KATIA CRISTINA DANTAS
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Patologia, Faculdade de Medicina
LIM/05 - Laboratório de Poluição Atmosférica Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/05 - Laboratório de Poluição Atmosférica Experimental, Hospital das Clínicas, Faculdade de Medicina
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
- Dynamics and Heterogeneity of the Lung Immunopathology in Severe COVID-19(2022) ERJEFALT, J.; COSTA, N. De Souza Xavier; JONSSON, J.; COZZOLINO, O.; DANTAS, K.; CLAUSSON, C.; SIDDHURAJ, P.; LINDO, C.; LOMBARDI, S. Ferreira Spina; MENDRONI JUNIOR, A.; ANTONANGELO, L.; FARIA, C. Silverio; DUARTE NETO, A. Nunes; MONTEIRO, R. De Almeida; PINHO, J. Rebello; GOMES-GOUVEA, M. Soares; PEREIRA, R. Verciano; MONTEIRO, J. Sirino; SETUBAL, J.; OLIVEIRA, E. Pierre De; THEODORO FILHO, J.; SANDEN, C.; ORENGO, J.; SLEEMAN, M.; SILVA, L. Ferraz Da; SALDIVA, P. Nascimento; DOLHNIKOFF, M.; MAUAD, T.
- Differentially expressed genes in Diffuse Alveolar Damage (DAD) patterns of COVID-19.(2022) COSTA, N. de Souza Xavier; MONTEIRO, J. Sirino; ERJEFALT, J.; JONSSON, J.; COZZOLINO, O.; DANTAS, K.; CLAUSSON, C.; SIDDHURAJ, P.; LINDO, C.; LOMBARDI, S. Ferreira Spina; MENDRONI JUNIOR, A.; ANTONANGELO, L.; FARIA, C. Silverio; DUARTE NETO, A. Nunes; MONTEIRO, R. Almeida; PINHO, J. R. Rebello; GOMES-GOUVEA, M. Soares; PEREIRA, R. Verciano; OLIVEIRA, E. Pierre De; THEODORO FILHO, J.; SANDEN, C.; ORENGO, J.; SLEEMAN, M.; SILVA, L. F. Ferraz Da; SALDIVA, P. Nascimento; DOLHNIKOFF, M.; MAUAD, T.; SETUBAL, J. C.
- Airborne microplastics and SARS-CoV-2 in total suspended particles in the area surrounding the largest medical centre in Latin America(2022) AMATO-LOURENCO, Luis Fernando; COSTA, Natalie de Souza Xavier; DANTAS, Katia Cristina; GALVA, Luciana dos Santos; MORALLES, Fernando Negri; LOMBARDI, Suzette Cleuza Ferreira Spina; JUNIOR, Alfredo Mendroni; LINDOSO, Jose Angelo Lauletta; ANDO, Romulo Augusto; LIMA, Felipe Gallego; CARVALHO-OLIVEIRA, Regiani; MAUAD, ThaisMicroplastics (MPs) have been reported in the outdoor/indoor air of urban centres, raising health concerns due to the potential for human exposure. Since aerosols are considered one of the routes of Coronavirus disease 2019 (COVID-19) transmission and may bind to the surface of airborne MPs, we hypothesize that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could be associated with the levels of MPs in the air. Our goal was to quantify the SARS-CoV-2 RNA and MPs present in the total suspended particles (TSP) collected in the area surrounding the largest medical centre in Latin America and to elucidate a possible association among weather variables, MPs, and SARS-CoV-2 in the air. TSP were sampled from three outdoor locations in the areas surrounding a medical centre. MPs were quantified and measured under a fluorescence microscope, and their polymeric composition was characterized by Fourier transform infrared (FT-IR) microspectroscopy coupled with attenuated total reflectance (ATR). The viral load of SARS-CoV-2 was quantified by an in-house real-time PCR assay. A generalized linear model (GzLM) was employed to evaluate the effect of the SARS-CoV-2 quantification on MPs and weather variables. TSP samples tested positive for SARS-CoV-2 in 22 out of 38 samples at the three sites. Polyester was the most frequent polymer (80%) found in the samples. The total amount of MPs was positively associated with the quantification of SARS-CoV-2 envelope genes and negatively associated with weather variables (temperature and relative humidity). Our findings show that SARS-CoV-2 aerosols may bind to TSP, such as MPs, and facilitate virus entry into the human body.
