WAGNER SILVA DANTAS
Projetos de Pesquisa
Unidades Organizacionais
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
15 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 15
- Exercise-Induced Increases in Insulin Sensitivity After Bariatric Surgery Are Mediated By Muscle Extracellular Matrix Remodeling (vol 69, pg 1675, 2020)(2021) DANTAS, Wagner S.; ROSCHEL, Hamilton; MURAI, Igor H.; GIL, Saulo; DAVULURI, Gangarao; AXELROD, Christopher L.; GHOSH, Sujoy; NEWMAN, Susan S.; ZHANG, Hui; SHINJO, Samuel K.; NEVES, Willian das; MEREGE-FILHO, Carlos; TEODORO, Walcy R.; CAPELOZZI, Vera L.; PEREIRA, Rosa Maria; BENATTI, Fabiana B.; SA-PINTO, Ana L. de; CLEVA, Roberto de; SANTO, Marco A.; KIRWAN, John P.; GUALANO, Bruno
conferenceObject Effects Of Exercise Training On Strength And Functionality In Obese Subjects Undergoing Bariatric Surgery: Preliminary Findings(2018) ROSCHEL, Hamilton; GIL, Saulo; DANTAS, Wagner S.; MURAI, Igor H.; MEREGE FILHO, Carlos; SANTO, Marco A.; CLEVA, Roberto; GUALANO, Bruno- Beneficial Effects Of Aerobic Exercise Training On Insulin Sensitivity And Signaling In Systemic Lupus Erythematosus(2016) MIYAKE, Cintia; ROSCHEL, Hamilton; GUALANO, Bruno; DANTAS, Wagner; NEVES, William; PINTO, Ana Lucia de Sa; LIMA, Fernanda; ZAMBELLI, Vanessa; ROSSI, Maria Elizabeth; BONFA, Eloisa; BENATTI, Fabiana B.
- Exercise Enhances the Effect of Bariatric Surgery in Markers of Cardiac Autonomic Function(2021) GIL, Saulo; PECANHA, Tiago; DANTAS, Wagner S.; MURAI, Igor Hisashi; MEREGE-FILHO, Carlos Alberto Abujabra; SA-PINTO, Ana Lucia de; PEREIRA, Rosa Maria Rodrigues; CLEVA, Roberto de; SANTO, Marco Aurelio; REZENDE, Diego Augusto Nunes; KIRWAN, John P.; GUALANO, Bruno; ROSCHEL, HamiltonBackground Bariatric surgery improves cardiovascular health, which might be partly ascribed to beneficial alterations in the autonomic nervous system. However, it is currently unknown whether benefits from surgery on cardiac autonomic regulation in post-bariatric patients can be further improved by adjuvant therapies, namely exercise. We investigated the effects of a 6-month exercise training program on cardiac autonomic responses in women undergoing bariatric surgery. Methods Sixty-two women eligible for bariatric surgery were randomly allocated to either standard of care (control) or an exercise training intervention. At baseline (PRE) and 3 (POST3) and 9 (POST9) months after surgery, we assessed chronotropic response to exercise (CR%; i.e., percentage change in heart rate from rest to peak exercise) and heart rate recovery (HRR30s, HRR60s, and HRR120s; i.e., decay of heart rate at 30, 60, and 120 s post exercise) after a maximal exercise test. Results Between-group absolute changes revealed higher CR% (Delta = 8.56%, CI95% 0.22-19.90, P = 0.04), HRR30s (Delta = 12.98 beat/min, CI95% 4.29-21.67, P = 0.01), HRR60s (Delta = 22.95 beat/min, CI95% 11.72-34.18, P = 0.01), and HRR120s (Delta = 34.54 beat/min, CI95% 19.91-49.17, P < 0.01) in the exercised vs. non-exercised group. Conclusions Our findings demonstrate that exercise training enhanced the benefits of bariatric surgery on cardiac autonomic regulation. These results highlight the relevance of exercise training as a treatment for post-bariatric patients, ensuring optimal cardiovascular outcomes.
