VALERIA APARECIDA DA COSTA HONG
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conferenceObject Impaired Baroreflex Sensitivity in Anabolic Steroid Users(2012) SANTOS, Marcelo Rodrigues dos; PORELLO, Rafael Armani; SAYEGH, Ana L. C.; HONG, Valeria; TOSCHI-DIAS, Edgar; BORTOLOTTO, Luiz A.; YONAMINE, Mauricio; NEGRAO, Carlos E.; ALVES, Maria-Janieire N. N.Purpose: Exacerbated sympathetic nerve activity and increased blood pressure have been documented in anabolic androgenic steroid users (AASU). We tested the hypothesis that arterial baroreflex sensitivity (BRS) and carotid distensibility would be reduced in AASU. Methods: Ten AASU and 10 age-paired anabolic androgenic steroid nonusers (AASNU) were studied. Both groups were involved in strength training (90% 1MR) and AASU were self-administered anabolic steroids for at least 2 years. The use of AAS was proved by urine. Heart rate (HR) was evaluated by EKG and blood pressure non-invasively on a beat to beat. BRS was analyzed by time domain through spontaneous fluctuations between systolic blood pressure (SBP) and HR. Carotid artery distensibility was measured by doppler (M-mode). Results: HR was higher in AASU compared to AASNU (69±3 vs. 59±3 bpm, P≤0.05). Systolic (123±4 vs. 118±2 mmHg, P=0.29), diastolic (72±2 vs. 67±2 mmHg, P=0.12) and mean blood pressure (90±3 vs. 85±2 mmHg, P=0.15) were not different between groups. BRS for increases (14.2±2 vs. 22.8±3 msec/mmHg, P=0.05) and decreases (13.3±1 vs. 19.2±2 msec/mmHg, P=0.04) were lower in AASU. Carotid distensibility was reduced in AASU (7±1 vs. 9±1 %, P≤0.05). Conclusion: Impaired BRS and reduced carotid distensibility may prematurely lead to increased cardiovascular risk in AASU.- Effect of fructooligosaccharide on endothelial function in CKD patients: a randomized controlled trial(2022) ARMANI, Rachel G.; CARVALHO, Aluizio B.; I, Christiane Ramos; HONG, Valeria; BORTOLOTTO, Luiz A.; CASSIOLATO, Jose Luiz; OLIVEIRA, Natacha F.; CIESLAROVA, Zuzana; LAGO, Claudimir L. do; KLASSEN, Aline; CUPPARI, Lilian; RAJ, Dominic S.; CANZIANI, Maria Eugenia F.Background. Microbiota-derived uremic toxins have been associated with inflammation that could corroborate with endothelial dysfunction (ED) and increase cardiovascular risk in patients with chronic kidney disease (CKD). This trial aimed to evaluate the effect of the prebiotic fructooligosaccharide (FOS) on endothelial function and arterial stiffness in nondialysis CKD patients. Methods. In a double-blind controlled trial, 46 nondiabetic CKD patients were randomized to receive 12 g/day of FOS or placebo (maltodextrin) for 3 months. Total p-cresyl sulfate (PCS) and indoxyl sulfate by high-performance liquid chromatography, urinary trimethylamine N-oxide by mass spectrometry, C-reactive protein, interleukin-6 (IL-6), serum nitric oxide and stroma-derived factor-1 alfa were measured at baseline and at the end of follow-up; endothelial function was assessed through flow-mediated dilatation (FMD) and arterial stiffness by pulse wave velocity (PWV). Results. The mean (+/- standard deviation) age of the study participants was 57.6 +/- 14.4 years, with an estimated glomerular filtration rate of 21.3 +/- 7.3 mL/min/1.73 m(2). During the follow-up, regarding the inflammatory markers and uremic toxins, there was a significant decrease in IL-6 levels (3.4 +/- 2.1 pg/mL versus 2.6 +/- 1.4 pg/mL; P = 0.04) and a trend toward PCS reduction (55.4 +/- 38.1 mg/L versus 43.1 +/- 32.4 mg/L, P = 0.07) only in the prebiotic group. Comparing both groups, there was no difference in FMD and PWV. In an exploratory analysis, including a less severe ED group of patients (FMD >= 2.2% at baseline), FMD remained stable in the prebiotic group, while it decreased in the placebo group (group effect P = 0.135; time effect P = 0.012; interaction P = 0.002). Conclusions. The prebiotic FOS lowered circulating levels of IL-6 in CKD patients and preserved endothelial function only in those with less damaged endothelium. No effect of FOS in arterial stiffness was observed.
