MARIA FERNANDA ABALEM DE SA CARRICONDO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/33 - Laboratório de Oftalmologia, Hospital das Clínicas, Faculdade de Medicina
LIM/33 - Laboratório de Oftalmologia, Hospital das Clínicas, Faculdade de Medicina
41 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 41
- The Michigan Vision-Related Anxiety Questionnaire: A Psychosocial Outcomes Measure for Inherited Retinal Degenerations(2021) LACY, Gabrielle D.; ABALEM, Maria Fernanda; ANDREWS, Chris A.; ABUZAITOUN, Rebhi; POPOVA, Lilia T.; SANTOS, Erin P.; YU, Gina; RAKINE, Hanan Y.; BAIG, Natasha; EHRLICH, Joshua R.; FAHIM, Abigail T.; BRANHAM, Kari H.; SWENOR, Bonnielin K.; LICHTER, Paul R.; DAGNELIE, Gislin; STELMACK, Joan A.; MUSCH, David C.; JAYASUNDERA, K. Thiranpatient-reported outcome measure for screening and monitoring vision-related anxiety in patients with inherited retinal degenerations. center dot DESIGN: Item-response theory and graded response modeling to quantitatively validate questionnaire items generated from qualitative interviews and patient feedback. center dot METHODS: Patients at the Kellogg Eye Center (University of Michigan, Ann Arbor, Michigan, USA) with a clinical diagnosis of an inherited retinal degeneration (n = 128) participated in an interviewer-administered questionnaire. The questionnaire consisted of 166 items, 26 of which pertained to concepts of ""worry""and ""anxiety.""The subset of vision-related anxiety questions was analyzed by a graded response model using the Cai Metropolis-Hastings Robbins-Monro algorithm in the R software mirt package. Item reduction was performed based on item fit, item information, and item discriminability. To assess test-retest variability, 25 participants completed the questionnaire a second time 4 to 16 days later. center dot RESULTS: The final questionnaire consisted of 14 items divided into 2 unidimensional domains: rod function anxiety and cone function anxiety. The questionnaire exhibited convergent validity with the Patient Health Questionnaire for symptoms of depression and anxiety. This vision-related anxiety questionnaire has high marginal reliability (0.81 for rod-function anxiety, 0.83 for cone-function anxiety) and exhibits minimal test-retest
conferenceObject Assessment of the outflow drainage system in AMD after multiple anti-VEGF intravitreous injections(2018) CARRICONDO, Pedro C.; ZACHARIAS, Leandro C.; RODRIGUES, Taurino; YAGAESHI, Larissa Y.; PIMENTEL, Sergio Luis G.; ABALEM, Maria Fernanda; MORAES, C. Gustavo De; SUSANNA, Remo- CASE REVIEW Unilateral retinopathy in a patient with diabetes and coronary heart disease(2018) ABALEM, Maria Fernanda; EAGLE, Kim A.; RAO, Rajesh C.
- The Michigan Retinal Degeneration Questionnaire: A Patient-Reported Outcome Instrument for Inherited Retinal Degenerations(2021) LACY, Gabrielle D.; ABALEM, Maria Fernanda; ANDREWS, Chris A.; POPOVA, Lilia T.; SANTOS, Erin P.; YU, Gina; RAKINE, Hanan Y.; BAIG, Natasha; EHRLICH, Joshua R.; FAHIM, Abigail T.; BRANHAM, Kari H.; STELMACK, Joan A.; SWENOR, Bonnielin K.; DAGNELIE, Gislin; MUSCH, David C.; JAYASUNDERA, K. Thirancenter dot PURPOSE: To create a psychometrically validated patient-reported outcome measure for inherited retinal degenerations. center dot DESIGN: Qualitative and quantitative patient-reported outcome (PROs) questionnaire development using item response theory validation. center dot METHODS: One hundred twenty-eight patients with a diagnosis of an inherited retinal degeneration at the Kellogg Eye Center (University of Michigan) were recruited and administered a 166-item questionnaire comprising 7 expert-defined domains. The questionnaire was re-administered 4-16 days later to a subset of 25 participants to assess test-retest variability. Graded response models were fit by Cai & rsquo;s Metropolis-Hastings RobbinsMonro algorithm using the R (version 3.6.3) package mirt. Model data were fit to assess questionnaire dimensionality, to estimate item information, and to score participants. Poorly functioning items were removed, and the model was refit to create the final questionnaire. center dot RESULTS: The psychometrically validated PROs measure was reduced to a 59-item questionnaire measuring 7 unidimesnional domains: central vision, color vision, contrast sensitivity, scotopic function, photopic peripheral vision, mesopic peripheral vision, and photosensitivity. A total of 39 items were removed because of poor factor loading, low item information, poor person ability differentiation, or high item-level interdependence. This novel questionnaire produces a reliable domain score for person ability that does not show significant test-retest variability across repeated administration. center dot CONCLUSIONS: The final PRO questionnaire, known as the Michigan Retinal Degeneration Questionnaire, is psychometrically validated and available for use in the evaluation of patients with inherited retinal degenerations. (Am J Ophthalmol 2021;222:60 & ndash;68.
