JACOB JEHUDA FAINTUCH
Índice h a partir de 2011
4
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
27 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 27
bookPart Quadros e portais úteis(2023) FAINTUCH, Joel; FAINTUCH, Jacob Jehuda; MISHALY, Asher- Precision medicine: The microbiome and metabolome(2019) FAINTUCH, J.; FAINTUCH, J. J.The microbiome gap, between just data accumulation and theoretical speculations from one side and clinical benefits to the patient from the other, is being rapidly filled. The microbiome is a crucial facet of the individual response to inflammation, cancer, metabolic and degenerative diseases, immunological conditions, neuropsychiatric pathology, diet, xenobiotic processing, surgical interventions, and even environmental stress. With the determination of key microorganisms, enzymes, metabolites, and pathways, advances are rapidly accumulating. Multilayer diagnostic and therapeutical algorithms, bedside microbiomics and metabolomics, new-generation probiotics and postbiotics, phage therapy, and patient-specific fecal transplantation are the foundations of the new era. It is not a distant vision anymore. Many applications are real and ready for clinical use. © 2019 Elsevier Inc. All rights reserved.
bookPart Complicações nuricionais após cirurgia bariátrica(2016) FAINTUCH, Joel; FAINTUCH, Jacob J.bookPart Síndrome metabólica, diabetes e obesidade: conceitos e rotinas básico(2016) FAINTUCH, Joel; FAINTUCH, Jacob J.bookPart Propostas inusitadas e contraintuitivas para o emagrecimento(2023) FAINTUCH, Joel; FAINTUCH, Jacob J.- Does Roux-en-Y gastrectomy for gastric cancer influence glucose homeostasis in lean patients?(2013) HAYASHI, Silvia Y.; FAINTUCH, Joel; YAGI, Osmar K.; YAMAGUCHI, Camila M.; FAINTUCH, Jacob J.; CECCONELLO, IvanCancer gastrectomy seems to benefit type 2 diabetes; however, results are conflicting. In a prospective protocol, including retrospective information, the aim was assessment of changes in glucose profile in patients with both normal and deranged preoperative glucose homeostasis. Patients (N = 164) with curative subtotal or total Roux-en-Y gastrectomy for gastric cancer (n = 92), or Roux-en-Y gastric bypass for morbid obesity (RYGB, n = 72) were preoperatively classified into diabetes (including prediabetes) and control group. Postoperative diabetes outcome was stratified as responsive or refractory, and results in controls were correspondingly defined as stable or new-onset diabetes (NOD), according to fasting blood glucose and HbA1c. Dietary intake and biochemical profile was documented. Statistical methods included analysis of variance, multivariate logistic regression, and propensity score matching according to postoperative weight loss. Age of cancer cases was 67.9 +/- A 11.5 years, 56.5 % males, initial body mass index (BMI) 24.7 +/- A 3.7, current BMI 22.6 +/- A 3.8 kg/m(2), and follow-up 102.1 +/- 51.0 months, whereas in bariatric individuals age was 51.4 +/- A 10.1 years, 15.3 % males, initial BMI 56.7 +/- A 12.2, current BMI 34.8 +/- A 8.1 kg/m(2), and follow-up 104.1 +/- 29.7 months. Refractory disease corresponded to 62.5 % (cancer) versus 23.5 % (bariatric) (P = 0.019), whereas NOD represented 69.2 versus 23.8 % respectively (P = 0.016). Weight loss (Delta BMI) was associated with diabetes response in cancer patients but not with NOD. No difference between subtotal and total gastrectomy was detected. Divergent outcomes (refractory vs. responsive) were confirmed in BMI-similar, propensity-matched cancer gastrectomy patients with preoperative diabetes, consistent with weight-dependent and -independent benefits. Diabetes response was confirmed, however with more refractory cases than in bariatric controls, whereas high proportions of NOD occurred. Such dichotomous pattern seems unusual albeit consistent with previous studies.
- Microbiome and metabolome glossary(2019) FAINTUCH, J.; FAINTUCH, J. J.
bookPart Funções e aberrações dos micronutrientes(2016) FAINTUCH, Joel; FAINTUCH, Jacob J.; MORAIS, Álvaro A. C.- Precision medicine glossary(2019) FAINTUCH, J.; FAINTUCH, J. J.The study of the multiple disciplines involved in Precision Medicine has expanded so rapidly that the vocabulary was sometimes unable to catch up. Of course, Genetics, Genomics, Metabolomics, Proteomics, Molecular Biology, and an array of related areas were extraordinarily helpful, lending not only tools and techniques but also the essential glossary. Nevertheless, neologisms are indispensable, with the inherent criticisms and conflicts, which such words entail. A basic glossary is here presented, aiming to unify a variety of concepts and contexts. A table with helpful internet sites is added as well. © 2020 Elsevier Inc. All rights reserved.
bookPart Portais da internet e tabelas úteis(2023) FAINTUCH, Joel; FAINTUCH, Jacob J.; MISHALY, Asher
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