- Prevalence of Metabolic Syndrome and Framingham Risk Score in Apparently Healthy Vegetarian and Omnivorous Men(2018) NAVARRO, Julio Cesar Acosta; ANTONIAZZI, Luiza; OKI, Adrian Midori; BONFIM, Maria Carlos; HONG, Valeria; BORTOLOTTO, Luiz Aparecido; ACOSTA-CARDENAS, Pedro; SANDRIM, Valeria; MINAME, Marcio Hiroshi; SANTOS FILHO, Raul Dias dosBackground: Recent studies have shown a lower prevalence of metabolic syndrome (MSyn) in vegetarians (VEG) despite the inconclusive evidence from others. Objective: To verify the association between diet and other lifestyle characteristics and the prevalence of MSyn, cardiovascular risk factors (CRF), and Framingham Risk Score (FRS) in apparently healthy VEG and omnivorous (OMN) men. Methods: In this cross-sectional study, 88 apparently healthy men >= 35 years, 44 VEG and 44 OMN, were assessed for anthropometric data, blood pressure, blood lipids, glucose, C-reactive protein (CRP) and FRS. To test the association between lifestyle and MSyn, Student t test, chi-square test, and multiple logistic regression model were used. A significance level of 5% was considered in all statistical analyses. Results: Several CRF were significantly lower in VEG than in OMN: body mass index, systolic blood pressure, diastolic blood pressure, fasting serum total cholesterol, LDL-cholesterol, apolipoprotein b, glucose, and glycated hemoglobin (all p < 0.05). The FRS mean was lower in VEG than in OMN (2.98 +/- 3.7 vs 4.82 +/- 4.8, p = 0.029). The percentage of individuals with MSyn was higher among OMN than among VEG (52.3 vs.15.9%) (p < 0.001). The OMN diet was associated with MSyn (OR: 6.28 95%CI 2.11-18.71) and alterations in most MSyn components in the multiple regression model independently of caloric intake, age and physical activity. Conclusion: The VEG diet was associated with lower CRF, FRS and percentage of individuals with MSyn.
- Shortening telomere is associated with subclinical atherosclerosis biomarker in omnivorous but not in vegetarian healthy men(2019) CINEGAGLIA, Naiara; ANTONIAZZI, Luiza; ROSA, Daniela; MIRANDA, Debora; ACOSTA-NAVARRO, Julio; BORTOLOTTO, Luiz; HONG, Valeria; SANDRIM, ValeriaTelomere length is considered to be a biomarker of biological aging and age-related disease. There are few studies that have evaluated the association between telomere length and diet, and none of them have evaluated the impact of a vegetarian diet on telomere length and its correlation with cardiovascular biomarkers in apparently healthy subjects. Therefore, our objectives were to evaluate leukocyte telomere length (LTL) in vegetarians and omnivorous subjects and its association with classical cardiovascular risk biomarkers. From the total of 745 participants initially recruited, 44 omnivorous and 44 vegetarian men apparently healthy were selected for this study and LTL was measured in 39 omnivorous and 41 vegetarians by Real-Time Quantitative PCR reaction. Although telomere length was not different between omnivorous and vegetarians, we found a strong negative correlation between LTL and IMT (intima-media thickness) in omnivorous, but not in vegetarian group. In addition, omnivorous who were classified with short telomere length had higher carotid IMT compared to vegetarians. Our data suggest that telomere length can be a marker of subclinical atherosclerosis in the omnivorous group.
