SAMUEL PADOVANI STEFFEN
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
19 resultados
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conferenceObject A New Allocation System for Priorization in Heart Transplantation in the State of Sao Paulo - Brazil: Its Impact on Patients in ECMO(2022) STEFFEN, Samuel P.; GAIOTTO, Fabio A.; GASPAR, Shyrline F.; SANTOS, Ronaldo Honorato B.; FILHO, Domingos D. L.; BACAL, Fernando; JATENE, Fabio B.- Heterotopic Heart Transplantation as a Left Ventricular Biological Assistance: a New Two-Stage Method Proposal(2020) GAIOTTO, Fabio Antonio; BARBOSA FILHO, Antonio Carlos de Almeida; TENORIO, Davi Freitas; STEFFEN, Samuel Padovani; JATENE, Fabio B.Since Barnard's first heterotopic heart transplant in 1974, Copeland's method has been the greatest contribution to heterotopic transplants but has the drawback of donor's right ventricular atrophy. This new method proposes a modification in the anastomosis of the superior vena cava aiming to pre-serve donor's right ventricular function by decompressing the pulmonary territory and reducing the pulmonary arterial pressure, as a biological ventricular assist device. Finally, a second intervention is proposed, where a ""twist"" is performed to place the donor's heart in an orthotopic position after re-moval of the native heart. A pioneering research on this method received approval from the ethics committee of the Heart Institute of Sao Paulo. We believe that this method has the potential to im-prove quality of life in a selected group of patients.
- Incidence of Right Ventricular Dysfunction in Adult Patients Submitted to Heart Transplantation According to the Presence of Pre-Transplant Pulmonary Hypertension(2019) LENSI, M. M.; RAMOS, A. S.; XAVIER JUNIOR, J.; SEGURO, L. B.; MANGINI, S.; AVILA, M. S.; CAMPOS, I. W.; DUQUE, A. P.; GAIOTTO, F.; STEFFEN, S. P.; BACAL, F.; MARCONDES-BRAGA, F. G.
conferenceObject COMMANDO SURGERY AS THE THIRD REOPERATION OF A RHEUMATIC PATIENT WITH SEVERE MITRAL-AORTIC-PROSTHESIS DYSFUNCTION AND MISMATCH: A CASE REPORT(2022) MAZETTO, Amanda Bergamo; GONCALVES, Rallyson De Oliveira; STEIN, Julien Ramos; ACCORSI, Tarso Augusto; STEFFEN, Samuel Padovani; TARASOUTCHI, Flavio; ROCHA, Aroni Marceu Sousa e; ANDRADE, Ana Flavia Diez de; CAMPOS, Joaquim Tenente Ana de; GAIOTTO, Fabio Antonio- Acute myocardial infarction in a patient with active actinic rectitis bleeding: Between the sword and the wall(2019) MANUEL, Valdano; STEFFEN, Samuel P.; GAIOTTO, Fabio A.; PUIG, Luiz B.A The coronary artery bypass graft (CABG) is common. Sometimes can be challenging. Here we present a 79-year-old man presented with unstable angina and simultaneous activelower gastrointestinal bleeding (hemoglobin level, 5.1 g/L) due to actinic rectitis after radiation therapy for prostate carcinoma performed 1 year previously. Coronary angiography showed marked stenosis of the left anterior descending artery. Antiplatelet aggregation therapy, such as percutaneous coronary intervention or systemic heparin therapy for coronary artery bypass, was not feasible owing to the active rectal bleeding. Therefore, off-pump CABG has performed without systemic heparin therapy and the patient recovered well. For specific cases, CABG without systemic heparin therapy can be safely performed.
conferenceObject VA ECMO SUPPORT IN A HEART TRANSPLANT CENTER: BRIDGE TO TRANSPLANT AND BRIDGE TO RECOVERY FROM SEVERE PRIMARY GRAFT DYSFUNCTION(2019) STEFFEN, Samuel; ABAURRE, Vitor; GAIOTTO, Fabio; HONORATO, Ronaldo; LOURECO, Domingos; GASPAR, Shirlyne; BRAGA, Fabiana; GRINBERG, Monica; MANGINI, Sandrigo; SEGURO, Luiz; WOSNIAK, Lascara; GALAS, Filomena; BACAL, Fernando; JATENE, Fabio- Quadricuspid Aortic Valve: Three Cases Report and Literature Review(2019) VERONESE, Elinthon Tavares; BRANDAO, Carlos Manuel de Almeida; STEFFEN, Samuel Padovani; POMERANTZEFF, Pablo; JATENE, Fabio B.Quadricuspid aortic valve (QAV) is a rare cardiac malformation. Many cases are incidentally diagnosed in aortic surgeries or autopsies and it usually appears as an isolated anomaly. The most widely classification used is the one by Hurwitz and Roberts[1], which divides 7 alphabetical subtypes based on the cusps size. The aim of this report is to describe three different anatomic presentations of this rare aortic valve anomaly.