conferenceObject Associations Between Physical Activity And Lower-Limb Strength With Bone Parameters In Healthy Young Women: A Pilot Study(2016) MURAI, Igor Hisashi; DANTAS, Wagner Silva; GIL, Saulo Dos Santos; TEIXEIRA, Eurimar Rogerio; ALVARENGA, Jackeline Couto; BENATTI, Fabiana; PEREIRA, Rosa Maria Rodrigues; ROSCHEL, Hamilton; GUALANO, Bruno- Reversal of Improved Endothelial Function After Bariatric Surgery Is Mitigated by Exercise Training(2018) DANTAS, Wagner Silva; GIL, Saulo; MURAI, Igor Hisashi; COSTA-HONG, Valeria; PECANHA, Tiago; MEREGE-FILHO, Carlos Alberto Abujabra; SA-PINTO, Ana Lucia de; CLEVA, Roberto de; SANTO, Marco Aurelio; PEREIRA, Rosa Maria Rodrigues; KIRWAN, John P.; ROSCHEL, Hamilton; GUALANO, Bruno
- DNA methylation pattern changes following a short-term hypocaloric diet in women with obesity(2020) NICOLETTI, C. F.; CORTES-OLIVEIRA, C.; NORONHA, N. Y.; PINHEL, M. A. S.; DANTAS, W. S.; JACOME, A.; MARCHINI, J. S.; GUALANO, B.; CRUJEIRAS, A. B.; NONINO, C. B.Background/Objectives We aimed to investigate the effects of short-term hypocaloric diet-induced weight loss on DNA methylation profile in leukocytes from women with severe obesity. Methods Eleven women with morbid obesity (age: 36.9 +/- 10.3 years; BMI: 58.5 +/- 10.5 kg/m(2)) were assessed before and after 6 weeks of a hypocaloric dietary intervention. The participants were compared with women of average weight and the same age (age: 36.9 +/- 11.8 years; BMI: 22.5 +/- 1.6 kg/m(2)). Genome-wide DNA methylation analysis was performed in DNA extracted from peripheral blood leukocytes using the Infinium Human Methylation 450 BeadChip assay. Changes (Delta beta) in the methylation level of each CpGs were calculated. A threshold with a minimum value of 10%, p < 0.001, for the significant CpG sites based on Delta beta and a false discovery rate of Results Dietary intervention changed the methylation levels at 16,064 CpG sites. These CpGs sites were related to cancer, cell cycle-related, MAPK, Rap1, and Ras signaling pathways. However, regardless of hypocaloric intervention, a group of 878 CpGs (related to 649 genes) remained significantly altered in obese women when compared with normal-weight women. Pathway enrichment analysis identified genes related to the cadherin and Wnt pathway, angiogenesis signaling, and p53 pathways by glucose deprivation. Conclusion A short-term hypocaloric intervention in patients with severe obesity partially restored the obesity-related DNA methylation pattern. Thus, the full change of obesity-related DNA methylation patterns could be proportional to the weight-loss rate in these patients after dietary interventions.
conferenceObject Exercise Suppresses The Ubiquitin-proteasome System In The Skeletal Muscle Of Obese Women Following Bariatric Surgery(2020) GIL, Saulo; GUALANO, Bruno; DANTAS, Wagner S.; MURAI, Igor H.; GHOSH, Sujoy; SHINJO, Samuel K.; MEREGE-FILHO, Carlos; TEODORO, Walcy R.; PEREIRA, Rosa Maria; BENATTI, Fabiana B.; SA-PINTO, Ana L. de; LIMA, Fernanda; CLEVA, Roberto de; SANTO, Marco A.; KIRWAN, John P.; ROSCHEL, HamiltonconferenceObject EXERCISE AS A TREATMENT TO ATTENUATE BONE LOSS IN WOMEN AFTER ROUX-EN-Y GASTRIC BY PASS : A RANDOMIZED CONTROLLED TRIAL(2019) MURAI, I. H.; ROSCHEL, H.; DANTAS, W. S.; GIL, S.; MEREGE-FILHO, C. A.; CAPARBO, V.; TAKAYAMA, L.; SA-PINTO, A. L.; CLEVA, R.; SANTO, M. A.; KIRWAN, J.; PEREIRA, R. M.; GUALANO, B.- Constraints of Weight Loss as a Marker of Bariatric Surgery Success: An Exploratory Study(2021) GIL, Saulo; GOESSLER, Karla; DANTAS, Wagner S.; MURAI, Igor Hisashi; MEREGE-FILHO, Carlos Alberto Abujabra; PEREIRA, Rosa Maria R.; CLEVA, Roberto de; SANTO, Marco Aurelio; KIRWAN, John P.; ROSCHEL, Hamilton; GUALANO, BrunoPurpose The aim of this exploratory study was to investigate whether the degree of weight loss properly reflects improvements in cardiometabolic health among patients who underwent Roux-en-Y gastric bypass. Methods In this ancillary analysis from a clinical trial, patients were clustered into tertiles according to the magnitude of the percentage weight loss (1st tertile: ""higher weight loss"": -37.1 +/- 5.8%; 2nd tertile: ""moderate weight loss"": -29.7 +/- 1.4%; 3rd tertile: ""lower weight loss"": -24.2 +/- 2.3%). Delta changes (9 months after surgery-baseline) in clustered cardiometabolic risk (i.e., blood pressure index, fasting glucose, high-density lipoprotein [HDL] and triglycerides [TG]), glycated hemoglobin (HbA1c), homeostasis model assessment (HOMA-IR), and C-reactive protein (CRP) were calculated. Results A total of 42 patients who had complete bodyweight data (age = 40 +/- 8 year; BMI = 47.8 +/- 7.1 kg/m(2)) were included. Surgery led to substantial weight loss (-37.9 +/- 11.3 kg, P < 0,001), and clinically significant improvements in blood pressure index (-17.7 +/- 8.2 mmHg, P < 0.001), fasting glucose (-36.6 +/- 52.5 mg/dL, P < 0.001), HDL (9.4 +/- 7.1 mg/dL, P < 0.001), TG (-35.8 +/- 44.1 mg/dL P < 0,001), HbA1c (-1.2 +/- 1.6%, P < 0.001), HOMA-IR (-4.7 +/- 3.9 mg/dL, P < 0.001) and CRP (-8.5 +/- 6.7 mu g/mL P < 0.001). Comparisons across tertiles revealed no differences for cardiometabolic risk score, fasting glucose, HbAc1, HOMA-IR, blood pressure index, CRP, HDL, and TG (P > 0.05 for all). Individual variable analysis confirmed cardiometabolic improvements across the spectrum on weight-loss. There were no associations between weight loss and any dependent variable. Conclusion Weight loss following bariatric surgery does not correlate with improvements in cardiovascular risk factors. These findings suggest that weight loss alone may be insufficient to assess the cardiometabolic success of bariatric surgery, and the search for alternate proxies that better predict surgery success are needed.