MARCOS DANIEL CABRAL SARAIVA
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/66, Hospital das Clínicas, Faculdade de Medicina
LIM/66, Hospital das Clínicas, Faculdade de Medicina
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- Nasopharyngeal carriage of Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus in a Brazilian elderly cohort(2019) ZANELLA, Rosemeire Cobo; BRANDILEONE, Maria Cristina de Cunto; ALMEIDA, Samanta Cristine Grassi; LEMOS, Ana Paula Silva de; SACCHI, Claudio Tavares; GONCALVES, Claudia R.; GONCALVES, Maria Gisele; FUKASAWA, Lucila Okuyama; SARAIVA, Marcos Daniel; RANGEL, Luis Fernando; CUNHA, Julia Lusis Lassance; ROTTA, Thereza Cristina Ariza; DOURADINHO, Christian; JACOB-FILHO, Wilson; MINAMISAVA, Ruth; ANDRADE, Ana LuciaWe aimed to investigate the nasopharyngeal colonization (NPC) by Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus in the elderly population and to assess the demographic factors associated with NPC. This was an observational cohort study in which outpatients aged >= 60 years were enrolled from April to August 2017, with a follow-up visit from September through December 2017. Nasopharyngeal (NP) swabs were collected, bacteria were detected and isolated, and isolates were subjected to phenotypic and molecular characterization using standard microbiological techniques. At enrolment, the rates of S. aureus, methicillin-resistant S. aureus (MRSA), H. influenzae, and S. pneumoniae among 776 elderly outpatients were 15.9%, 2.3%, 2.5%, and 2.2%, respectively. Toxin production was detected in 21.1% of methicillin-susceptible S. aureus, and three SCCmec types were identified: II/IIb, IVa, and VI. At the follow-up visit, all carriage rates were similar (p > 0.05) to the rates at enrolment. Most of S. pneumoniae serotypes were not included in pneumococcal conjugate vaccines (PCVs), except for 7F, 3, and 19A. All strains of H. influenzae were non-typeable. Previous use of antibiotics and 23-valent pneumococcal polysaccharide vaccination (p < 0.05) were risk factors for S. aureus and MRSA carriage; S. aureus colonization was also associated with chronic kidney disease (p = 0.021). S. pneumoniae carriage was associated with male gender (p = 0.032) and an absence of diabetes (p = 0.034), while not receiving an influenza vaccine (p = 0.049) and chronic obstructive pulmonary disease (p = 0.031) were risk factors for H. influenzae colonization. The frailty of study participants was not associated with colonization status. We found a higher S. aureus carriage rate compared with the S. pneumoniae- and H. influenzae-carriage rates in a well attended population in a geriatric outpatient clinic. This is one of the few studies conducted in Brazil that can support future colonization studies among elderly individuals.
bookPart Escalas(2019) SARAIVA, Marcos Daniel; ALIBERTI, Márlon Juliano Romero; SERRANO, Priscila Gonçalves; ONODERA, Eduardo Sho; APOLINARIO, Daniel; MAGALDI, Regina Miksian; FORTES FILHO, Sileno de Queiroz; MELO, Juliana de Araújo; ROTTA, Thereza Cristina Ariza; LIN, Sumika Mori; RANGEL, Luis Fernando; SILVA, Marina Maria Biella; APRAHAMIAN, Ivan; MAUER, Sivan; SIQUEIRA, Alaise Silva Santos de; MORILLO, Lilian Schafirovits; ARAúJO, Juliano Silveira de; STORNIOLO, Luana VergianconferenceObject Nasopharyngeal carriage of Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus in outpatient elderly in Brazil(2019) ZANELLA, R.; ALMEIDA, S.; BRANDILEONE, M.; LEMOS, A.; SACCHI, C.; GONCALVES, C.; GONCALVES, M.; FUKASAWA, L.; SARAIVA, M. D.; RANGEL, L.; CUNHA, J. Lassance; ROTTA, T.; DOURADINHO, C.; JACOB-FILHO, W.; MINAMISAVA, R.; ANDRADE, A.bookPart Avaliação global do idoso(2019) ALIBERTI, Márlon Juliano Romero; SARAIVA, Marcos Daniel; RIBEIRO, Octávio GonçalvesconferenceObject AMPI-AB accuracy: a multidimensional questionnaire for the management of the public healthcare for older people in the city of Sao Paulo, Brazil(2019) SARAIVA, M. D.; VENYS, A.; ABDALLA, F.; BIANCONI, B.; SOUSA, D.; HENRIQUE, E.; FERNANDES, M.; PISOLI, P.; CAVALHEIRO, M.; SUZUKI, G.; SERRANO, P.; MAZZA, M.; LIMA, L.; HIRATSUKA, M.; JACOB-FILHO, W.; PASCHOAL, S.