- Four Years of Experience with the Sao Paulo University Medical School Community Garden(2018) DANTAS, Katia Cristina; ZEMBRUSKI, Paulo Sergio; KUBRUSLY, Marcia Saldanha; CARVALHO-OLIVEIRA, Regiani; MAUAD, ThaisThe School of Medicine, Sao Paulo University Community Garden (FMUSP Community Garden), formed in June 2013, occupies an area of 520 m(2). In the concreted area, vegetables and herbs are grown in large vessels (http://www.facebook.com/HortaDaFmusp). The garden runs on an agroecological basis using locally made compost (garden leaves and horse manure) and bio fertilizers provided by volunteers and the local restaurant (coffee powder). In the garden several herbs, medicinal plants, wild food plants and different types of seasonal vegetables are cultivated. The harvest is open for the entire community. Five medical students received financial support from the University to work 40 h per month to maintain the FMUSP Community Garden. Educational activities for the community include workshops (on medicinal herbs and wild food plants) and cooking events with students and volunteers including an elderly group, focused on healthy eating. In addition, a Ph.D. student conducted studies addressing the role of air pollution on urban gardens using the garden as an experimental site. In summary, the FMUSP Community Garden has provided sustainable, educational and research activities focused on sustainability and healthy eating in the medical campus, on a low budget, for the community. We believe this paper is important because it describes how this experience has benefited many health-related professionals and complements medical teaching. The FMUSP Community Garden has shown that agriculture in large urban centers is possible. The results were very promising, involving students, staff, patients and the surrounding community.
article Preservation methods of fungi in 35 years old stock culture storages: A comparative study(2011) FREITAS, Roseli Santos; DANTAS, Katia Cristina; PEREIRA, Cristiane Neves; LEVI, Jose Eduardo; MARTINS, Jose Eduardo CostaThe maintenance of fungi isolates and the development of methodologies were available from their phenotypic and genotypic characteristics. Alterations of Histoplasma capsulatum and Candida spp. Strains preserved by continuous subculturing on fungal collection and by lyophilization for 35 years were evaluated. Candida isolates maintained by lyophilized methodology were viable and preserved by the typical characteristics of each species. Only one lyophilized isolate from H. capsulatum was viable and demonstrated typical morphology. Both genus, which were preserved by continuous subculturing, revealed morphologic alterations and lost their sporulation capacity. The DNA from these isolates was sequenced (conserved 28S rDNA) in order to confirm their identity. Random amplified polymorphism DNA (RAPD)-based comparative analysis of the two preservation methods revealed alterations in the band profiles in 28 and 33% in Candida spp. and Histoplasma capsulatum strains respectively. The RAPD-based results confirm that the subculturing method alters phenotypic and genotypic characteristics by deleting or inserting nucleotides. Otherwise, the lyophilization was effective to yeasts, but it was not effective for dimorphic fungi.- Correlation between lung inflammatory cells, viral load and cytokines in fatal COVID-19(2022) COSTA, N. de Souza Xavier; ERJEFALT, J.; JONSSON, J.; COZZOLINO, O.; DANTAS, K.; CLAUSSON, C.; SIDDHURAJ, P.; LINDO, C.; LOMBARDI, S. Ferreira Spina; MENDRONI JUNIOR, A.; ANTONANGELO, L.; FARIA, C. Silverio; DUARTE NETO, A. Nunes; MONTEIRO, R. Almeida; PINHO, J. R. Rebello; GOMES-GOUVEA, M. Soares; PEREIRA, R. Verciano; MONTEIRO, J. Sirino; SETUBAL, J. C.; OLIVEIRA, E. Pierre De; THEODORO FILHO, J.; SANDEN, C.; ORENGO, J.; SLEEMAN, M.; SILVA, L. F. Ferraz Da; SALDIVA, P. Nascimento; DOLHNIKOFF, M.; MAUAD, T.