals (50 with a single right vascular lesion in the MCA territory and 75 cognitively healthy controls) using a task of picture-based discourse production. Discourse production was analyzed in its macro-and microlinguistic aspects to characterize better the linguistic mechanisms underlying RH patients' performance. Results: The RH group produced more words and elocutions than controls, with a lower rate of informational content and a higher percentage of global coherence errors (all p-values <0.0001). Conclusion: Individuals with RH lesions showed formal lexical and syntactic aspects of discourse mostly preserved. Alterations in the macrostructure of discourse prevailed over microstructural alterations in our sample, according to most literature studies. The group of individuals with RH lesions produced narratives containing more words and utterances, with a lesser degree of lexical information and more global coherence errors. © 2022
conferenceObject COGNITIVE PROFILE OF ADULTS AND SENIORS WITH DOWN'S SYNDROME: DATA FROM THE CAMBRIDGE EXAMINATION FOR MENTAL DISORDERS OF OLDER PEOPLE WITH DOWN SYNDROME BRAZILIAN VERSION - CAMDEX-DS ADAPTED AND VALIDATED FOR THE BRAZILIAN POPULATION(2019) CARVALHO, C. L.; ARAUJO, M. C. Cristianini; NOGUEIRA, C.; GONCALVES, A.; BELAN, A.; BRAM, J.; SANTANA, L.; BECKER, A.; RADANOVIC, M.; FORLENZA, O.- Sentence processing in mild cognitive impairment(2022) PEREIRA, Diana Nakamura; SOUZA, Wellington da Cruz; BELAN, Ariella Fornachari Ribeiro; CAMARGO, Marina von Zuben de Arruda; FORLENZA, Orestes Vicente; RADANOVIC, MarciaDifficulties in sentence processing have been reported in patients with Mild Cognitive Impairment (MCI), which may be due to impairment in primary syntactic abilities or short-term memory. In the present study, we investigated the relationship between overt sentence production (SP) and comprehension (SC) with short-term memory performance in MCI. Cognitively healthy elderly (n = 34), amnestic MCI (aMCI,n = 22), non-amnestic MCI (naMCI,n = 45), and Alzheimer's disease (AD,n = 18) patients were asked to complete tests of constrained SP and oral SC. We tested the association between performance in SP and SC with memory tasks and performed a qualitative analysis of the frequency and type of errors in SC. Our results showed that there were no intergroup differences in SC and SP performances. SC scores were associated with delayed recall for words in the naMCI group (p = 0.003), and immediate (p = 0.001) and delayed recall for shapes (p = 0.031) in AD. There were no predictors for NAT scores in any group. In conclusion, the three groups performed similarly in SC and SP tasks. Short-term memory was not associated with performance in the SP task. There was an association between performance in the SC task and verbal memory in naMCI and non-verbal memory in AD; the latter may reflect visuospatial processing demands embedded in the SC task.
- Diagnostic Performance of an Eye-Tracking Assisted Visual Inference Language Test in the Assessment of Cognitive Decline due to Alzheimer's Disease(2023) BELAN, Ariella Fornachari Ribeiro; PAIS, Marcos Vasconcelos; CAMARGO, Marina von Zuben de Arruda; ANA, Livea Carla Fidalgo Garcez Sant'; RADANOVIC, Marcia; FORLENZA, Orestes VicenteBackground: The assessment of language changes associated with visual search impairment can be an important diagnostic tool in the Alzheimer's disease (AD) continuum. Objective: Investigate the performance of an eye-tracking assisted visual inference language task in differentiating subjects with mild cognitive impairment (MCI) or AD dementia from cognitively unimpaired older adults (controls). Methods: We assessed a group of 95 older adults (49 MCI, 18 mild dementia due to AD, and 28 controls). The subjects performed the same task under multiple experimental conditions which generate correlated responses that need to be taken into account. Thus, we performed a non-parametric repeated measures ANOVA model for verbal answers, and a linear mixed model (LMM) or its generalized version for the analysis of eye tracking variables. Results: Significant differences were found in verbal answers across all diagnostic groups independently of type of inference, i.e., logic or pragmatic. Also, eye-tracking parameters were able to discriminate AD from MCI and controls. AD patients did more visits to challenge stimulus (Control-AD, -0.622, SE = 0.190, p = 0.004; MCI-AD, -0.514, SE = 0.173, p = 0.011), more visits to the correct response stimulus (Control-AD, -1.363, SE = 0.383, p = 0.002; MCI-AD, -0.946, SE = 0.349, p = 0.022), more fixations on distractors (Control-AD, -4.580, SE = 1.172, p = 0.001; MCI-AD, -2.940, SE = 1.070, p = 0.020), and a longer time to first fixation on the correct response stimulus (Control-AD, -0.622, SE = 0.190, p = 0.004; MCI-AD, -0.514, SE = 0.173, p = 0.011). Conclusion: The analysis of oculomotor behavior along with language assessment protocols may increase the sensitivity for detection of subtle deficits in the MCI-AD continuum, representing an important diagnostic tool.
