MARIA CANDIDA PINHEIRO BARACAT REZENDE
Projetos de Pesquisa
Unidades Organizacionais
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular, Hospital das Clínicas, Faculdade de Medicina
64 resultados
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Agora exibindo 1 - 10 de 64
bookPart Análogos do hormônio liberador de gonadotrofina(2014) JúNIOR, José Maria Soares; AMARAL, Vínicius Cestari do; BARACAT, Maria Cândida Pinheiro; SIMõES, Ricardo dos Santos; BARACAT, Edmund ChadaconferenceObject Expression of vascular endothelial growth factor (VEGF) in the endometrium of women with polycystic ovary syndrome (PCOS)(2013) SIMOES, Ricardo S.; SASSO, Gisela R.; FLORENCIO-SILVA, Rinaldo; MAGANHIN, Carla C.; SOARES- JR., Jose M.; BARACAT, Maria Candida P.; BARACAT, Edmund C.bookPart Transição para a menopausa e pós-menopausa: conceitos e classificação(2016) JúNIOR, José Maria Soares; SORPRESO, Isabel Cristina Esposito; BARACAT, Maria Cândida Pinheiro; BARACAT, Edmund Chada- Evidence that Melatonin Increases Inhibin Beta-A and Follistatin Gene Expression in Ovaries of Pinealectomized Rats(2020) MAGANHIN, Carla C.; BARACAT, Maria Candida P.; CARVALHO, Katia C.; SEGANFREDO, Isadora Braga; LUQUETTI, Camilla Maganhin; SIMOES, Ricardo Dos Santos; CARBONEL, Adriana Aparecida Ferraz; SIMOES, Manuel de Jesus; CIPOLLA-NETO, Jose; GIRAO, Manoel Joao Batista Castello; BARACAT, Edmund C.; SOARES-JR, Jose M.Melatonin plays an important role in the regulation of ovarian function including oocyte maturation in different mammalian species. Many studies indicate that melatonin has an impact on the ovarian function of a variety of ovarian cells. However, the information on the exact mechanism and involved hormones is low. To evaluate inhibin beta-A (INHBA) and follistatin (FST) expression in the ovaries of pinealectomized rats treated with melatonin, thirty adult female Wistar rats were randomized into three groups of ten animals each: group 1 (GSh), sham-operated controls receiving vehicle; group 2 (GPx), pinealectomized animals receiving vehicle; and group 3 (GPxMe), pinealectomized animals receiving replacement melatonin (1.0 mg/kg body weight. It was assumed that each animal drank 6.5 +/- 1.2 ml per night and weighs approximately 300 g.) for 60 consecutive days. The ovaries were collected for mRNA abundance and protein of INHBA and FST by qRT-PCR and immunohistochemical analyses, respectively. Treatment with melatonin resulted in the upregulation of INHBA and FST genes in the ovarian tissue of the melatonin-treated animals (GPxMe), when compared with GPx. These findings were then confirmed by analyzing the expression of protein by immunohistochemical analyses, which revealed higher immunoreactivity of INHBA and FST in GPxMe animals in the follicular cells compared with GSh and GPx rats. Melatonin increases the expression of INHBA and FST in the ovaries of pinealectomized female rats.
bookPart Histeroscopia na infância e na adolescência(2021) PINHEIRO, Walter da Silva; SIMõES, Ricardo Santos; PEREIRA, Anne Kristhine C.; REZENDE, Maria Cândida Pinheiro Baracat; JúNIOR, José Maria Soares- Polycystic ovary syndrome: controversies and challenges(2015) SOARES JUNIOR, Jose Maria; BARACAT, Maria Candida P.; MACIEL, Gustavo Arantes Rosa; BARACAT, Edmund Chada
bookPart Pólipo endometrial(2013) JúNIOR, José Maria Soares; BARACAT, Maria Cândida Pinheiro; MATSUZAKI, Walter Pinheiro; BARACAT, Edmund ChadabookPart Doença inflamatória pélvica(2016) MOTTA, Eduardo Vieira da; JúNIOR, José Maria Soares; BARACAT, Maria Cândida Pinheiro; BARACAT, Edmund ChadabookPart Histeroscopia: diagnóstico e indicações(2016) KRöGER, Gustavo Burcovschi; EJZENBERG, Dani; PEREIRA, Anne Kristhine Cavalcante; PINHEIRO, Walter; BARACAT, Maria Cândida Pinheiro; BARACAT, Edmund Chada- Systematic review of cell adhesion molecules and estrogen receptor expression in the endometrium of patients with polycystic ovary syndrome(2015) BARACAT, Maria Candida P.; SERAFINI, Paulo C.; SIMOES, Ricardo dos S.; MACIEL, Gustavo A. R.; SOARES- JR., Jose M.; BARACAT, Edmund C.Background: Infertility associated with polycystic ovary syndrome (PCOS) could be related to many mechanisms including endometrial factors. Objectives: To review cell adhesion molecule and estrogen receptor expression in the endometrium. Search strategy: A systematic review was performed of the Medline and Cochrane databases for papers published in any language between 2004 and 2014. The search term was ""'polycystic ovary syndrome' OR 'Stein Leventhal syndrome' OR 'anovulation' AND 'endometrium' OR 'endometria."" Selection criteria: Research studies on endometrial cell adhesion molecules and estrogen receptor expression among women with PCOS diagnosed according to the Rotterdam criteria were included. Data collection and analysis: Data were extracted from identified studies and the quality of assessment was analyzed. Main results: Six studies were included. Data were controversial with respect to MUC1 and alpha V beta 3 integrin expression with significantly higher and lower levels, respectively, in women with PCOS. Estrogen receptor expression was enhanced among patients with PCOS as compared with healthy women. Conclusions: Endometrial factors influence embryo receptivity as indicated by the molecular mediators identified in the studies, including cell adhesion molecules and the estrogen receptor.