FREDERICO CASTELO MOURA
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/33 - Laboratório de Oftalmologia, Hospital das Clínicas, Faculdade de Medicina
LIM/33 - Laboratório de Oftalmologia, Hospital das Clínicas, Faculdade de Medicina
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article 4 Citação(ões) na Scopus Linfoma não-Hodgkin bilateral do seio cavernoso como manifestação inicial da síndrome de imunodeficiência adquirida: relato de caso(2011) BARREIRA JUNIOR, Alan Kardec; MOURA, Frederico Castelo; MONTEIRO, Mario Luiz RibeiroCase report of bilateral cavernous sinus syndrome due to primary non-Hodgkin lymphoma of the central nervous system in a patient infected by the human immunodeficiency virus. A 51-year-old male patient infected by the human immunodeficiency virus but without antiretroviral treatment developed paralysis of the V and VI cranial nerves. Imaging studies were obtained to investigate an orbital apex and a cavernous sinus syndrome. A computerized tomography scan of the orbit was normal but a high-resolution magnetic resonance imaging demonstrated bilateral enlargement of the cavernous sinus. Although primary lymphoma of the central nervous system is a rare condition, it should be considered in the differential diagnosis in immunocompromised patients who develop ocular motility abnormalities and imaging signs suggestive of infiltrative cavernous sinus lesions.article 2 Citação(ões) na Scopus Acometimento orbitário na doença de Rosai-Dorfman(2011) OLIVEIRA, Cristiana Dumaresq de; GONCALVES, Allan C. Pieroni; MOURA, Frederico Castelo; ROSSATO, Luiz Angelo; MONTEIRO, Mario Luiz RibeiroRosai-Dorfman disease or sinus histiocytosis with massive lymphadenopathy is a rare idiopathic and benign clinical entity, characterized by histiocytic proliferation with linfofagocitosis. It usually presents with cervical lymphadenopathy although extranodal involvement may occur. The orbital region is one of the most common extranodal sites. It is usually a self-limiting disease with spontaneous resolution but surgical excision, corticosteroids and radiotherapy may be necessary. We describe the case of a 29-years-old male patient complaining of an orbital mass sensation for 6 months and a history of previous sinus involvement from Rosai-Dorfman disease. Ophthalmic examination showed proptosis of the right eye and swelling of right lower eyelid. Computed tomography of the orbits disclosed a solid extraconal lesion in the inferior right orbit. After surgical excision there was a significant clinical improvement. Histopathologic examination confirmed the diagnosis of Rosai-Dorfman disease. We also review the clinical picture and differential diagnosis of this condition.article 7 Citação(ões) na Scopus Optical coherence tomography evaluation of retinal nerve fiber layer in longitudinally extensive transverse myelitis(2011) MOURA, Frederico C.; FERNANDES, Danilo B.; APOSTOLOS-PEREIRA, Samira L.; CALLEGARO, Dagoberto; MARCHIORI, Paulo E.; MONTEIRO, Mario L. R.Objective: To compare optical coherence tomography (OCT) measurements on the retinal nerve fiber layer (RNFL) of healthy controls and patients with longitudinally extensive transverse myelitis (LETM) without previous optic neuritis. Method: Twenty-six eyes from 26 patients with LETM and 26 control eyes were subjected to automated perimetry and OCT for comparison of RNFL measurements. Results: The mean deviation values from perimetry were significantly lower in patients with LETM than in controls (p<0.0001). RNFL measurements in the nasal quadrant and in the 3-o'clock segment were significantly smaller in LETM eyes than in controls. (p=0.04 and p=0.006, respectively). No significantly differences in other RNFL measurements were found. Conclusion: Patients with LETM may present localized RNFL loss, particularly on the nasal side of the optic disc, associated with slight visual field defects, even in the absence of previous episodes of optic neuritis. These findings emphasize the fact that patients with LETM may experience attacks of subclinical optic nerve damage.