MARIO DIEGO TELES CORREIA
Projetos de Pesquisa
Unidades Organizacionais
LIM/51 - Laboratório de Emergências Clínicas, Hospital das Clínicas, Faculdade de Medicina
5 resultados
Resultados de Busca
Agora exibindo 1 - 5 de 5
- Adaptação metabólica diante de hipercapnia persistente aguda em pacientes submetidos à ventilação mecânica por síndrome do desconforto respiratório agudo(2016) ROMANO, Thiago Gomes; CORREIA, Mario Diego Teles; MENDES, Pedro Vitale; ZAMPIERI, Fernando Godinho; MACIEL, Alexandre Toledo; PARK, MarceloABSTRACT Objective: Hypercapnia resulting from protective ventilation in acute respiratory distress syndrome triggers metabolic pH compensation, which is not entirely characterized. We aimed to describe this metabolic compensation. Methods: The data were retrieved from a prospective collected database. Variables from patients' admission and from hypercapnia installation until the third day after installation were gathered. Forty-one patients with acute respiratory distress syndrome were analyzed, including twenty-six with persistent hypercapnia (PaCO2 > 50mmHg > 24 hours) and 15 non-hypercapnic (control group). An acid-base quantitative physicochemical approach was used for the analysis. Results: The mean ages in the hypercapnic and control groups were 48 ± 18 years and 44 ± 14 years, respectively. After the induction of hypercapnia, pH markedly decreased and gradually improved in the ensuing 72 hours, consistent with increases in the standard base excess. The metabolic acid-base adaptation occurred because of decreases in the serum lactate and strong ion gap and increases in the inorganic apparent strong ion difference. Furthermore, the elevation in the inorganic apparent strong ion difference occurred due to slight increases in serum sodium, magnesium, potassium and calcium. Serum chloride did not decrease for up to 72 hours after the initiation of hypercapnia. Conclusion: In this explanatory study, the results indicate that metabolic acid-base adaptation, which is triggered by acute persistent hypercapnia in patients with acute respiratory distress syndrome, is complex. Furthermore, further rapid increases in the standard base excess of hypercapnic patients involve decreases in serum lactate and unmeasured anions and increases in the inorganic apparent strong ion difference by means of slight increases in serum sodium, magnesium, calcium, and potassium. Serum chloride is not reduced.
bookPart Sepse e Inflamação Sistêmica(2016) CORREIA, Mario Diego Teles; MACHADO, Marcel Cerqueira César; SILVA, Fabiano Pinheiro da- Bacterial Proliferation May Be the Key Component of Sepsis Mortality(2018) TYMOWSKI, Christian de; CORREIA, Mario D. T.; MONTEIRO, Renato C.; MONTRAVERS, Philippe; MKADDEM, Sanae Ben
- Overwhelming Post-Splenectomy Infection: Narrative Review of the Literature(2014) TANIGUCHI, Leandro Utino; CORREIA, Mario Diego Teles; ZAMPIERI, Fernando GodinhoBackground: Almost 100 years have passed since the first evidence appeared of the immunologic function of the spleen against infections. The spleen now is recognized as the host for immune cells essential for antibody production and elimination of blood-borne pathogens, particularly encapsulated bacteria. Since the early 1900s, splenectomy has been a frequently performed surgical procedure with multiple indications. Unfortunately, removal of the spleen is associated with increased susceptibility to infection, which may be life-long, and death. Methods: Review of the pertinent English-language literature. Results: Splenectomized patients are predisposed to overwhelming fulminant infections caused by encapsulated bacteria that are refractory to the usual treatment, with a case-fatality rate of 40% to 54%. Recent studies demonstrate high morbidity. Conclusions: Because of this high mortality rate and the challenging treatment, prevention of infection by vaccination is a key feature of the management of splenectomized adult patients.
- CD89 Is a Potent Innate Receptor for Bacteria and Mediates Host Protection from Sepsis(2019) TYMOWSKI, Christian de; HEMING, Nicholas; CORREIA, Mario D. T.; ABBAD, Lilia; CHAVAROT, Nathalie; STANG, Marie-Benedicte Le; FLAMENT, Heloise; BEX, Julie; BOEDEC, Erwan; BOUNAIX, Carine; SOLER-TORRONTERAS, Rafael; DENAMUR, Erick; GALICIER, Lionel; OKSENHENDLER, Eric; FEHLING, Hans Joerg; SILVA, Fabiano Pinheiro da; BENHAMOU, Marc; MONTEIRO, Renato C.; MKADDEM, Sanae BenDirect bacterial recognition by innate receptors is crucial for bacterial clearance. Here, we show that the IgA receptor CD89 is a major innate receptor that directly binds bacteria independently of its cognate ligands IgA and c-reactive protein (CRP). This binding is only partially inhibited by serum IgA and induces bacterial phagocytosis by CD11c(+) dendritic cells and monocytes and/or macrophages, suggesting a physiological role in innate host defense. Blood phagocytes from common variable immunodeficiency patients bind, internalize, and kill bacteria in a CD89-dependent manner, confirming the IgA independence of this mechanism. In vivo, CD89 transgenic mice are protected in two different models of sepsis: a model of pneumonia and the cecal ligation and puncture (CLP) polymicrobial model of infection. These data identify CD89 as a first-line innate receptor for bacterial clearance before adaptive responses can be mounted. Fc receptors may emerge as a class of innate receptors for various bacteria with pleiotropic roles.