JESSICA MAYUMI MARUYAMA
Projetos de Pesquisa
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LIM/39 - Laboratório de Processamento de Dados Biomédicos, Hospital das Clínicas, Faculdade de Medicina
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- Depression moderates the association between pregnancy and suicidal ideation among pregnant and non-pregnant reproductive age women in Brazil(2022) FAISAL-CURY, Alexandre; TABB, Karen M.; MARUYAMA, Jessica Mayumi; MATIJASEVICH, AliciaBackgroundMaternal mental health problems are a serious public health concern. Previous data reported that pregnancy might have a protective effect against suicide. In contrast, more recent studies suggested that the prevalence of suicidal ideation (SI) is higher among pregnant women compared to the general population. Using a nationally representative population-based sample of Brazilian reproductive-aged women, this study aims to assess whether SI is more prevalent among pregnant women in comparison with nonpregnant woman. MethodsWe used data from the Brazilian National Health Survey (PNS) of 2019, a cross-sectional study that comprised a representative sample of residents in private households in Brazil. For the analysis of this study, we selected women aged between 15 and 49 years old who have answered the questionnaire of the Selected Resident of the PNS, which comprised a sample of 27,249 women. Logistic regression models were performed to obtain crude and adjusted odds ratios (OR) and 95% confidence intervals (95%CI) for the association between pregnancy status and SI. ResultsThe prevalence of SI during pregnancy was 6.8% (95% CI: 6.2-7.4). The association between pregnancy status and SI was modified according to the recent clinical diagnosis of depression (interaction term: OR = 41.72, 95% CI: 5.64-308.45, p < 0.001). Our findings indicated that among nondepressed women, pregnancy status seems to decrease the probability of SI. Additionally, SI is associated with a vulnerable profile that includes being an adolescent, having an unpartnered/not married status, lower family income, lower education, and a recent clinical diagnosis of depression. ConclusionSI is a common problem for reproductive-age women. In the presence of a recent depression clinical diagnosis, pregnancy increases the risk of SI. Management of SI among pregnant women should correctly identify sociodemographic risk factors and the presence of a recent clinical diagnosis of depression.
bookPart Fatores de risco e proteção dos transtornos mentais(2021) MARUYAMA, Jessica Mayumi; MATIJASEVICH, Alicia- Continuity of psychiatric disorders between 6 and 11 years of age in the 2004 Pelotas Birth Cohort(2020) MAISON, Carolina La; MARUYAMA, Jessica M.; MUNHOZ, Tiago N.; SANTOS, Ina S.; AMARAL, Mariana R. do; ANSELMI, Luciana; BARROS, Fernando C.; PASTOR-VALERO, Maria; MATIJASEVICH, AliciaObjective: To investigate the incidence and homotypic and heterotypic continuity of psychiatric disorders between ages 6 and 11. Methods: In 2004, all live births in the city of Pelotas, Brazil, were recorded (n=4,231). Psychiatric disorders were assessed by the Strengths and Difficulties Questionnaire (SDQ). SDQ subscale scores (emotional symptoms, conduct problems, hyperactivity/inattention, and peer relationship problems) were categorized as normal or abnormal. To examine associations between problems over time, odds ratios were computed using logistic regression. Results: Any SDQ difficulty was observed in 350 children (10.4%, 95%CI 9.4-11.5) at age 6 and 476 (14.2%, 95%CI 13.0-15.4) at age 11, with a higher prevalence among boys at both ages. Between ages 6 and 11, there was a 50 and a 45% increase in the prevalence of emotional and hyperactivity/inattention symptoms, respectively. Among those who had any SDQ difficulty at age 6, that status persisted in 81% at age 11. We found homotypic continuity of emotional symptoms, conduct problems, hyperactivity/inattention, and peer relationship problems. Conclusions: Our results indicate an increasing incidence of psychiatric disorders in this age group, with rates of disorders and continuity patterns similar to those observed in other studies.
