LILIANA MITIE SUGANUMA
Índice h a partir de 2011
3
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
16 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 16
bookPart Porfirias(2017) MARIANO, Livia Caroline Barbosa; SUGANUMA, Liliana MitieconferenceObject NIH Bayesian Score As a Stratification Tool in Sickle Cell Disease - Results from a Single Center Cohort in Brazil(2017) FONSECA, Guilherme Henrique Hencklain; GRACA, Lutu Ima Viana da; SOUZA, Rogerio; SUGANUMA, Liliana Mitie; ROCHA, Vanderson; GUALANDRO, Sandra FatimaconferenceObject PAROXYSMAL NOCTURNAL HEMOGLOBINURIA: CLINICAL FEATURES AND OUTCOME IN 124 PATIENTS EVALUATED IN A SINGLE CENTER(2016) ZANICHELLI, M.; MOROMIZATO, D.; FONSECA, G.; SUGANUMA, L.; GUALANDRO, S.conferenceObject Correlation of Morphological Dysplasia and Immunophenotypic Features in Myelodysplastic Syndromes(2016) VELLOSO, Elvira D. Rodrigues Pereira; COSENTINO, Rosana M.; SUGANUMA, Liliana Mitie; BARROSO, Rodrigo de Souza; BACAL, Nydia Strachman; COLOMBINI, Marjorie P.; SILVEIRA, PaulobookPart Porfirias(2023) MARIANO, Lívia; SUGANUMA, Liliana MitiebookPart Anemias(2015) MARIANO, Lívia Caroline Barbosa; SUGANUMA, Liliana Mitie- Cohort study of adult patients with haemoglobin SC disease: clinical characteristics and predictors of mortality(2015) GUALANDRO, Sandra F. Mm; FONSECA, Guilherme H. H.; YOKOMIZO, Iara K.; GUALANDRO, Danielle M.; SUGANUMA, Liliana M.Haemoglobin (Hb) SC disease is the second most common subtype of sickle cell disease and is potentially fatal. This study aimed to determine the clinical characteristics, outcome and predictors of mortality in HbSC disease patients, and to compare these findings with patients followed-up in different centres. Clinical, laboratory and outcome data were collected from a cohort of adult patients with HbSC disease followed between 1991 and 2103. Cox regression multivariate analysis was used to determine predictors of mortality. One hundred and fifty-five patients were followed-up over 20years: 9% died and 708% had at least one complication. The most common complications were: painful crises (383%), retinopathy (338%), cholelithiasis (303%), osteonecrosis (248%) and sensorineural hearing disorders (97%). Frequency of chronic complications was similar in most studies. In multivariate analysis, hearing disorders remained an independent predictor of mortality (Odds Ratio 926, 95% confidence interval 11-748; P=003). It was concluded that patients with HbSC disease receive a late diagnosis and there is remarkable similarity between the studies conducted in different centres around the world. Sensorineural hearing disorders were an independent predictor of mortality, suggesting that it may be useful to implement routine diagnostic screening.
- Heterogeneous phenotype of Hereditary Xerocytosis in association with PIEZO1 variants(2020) OLIVEIRA, Priscila de Meira; BALAN, Andrea; MUTO, Nair H.; CERVATO, Murilo C.; FONSECA, Guilherme H. H.; SUGANUMA, Liliana M.; GUALANDRO, Sandra; PINHO, Joao R. R.; MOHANDAS, Narla; SILVEIRA, Paulo A. A.; SITNIK, RobertaHereditary Xerocytosis (HX) is an autosomal dominantly inherited congenital hemolytic anemia associated with erythrocyte dehydration due to decreased intracellular potassium content resulting in increased mean corpuscular hemoglobin concentration. The affected members of HX families show compensated anemia with splenomegaly, hemosiderosis, and perinatal edema but are in large part transfusion independent. Functional studies show a link between mutations in mechanosensitive ion channel, encoded by PIEZO1 gene and the HX. We identified new PIEZO1 variants that are likely pathogenic in three phenotypically characterized multi-generational HX Brazilian families. Interestingly, one missense variant of the PIEZO1 gene identified, p.E2494V was associated in trans with the previously reported most frequent pathogenic duplication p.E2496ELE. The three-dimensional structure of the human protein modeled using structural coordinates of the mouse Piezol solved by cryo-electron microscopy (Cryo-ME) showed that the two identified variants, p.M2007L and p.T2014I, are localized to an important mechanosensitive transmembrane domain suggesting a conformational mechanism for altered channel's gating. The p.E2496ELE variant identified alters the extension of helix al bringing it much closer to the beam affecting the position of it structure at the end of the pore.
- Patients with Sickle Cell Disease Treated with Hidroxiurea Have Higher Expression of PD-L1 in Monocytes(2022) GERVATAUSKAS, Kasys Meira; ROS, Felipe Augusto; FONSECA, Guilherme Henrique Hencklain; SILVA, Pedro Victor de Castro e; NOGUEIRA, Felipe Melo; OTSUKA, Liliana Suganuma; CARDOSO, Afonso Celso Almeida; GUALANDRO, Sandra Fatima Menosi; ROCHA, Vanderson; TOZATTO-MAIO, Karina
bookPart Porfirias(2015) MARIANO, Lívia Caroline Barbosa; SUGANUMA, Liliana Mitie