(Fonte: Lattes)
Índice h a partir de 2011
Projetos de Pesquisa
Unidades Organizacionais
Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina

Resultados de Busca

Agora exibindo 1 - 10 de 30
  • conferenceObject
    The impact of structured physical exercise on cognitive function of bipolar patients: A study protocol for a randomized controlled trial
    (2023) BELIZARIO, Gabriel; DUARTE, Cicera; NEVES, Lucas; MATHIAS, Karla; LAFER, Beny
  • bookPart
    Depressão e distimia
    (2019) MAIA, Eduardo Barreto; LAFER, Beny; ALMEIDA, Karla Mathias de
  • conferenceObject
    Structured physical exercise in bipolar depression: A pilot study
    (2020) DUARTE, Cicera; BELIZARIO, Gabriel O.; MATHIAS, Karla; SILVA, Michele; ROBERTO, Paulo; GREVE, Julia; LAFER, Beny
  • bookPart
    Transtornos afetivos
    (2023) BERALDI, Gabriel Henrique; TOKESHI, Lucas; GONçALVES, Luca Schilling; CORREIA, Aline Villalobo; SANT, Renato Del; ALMEIDA, Karla Mathias de
  • conferenceObject
    Exercise and ventilatory threshold in bipolar depression: A pilot study
    (2019) DUARTE, C.; SILVA, M.; ALMEIDA, K.; GREVE, J.; SILVA, P.; LAFER, B.
  • article 8 Citação(ões) na Scopus
    A Sib-Pair analysis of impulsivity in bipolar disorder type I
    (2013) ALMEIDA, Karla Mathias de; NERY, Fabiano Goncalves; MORENO, Ricardo Alberto; GORENSTEIN, Clarice; LAFER, Beny
    Objective: The aim of this study was to compare impulsivity among patients with bipolar disorder, their siblings, and healthy controls in order to examine whether impulsivity in bipolar disorder is related to genetic liability for the illness. Methods: Using the Barratt Impulsiveness Scale, we assessed 204 subjects: 67 euthymic outpatients with bipolar disorder type I, 67 siblings without bipolar disorder, and 70 healthy controls. Results: Impulsivity scores were higher among patients with bipolar disorder than among healthy controls. Siblings showed higher motor impulsivity scores than did healthy controls. Conclusions: Our results suggest that motor impulsivity may be a vulnerability marker for bipolar disorder. Our data may contribute to further improve preventive strategies in subjects at high risk for bipolar disorder.
  • article 1 Citação(ões) na Scopus
    Chronic mood instability: Bipolar, borderline, or both?
    (2018) BERALDI, Gabriel H.; ALMEIDA, Karla M.; LAFER, Beny
  • article 22 Citação(ões) na Scopus
    Association between duration of untreated bipolar disorder and clinical outcome: data from a Brazilian sample
    (2016) MEDEIROS, Gustavo C.; SENCO, Sofia B.; LAFER, Beny; ALMEIDA, Karla M.
    Objective: Bipolar disorder (BD) is often left untreated for long periods, and this delay in treatment correlates with unfavorable prognosis. The present study sought to assess the magnitude of duration of untreated bipolar disorder (DUB) in Brazil. We hypothesized that DUB would be longer in Brazil than in developed countries, and would be associated with poor clinical outcomes. Methods: One hundred and fifty-two psychiatric outpatients were evaluated for BD diagnosis, demographics, DUB, and clinical outcomes. Results: The mean age and mean DUB were, respectively, 38.9 +/- 10.8 and 10.4 +/- 9.8 years. An extended DUB was associated with early onset of BD (p < 0.001), depression as first mood episode (p = 0.04), and presence of BD in a first-degree relative (p = 0.012). Additionally, a longer DUB was associated with poorer clinical outcomes, such as elevated rates of rapid cycling (p = 0.004) and anxiety disorders (p = 0.016), as well as lower levels of current full remission (p = 0.021). Conclusion: As DUB may be a modifiable variable, better medical education regarding mental health, more structured medical services, and population-wide psychoeducation might reduce the time between onset and proper management of BD, thus improving outcome.
  • conferenceObject
    Structured physical exercise for bipolar depression: An open pilot trial
    (2019) DUARTE, C. C.; ALMEIDA, K. M.; SILVA, M.; LAFER, B.
  • article 9 Citação(ões) na Scopus
    Gray matter volumes in patients with bipolar disorder and their first-degree relatives
    (2015) NERY, Fabiano G.; GIGANTE, Alexandre Duarte; AMARAL, Jose A.; FERNANDES, Francy B. F.; BERUTTI, Mariangeles; ALMEIDA, Karla M.; CARNEIROC, Camila de Godoi; DURAN, Fabio Luis Souza; OTADUY, Maria G.; LEITE, Claudia Costa; BUSATTO, Geraldo; LAFER, Beny
    Bipolar disorder (BD) is highly heritable. First-degree relatives of BD patient have an increased risk to develop the disease. We investigated abnormalities in gray matter (GM) volumes in healthy first-degree relatives of BD patients to identify possible brain structural endophenotypes for the disorder. 3D T1-weighted magnetic resonance images were obtained from 25 DSM-IV BD type I patients, 23 unaffected relatives, and 27 healthy controls (HC). A voxel-based morphometry protocol was used to compare differences in GM volumes between groups. BD patients presented reduced GM volumes bilaterally in the thalamus compared with HC. Relatives presented no global or regional GM differences compared with HC. Our negative results do not support the role of GM volume abnormalities as endophenotypes for BD. Thalamic volume abnormalities may be associated the pathophysiology of the disease.