- Vitamin D insufficiency, excessive weight gain, and insulin resistance during pregnancy(2022) RODRIGUES, Caroline Z.; CARDOSO, Marly A.; MARUYAMA, Jessica M.; NEVES, Paulo A. R.; QI, Lu; LOURENCO, Barbara H.Background and aims: Vitamin D insufficiency has been related to metabolic complications during pregnancy, including insulin resistance. There is evidence that excessive weight gain can negatively influence 25-hydroxyvitamin D (25(OH)D) concentrations. We aimed to investigate the association of vitamin D insufficiency during pregnancy (25(OH)D3 < 75 nmol/ L in the second and third trimesters) with insulin resistance, and explore whether excessive gestational weight gain (GWG) could modify such relationship. Methods and results: A prospective longitudinal analysis was conducted within the MINA-Brazil Study among 444 pregnant women enrolled in antenatal care and with complete data on 25(OH) D3, weight gain, insulin, and homeostatic model assessment of insulin resistance (HOMA-IR). Quantile and logistic regression models were conducted with adjustment for sociodemographic, obstetric, and lifestyle characteristics, as well as gestational age and seasonality at outcome assessment. Predicted probabilities for insulin resistance (HOMA-IR>2.71) were estimated according to excessive GWG. Persistent vitamin D insufficiency was associated with increasing insulin concentrations (p for trend = 0.04); pregnant women with vitamin D insufficiency in the second or third trimester had an odds ratio of 1.83 (95% confidence interval (95% CI) = 1.03, 3.27) for insulin resistance, with significant modification by GWG (p = 0.038). Among participants without excessive GWG, the predicted probability for insulin resistance was 0.345 (95% CI = 0.224, 0.467) for those with persistent vitamin D insufficiency, and 0.134 (95% CI = 0.046, 0.221) for those who were sufficient in vitamin D. Probabilities for insulin resistance did not vary according to vitamin D status among participants with excessive GWG.Conclusion: Vitamin D insufficiency was associated with insulin resistance in the third trimester of pregnancy, dependent on excessive GWG.(c) 2022 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University.
- Authors' reply to the letter to the editor from Peres KG, Feldens CA, Nascimento GG, Peres MA, Vitolo MR and Barros AJD(2023) ABANTO, Jenny; MARUYAMA, Jessica Mayumi; PINHEIRO, Emanuella; MATIJASEVICH, Alicia; ANTUNES, Jose Leopoldo Ferreira; BONECKER, Marcelo; CARDOSO, Marly Augusto
- Maternal depression trajectories and offspring positive attributes and social aptitudes at early adolescence: 2004 Pelotas birth cohort(2021) MARUYAMA, Jessica Mayumi; SANTOS, Ina S.; MUNHOZ, Tiago Neuenfeld; MATIJASEVICH, AliciaThere is growing evidence that adolescent positive attributes and social aptitudes are associated with beneficial outcomes, including higher educational attainment and lower risk of later psychiatric disorder. Although maternal depression is a well-known risk factor for a variety of offspring adverse outcomes, less is known on its repercussion on children's positive behavioral traits. This study aimed to evaluate the impact of maternal depression trajectories on offspring positive attributes and social aptitudes, testing sex-moderated models for the studied association. The 2004 Pelotas Birth Cohort is an ongoing cohort originally comprised by 4231 live births from Brazil. We included 3465 11-year-old adolescents (48.6% female; maternal self-reported skin color: 27.0% non-white). Maternal depressive symptoms were assessed by the Edinburgh Postnatal Depression Scale (EPDS) at all follow-ups. Adolescent positive attributes and social aptitudes were ascertained by specific subscales of Development and Well-Being Assessment (DAWBA). Multivariate linear regression was used to examine the effect of maternal depression trajectories on offspring's outcomes, adjusting for potential confounding variables. Moderation was assessed with interaction terms. Adolescents from mothers who presented high-chronic levels of depressive symptoms during offspring's life have lower scores of positive attributes and social aptitudes. Boys exposed to maternal depression during their lifetime are more affected than girls regarding positive attributes, but this sex difference was not observed for social aptitudes. Interventions targeting the promotion of adaptive behavioral traits may represent an effective way to buffer the adverse impact of maternal depression on offspring development, especially for vulnerable groups such as male adolescents.
