VALERIA APARECIDA DA COSTA HONG
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- Shortening telomere is associated with subclinical atherosclerosis biomarker in omnivorous but not in vegetarian healthy men(2019) CINEGAGLIA, Naiara; ANTONIAZZI, Luiza; ROSA, Daniela; MIRANDA, Debora; ACOSTA-NAVARRO, Julio; BORTOLOTTO, Luiz; HONG, Valeria; SANDRIM, ValeriaTelomere length is considered to be a biomarker of biological aging and age-related disease. There are few studies that have evaluated the association between telomere length and diet, and none of them have evaluated the impact of a vegetarian diet on telomere length and its correlation with cardiovascular biomarkers in apparently healthy subjects. Therefore, our objectives were to evaluate leukocyte telomere length (LTL) in vegetarians and omnivorous subjects and its association with classical cardiovascular risk biomarkers. From the total of 745 participants initially recruited, 44 omnivorous and 44 vegetarian men apparently healthy were selected for this study and LTL was measured in 39 omnivorous and 41 vegetarians by Real-Time Quantitative PCR reaction. Although telomere length was not different between omnivorous and vegetarians, we found a strong negative correlation between LTL and IMT (intima-media thickness) in omnivorous, but not in vegetarian group. In addition, omnivorous who were classified with short telomere length had higher carotid IMT compared to vegetarians. Our data suggest that telomere length can be a marker of subclinical atherosclerosis in the omnivorous group.
- Hypertensive heart disease: Benefit of carvedilol in hemodynamic, left ventricular remodeling, and survival(2019) DOMINGUEZ, Renata F.; COSTA-HONG, Valeria A. da; FERRETTI, Luan; FERNANDES, Fabio; BORTOLOTTO, Luiz A.; CONSOLIM-COLOMBO, Fernanda M.; EGAN, Brent M.; LOPES, Heno F.Objectives: The aim of this study was to determine if carvedilol improved structural and functional changes in the left ventricle and reduced mortality in patients with hypertensive heart disease. Methods: Blood pressure, heart rate, echocardiographic parameters, and laboratory variables, were assessed pre and post treatment with carvedilol in 98 eligible patients. Results: Carvedilol at a median dose of 50 mg/day during the treatment period in hypertensive heart disease lowered blood pressure 10/10 mmHg, heart rate 10 beats/min, improved left ventricular ejection fraction from baseline to follow-up (median: 6 years) (36%-47%)) and reduced left ventricular end-diastolic and end-systolic dimensions (62 vs 56 mm; 53 vs 42 mm, respectively, all p-values <0.01). Left ventricular ejection fraction increased in 69% of patients. Patients who did not have improved left ventricular ejection fraction had nearly six-fold higher mortality than those that improved (relative risk; 5.7, 95% confidence interval: 1.3-25, p = 0.022). Conclusion: Carvedilol reduced cardiac dimensions and improved left ventricular ejection fraction and cardiac remodeling in patients with hypertensive heart disease. These treatment-related changes had a favorable effect on survival.
conferenceObject Sleep Quality and Quantity, Sleepiness and Cardiovascular Parameters of Bed Partners of Patients with Obstructive Sleep Apnea: Cross-Sectional Data from the SLEEP-PARTNERS Study(2019) GIAMPA, S.; COSTA-HONG, V.; FREITAS, L. S.; FURLAN, S. F.; AZAM, I. F. B.; BORTOLOTTO, L. A.; LORENZI-FILHO, G.; DRAGER, L. F.- Consumption of animal-based and processed food associated with cardiovascular risk factors and subclinical atheroscerosis biomarkers in men(2019) ACOSTA-NAVARRO, Julio Cesar; OKI, Adriana Midori; ANTONIAZZI, Luiza; BONFIM, Maria Aparecida Carlos; HONG, Valeria; GASPAR, Maria Cristina de Almeida; SANDRIM, Valeria Cristina; NOGUEIRA, AdrianaOBJECTIVE: To evaluate the frequency of food consumption in apparently healthy men and their association with cardiovascular risk factors and biomarkers of subclinical atherosclerosis. METHODS: In this observational study, 88 men had their food standard obtained through the food frequency questionnaire (FFQ). Associations of dietary patterns with cardiovascular risk factors, such as anthropometric data, laboratory and clinical evaluations, carotid-femoral arterial stiffness (IMT) and pulse wave velocity were evaluated. RESULTS: The highest values were observed, for most of the risk factors evaluated, with the highest frequency of weekly consumption of dairy products, meats, sweets, fats, cold meats, sodas, milk and white chocolate; and lower frequency of weekly consumption of fruits, cereals, vegetables, legumes, oilseeds, and soy. There was no significant difference for coffee and dark chocolate CONCLUSIONS: A diet with high consumption of animal products has a higher correlation with cardiovascular risk factors; the opposite is true for the consumption of plant-based food, associated with the profile of more favorable biomarkers for cardiovascular health and better biochemical and structural parameters.
- DIETARY ADVANCED GLYCATION ENDPRODUCTS (AGE) IMPAIRED THE ENDOTHELIAL FUNCTION IN HEALTHY EUTROPHIC IN AGING PROCESS(2019) PEREIRA, R.; HONG, V. A. D. C.; BORTOLOTTO, L.; PINTO, R. D. S.; PASSARELLI, M.; MACHADO-LIMA, A.