ISABELLA BATISTA MARTINS PORTUGAL
Projetos de Pesquisa
Unidades Organizacionais
LIM/24 - Laboratório de Oncologia Experimental, Hospital das Clínicas, Faculdade de Medicina
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- Income-inequality and rate of doctors per inhabitant and their influence on esophageal cancer mortality in Brazil.(2021) SCHOUERI, Jean Henri; CARVALHO, Luis Eduardo Werneck De; PORTUGAL, Isabella Batista Martins; ROEDIGER, Manuela de Almeida; SANTOS, Edige Felipe de Sousa; PAIVA, Laercio da Silva; ABREU, Luiz Carlos de; FONSECA, Fernando Luiz Affonso; NASCIMENTO, Vania Barbosa do; ADAMI, Fernando
- Evolution of mortality and lethality due to COVID-19 in the State of Roraima, Brazil, from march 2020 to july 2021(2021) VALENZUELA, E. V.; MORAIS, T. C. de; DABOIN, B. G.; CAVALCANTI, M. P. E.; PORTUGAL, I. B. M.; SOUZA, I. S. de; RIBEIRO, M. A. L.; MONTEIRO, C. B. de Mello; ABREU, L. C. deIntroduction: the context of the Covid-19 pandemic in the Brazilian North region is worrying. There is a lack of resources for Public Health,a low human development index, and poverty indicators above thenational average.Objective: to analyze mortality and lethality from COVID-19 in theState of Roraima, Brazil.Methods: this is an ecological time-series study of secondary dataon COVID-19 in Roraima, Northern Brazil, from March 2020 to July2021. The incidence, mortality, and lethality rates due to COVID-19were calculated. The Prais-Winsten regression model was used tocalculate the time series trends. Trends were classified as increasing,decreasing, or stationary. The trend was considered static when thep-value was not significant (p>0.05).Results: in the state of Roraima, from March 2020 to July 2021, therewere 123,125 cases and 1,903 accumulated deaths due to COVID-19.The first wave (March 2020 to October 2021) of COVID-19 recordedthe incidence rate (2,995.30 new cases per 100,000 inhabitants - July2020) and mortality (56.32 deaths per 100,000 inhabitants - June2020) higher lethality. However, in the second wave (November 2020to July 2021), the highest lethality rate was observed (3.47% - February2021). It was observed that during the first wave, the incidence rate ofCOVID-19 showed increasing trends. During this period, the mortalityrate had a stationary tendency (p>0.05) and the percentage lethalitywith a decreasing trend (p<0.05). During the second wave, there wasa more aggravating scenario for lethality, which changed from a dailyreduction rate of 0.90% to stationary trends.Conclusion: the pandemic in the state of Roraima is not yet undercontrol, so it is necessary to strengthen strategies to mitigate thespread of the pandemic in the region and prevent the formation ofnew waves © The authors (2021), this article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons. org/licenses/by/4. 0/)
- Análise da mortalidade e letalidade por COVID-19 em uma região de baixa renda:um estudo ecológico de série temporal no Tocantins, Amazônia Brasileira(2021) CESAR, A. E. M.; DABOIN, B. E. G.; MORAIS, T. C.; PORTUGAL, I.; ECHEIMBERG, J. de Oliveira; RODRIGUES, L. M. R.; JACINTHO, L. C.; RAIMUNDO, R. D.; ELMUSHARAF, K.; SIQUEIRA, C. E.Introduction: Inserted in the vulnerable context of the Brazilian Amazon, the state of Tocantins has suffered damages with the dissemination of COVID-19 in its territory; however, little evidence is published from this state.Objective: This study aims to analyze the case-fatality, mortality, and incidence of COVID-19 in Tocantins.Methods: This is an ecological study, population-based, time-series analysis of COVID-19 cases and deaths in the state of Tocantins from March 2020 to August 2021.Results: During the examined period, 219,031 COVID-19 cases, and 3,594 deaths were registered due to disease. Two possible occurrence peaks were characterized in this time-series analysis. Remarkably, the Second Wave had the highest lethality rates (3.02% - April 2021), mortality (39.81 deaths per 100,000 inhabitants – March 2021), and incidence (1,938.88 cases per 100,000 inhabitants – March 2021). At the end of the period, mortality, incidence, and lethality showed flat trends, suggesting a positive outcome of the vaccination program.Conclusion: The prevention, surveillance, and control actions of COVID-19 cases in Tocantins State have been directed to mitigate the deleterious effects of the pandemic. Nevertheless, efforts are still needed to decrease lethality, mortality, and incidence trends, and ultimately to achieve control of the COVID-19 pandemic in the region. © 2021. Journal of Human Growth and Development. All Rights Reserved.
