JACQUELINE DE FATIMA JACYSYN
Projetos de Pesquisa
Unidades Organizacionais
LIM/08 - Laboratório de Anestesiologia, Hospital das Clínicas, Faculdade de Medicina
4 resultados
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conferenceObject Proliferative Activity and Neovascularization of the Ovarian Graft in Rats Treated with N-Acetylcysteine(2012) DURANDO, M. C. S.; GOMES, E. A. M.; DAMOUS, L. L.; SIMOES, M. J.; JACYSYN, J. F.; MONTERO, E. F. S.conferenceObject Immunomodulation of the Intestinal Graft in Fetal Mouse Model Transplant: Remote Ischemic Preconditioning and N-Acetylcysteine(2012) ABRAHAO, M. S.; VICTO, N. C.; SILVA, R. C.; KOIKE, M. K.; CAMARA, N. O. S.; JACYSYN, J. F.; MONTERO, E. F. S.- Cytotoxicity of cashew flavonoids towards malignant cell lines(2012) KONAN, Nzi Andre; LINCOPAN, Nilton; DIAZ, Ingrit Elida Collantes; JACYSYN, Jacqueline de Fatima; TIBA, Mirtes Midori Tanae; MENDES, Joao Gustavo Pessini Amarante; BACCHI, Elfriede Marianne; SPIRA, BenyThe leaves of the Cashew plant (Anacardium occidentale L.) are used by the folk medicine in South America and West Africa. This plant is rich in flavonoids, which are polyphenolic compounds widespread in plants, and that have diverse physiological effects. In a sub-acute toxicity assay it was found that an ethanolic extract of Cashew leaves elicited lymphopenia in rats. The extract was also found to be cytotoxic and to induce apoptosis in Jurkat (acute lymphoblastic leukemia) cells. The crude ethanolic extract was fractionated and resolved by HPLC. One of the four fractions obtained led to the isolation of the biflavonoid agasthisflavone. [H-3]-thymidine incorporation assays and flow cytometry analysis showed that the isolated compound displayed a high anti-proliferative effect in Jurkat cells with an IC50 of 2.4 mu g/ml (4.45 mu M). The effect of agathisflavone on the acute promyelocytic leukemia cell line HL60, Burkitt lymphoma Raji cells and Hep-2 laryngeal carcinoma cells was also tested. The two latter ones were only mildly affected by agathisflavone. It is also shown that agathisflavone induces apoptosis in Jurkat cells and it this proposed that this is the likely mechanism of agathisflavone specific cytotoxicity.
conferenceObject Morphological and Functional Aspects of the Ovarian Graft in Transplated Rats Treated with N-Acetylcysteine(2012) GOMES, E. A. M.; DAMOUS, L. L.; DURANDO, M. C. S.; SIMOES, M. J.; JACYSYN, J. F.; MONTERO, E. F. S.