VALERIA TRUNKL SERRAO
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article Cognitive deficits in patients with mild to moderate traumatic brain injury (vol 68, pg 862, 2010)(2011) MIOTTO, Eliane Correa; CINALLI, Fernanda Zanetti; SERRAO, Valeria Trunkl; BENUTE, Glaucia Guerra; LUCIA, Mara Cristina Souza; SCAFF, MilbertoTraumatismo craniencefálico (TCE) é uma das causas mais freqüentes de lesão cerebral. São relatados na literatura déficits cognitivos após TCE moderado-grave relacionados à memória, linguagem, funções executivas, atenção e velocidade de processamento de informações. Estudos em pacientes com TCE leve são escassos embora alterações neuropsicológicas sejam encontradas nestes pacientes. OBJETIVO: Investigar o funcionamento cognitivo de pacientes com TCE leve e moderado através de um protocolo abrangente (PN01) de testes neuropsicológicos. MÉTODO: Foram avaliados 12 pacientes com TCE leve e moderado. RESULTADOS: Foram identificados déficits graves de memória episódica verbal para evocação imediata, tardia e de reconhecimento, de memória episódica visuo-espacial para evocação imediata e tardia, nomeação, fluência verbal nominal e velocidade de processamento de informações. CONCLUSÃO: Os resultados do estudo argumentam a favor da importância de avaliação neuropsicológica abrangente mesmo em casos de TCE leve a fim de se identificar funções comprometidas e preservadas, proporcionando condutas e programas de reabilitação adequados a cada caso.- Performance of a sample of patients with Mild Cognitive Impairment (MCI), Alzheimer's Disease (AD) and healthy elderly on a lexical decision test (LDT) as a measure of pre-morbid intelligence(2015) SERRAO, Valéria Trunkl; BRUCKI, Sônia Maria Dozzi; CAMPANHOLO, Kenia Repiso; MANSUR, Letícia Lessa; NITRINI, Ricardo; MIOTTO, Eliane CorreaObjective: The objective of this study was to describe the performance of healthy elderly patients with aging-related pathologies (MCI) and patients with AD on a lexical decision test. Methods: The study included 38 healthy elderly subjects, 61 MCI and 26 AD patients from the Neurology Department of the Hospital das Clinicas, Behavioral and Cognitive Neurology Group. The neuropsychological instruments included the episodic memory test (RAVLT), subtests from the WAIS-III (Matrix Reasoning and Vocabulary) to determine estimated IQ, the Boston naming test (BNT) and Lexical Decision Test (LDT).Results:All groups differed on the MMSE, as expected according to their pathologies, memory tests, naming and estimated IQ. For the vocabulary and the LDT - measures of crystalized intelligence no differences were found. Conclusion: The LDT demonstrated that lexical decision can be used as a measure of pre-morbid IQ among the individuals assessed in a Brazilian sample.
- Performance of an adult Brazilian sample on the Trail Making Test and Stroop Test(2014) CAMPANHOLO, Kenia Repiso; ROMÃO, Marcos Antunes; MACHADO, Melissa de Almeida Rodrigues; SERRAO, Valéria Trunkl; COUTINHO, Denise Gonçalves Cunha; BENUTE, Gláucia Rosana Guerra; LUCIA, Mara Cristina Souza deABSTRACT Objective: The Trail Making Test (TMT) and Stroop Test (ST) are attention tests widely used in clinical practice and research. The aim of this study was to provide normative data for the adult Brazilian population and to study the influence of gender, age and education on the TMT parts A and B, and ST cards A, B and C. Methods: We recruited 1447 healthy subjects aged ≥18 years with an educational level of 0-25 years who were native speakers of Portuguese (Brazilian). The subjects were evaluated by the Matrix Reasoning and Vocabulary subtests of the Wechsler Adult Intelligence Scale-III, along with the TMTA, TMTB and ST A, B and C. Results: Among the participants, mean intellectual efficiency was 103.20 (SD: 12.0), age 41.0 (SD: 16.4) years and education 11.9 (SD: 5.6) years. There were significant differences between genders on the TMTA (p=0.002), TMTB (p=0.017) and STC (p=0.024). Age showed a positive correlation with all attention tests, whereas education showed a negative correlation. Gender was not found to be significant on the multiple linear regression model, but age and education maintained their interference. Conclusion: Gender did not have the major impact on attentional tasks observed for age and education, both of which should be considered in the stratification of normative samples.
- Cognitive Effects of Intentional Weight Loss in Elderly Obese Individuals With Mild Cognitive Impairment(2016) HORIE, Nidia Celeste; SERRAO, Valeria T.; SIMON, Sharon Sanz; GASCON, Maria Rita Polo; SANTOS, Alessandra Xavier dos; ZAMBONE, Maria Aquimara; FREITAS, Marta Merenciana del Bigio de; CUNHA-NETO, Edecio; MARQUES, Emerson Leonildo; HALPERN, Alfredo; MELO, Maria Edna de; MANCINI, Marcio C.; CERCATO, CintiaContext: Obesity in midlife is a risk factor for dementia, but it is unknown if caloric restriction-induced weight loss could prevent cognitive decline and therefore dementia in elderly patients with cognitive impairment. Objective: To evaluate the cognitive effect of intentional weight loss in obese elderly patients with mild cognitive impairment (MCI), considering the influence of age, apolipoprotein E (APOE) genotype, physical activity, biochemical markers, and diet. Design: Single-center, prospective controlled trial. Setting: Academic medical center. Participants: Eighty obese patients with MCI, aged 60 or older (68.1 +/- 4.9 y, body mass index [BMI] 35.5 +/- 4.4 kg/m(2), 83.7% women, 26.3% APOE allele epsilon 4 carriers). Intervention: Random allocation to conventional medical care alone (n = 40) or together with nutritional counselling (n = 40) in group meetings aiming to promote weight loss through caloric restriction for 12 months. Outcome Measurements: clinical data, body composition, neuropsychological tests (main outcome), serum biomarkers, APOE genotype, physical performance, dietary recalls. Results: Seventy-five patients completed the follow-up. BMI, on average, decreased 1.7 +/- 1.8kg/m(2) (P = .021), and most of the cognitive tests improved, without difference between the groups. In analysis with linear generalized models, the BMI decrease was associated with improvements in verbal memory, verbal fluency, executive function, and global cognition, after adjustment for education, gender, physical activity, and baseline tests. This association was strongest in younger seniors (for memory and fluency) and in APOE allele epsilon 4 carriers (for executive function). Changes in homeostasis model assessment-estimated insulin resistance, C-reactive protein, leptin and intake of energy, carbohydrates, and fats were associated with improvement in cognitive tests. Conclusions: Intentional weight loss through diet was associated with cognitive improvement in patients with MCI.
- Hopkins verbal learning test-revised and brief visuospatial memory test-revised: preliminary normative data for the Brazilian population(2012) MIOTTO, Eliane Correa; CAMPANHOLO, Kenia Repiso; RODRIGUES, Melissa Machado; SERRAO, Valeria Trunkl; LUCIA, Mara C. S. de; SCAFF, Milberto