- Trends in COVID-19 lethality and mortality rates in the State of Pernambuco, Brazil: a time series analysis from april 2020 to june 2021(2022) CAVALCANTIA, M. P. E.; SIQUEIRA, E.; MORAES, T. C.; GUERRERO, B.; PORTUGAL, I. B. M.; PIMENTEL, R. M. M.; SILVA, H. M. R. da; JACINTHO, L. C.; ELMUSHARAF, K.; ABREUA, L. C. decontinual mutations of the sars-cov-2 virus, with the possibility of reinfection or reactivation of the virus, can lead to a further spread of the virus and consequently new infection periods. The state of pernambuco, brazil, has faced many adversities amidst the pandemic, requiring studies and new spatiotemporal techniques to understand the pandemic development and planning actions to reverse the current situation.Objective: the aim was to evaluate the mortality and lethality trends of covid-19 from april 2020 to june 2021 in the state of pernambuco, brazil, with the division into two periods according to the waves of infection to date (1st period and 2nd period). Methods: an ecological time-series study was carried out with population data from the pernambuco state health department. We collected the number of confirmed cases and deaths for covid-19. The trends were analyzed according to the praiswinsten regression model in two moments from march 2020 to september 2020 and the second from october 2021 to june 2022. Differences were considered significant when p<0.05. Results: the state of pernambuco had 581,594 confirmed cases of covid-19, where 51,370 were severe cases, and 530,224 were mild cases, in addition to 18,444 deaths. Given the trends analyzed, mortality was increasing in the second period (april/2020 to june/2021), while lethality decreased in the first period and was stationary in the second period. Conclusion: this study found an increasing trend in mortality of covid-19 in the state of pernambuco, brazil in the second period, highlighting an urgent need to develop surveillance measures as well as public policies for vulnerable populations, in addition to continuing preventive measures. © 2022. Journal of Human Growth and Development
- Deciphering Multifactorial Correlations of COVID-19 Incidence and Mortality in the Brazilian Amazon Basin(2022) DABOIN, Blanca Elena Guerrero; BEZERRA, Italla Maria Pinheiro; MORAIS, Tassiane Cristina; PORTUGAL, Isabella; ECHEIMBERG, Jorge de Oliveira; CESAR, Andre Evaristo Marcondes; CAVALCANTI, Matheus Paiva Emidio; JACINTHO, Lucas Caue; RAIMUNDO, Rodrigo Daminello; ELMUSHARAF, Khalifa; SIQUEIRA, Carlos Eduardo; ABREU, Luiz Carlos deAmazonas suffered greatly during the COVID-19 pandemic. The mortality and fatality rates soared and scarcity of oxygen and healthcare supplies led the health system and funerary services to collapse. Thus, we analyzed the trends of incidence, mortality, and lethality indicators of COVID-19 and the dynamics of their main determinants in the state of Amazonas from March 2020 to June 2021. This is a time-series ecological study. We calculated the lethality, mortality, and incidence rates with official and public data from the Health Department. We used the Prais-Winsten regression and trends were classified as stationary, increasing, or decreasing. The effective reproduction number (Rt) was also estimated. Differences were considered significant when p < 0.05. We extracted 396,772 cases of and 13,420 deaths from COVID-19; 66% of deaths were in people aged over 60; 57% were men. Cardiovascular diseases were the most common comorbidity (28.84%), followed by diabetes (25.35%). Rural areas reported 53% of the total cases and 31% of the total deaths. The impact of COVID-19 in the Amazon is not limited to the direct effects of the pandemic itself; it may present characteristics of a syndemic due to the interaction of COVID-19 with pre-existing illnesses, endemic diseases, and social vulnerabilities.
