MARIA CLAUDIA COSTA IRIGOYEN

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Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/59 - Laboratório de Biologia Celular, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/05 - Laboratório de Poluição Atmosférica Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/65, Hospital das Clínicas, Faculdade de Medicina

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  • article 20 Citação(ões) na Scopus
    Exercise training program based on minimum weekly frequencies: effects on blood pressure and physical fitness in elderly hypertensive patients
    (2012) MORAES, Wilson M. De; SOUZA, Pamella R. M.; PINHEIRO, Monica H. N. P.; IRIGOYEN, Maria C.; MEDEIROS, Alessandra; KOIKE, Marcia K.
    Background: Exercise training (ET) can reduce blood pressure (BP) and prevent functional disability. However, the effects of low volumes of training have been poorly studied, especially in elderly hypertensive patients. Objectives: To investigate the effects of a multi-component ET program (aerobic training, strength, flexibility, and balance) on BP, physical fitness, and functional ability of elderly hypertensive patients. Methods: Thirty-six elderly hypertensive patients with optimal clinical treatment underwent a multi-component ET program: two 60-minute sessions a week for 12 weeks at a Basic Health Unit. Results: Compared to pre-training values, systolic and diastolic BP were reduced by 3.6% and 1.2%, respectively (p < 0.001), body mass index was reduced by 1.1% (p < 0.001), and peripheral blood glucose was reduced by 2.5% (p= 0.002). There were improvements in all physical fitness domains: muscle strength (chair-stand test and elbow flexor test; p < 0.001), static balance test (unipedal stance test; p < 0.029), aerobic capacity (stationary gait test; p < 0.001), except for flexibility (sit and reach test). Moreover, there was a reduction in the time required to perform two functional ability tests: ""put on sock"" and ""sit down, stand up, and move around the house"" (p < 0.001). Conclusions: Lower volumes of ET improved BP, metabolic parameters, and physical fitness and reflected in the functional ability of elderly hypertensive patients. Trial Registration RBR-2xgjh3.
  • conferenceObject
    DIURETIC ASSOCIATED WITH CONCURRENT EXERCISE PROMOTES ADDITIONAL PHYSICAL, AUTONOMIC AND INFLAMMATORY ADAPTATIONS IN HYPERTENSIVE RATS SUBMITTED TO OVARIAN HORMONE PRIVATION
    (2022) FERREIRA, Maycon Junior; SILVA, Gabriel Do Carmo; BERNARDES, Nathalia; ARAUJO, Amanda Aparecida De; DIAS, Danielle Da Silva; IRIGOYEN, Maria Claudia; ANGELIS, Katia De
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    Treatment with empagliflozin improves cardiac function in infarcted animals associated with increased baroreflex sensitivity
    (2023) SILVA, B. Da; NASCIMENTO-CARVALHO, B.; SOUZA, L. I. De; SILVA, M. B. Da; MARQUES, J. R.; DOURADO, P. M. M.; CONSOLIM-COLOMBO, F.; IRIGOYEN, M. C. C.
  • article 0 Citação(ões) na Scopus
    Brazilian guidelines for arterial hypertension: the reality of nursing in a specialty hospital
    (2012) BOLL, Liliana Fortini Cavalheiro; IRIGOYEN, Maria Claudia; GOLDMEIER, Silvia
    Objective: To evaluate knowledge about the technique of blood pressure measurement among nursing professionals in a health care institution. To identify the relationship between professional qualification and the proper development of technique. Methods: The researcher applied a questionnaire to nursing professionals during the verification of arterial pressure of patients. These questions related to the Brazilian Guidelines on Arterial Hypertension V. Results: Of the nursing professionals, technicians and assistants, 8.41% attained the cutoff point stipulated as adequate correct answers (80%). There was a direct relationship between professional qualification and the number of correct answers. Conclusion: Brazilian Guidelines on Arterial Hypertension V were not followed in their entirety by nursing professionals. A wide dissemination of guidelines, the implementation of training programs and monitoring of the technique should be encouraged.