bookPart Doenças sistêmicas com comprometimento retiniano(2022) GRAZIANO, Rosa Maria; ABALEM, Maria FernandaconferenceObject Peripheral pigmented lesions in Stargardt disease(2017) ABALEM, Maria Fernanda; ZHAO, Peter Yu Cheng; NADELMAN, Daniel; QIAN, Cynthia Xin-Ya; BRANHAM, Kari E.; SCHLEGEL, Dana; KHAN, Naheed Wali; HECKENLIVELY, John R.; JAYASUNDERA, Thiran- Short-term effects of intravitreal bevacizumab in contrast sensitivity of patients with diabetic macular edema and optimizing glycemic control(2019) MOTTA, Augusto A. L.; BONANOMI, Maria Teresa B. C.; FERRAZ, Daniel A.; PRETI, Rony C.; SOPHIE, Raafay; ABALEM, Maria F.; QUEIROZ, Marcia S.; PIMENTEL, Sergio L. G.; TAKAHASHI, Walter Y.; DAMICO, Francisco M.Aims: To analyze contrast sensitivity of intravitreal bevacizumab injections with optimizing glycemic control versus optimizing glycemic control (in combination with sham injections) in eyes with Diabetic Macular Edema (DME). Design: Prospective, interventional, masked, randomized controlled trial. Methods: Forty-one eyes of 34 patients with type 2 diabetes mellitus and DME with glycated hemoglobin (HbA1c) < 11% received either intravitreal bevacizumab injection (Group 1) or sham injection (Group 2) at 0 and 6 weeks along with optimizing glycemic control. Mean change in best-corrected visual acuity (BCVA), contrast sensitivity (CS), optical coherence tomography (OCT)-measured by central macular thickness (CMT) were compared and correlated at baseline, 2, 6 and 12 weeks. Results: The study showed a mean CS improved in group 1 from 1.14 +/- 0.36 logCS to 1.32 +/- 0.24 logCS and also in group 2 from 1.11 +/- 0.29 logCS to 1.18 +/- 0.29 logCS at 12 weeks (P = 0.12). CS and CMT promptly decreased in group 1 compared to group 2 at 2 weeks (Delta CS = 0.15 +/- 0.25 vs. 0.03 +/- 0.15 logCS; P = 0.04; Delta CMT = 116 +/- 115 vs. 17 +/- 71 mu m; P = 0.01). There was a mean reduction of approximately 0.5% in HbA1c levels in both groups at 12 weeks (P = 0.002). Conclusion: The use of bevacizumab in combination with optimizing glycemic control results in earlier improvement of contrast sensitivity in type 2 diabetes patients with DME. However, the optimizing glycemic control itself has shown also to be effective at 12 weeks.
- Progressive Bilateral Cecocentral Scotomata(2019) ABALEM, Maria Fernanda; JOHNSON, Mark W.; JAYASUNDERA, Thiran
- Construct Validity of Inherited Retinal Disease-Specific Patient-Reported Outcome Measures(2023) JAYASUNDERA, K. Thiran; ABUZAITOUN, Rebhi O.; POPOVA, Lilia; ABALEM, Maria Fernanda; ANDREWS, Chris A.; LACY, Gabrielle D.; FRESCO, David M.; MUSCH, David C.PURPOSE: To evaluate aspects of construct validity of the Michigan Retinal Degeneration Questionnaire (MRDQ) and the Michigan Vision-related Anxiety Ques-tionnaire (MVAQ). center dot METHODS: Subjects with a clinical diagnosis of an inherited retinal disease (IRD) were recruited prospec-tively and 3 tests were used to assess construct valid-ity: the ability to distinguish different IRD phenotypes; test a priori hypothesis of an association between vision-related anxiety and vision-related disabilities; and corre-late MRDQ and MVAQ with the National Eye Insti-tute Visual Functioning Questionnaire 25 (NEI VFQ-25) and the Impact of Vision Impairment (IVI). One-way analysis of variance (ANOVA) was used to com-pare different phenotypes for mean domain scores for MRDQ/MVAQ. Pearson correlations were performed be-tween; Cone-Function Anxiety and Central Vision con-trolling for better eye visual acuity, Rod-Function Anxi-ety and Scotopic Function controlling for visual field area (III4e and IV4e), and scores of MRDQ/MVAQ, NEI VFQ-25, and IVI. center dot RESULTS: The study sample consisted of 146 pa-tients evenly divided between males and females, and mean age was 50 years. The 1-way ANOVA test was significant for distinguishing IRD phenotypes in 6 do-mains of MRDQ/MVAQ. Cone-Function Anxiety corre-lated with Central Vision controlling for visual acuity, Rod-Function Anxiety correlated with Scotopic Func-tion controlling for visual field area, and all domains in MRDQ/MVAQ had significant correlations with NEI VFQ-25 and IVI composite scores. center dot CONCLUSION: MRDQ and MVAQ domenstrate aspects of construct-validity set forth by the US Food and Drug Administration. The study futher supports the use of both patient-reported outcome measures in IRD clinical trials and natural history studies. (Am J Ophthalmol 2023;248: 116-126. (c) 2022 Elsevier Inc. All rights re-served.)
- A Flushed Face and Dilated Retinal Veins(2018) ZHAO, Peter Y.; ABALEM, Maria Fernanda; RAO, Rajesh C.