- Answer: Heterotopic Heart Transplant History and Concepts Cannot Be Neglected - Witnessing the History and Learning with Previous Practices(2021) GAIOTTO, Fabio Antonio; BARBOSA-FILHO, Antonio Carlos de Almeida; TENORIO, Davi Freitas; STEFFEN, Samuel Padovani
- Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy(2022) BROCHET, Pauline; IANNI, Barbara Maria; LAUGIER, Laurie; FRADE, Amanda Farage; NUNES, Joao Paulo Silva; TEIXEIRA, Priscila Camillo; MADY, Charles; FERREIRA, Ludmila Rodrigues Pinto; FERRE, Quentin; SANTOS, Ronaldo Honorato Barros; KURAMOTO, Andreia; CABANTOUS, Sandrine; STEFFEN, Samuel; STOLF, Antonio Noedir; POMERANTZEFF, Pablo; FIORELLI, Alfredo Inacio; BOCCHI, Edimar Alcides; PISSETTI, Cristina Wide; SABA, Bruno; CANDIDO, Darlan da Silva; DIAS, Fabricio C.; SAMPAIO, Marcelo Ferraz; GAIOTTO, Fabio Antonio; MARIN-NETO, Jose Antonio; FRAGATA, Abilio; ZANIRATTO, Ricardo Costa Fernandes; SIQUEIRA, Sergio; PEIXOTO, Giselle De Lima; RIGAUD, Vagner Oliveira-Carvalho; BACAL, Fernando; BUCK, Paula; ALMEIDA, Rafael Ribeiro; LIN-WANG, Hui Tzu; SCHMIDT, Andre; MARTINELLI, Martino; HIRATA, Mario Hiroyuki; DONADI, Eduardo Antonio; PEREIRA, Alexandre Costa; RODRIGUES JUNIOR, Virmondes; PUTHIER, Denis; KALIL, Jorge; SPINELLI, Lionel; CUNHA-NETO, Edecio; CHEVILLARD, ChristopheChagas disease, caused by the protozoan Trypanosoma cruzi, is an endemic parasitic disease of Latin America, affecting 7 million people. Although most patients are asymptomatic, 30% develop complications, including the often-fatal Chronic Chagasic Cardiomyopathy (CCC). Although previous studies have demonstrated some genetic deregulations associated with CCCs, the causes of their deregulations remain poorly described. Based on bulk RNA-seq and whole genome DNA methylation data, we investigated the genetic and epigenetic deregulations present in the moderate and severe stages of CCC. Analysis of heart tissue gene expression profile allowed us to identify 1407 differentially expressed transcripts (DEGs) specific from CCC patients. A tissue DNA methylation analysis done on the same tissue has permitted the identification of 92 regulatory Differentially Methylated Regions (DMR) localized in the promoter of DEGs. An in-depth study of the transcription factors binding sites (TFBS) in the DMRs corroborated the importance of TFBS's DNA methylation for gene expression in CCC myocardium. TBX21, RUNX3 and EBF1 are the transcription factors whose binding motif appears to be affected by DNA methylation in the largest number of genes. By combining both transcriptomic and methylomic analysis on heart tissue, and methylomic analysis on blood, 4 biological processes affected by severe CCC have been identified, including immune response, ion transport, cardiac muscle processes and nervous system. An additional study on blood methylation of moderate CCC samples put forward the importance of ion transport and nervous system in the development of the disease.
- Recurrent Cardiac Myxoma Treated by Heart Transplantation(2021) CARDOSO, Lucas Figueredo; STEFFEN, Samuel Padovani; GASPAR, Shirlyne Fabianni Dias; BACAL, Fernando; JATENE, Fabio Biscegli