MATHEUS SCHMIDT SOARES
Projetos de Pesquisa
Unidades Organizacionais
LIM/26 - Laboratório de Pesquisa em Cirurgia Experimental, Hospital das Clínicas, Faculdade de Medicina
10 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 10
- Psychosurgery for schizophrenia: history and perspectives(2013) SOARES, Matheus Schmidt; PAIVA, Wellingson Silva; GUERTZENSTEIN, Eda Z.; AMORIM, Robson Luis; BERNARDO, Luca Silveira; PEREIRA, Jose Francisco; FONOFF, Erich Talamoni; TEIXEIRA, Manoel JacobsenFollowing the early studies of Moniz and Lima, psychosurgery had considerable scientific credibility until the advent of modern antipsychotics in the mid 1950s. Thereafter, psychosurgery was almost abandoned in large medical centers as a common treatment for schizophrenia, although is still used for some affective and anxiety disorders. We reviewed relevant papers cited in the Medline/Index Medicus, Cochrane, and Scielo databases from 1930 to 2012. In our review of the literature, we show from recent studies that there are still many patients with schizophrenia who have serious deficits even after being treated with current noninvasive therapies. The value of psychosurgery remains controversial. There are no data available to support the use of stereotactic procedures for schizophrenia. Well designed controlled trials are needed to establish the effectiveness of psychosurgery in patients with schizophrenia.
- Cervical myelopathy caused by ligamentum flavum ossification(2012) PAIVA, Wellingson Silva; SOARES, Matheus Schimidt; BERNARDO, Luca Silveira; BROCK, Roger Schimidt; TEIXEIRA, Manoel Jacobsen
- Experimental rnodel of intracranial hypertension with continuous multiparametric monitoring in swine(2013) ANDRADE, Almir Ferreira de; SOARES, Matheus Schmidt; PATRIOTA, Gustavo Cartaxo; BELON, Alessandro Rodrigo; PAIVA, Wellingson Silva; BOR-SENG-SHU, Edson; OLIVEIRA, Marcelo de Lima; NASCIMENTO, Clarissa Nobrega; NOLETO, Gustavo Sousa; ALVES JUNIOR, Aderaldo Costa; FIGUEIREDO, Eberval Gadelha; OTOCH, Jose Pinhata; TEIXEIRA, Manoel JacobsenObjective: Intracranial hypertension (IN) develops in approximately 50% of all patients with severe traumatic brain injury (TBI). Therefore, it is very important to identify a suitable animal model to study and understand the pathophysiology of refractory IH to develop effective treatments. Methods: We describe a new experimental porcine model designed to simulate expansive brain hematoma causing IH. Under anesthesia, was simulated with a balloon insufflation. The IH variables were measured with intracranial pressure (ICP) parenchymal monitoring, epidural, cerebral oximetry, and transcranial Doppler (TCD). Results: None of the animals died during the experiment. The ICP epidural showed a slower rise compared with parenchymal ICP. We found a correlation between ICP and cerebral oximetry. Conclusion: The model described here seems useful to understand some of the pathophysiological characteristics of acute IH.
- Evaluation of cerebral hemodynamics by transcranial Doppler ultrasonography and its correlation with intracranial pressure in an animal model of intracranial hypertension(2022) SOARES, Matheus Schmidt; ANDRADE, Almir Ferreira de; BRASIL, Sergio; DE-LIMA-OLIVEIRA, Marcelo; BELON, Alessandro Rodrigo; BOR-SENG-SHU, Edson; NOGUEIRA, Ricardo de Carvalho; GODOY, Daniel Agustin; PAIVA, Wellingson SilvaBackground: Transcranial Doppler has been tested in the evaluation of cerebral hemodynamics as a non-invasive assessment of intracranial pressure (ICP), but there is controversy in the literature about its actual benefit and usefulness in this situation. Objective: To investigate cerebral blood flow assessed by Doppler technique and correlate with the variations of the ICP in the acute phase of intracranial hypertension in an animal model. Methods:An experimental animal model of intracranial hypertension was used. The experiment consisted of two groups of animals in which intracranial balloons were implanted and inflated with 4 mL (A) and 7 mL (B) for controlled simulation of different volumes of hematoma. The values of ICP and Doppler parameters (systolic [FVs], diastolic [FVd], and mean [FVm] cerebral blood flow velocities and pulsatility index [PI]) were collected during the entire procedure (before and during hematoma simulations and venous hypertonic saline infusion intervention). Comparisons between Doppler parameters and ICP monitoring were performed. Results: Twenty pigs were studied, 10 in group A and 10 in group B. A significant correlation between PI and ICP was obtained, especially shortly after abrupt elevation of ICP. There was no correlation between ICP and FVs, FVd or FVm separately. There was also no significant change in ICP after intravenous infusion of hypertonic saline solution. Conclusions:These results demonstrate the potential of PI as a parameter for the evaluation of patients with suspected ICP elevation.