- Reduced subclinical carotid vascular disease and arterial stiffness in vegetarian men: The CARVOS Study(2017) ACOSTA-NAVARRO, Julio; ANTONIAZZI, Luiza; OKI, Adriana Midori; BONFIM, Maria Carlos; HONG, Valeria; ACOSTA-CARDENAS, Pedro; STRUNZ, Celia; BRUNORO, Eleonora; MINAME, Marcio Hiroshi; SALGADO FILHO, Wilson; BORTOLOTTO, Luiz Aparecido; SANTOS, Raul D.Background: Dietary habits play an important role in the development of atherosclerosis, the most important cause of morbidity and mortality in the world. The objective of this study was to verify if vegetarian (VEG) diet could be related a better profile of subclinical vascular disease evaluated by arterial stiffness and functional and structural properties of carotid arteries, compared to omnivorous (OMN) diet. Methods: In this cross-sectional study, 44 VEG and 44 OMN apparently healthymen >= 35 years of age, in order to not have confounding risk factors of subclinical atherosclerosis, were assessed for anthropometric data, blood pressure, blood lipids, glucose, C reactive protein (CRP), and arterial stiffness determined by carotid-femoral pulse wave velocity (PWV). Also, carotid intima-media thickness (c-IMT) and distensibility were evaluated. Results: VEG men had lower body mass index, systolic and diastolic blood pressures, fasting serum total cholesterol, LDL and non-HDL-cholesterol, apolipoprotein B, glucose and glycated hemoglobin values in comparison with OMN individuals (all p values <0.05). Markers of vascular structure and function were different between VEG and OMN: PWV 7.1 +/- 0.8 m/s vs. 7.7 +/- 0.9 m/s (p < 0.001); c-IMT 593 +/- 94 vs. 661 +/- 128 mu m (p = 0.003); and relative carotid distensibility 6.39 +/- 1.7 vs. 5.72 +/- 1.8% (p = 0.042), respectively. After a multivariate linear regression analysis, a VEG diet was independently and negatively associated with PWV (p value 0.005). Conclusions: A VEG diet is associated with a more favorable cardiovascular diseases biomarker profile and better vascular structural and functional parameters.
- Consumption of animal-based and processed food associated with cardiovascular risk factors and subclinical atheroscerosis biomarkers in men(2019) ACOSTA-NAVARRO, Julio Cesar; OKI, Adriana Midori; ANTONIAZZI, Luiza; BONFIM, Maria Aparecida Carlos; HONG, Valeria; GASPAR, Maria Cristina de Almeida; SANDRIM, Valeria Cristina; NOGUEIRA, AdrianaOBJECTIVE: To evaluate the frequency of food consumption in apparently healthy men and their association with cardiovascular risk factors and biomarkers of subclinical atherosclerosis. METHODS: In this observational study, 88 men had their food standard obtained through the food frequency questionnaire (FFQ). Associations of dietary patterns with cardiovascular risk factors, such as anthropometric data, laboratory and clinical evaluations, carotid-femoral arterial stiffness (IMT) and pulse wave velocity were evaluated. RESULTS: The highest values were observed, for most of the risk factors evaluated, with the highest frequency of weekly consumption of dairy products, meats, sweets, fats, cold meats, sodas, milk and white chocolate; and lower frequency of weekly consumption of fruits, cereals, vegetables, legumes, oilseeds, and soy. There was no significant difference for coffee and dark chocolate CONCLUSIONS: A diet with high consumption of animal products has a higher correlation with cardiovascular risk factors; the opposite is true for the consumption of plant-based food, associated with the profile of more favorable biomarkers for cardiovascular health and better biochemical and structural parameters.