  • article 2 Citação(ões) na Scopus
    Concurrent exercise training induces additional benefits to hydrochlorothiazide: Evidence for an improvement of autonomic control and oxidative stress in a model of hypertension and postmenopause
    (2023) FERREIRA, Maycon Junior; SILVA, Michel Pablo dos Santos Ferreira; DIAS, Danielle da Silva; BERNARDES, Nathalia; IRIGOYEN, Maria Claudia; ANGELIS, Katia De
    ObjectiveThis study aimed to evaluate whether exercise training could contribute to a better modulation of the neurohumoral mechanisms linked to the pathophysiology of arterial hypertension (AH) in postmenopausal hypertensive rats treated with hydrochlorothiazide (HCTZ). MethodsFemale spontaneously hypertensive rats (SHR) (150-200g, 90 days old) were distributed into 5 hypertensive groups (n = 7-8 rats/group): control (C), ovariectomized (O), ovariectomized treated with HCTZ (OH), ovariectomized submitted to exercise training (OT) and ovariectomized submitted to exercise training and treated with HCTZ (OTH). Ovarian hormone deprivation was performed through bilateral ovariectomy. HCTZ (30mg/kg/day) and concurrent exercise training (3d/wk) were conducted lasted 8 weeks. Arterial pressure (AP) was directly recorded. Cardiac effort was evaluated using the rate-pressure product (RPP = systolic AP x heart rate). Vasopressin V1 receptor antagonist, losartan and hexamethonium were sequentially injected to evaluate the vasopressor systems. Inflammation and oxidative stress were evaluated in cardiac tissue. ResultsIn addition to the reduction in AP, trained groups improved RPP, AP variability, bradycardic (OT: -1.3 & PLUSMN; 0.4 and OTH: -1.6 & PLUSMN; 0.3 vs. O: -0.6 & PLUSMN; 0.3 bpm/mmHg) and tachycardic responses of baroreflex sensitivity (OT: -2.4 & PLUSMN; 0.8 and OTH: -2.4 & PLUSMN; 0.8 vs. O: -1.3 & PLUSMN; 0.5 bpm/mmHg), NADPH oxidase and IL-10/TNF-& alpha; ratio. Hexamethonium injection revealed reduced sympathetic contribution on basal AP in OTH group (OTH: -49.8 & PLUSMN; 12.4 vs. O: -74.6 & PLUSMN; 18.1 mmHg). Furthermore, cardiac sympathovagal balance (LF/HF ratio), IL-10 and antioxidant enzymes were enhanced in OTH group. AP variability and baroreflex sensitivity were correlated with systolic AP, RPP, LF/HF ratio and inflammatory and oxidative stress parameters. ConclusionThe combination of HCTZ plus concurrent exercise training induced additional positive adaptations in cardiovascular autonomic control, inflammation and redox balance in ovariectomized SHR. Therefore, combining exercise and medication may represent a promising strategy for managing classic and remaining cardiovascular risks in AH.
  • conferenceObject
    Vitamin C Protects Against Doxorubicin-Induced Muscle Oxidative Stress
    (2022) NASCIMENTO FILHO, Antonio Viana Do; STOYELL-CONTI, Filipe F.; AKOLKAR, Gauri; MIRANDA, Victor Hugo M. De; SINGAL, Pawan; IRIGOYEN, Maria Claudia; ANGELIS, Katia De; DIAS, Danielle Da Silva
  • conferenceObject
    Baroreceptor Deafferentation Impairs the Exercise Training-and Drug Treatment-Induced Adaptations in a Hypertensive Model of Menopause
    (2022) FERREIRA, Maycon J.; SILVA, Gabriel Do Carmo; BERNARDES, Nathalia; ARAUJO, Amanda A. De; DIAS, Danielle Da Silva; IRIGOYEN, Maria C.; ANGELIS, Katia De
  • article 0 Citação(ões) na Scopus
    Enteral administration of the protease inhibitor gabexate mesilate preserves vascular function in experimental trauma/hemorrhagic shock
    (2023) MOREIRA, Nathalia J. D.; SANTOS, Fernando dos; LI, Joyce B.; ALETTI, Federico; IRIGOYEN, Maria Claudia C.; KISTLER, Erik B.
    Preserving vascular function is crucial for preventing multiorgan failure and death in ischemic and low-pressure states such as trauma/hemorrhagic shock (T/HS). It has recently been reported that inhibiting circulating proteases released from the bowel to the circulation during T/HS may preserve vascular function and improve outcomes following T/HS. This study aimed to evaluate the role of the serine protease inhibitor gabexate mesilate (GM) in preserving vascular function during T/HS when given enterally. We studied the vascular reactivity of mesenteric arteries from male Wistar rats treated with enteral GM (10 mg/kg) (GM-treated, n = 6) or control (Shock-control, n = 6) following (T/HS) using pressure myography. Concentration-response curves of endothelial-dependent and endothelial-independent agonists (e.g., acetylcholine, sodium nitroprusside) ranging from 10(-10) to 10(-5) M were performed. In a second set of experiments, ex-vivo arteries from healthy rats were perfused with plasma from shocked animals from both groups and vascular performance was similarly measured. Arteries from the GM-treated group demonstrated a preserved concentration-response curve to the & alpha;(1) adrenergic agonist phenylephrine compared to arteries from Shock-control animals (- logEC(50): - 5.73 & PLUSMN; 0.25 vs. - 6.48 & PLUSMN; 0.2, Shock-control vs. GM-treated, p = 0.04). When perfused with plasma from GM-treated rats, healthy arteries exhibited an even greater constriction and sensitivity to phenylephrine (- logEC(50): - 6.62 & PLUSMN; 0.21 vs. - 7.13 & PLUSMN; 0.21, Shock-control vs. GM-treated, p = 0.02). Enteral GM also preserved the endothelium-dependent vascular response to agonists following T/HS and limited syndecan-1 shedding as a marker of glycocalyx compromise (41.84 & PLUSMN; 9 vs. 17.63 & PLUSMN; 3.97 ng/mL, Shock-control vs. GM-treated, p = 0.02). Syndecan-1 cleavage was correlated with plasma trypsin-like activity (r(2) = 0.9611). Enteral gabexate mesilate was able to maintain vascular function in experimental T/HS, which was reflected by improved hemodynamics (mean arterial pressure 50.39 & PLUSMN; 7.91 vs. 64.95 & PLUSMN; 3.43 mmHg, Shock-control vs. GM treated, p = 0.0001). Enteral serine protease inhibition may be a potential therapeutic intervention in the treatment of T/HS.
