CLOVIS EDUARDO SANTOS GALVAO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/60 - Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas, Faculdade de Medicina
LIM/60 - Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas, Faculdade de Medicina
44 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 44
- Sensitization to cat allergen and its association with respiratory allergies: cross-sectional study(2017) GALVAO, Clovis Eduardo Santos; GRAUDENZ, Gustavo Silveira; KALIL, Jorge; CASTRO, Fabio Fernandes MoratoCats are a significant source of allergens that contribute towards worsening of allergic diseases. The aim of this study was to investigate the association between sensitization to cat allergens and allergic respiratory diseases. This was an observational retrospective study based on the skin prick tests results of patients at a tertiary-level hospital in Sao Paulo. A total of 1,985 test results were assessed. The prevalence of sensitization to cat allergen was 20% (399 patients). Our data indicated that in this population of atopic patients, a positive skin prick test result for cat allergen was not associated significantly with a diagnosis of respiratory allergy.
bookPart Controle de exposição ambiental(2021) SOUZA, Bárbara de; GALVãO, Clóvis Eduardo Santos; AGONDI, Rosana CâmarabookPart Rinossinusite(2015) GALVãO, Clóvis Eduardo Santos- Efficacy of House Dust Mite Sublingual Immunotherapy in Patients with Atopic Dermatitis: A Randomized, Double-Blind, Placebo-Controlled Trial(2022) LANGER, Sarah Sella; CARDILI, Renata Nahas; MELO, Janaina Michelle Lima; FERRIANI, Mariana Paes Leme; MORENO, Adriana Santos; DIAS, Marina Mendonca; BUENO-FILHO, Roberto; POCENTE, Renata Helena Candido; ROXO-JUNIOR, Persio; SILVA, Jorgete; VALERA, Fabiana Cardoso Pereira; COELHO, Eduardo Barbosa; GALVAO, Clovis Eduardo Santos; CARMONA, Fabio; ARAGON, Davi Casale; ARRUDA, Luisa KarlaBACKGROUND: Sensitization to house dust mites (HDMs) is frequent in patients with atopic dermatitis. OBJECTIVE: To investigate the efficacy of sublingual immunotherapy (SLIT) with Dermatophagoides pteronyssinus extract in patients with atopic dermatitis sensitized to HDM. METHODS: In this randomized, double-blind, placebo-controlled trial, we enrolled 91 patients 3 years or older, with SCORing Atopic Dermatitis (SCORAD) score greater than or equal to 15 and positive skin test result and/or IgE to D pter-onyssinus. Patients were stratified according to age (<12 and >= 12 years) to receive HDM SLIT or placebo for 18 months. Primary outcome was a greater than or equal to 15-point decrease in SCORAD score. Secondary outcomes were decreases in SCORAD and objective SCORAD, Eczema Area and Severity Index, visual analog scale for symptoms, and pruritus scale scores; Investigator's Global Assessment 0/1; and decrease greater than or equal to 4 points in Dermatology Life Quality Index. Background therapy was maintained. RESULTS: A total of 66 patients completed the study (35 HDM SLIT, 31 placebo). After 18 months, 74.2% and 58% of patients in the HDM SLIT group and the placebo group, respectively, showed greater than or equal to 15-point decrease in SCORAD score (relative risk, 1.28; 95% CI, 0.89-1.83). Significant SCORAD score decreases from baseline of 55.6% and 34.5% in HDM SLIT and placebo groups (mean difference, 20.4; 95% CI, 3.89-37.3), significant objective SCORAD score decreases of 56.8% and 34.9% in HDM SLIT and placebo groups (mean difference, 21.3; 95% CI, 0.66-41.81), and more patients with Investigator's Global Assessment 0/1 in the HDM SLIT group as compared with the placebo group (14 of 35 vs 5 of 31; relative risk, 2.63; 95% CI, 1.09-6.39) were observed at 18 months. CONCLUSIONS: Our results suggest that HDM SLIT may be effective in HDM-sensitized patients as an add-on treatment for atopic dermatitis. (C) 2021 The Authors.
bookPart Abordagem clínica do paciente com doenças imunoalérgicas(2022) GALVãO, Clóvis Eduardo Santos; CASTRO, Fábio Fernandes Morato- IgE and IgG4 Epitopes of Dermatophagoides and Blomia Allergens before and after Sublingual Immunotherapy(2023) FIGO, Daniele Danella; MACEDO, Priscilla Rios Cordeiro; GADERMAIER, Gabriele; REMUZGO, Cesar; CASTRO, Fabio Fernandes Morato; KALIL, Jorge; GALVAO, Clovis Eduardo Santos; SANTOS, Keity SouzaSublingual immunotherapy (SLIT) is used worldwide to treat house dust mites (HDM) allergy. Epitope specific immunotherapy with peptide vaccines is used far less, but it is of great interest in the treatment of allergic reactions, as it precludes the drawbacks of allergen extracts. The ideal peptide candidates would bind to IgG, blocking IgE-binding. To better elucidate IgE and IgG4 epitope profiles during SLIT, sequences of main allergens, Der p 1, 2, 5, 7, 10, 23 and Blo t 5, 6, 12, 13, were included in a 15-mer peptide microarray and tested against pooled sera from 10 patients pre- and post-1-year SLIT. All allergens were recognized to some extent by at least one antibody isotype and peptide diversity was higher post-1-year SLIT for both antibodies. IgE recognition diversity varied among allergens and timepoints without a clear tendency. Der p 10, a minor allergen in temperate regions, was the molecule with more IgE-peptides and might be a major allergen in populations highly exposed to helminths and cockroaches, such as Brazil. SLIT-induced IgG4 epitopes were directed against several, but not all, IgE-binding regions. We selected a set of peptides that recognized only IgG4 or were able to induce increased ratios of IgG4:IgE after one year of treatment and might be potential targets for vaccines.
bookPart Anafilaxia(2016) LIMA, Cynthia Mafra Fonseca de; YANG, Ariana Campos; GALVãO, Clóvis Eduardo Santos; CASTRO, Fábio Fernandes MoratobookPart Imunoterapia alérgeno-específica(2021) WATANABE, Alexandra Sayuri; GALVãO, Clóvis Eduardo Santos- Work-related asthma (WRA) has worst socioeconomic status, quality of life and asthma control: a brazilian study(2019) ROIO, Lavinia Clara Del; TERRA-FILHO, Mario; ALGRANTI, Eduardo; GALVAO, Clovis Eduardo Santos; FREITAS, Jefferson Benedito Pires De; SANTOS, Ubiratan Paula
- Airway inflammatory profile among cleaning workers from different workplaces(2016) FELIX, Soraia Nogueira; AVONA, Monise Dematte; SANTOS, Bruna Gabryela Busoletto dos; PAZ, Edineia Rosa da; ALMEIDA, Francine Maria de; GENARO, Isabella Santos de; LIMA, Cynthia Mafra Fonseca de; GALVAO, Clovis Eduardo Santos; GARCIA, Maria Lucia Bueno; MARTINS, Milton de Arruda; ROMANHOLO, Beatriz Mangueira Saraiva