conferenceObject The Influence Of Religiosity On The Embracement Vs. Technology Based Distance Learning In Therapy Adherence In Patient Hypertensive(2016) GUERRA, Grazia M.; WEN, Chao L.; VIEIRA, Margarida; FISTAROL, Isabela; TSUNEMI, Miriam H.; GIORGI, Dante M.; MOTTA, Raquel A.; OLIVEIRA, Jefferson C.; HONG, Valeria; LOPES, Heno F.- Reference intervals for common carotid intima-media thickness measured with echotracking: relation with risk factors(2013) ENGELEN, Lian; FERREIRA, Isabel; STEHOUWER, Coen D.; BOUTOUYRIE, Pierre; LAURENT, Stephane; BOUTOUYRIE, Pierre; LAURENT, Stephane; JOUVEN, Xavier; EMPANA, Jean-Philippe; BOZEC, Erwan; SIMON, Tabassome; PANNIER, Bruno; MATTACE-RASO, Francesco U. S.; HOFMAN, Albert; FRANCO, Oscar H.; KAVOUSI, Maryam; ROOIJ, Frank J. van; WITTEMAN, Jacqueline; RIETZSCHEL, Ernst; VERMEERSCH, Sebastian; SEGERS, Patrick; BORTEL, Luc Van; BACQUER, Dirk De; DAELE, Caroline Van; BUYZERE, Marc De; BOTS, Michiel L.; SCHOUW, Yvonne T. van der; GROBBEE, Diederick E.; UITERWAAL, Cuno S.; EVELEIN, Annemieke; GRAAF, Yolanda van der; VISSEREN, Frank L. J.; STEHOUWER, Coen; FERREIRA, Isabel; DEKKER, Jacqueline; NIJPELS, Giel; TWISK, Jos; SMULDERS, Yvo; SCHALKWIJK, Casper; GREEVENBROEK, Marleen van; KALLEN, Carla van der; LAAR, Roel van de; FESKENS, Edith; STAESSEN, Jan; THIJS, Lutgarde; KOUZNETSOVA, Tatyana; JIN, Yu; LIU, Yanping; BENETOS, Athanase; LABAT, Carlos; LACOLLEY, Patrick; WANG, Jiguang; LI, Yan; FISCHER, Joachim; TERRIS, Darcey; JARCZOK, Marc; THOLE, Maren; HEUTEN, Hilde; GOOVAERTS, Inge; ENNEKENS, Guy; VRINTS, Christiaan; RYLISKYTE, Ligita; LAUCEVICIUS, Aleksandras; RYLISKIENE, Kristina; KUZMICKIENE, Jurgita; BIANCHINI, Elisabetta; GHIADONI, Lorenzo; BRUNO, Rosa Maria; CARTONI, Giulia; TADDEI, Stefano; TOLEZANI, Elaine C.; HONG, Valeria; BORTOLOTTO, Luiz; VERMEER, Cees; BRAAM, Lavienja; KNAPEN, Marjo; DRUMMEN, Nadja; RIMOLDI, Stefano F.; STUCKI, Fabian; HUTTER, Damian; REXHAJ, Emrush; FAITA, Francesco; SARTORI, Claudio; SCHERRER, Urs; ALLEMANN, Yves; DELAHOUSSE, Michel; KARRAS, Alexandre; GIANNATTASIO, Cristina; CESANA, Francesca; NAVA, Stefano; MALOBERTI, Alessandro; KOLLAI, Mark; PINTER, Alexandra; HORVATH, Tamas; NARKIEWICZ, Krzysztof; SZYNDLER, Anna; HOFFMANN, Michal; NOWAK, Robert; POLONIS, Katarzyna; THUILLEZ, Christian; JOANNIDES, Robinson; BELLIEN, Jeremy; ANGEL, Kristin; ATAR, Dan; FILIPOVSKY, Jan; AGHARAZII, Mohsen; BRIET, MarieAims Common carotid artery intima-media thickness (CCIMT) is widely used as a surrogate marker of atherosclerosis, given its predictive association with cardiovascular disease (CVD). The interpretation of CCIMT values has been hampered by the absence of reference values, however. We therefore aimed to establish reference intervals of CCIMT, obtained using the probably most accurate method at present (i.e. echotracking), to help interpretation of these measures. Methods and results We combined CCIMT data obtained by echotracking on 24 871 individuals (53 men; age range 15-101 years) from 24 research centres worldwide. Individuals without CVD, cardiovascular risk factors (CV-RFs), and BP-, lipid-, and/or glucose-lowering medication constituted a healthy sub-population (n = 4234) used to establish sex-specific equations for percentiles of CCIMT across age. With these equations, we generated CCIMT Z-scores in different reference sub-populations, thereby allowing for a standardized comparison between observed and predicted (normal) values from individuals of the same age and sex. In the sub-population without CVD and treatment (n = 14 609), and in men and women, respectively, CCIMT Z-scores were independently associated with systolic blood pressure [standardized s 0.19 (95 CI: 0.16-0.22) and 0.18 (0.15-0.21)], smoking [0.25 (0.19-0.31) and 0.11 (0.04-0.18)], diabetes [0.19 (0.05-0.33) and 0.19 (0.02-0.36)], total-to-HDL cholesterol ratio [0.07 (0.04-0.10) and 0.05 (0.02-0.09)], and body mass index [0.14 (0.12-0.17) and 0.07 (0.04-0.10)]. Conclusion We estimated age- and sex-specific percentiles of CCIMT in a healthy population and assessed the association of CV-RFs with CCIMT Z-scores, which enables comparison of IMT values for (patient) groups with different cardiovascular risk profiles, helping interpretation of such measures obtained both in research and clinical settings.