PRISCILA DE ARRUDA TRINDADE

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  • bookPart
    Farmacoeconomia em anestesia
    (2017) MELO, Daniela Oliveira de; TRINDADE, Priscila de Arruda; TRINDADE, Evelinda
  • article 4 Citação(ões) na Scopus
    Susceptibility to chlorhexidine and mupirocin among methicillin-resistant Staphylococcus aureus clinical isolates from a teaching hospital
    (2021) BES, Taniela Marli; PERDIGAO-NETO, Lauro; MARTINS, Roberta Ruedas; HEIJDEN, Inneke; TRINDADE, Priscila de Arruda; CAMILO, Gaspar; NAGANO, Debora Satie; MONGELOS, Diego; MARCHI, Ana Paula; TOMAZ, Mariama; OLIVEIRA, Larissa Marques de; ROSSI, Flavia; LEVIN, Anna Sara; COSTA, Silvia Figueiredo
    Despite the widespread use of chlorhexidine (CHX) to prevent infection, data regarding the in vitro action of CHX against methicillin-resistant Staphylococcus aureus (MRSA) are limited. Clinical isolates from Hospital das Clinicas, Sao Paulo, Brazil, identified during 2002/2013 and 2012/2013 were studied to describe the susceptibility to CHX and mupirocin, molecular characteristics, and virulence profile of MRSA. Susceptibility test to Mupirocin was performed by the disk diffusion method and to CHX by the agar dilution technique. PCR for virulence genes, mecA gene and Staphylococcal Cassette Chromosome mec (SCCmec) types were investigated as well. Mupirocin- and CHX-resistant isolates were sequenced using the Illumina (TM) plataform. Two hundred and sixteen MRSA clinical isolates were evaluated: 154 from infected and 62 from colonized patients. Resistance to mupirocin was observed in four isolates assigned as SCOnec type III and STs (ST05; ST239 and ST105) carrying mupA and blaZ, two of them co-harboring the ileS gene. Only one isolate assigned as SCCmec type III was resistant to CHX (MIC of 8.0 mu g.mL(-1)) and harbored the qacA gene. Resistance to chlorhexidine and mupirocin were found in isolates carrying qacA and mupA in our hospital. Since these genes are plasmid-mediated, this finding draws attention to the potential spread of resistance to mupirocin in our hospital.