- Impact of maternal depression trajectories on offspring socioemotional competences at age 11: 2004 Pelotas Birth Cohort(2019) MARUYAMA, Jessica Mayumi; PASTOR-VALERO, Maria; SANTOS, Ina S.; MUNHOZ, Tiago N.; BARROS, Fernando C.; MATIJASEVICH, AliciaBackground: Maternal depression is associated with impairments in child behavioural and emotional development although the effect of exposure to maternal depression until adolescence is underexplored in most studies. This longitudinal study examined the association between maternal depressive symptoms trajectories and offspring socioemotional competences at age 11. Methods: We included 3,437 11-year-old adolescents from the 2004 Pelotas Birth Cohort Study. Maternal depressive symptoms were assessed during the follow-up waves. Adolescent socioemotional competences were peer relationship problems and prosocial behaviour, both assessed by Strengths and Difficulties Questionnaire (SDQ), and Locus of Control (LoC), assessed by Nowick-Strickland Internal-External Scale. We used multivariate linear and logistic regression models to examine the effects of maternal depression trajectories on offspring's socioemotional competences, adjusting for potential confounding variables. Results: We identified five trajectories of maternal depressive symptoms: a ""low"" trajectory (32.6%), a ""moderate low"" (42.2%), a ""increasing"" (11.1%), a ""decreasing"" (9.2%), and a ""high-chronic"" trajectory (4.9%). Adolescents whose mothers had persistent depressive symptoms, either intermediate or high, had greater levels of peer relationship problems and lower levels of prosocial behaviour than those whose mothers had low depressive symptoms. These differences were not explained by socioeconomic, maternal, and child characteristics. Maternal depressive symptoms during offspring's life was not a predictor of LoC orientation. Limitations: Nearly 20% of original cohort were not included in the analysis due to missing data. Adolescent's socioemotional competences were ascertained by maternal report. Conclusion: Our study extended the evidences of the negative impact of severe and recurrent maternal depression on offspring's socioemotional competences until early adolescence.
- Impact of covid-19 pandemic over depressive symptoms among mothers from a population-based birth cohort in southern brazil(2023) SANTOS, Ina S.; TOVO-RODRIGUES, Luciana; MARUYAMA, Jessica M.; BARROS, Aluisio J. D.; BIERHALS, Isabel; PONTE, Bianca Del; MATIJASEVICH, AliciaPurposeOur aim was to assess the impact of COVID-19 on depressive symptoms among mothers from a population-based birth cohort in Pelotas, Southern Brazil.MethodsA subgroup of mothers from the Pelotas 2004 Birth Cohort was assessed pre-pandemic (November,2019 to March,2020) and mid-pandemic (August-December,2021). In both follow-ups, depressive symptoms were assessed using the Edinburgh Postnatal Depression Scale (EPDS). Pre-pandemic (T-1) and pandemic-related predictors (T-2) were analyzed. Prevalence of depression (EPDS score >= 13) at T-1 and T-2 were compared with chi-square test. Changes in EPDS from T-1 to T-2 were estimated by multivariate latent change score modelling.Results1,550 women were assessed. Prevalence of depression increased 38.1% (from 18.9% at T-1 to 26.1% at T-2) (p < 0.001). At T-1, higher schooling, higher family income and being employed or working were related to lower EPDS, whereas being beneficiary of a cash transfer program and a larger number of people living in the household predicted higher EPDS. The deterioration of ones' own perception of quality of overall health (beta = 0.191; SE = 0.028; p < 0.001) and worst family financial situation due to the pandemic (beta = 0.083; SE = 0.024; p = 0.001) predicted the increase in EPDS from T-1 to T-2.ConclusionAlmost two years after the beginning of the pandemic, the prevalence of depressive symptoms among the women was higher than before the pandemic. The deterioration of ones' own perception of quality of overall health and worst family financial situation due to the pandemic are proxies for the effect of COVID-19 pandemic (the true exposure of interest) in the women mental health.