bookPart Fonoaudiologia ao longo da vida(2021) PANTANO, Telma; STIVANIN, Luciene; BELAN, Ariella Fornachari RibeiroconferenceObject SYMPTOMS OF DEPRESSION IN ADULTS AND ELDERS WITH DOWN SYNDROME: DATA FROM A PILOT STUDY IN BRAZIL(2019) NOGUEIRA, C.; CARVALHO, C. L.; GONCALVES, A.; BELAN, A.; BRAM, J.; SANTANA, L.; RADANOVIC, M.; BECKER, A.; FORLENZA, O.- Textual Inference Comprehension in Mild Cognitive Impairment: The Influence of Semantic Processing and Verbal Episodic Memory(2021) MAZIERO, Maria Paula; BELAN, Ariella Fornachari Ribeiro; CAMARGO, Marina von Zuben de Arruda; SILAGI, Marcela Lima; FORLENZA, Orestes Vicente; RADANOVIC, MarciaLanguage complaints, especially in complex tasks, may occur in mild cognitive impairment (MCI). Various language measures have been studied as cognitive predictors of MCI conversion to Alzheimer's type dementia. Understanding textual inferences is considered a high-demanding task that recruits multiple cognitive functions and, therefore, could be sensitive to detect decline in the early stages of MCI. Thus, we aimed to compare the performance of subjects with MCI to healthy elderly in a textual inference comprehension task and to determine the best predictors of performance in this ability considering one verbal episodic memory and two semantic tasks. We studied 99 individuals divided into three groups: (1) 23 individuals with amnestic mild cognitive impairment (aMCI), (2) 42 individuals with non-amnestic mild cognitive impairment (naMCI), (3), and (4) 34 cognitively healthy individuals for the control group (CG). A reduced version of The Implicit Management Test was used to assess different types of inferential reasoning in text reading. MCI patients performed poorer than healthy elderly, and there were no differences between MCI subgroups (amnestic and non-amnestic). The best predictors for inference-making were verbal memory in the aMCI and semantic tasks in the naMCI group. The results confirmed that the failure to understand textual inferences can be present in MCI and showed that different cognitive skills like semantic knowledge and verbal episodic memory are necessary for inference-making.
conferenceObject AVALIANDO A CARGA DE CUIDADORES E FAMILIARES DE ADULTOS E IDOSOS COM SINDROME DE DOWN: DADOS DA ESCALA DE ZARIT(2019) CARVALHO, C. L.; ARAUJO, M. C. C.; FERRO, K. N.; SENA, R. C.; KATSUKI, A. M. I.; NOGUEIRA, C.; BRAM, J.; SANTANA, L.; BELAN, A.; GONCALVES, A.; RADANOVIC, M.; FORLENZA, O.; DIAS, R.- Visual Search Efficiency in Mild Cognitive Impairment and Alzheimer's Disease: An Eye Movement Study(2020) PEREIRA, Marta Luisa Goncalves de Freitas; CAMARGO, Marina von Zuben de Arruda; BELLAN, Ariella Fornachari Ribeiro; TAHIRA, Ana Carolina; SANTOS, Bernardo dos; SANTOS, Jessica dos; MACHADO-LIMA, Ariane; NUNES, Fatima L. S.; FORLENZA, Orestes VicenteBackground: Visual search abilities are essential to everyday life activities and are known to be affected in Alzheimer's disease (AD). However, little is known about visual search efficiency in mild cognitive impairment (MCI), a transitive state between normal aging and dementia. Eye movement studies and machine learning methods have been recently used to detect oculomotor impairments in individuals with dementia. Objective: The aim of the present study is to investigate the association between eye movement metrics and visual search impairment in MCI and AD. Methods: 127 participants were tested: 43 healthy controls, 51 with MCI, and 33 with AD. They completed an eyetracking visual search task where they had to find a previously seen target stimulus among distractors. Results: Both patient groups made more fixations on the screen when searching for a target, with longer duration than controls. MCI and AD fixated the distractors more often and for a longer period of time than the target. Healthy controls were quicker and made less fixations when scanning the stimuli for the first time. Machine-learning methods were able to distinguish between controls and AD subjects and to identify MCI subjects with a similar oculomotor profile to AD with a good accuracy. Conclusion: Results showed that eye movement metrics are useful for identifying visual search impairments in MCI and AD, with possible implications in the early identification of individuals with high-risk of developing AD.
- Inferential abilities based on pictorial stimuli in patients with right hemisphere damage: Influence of schooling(2014) RIBEIRO, Ariella Fornachari; RADANOVIC, MarciaInferences are mental representations, formed through the interaction between explicit linguistic information and an individual's world knowledge. It is well known that individuals with brain damage in the right hemisphere (RH) often fail on this task and that schooling may be a variable affecting this.OBJECTIVE:Objective: To compare the effect of schooling on an inference comprehension task based on pictorial stimuli in patients with RH lesion.METHODS:The inferential abilities of 75 controls and 50 patients with RH lesion were assessed through the pictorial stimuli from the instrument ""300 exercises of comprehension of logical and pragmatic inferences and causal chains"". Both groups were stratified into two subgroups according to schooling level: 4 to 8 years and 9 or more years.RESULTS AND CONCLUSION:Highly educated subjects performed better than low educated individuals, both on intergroup and intragroup comparisons (p<0.0001) for logical and pragmatic inference ability.