GABRIELLA MELO FONTES SILVA DIAS
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Projetos de Pesquisa
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LIM/60 - Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas, Faculdade de Medicina
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conferenceObject Chronic spontaneous urticaria and autoimmunity: a follow up study of patients with chronic urticaria for 16 years(2018) MOUCO, Claudia Castilho; ZANANDREA, Andressa; ASSIS, Joao Paulo de; CASTRO, Raisa Borges; DIAS, Gabriella Melo Fontes Silva; KALIL, Jorge; MOTTA, Antonio Abilio; AGONDI, Rosana C.- AERD: PERSPECTIVE OF THE USE OF LICENSED MONOCLONALS FOR TREATMENT BASED ON THEIR PHENOTYPES(2019) DIAS, Gabriella M. F. S.; ASSIS, Joao Paulo de; CASTRO, Raisa Borges; KALIL, Jorge; GIAVINA-BIANCHI, Pedro; AGONDI, Rosana C.
- Hypersensitivity to dipyrone in aspirin-exacerbated respiratory disease patients is associated with urticaria(2020) AGONDI, Rosana Camara; DIAS, Gabriella Melo Fontes Silva; ASSIS, Joao Paulo de; PACHECO, Rosilane; KALIL, Jorge; GIAVINA-BIANCHI, PedroObjective: To phenotype patients with aspirin-exacerbated respiratory disease (AERD) according to the presence of atopy, urticaria and level of peripheral eosinophils. Methods: This study included adult asthmatic patients with AERD followed up at a tertiary hospital. They were classified according to atopy and/or urticaria, assessing clinical and laboratorial differences among the groups in order to identify possible aggravating factors of the disease. Results: We included 73 patients, 78.1% being female with a mean age of 54.0 years. Severe asthma was observed in 68.5% and respiratory exacerbation with dipyrone in 67.1% of these patients. They had median total serum IgE of 191.6 IU/mL, mean peripheral eosinophils of 718.5 cells/mm(3), and 50.7% were atopic. Urticaria was observed in 32.9% of them, and exacerbations were more often triggered by dipyrone (p = .016). Atopic patients were younger than nonatopic patients (p = .023), and had, on average, higher total serum IgE levels (p = .022). We observed a good correlation between asthma severity and peripheral eosinophils count (r(2) = 026; p = .021). Conclusions: In this study, severe asthma was highly prevalent in AERD patients. Likewise, urticaria was quite prevalent and its presence was associated with dipyrone induced hypersensitivity reaction. Atopy was found in half of the patients, with no association with asthma severity. Patients with higher levels of peripheral eosinophils had more severe asthma. Dypirone hypersensitivity may be a marker for concomitant respiratory and cutaneous hypersensitivity reactions.
conferenceObject Angioedema in patients with chronic spontaneous urticaria: assessment of disease severity and response to treatment(2018) ASSIS, Joao Paulo de; DIAS, Gabriella Melo Fontes Silva; MOUCO, Claudia Castilho; ZANANDREA, Andressa; CASTRO, Raisa Borges; KALIL, Jorge; MOTTA, Antonio Abilio; AGONDI, Rosana C.bookPart Antileucotrienos(2022) ASSIS, João Paulo de; DIAS, Gabriella Melo Fontes Silva; CASTRO, Fábio Fernandes MoratoconferenceObject Are N-ERD really a non atopic disease? Comparative between the phenotype allergic and nonallergic in N-ERD in a Brazilian cohort(2020) DIAS, G. M. F. S.; KALIL, J.; GIAVINA-BIANCHI, P.; AGONDI, R. C.conferenceObject Severity of allergic asthma associated with sensitization to food allergens(2019) CASTRO, R. B.; DIAS, G. M.; ZANANDREIA, A.; KALIL, J.; GIAVINA-BIANCHI, P.; AGONDI, R.conferenceObject Eosinophilia in asthmatic patients and its relationship with Aspirin-Exacerbated Respiratory Disease(2020) CUNHA, La Is; DIAS, Gabriella; GIAVINA-BIANCHI, Pedro; KALIL, Jorge; AGONDI, RosanabookPart Anti-histamínicos(2022) DIAS, Gabriella Melo Fontes Silva; ASSIS, João Paulo de; CASTRO, Fábio Fernandes MoratoconferenceObject Diagnosis and treatment of AERD: clinical practice realities(2018) DIAS, Gabriella Melo Fontes Silva; ASSIS, Joao Paulo de; ANDRADE, Mayra Coutinho; CASTRO, Raisa Borges; MOUCO, Claudia Castilho; ZANANDREA, Andressa; AUN, Marcelo V.; KALIL, Jorge; GIAVINA-BIANCHI, Pedro; AGONDI, Rosana C.