- Mental health resilience in offspring of depressed parents: a systematic literature review protocol(2022) PADAIGAITE, Egle; MARUYAMA, Jessica Mayumi; HAMMERTON, Gemma; RICE, Frances; COLLISHAW, StephanBackground: Parental depression is associated with a range of mental health conditions and other difficulties in the offspring. Nevertheless, some offspring exposed to parental depression do not develop mental health problems, indicating the presence of protective factors that may buffer parental depression-related risk effects. However, evidence of protective factors that might explain good sustained mental health in offspring of depressed parents is limited and systematic synthesis of these factors is still needed. Therefore, as far as we are aware, this will be the first systematic review that will identify parent, family, child, social, and lifestyle factors associated with mental health resilience in offspring of depressed parents, examine evidence for sex-, developmental stage-, and outcome-specific factors and define mental health resilience in the parental depression context. Methods: This protocol has been developed according to the PRISMA-P guidelines. Electronic searches will be performed for articles published up to 2022 in PsycINFO, Embase, MEDLINE, Web of Science Core Collection, and Cochrane Library. Two reviewers will independently screen titles/abstracts and full-texts against eligibility criteria, extract the data, and assess the overall quality of evidence. Both observational and RCT studies will be eligible for inclusion if they report offspring mental health resilience/outcome and depressive symptoms or depressive disorder in at least one of the parents/caregivers. Risk of bias will be assessed using The Joanna Briggs Institute (JBI) critical appraisal checklists and The Revised Cochrane risk of bias tool for randomised trials (RoB 2). It is expected that studies will be heterogeneous; therefore, meta-analysis will not be attempted. Studies will be systematically retrieved and collated using numerical, graphical, tabular, and narrative summaries and grouped by their design, scope, or overall quality. Further sub-group analyses will be performed to examine sex-, developmental stage-, and outcome-specific protective factors. Discussion: The proposed systematic review will be the first to summarise and critically assess quality and strength of evidence of protective factors associated with mental health resilience in offspring of depressed parents. Directions and effect sizes of the protective factors will be discussed as well as differences between the studies, their limitations, and research gaps and future directions. Strengths and limitations of the proposed systematic review will be also discussed. The proposed systematic review findings are expected to help better understand mental health resilience and identify targets for evidence-based prevention and intervention strategies for those in need.
- Factors associated with risk behaviors in adolescence: a systematic review(2021) BOZZINI, Ana Beatriz; BAUER, Andreas; MARUYAMA, Jessica; SIMOES, Ricardo; MATIJASEVICH, AliciaObjective: Understanding the distal (p 6 years of age) and proximal (<= 6 years of age and early adolescence) factors in adolescent risk behavior is important for preventing and reducing morbidity and mortality in this population. This study sought to investigate the factors associated with the following adolescent risk behaviors: i) aggressiveness and violence, ii) tobacco, alcohol, and illicit substance use, iii) depressive behavior and self-harm (including suicidal ideation and attempts), iv) sexual risk behavior, and v) multiple risk behavior. Methods: A systematic review was conducted to identify longitudinal studies that examined factors associated with adolescent risk behaviors. The PubMed, PsycINFO, and LILACS databases were searched. Results: Of the 249 included studies, 23% reported distal risk factors, while the remaining reported proximal risk factors. Risk factors were related to sociodemographic characteristics (neighborhood, school, and peers), family patterns, and the presence of other adolescent risk behaviors. Conclusion: Distal and proximal factors in adolescent risk behavior that are not exclusively socioeconomic, familial, environmental, or social should be explored more thoroughly.