- Epidemiological profile of COVID-19 in the State of Espírito Santo, Brazil, from march 2020 to june 2021(2021) SOUSA, C. D. K. de; MORAIS, T. C.; DABOIN, B. E. G.; PORTUGAL, I.; CAVALCANTI, M. P. E.; ECHEIMBERG, J. de Oliveira; JACINTHO, L. C.; RAIMUNDO, R. D.; ELMUSHARAF, K.; SIQUEIRA, C. E.Introduction: coronavirus 2019 Disease (COVID-19) was quickly declared a pandemic, and Brazil is facing the most significant health and hospital crisis in its history. From March to June 2021 represented 50.8% of all deaths in the State of Espirito Santo. Objective: to analyze the lethality and mortality by COVID-19 in the State of Espirito Santo from March 2020 to June 2021. Methods: an ecological study was carried out, using a time series of public and official data available on the Health Department of the State of Espirito Santo, Brazil. Were considered information about cases and deaths (from March 2020 to June 2021) of COVID-19. Percentage case-fatality and mortality and incidence rates per 100,000 population were calculated. Time-series analyses were performed using the Prais-Winsten regression model, estimating the Daily Percent Change (DPC), and the trends were classified as flat, increasing, or decreasing. Significant differences were considered when p<0.05. Results: 524,496 confirmed cases of COVID-19 as of June 30, 2021, and 11,516 progressed to death. The presence of cardiovascular diseases represents more than half of confirmed comorbidities (54.37%) in patients with COVID-19, followed by diabetes (19.95%) and obesity (9.34%). Men had higher mortality and lethality, especially in older age groups, but the incidence was higher among women. A characteristic profile of two waves was observed; the first wave was extended from March to October 2020 and the second complete wave from November 2020 to June 2021. During the second wave, high peaks of incidence, lethality, and mortality were recorded. At the end of the second wave, the incidence rate remained with increasing trends (p < 0.05), with a DPC of 2.06%. Conclusion: the peak concentration of cases, deaths, and indicators of lethality, mortality evidenced even after one year of pandemic, characterizes the severity of the COVID-19 pandemic, still in entire evolution in the State Espirito Santo and Brazil. © 2021. Journal of Human Growth and Development. All Rights Reserved.
- Trends in COVID-19 mortality and case-fatality rate in the State of Paraná, South Brazil: spatiotemporal analysis over one year of the Pandemic(2021) SIQUEIRA JUNIOR, D. de; MORAIS, T. C.; PORTUGAL, I.; CAVALCANTI, M. P. E.; DABOIN, B. E. G.; RAIMUNDO, R. D.; JACINTHO, L. C.; ECHEIMBERG, J. de Oliveira; ELMUSHARAF, K.; SIQUEIRA, C. E.Introduction: By late 2019, China notified a new disease rising, and with the agent’s identification, it was called COVID-19. Despitethe efforts of the World Health Organization (WHO) and worldwidecountries, the disease spread out of control; on March 11, WHOdeclared the pandemic state. Brazil is the biggest country in SouthAmerica, demarcated into 26 states with different economic, cultural,and social aspects. Paraná is one of the Brazilian federative units, it isthe sixth more economically important and ranks second in Education.Its first COVID-19 case was confirmed on March 12, 2020, and thefirst death was on March 27, two weeks after the first death in Brazil.Objective: This study objective is to determine the mortality andcase-fatality rates of COVID-19 in the State of Paraná, Brazil, fromMarch 1, 2020, to March 31, 2021.Methods: It is an ecological time-series study, using all cases(854,326) and deaths (17,229 deaths) of COVID-19 reported in publicand official database of the State of Paraná Health Department.Case fatality and mortality rates were stratified by sex and age. Fortrend analysis, the period was divided into a first “wave” (March toNovember 2020) and a second “wave” (December 2020 to March2021). The Prais-Winsten regression model for population mortalityand case-fatality rates allowed classifying whether it increased,decreased, or was flat.Results: Women were more affected by the number of cases, with454,056 cases (53.15%) confirmed and 7,257 fatalities (42.12%). Atotal of 400,270 men (46.85%) were infected and 9,972(57.87%) died.For the first year of COVID-19, in the State of Paraná, the incidencewas calculated as 7404.12/100,000 inhabitants, the mortality was149.32/100,000 inhabitants, and the case-fatality rate was 2.02%. Wesaw a tendency for decreasing the case-fatality rate (DPC = -0,18;p<0,001). The mortality and incidence showed an increasing trend(DPC=1,13, p<0,001; DPC=1,58, p<0,001, respectively).Conclusion: The level and variability of transmission during this firstyear of pandemic suggest that the disease in the State of Paraná wasnever under control © 2021. Journal of Human Growth and Development. All Rights Reserved.
- Reduction in prostate cancer hospitalizations in the COVID-19 pandemic epicenter of Latin America.(2021) PORTUGAL, Isabella Batista Martins; ADAMI, Fernando; SCHOUERI, Jean Henri; REZENDE, Leandro Fornias Machado; FONSECA, Fernando Luiz Affonso; FERRARI, Gerson; ABREU, Luiz Carlos de; CARVALHO, Luis Eduardo Werneck De
- Impact of COVID-19 pandemic in hospitalizations due to brain tumors from the epicenter of Latin America.(2021) PORTUGAL, Isabella Batista Martins; CARVALHO, Luis Eduardo Werneck de; SCHOUERI, Jean Henri; REZENDE, Leandro Fornias Machado; FONSECA, Fernando Luiz Affonso; FERRARI, Gerson; ABREU, Luiz Carlos de; ADAMI, Fernando