CARLOS ALBERTO ABUJABRA MEREGE FILHO

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LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina

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  • article 2 Citação(ões) na Scopus
    Acute Effects of Resistance and Functional-Task Exercises on Executive Function of Obese Older Adults: Two Counterbalanced, Crossover, Randomized Exploratory Studies
    (2021) ALMEIDA, Stephany Silva de; TEIXEIRA, Emerson Luiz; MEREGE-FILHO, Carlos Alberto Abujabra; BRUCKI, Sonia Maria Dozzi; PAINELLI, Vitor de Salles
    We explored the acute effect of different intensities of resistance exercise (RE: Study A) or functional-task exercise (FE; Study B) on cognitive function of obese older adults. In Study A, 15 obese older adults (age: 67 +/- 4 years; height: 1.61 +/- 0.05 m; body mass: 91.8 +/- 18.9 kg; body mass index: 35.3 +/- 7.1 kg/m(2); waist-hip ratio: 1.00 +/- 0.08) were submitted, in a counterbalanced, crossover, randomized fashion, to three conditions: (a) RE at 50% one-repetition maximum, (b) RE at 70% one-repetition maximum, and (c) control (CON, no exercise). In a similar design. in Study B, 16 obese older women (age: 65 +/- 2 years; height: 1.62 +/- 0.02 m; body mass: 94.0 +/- 8.8 kg; body mass index: 35.5 +/- 3.6 kg/m(2); waist-hip ratio: 0.97 +/- 0.04) were submitted to (a) FE and (b) CON. At pre- and postconditions, cognitive function was measured by the Stoop Test (ST, Parts A, B. and C) and the Trail Making Test (TMT, Parts A and B). In Study A, independent of intensity, RE significantly decreased time to complete the TMT-B, ST-B, and ST-C (all p < .05). whereas performance in CON was unchanged (all p > .05). Similar results were demonstrated in Study B. where time to complete TMT-A, TMT-B, ST-A. ST-B, and ST-C significantly reduced with FE (all p < .05), but not in CON (all p > .05). Both FE and RE acutely improved executive functions. Such positive effect seems to be independent of task, intensity, and executive function.
  • article 1 Citação(ões) na Scopus
    Exercise modifies hypothalamic connectivity and brain functional networks in women after bariatric surgery: a randomized clinical trial
    (2023) MEREGE-FILHO, Carlos A. A.; GIL, Saulo S.; KIRWAN, John P.; MURAI, Igor H.; DANTAS, Wagner S.; NUCCI, Mariana P.; PASTORELLO, Bruno; LIMA, Alisson Padilha de; BAZAN, Paulo R.; PEREIRA, Rosa M. R.; SA-PINTO, Ana L. de; LIMA, Fernanda R.; BRUCKI, Sonia M. D.; CLEVA, Roberto de; SANTO, Marco A.; LEITE, Claudia da Costa; OTADUY, Maria Concepcion Garcia; ROSCHEL, Hamilton; GUALANO, Bruno
    BackgroundObesity is a disease that may involve disrupted connectivity of brain networks. Bariatric surgery is an effective treatment for obesity, and the positive effects on obesity-related conditions may be enhanced by exercise. Herein, we aimed to investigate the possible synergistic effects of Roux-en-Y Gastric Bypass (RYGB) and exercise training on brain functional networks. MethodsThirty women eligible for bariatric surgery were randomly assigned to a Roux-en-Y gastric bypass (RYGB: n = 15, age = 41.0 & PLUSMN; 7.3 years) or RYGB plus Exercise Training (RYGB + ET: n = 15, age = 41.9 & PLUSMN; 7.2 years). Clinical, laboratory, and brain functional connectivity parameters were assessed at baseline, and 3 (POST3) and 9 months (POST9) after surgery. The 6-month, three-times-a-week, exercise intervention (resistance plus aerobic exercise) was initiated 3 months post-surgery (for RYGB + ET). ResultsExercise superimposed on bariatric surgery (RYGB + ET) increased connectivity between hypothalamus and sensorial regions (seed-to-voxel analyses of hypothalamic connectivity), and decreased default mode network (DMN) and posterior salience (pSAL) network connectivity (ROI-to-ROI analyses of brain networks connectivity) when compared to RYGB alone (all p-FDR < 0.05). Increases in basal ganglia (BG) network connectivity were only observed in the exercised training group (within-group analyses). ConclusionExercise training is an important component in the management of post-bariatric patients and may improve the hypothalamic connectivity and brain functional networks that are involved in controlling food intake.