- Evaluation of the Maintained Effect of 3% Hypertonic Saline Solution in an Animal Model of Intracranial Hypertension(2016) SOUSA JR., Leonardo M.; ANDRADE, Almir F. de; BELON, Alessandro R.; SOARES, Matheus S.; AMORIM, Robson Luis; OTOCHI, Jose Pinhata; TEIXEIRA, Manoel J.; PAIVA, Wellingson S.Background: Current clinical treatment methods for refractory intracranial hypertension include elevation of the decubitus, ventilation adjustment, and use of hypertonic solutions such as hypertonic saline and mannitol solutions. Previous studies have shown that hypertonic solutions are particularly effective. Although several concentrations of saline solution have been proposed, a 3% solution is the most widely used. The aim of this study was to evaluate the maintained efficacy of a 3% hypertonic saline solution in an experimental model of intracranial hypertension. Material/Methods: A porcine model of reversible intracranial hypertension was created by inserting a balloon catheter into the brain parenchyma, which was inflated and deflated to simulate intracranial hypertension and its surgical correction. The experiment included 3 groups of animals (A, B, and C) with different balloon inflation volumes. In group B, balloons were inflated 2 times to simulate reexpansion. A 20 mL/kg bolus of 3% saline solution was infused using a pump 90 minutes after the start of balloon inflation, and the effects of intracranial pressure were evaluated 60 minutes after infusion. Results: No increases outside of the normal range were observed in mean serum sodium concentrations (p=0.09). In addition, we identified no differences within each group in serum sodium levels measured during hypertonic saline infusion (p=0.21). No significant reductions in intracranial pressure were observed in any of the 3 groups. Conclusions: Bolus infusion of 3% hypertonic saline solution with the aid of a pump does not significantly reduce intracranial pressure in an animal model of intracranial hypertension.
bookPart Lesão Axonial Difusa(2015) AMORIM, Robson Luis Oliveira de; SOARES, Matheus Schmidt; ANDRADE, Almir Ferreira de; PAIVA, Wellingson Silva- Letter to the Editor Regarding ""Subdural Hematoma in Patients with Hematologic Malignancies: An Outcome Analysis and Examination of Risk Factors of Operative and Nonoperative Management""(2020) FAGUNDES, Caroline Ferreira; SOUZA, Matheus Rodrigues de; SOARES, Matheus Schmidt; PAIVA, Wellingson Silva
- Morbidity following sural nerve harvesting: A prospective study(2012) MARTINS, Roberto S.; BARBOSA, Rafael A.; SIQUEIRA, Mario G.; SOARES, Matheus S.; HEISE, Carlos Otto; FORONI, Luciano; TEIXEIRA, Manoel J.Objective: To evaluate donor site morbidity following sural nerve harvesting, with special attention to the recovery of sensory loss. Methods: We prospectively followed 38 subjects who underwent sural nerve harvest, including two with bilateral nerve excision. Symptoms related to sural nerve excision were evaluated and demarcation of the area with reduced touch sensation was quantified. Assessments were performed periodically up to 1 year after surgery and the results of different sensory evaluations were compared. Results: A significant reduction of sensory deficit was identified between consecutive evaluations (p < 0.05). Decreases of 26.85%, 20.69% and 24.29% were observed 3, 6 and 12 months after surgery, respectively. Shock-like pain (7.5%), stabbing pain (7.5%), and numbness (5%) were the most frequently reported symptoms. All symptoms were brief and resolved spontaneously 3-6 months after surgery. Conclusion: Sural nerve harvest can be performed with acceptable morbidity. When present, symptoms resolve between the third and sixth month after surgery and a significant reduction of sensory loss in the area innervated by the sural nerve was observed during the first year of follow-up.
bookPart Maus-tratos e Traumatismo Cranioencefálico em Crianças(2015) SOARES, Matheus Schmidt; AMORIM, Robson Luis Oliveira de; PAIVA, Wellingson Silva; ANDRADE, Almir Ferreira dearticle 11 Citação(ões) na Scopus TRAUMATIC BRAIN INJURY AND SHAKEN BABY SYNDROME(2011) PAIVA, Wellingson S.; SOARES, Matheus S.; AMORIM, Robson L. O.; ANDRADE, A. Ferreira de; MATUSHITA, Hamilton; TEIXEIRA, Manoel J.Shaken baby syndrome is a serious form of physical child abuse, which is frequently overlooked. It is defined as vigorous manual shaking of an infant who is being held by the extremities or shoulders, leading to whiplashinduced intracranial and intraocular bleeding and no external signs of head trauma. This syndrome is seen most commonly in children under 2 years, mainly in children under 6 months. This article summarizes issues related to clinical presentation, diagnosis, risk factors, and interventions for healthcare professionals.