  • article 0 Citação(ões) na Scopus
    Combined Exercise Training Promotes More Benefits on Cardiovascular Autonomic Modulation in Ovariectomized Rats Than Isolated Aerobic or Resistance Training
    (2023) COSTA-SANTOS, Nicolas Da; COSTA, Gabrielly Minguta Santos; DOS-SANTOS, Adriano; NASCIMENTO-CARVALHO, Bruno; RIBEIRO, Thayna Fabiana; FREITAS, Sarah Cristina Ferreira; CAPERUTO, Erico; IRIGOYEN, Maria -Claudia; ANGELIS, Katia De; SCAPINI, Katia Bilhar; SANCHES, Iris Callado
    Introduction: Cardiovascular risk increase after ovarian deprivation has been extensively demonstrated by our research group through cardiovascular autonomic analysis. Interventions involving different types of exercises, such as resistance exercises or combined exercises (aerobic and resistance) have been widely recommended to prevent or minimize neuromuscular decline in postmenopausal women, which is aggravated by a sedentary lifestyle. Experimentally, the cardiovascular effects of resistance or combined training, as well as comparison between aerobic, resistance, and combined training, in ovariectomized animals are scarce. Purpose: In this study, we hypothesized that the combination of aerobic and resistance training may be more effective in preventing muscle mass loss, as well as improving cardiovascular autonomic modulation and baroreflex sensitivity, than aerobic or resistance training individually in ovariectomized rats. Animals and Methods: Female rats were divided into 5 groups: sedentary (C); ovariectomized (Ovx); trained ovariectomized submitted to aerobic training (OvxAT); resistance training (OvxRT); combined training (OvxCT). Exercise training lasted 8 weeks, with the combined group alternating between aerobic training and resistance training every other day. At the end of the study, glycemia and insulin tolerance were evaluated. Arterial pressure (AP) was directly recorded. Baroreflex sensitivity was assessed by heart rate response to changes in arterial pressure. Cardiovascular autonomic modulation was evaluated by spectral analysis. Results: Combined training was the only training regime that increased baroreflex sensitivity for tachycardic response and reduced all systolic blood pressure variability parameters. Furthermore, all animals submitted to exercise training on a treadmill (OvxAT and OvxCT) presented lower systolic, diastolic, and mean pressure, as well as improvements in the autonomic modulation for the heart. Conclusion: Combined training showed to be more effective than isolated aerobic and resistance training, mixing the isolated benefits of each modality. It was the only modality able to increase baroreflex sensitivity to tachycardic responses, reduce arterial pressure and all parameters of vascular sympathetic modulation.
  • article 4 Citação(ões) na Scopus
    SEDENTARY LIFESTYLE IN ADOLESCENTS IS ASSOCIATED WITH IMPAIRMENT IN AUTONOMIC CARDIOVASCULAR MODULATION
    (2019) NASCIMENTO, Romilson Domingues; VIANA, Ariane; SARTORI, Michelle; ZAFFALON JUNIOR, Jose Robertto; DIAS, Danielle da Silva; MONZANI, Janaina de Oliveira Brito; BERNARDES, Nathalia; IRIGOYEN, Maria Claudia; ANGELIS, Katia De
    Introduction: Regular physical exercise, or a more active lifestyle, are important to prevent cardiovascular diseases, reducing not only cardiovascular mortality but also promoting a reduction in the risk factors related to these diseases. Objective: To assess the association between physical inactivity and heart rate variability (HRV) in adolescents. Methods: This was a cross-sectional study of the Diagnostic Type with Level of Evidence II according to the Oxford table. One hundred and twenty-nine adolescents were evaluated, aged 15 and 17 years old, divided into four groups: male teenagers who were insufficiently active (IAM n = 28) or physically active (FAM n = 29), and female teenagers who were insufficiently active (IAF n = 42) or physically active (FAF n = 30). The level of physical activity was assessed by the IPAQ. The HRV was evaluated in the time and frequency domains. Results: Reduced pulse interval variance was observed in the insufficiently active male or female groups (5089 +/- 378 ms(2) and 4335 +/- 276 ms(2) respectively) compared to the physically active groups (9106 +/- 606 ms(2) and 6182 +/- 366 ms(2) respectively). Moreover, the insufficiently active groups presented higher cardiac sympathetic/vagal balance values (0.81 +/- 0.05 and 0.80 +/- 0.05 respectively) compared to the physically active groups (0.63 +/- 0.05 and 0.55 +/- 0.05 respectively). Conclusion: A physically active lifestyle was associated with better cardiovascular autonomic modulation in adolescents.