ADALBERTO STUDART NETO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
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conferenceObject The Value of Brain FDG-PET or SPECT in predicting the clinical features of Corticobasal Syndrome(2018) PARMERA, Jacy; ARANHA, Mateus; COUTINHO, Artur; STUDART, Adalberto; ONO, Carla; NITRINI, Ricardo; BUCHPIGUEL, Carlos; BRUCKI, SoniaconferenceObject Corticobasal syndrome: is [F-18]FDG-PET a feasible tool to predict underlying Alzheimer's pathology?(2019) COUTINHO, A. M. N.; PARMERA, J. B.; ARANHA, M. R.; STUDART NETO, A.; ONO, C. R.; BARBOSA, E. R.; NITRINI, R.; BUCHPIGUEL, C. A.; BUCKI, S. M. D.conferenceObject FDG-PET degeneration patterns predict amyloid deposition in Corticobasal Syndrome(2020) PARMERA, J.; COUTINHO, A.; NETO, A.; ONO, C.; ARANHA, M.; BUCHPIGUEL, C.; NITRINI, R.; BARBOSA, E.; BRUCKI, S.- FDG-PET Patterns Predict Amyloid Deposition and Clinical Profile in Corticobasal Syndrome(2021) PARMERA, Jacy Bezerra; COUTINHO, Artur Martins; ARANHA, Mateus Rozalem; STUDART-NETO, Adalberto; CARNEIRO, Camila de Godoi; ALMEIDA, Isabel Junqueira de; SOLLA, Davi J. Fontoura; ONO, Carla Rachel; BARBOSA, Egberto Reis; NITRINI, Ricardo; BUCHPIGUEL, Carlos Alberto; BRUCKI, Sonia Maria DozziBackground Corticobasal syndrome (CBS) is an atypical parkinsonian syndrome related to multiple underlying pathologies. Objective To investigate if individual brain [F-18]fluorodeoxyglucose-positron emission tomography (FDG-PET) patterns could distinguish CBS due to Alzheimer's disease (AD) from other pathologies based on [C-11]Pittsburgh Compound-B (PIB)-PET. Methods Forty-five patients with probable CBS were prospectively evaluated regarding cognitive and movement disorders profile. They underwent FDG-PET and were distributed into groups: likely related to AD (CBS FDG-AD) or likely non-AD (CBS FDG-nonAD) pathology. Thirty patients underwent PIB-PET on a hybrid PET-magnetic resonance imaging equipment to assess their amyloid status. FDG and PIB-PET images were classified individually based on visual and semi-quantitative analysis, blinded to each other. Quantitative group analyses were also performed. Results CBS FDG-AD group demonstrated worse cognitive performances, mostly concerning attention, memory, visuospatial domains, and displayed more myoclonus and hallucinations. The non-AD metabolic group presented more often limb dystonia, ocular motor dysfunction, motor perseveration, and dysarthria. All patients classified as CBS FDG-AD tested positive at PIB-PET compared to 3 of 20 in the non-AD group. The individual FDG-PET classification demonstrated 76.92% of sensitivity, 100% of specificity and positive predictive value and 88.5% of balanced accuracy to detect positive PIB-PET scans. Individuals with positive and negative PIB-PET showed hypometabolism in posterior temporoparietal areas and in thalamus and brainstem, respectively, mainly contralateral to most affected side, disclosing possible metabolic signatures of CBS variants. Conclusion FDG-PET was useful to predict AD and non-AD CBS variants depicting their specific degeneration patterns, different clinical features, and brain amyloid deposition. (c) 2020 International Parkinson and Movement Disorder Society
conferenceObject Corticobasal Syndrome variants: Is functional nuclear imaging with FDG-PET or SPECT patterns capable of predicting clinical features?(2018) PARMERA, J.; COUTINHO, A. M.; ARANHA, M. R.; STUDART, A.; ONO, C. R.; NITRINI, R.; BUCHPIGUEL, C. A.; BRUCKI, S.conferenceObject Corticobasal Syndrome Variants: Is Functional Nuclear Imaging with FDG-PET or SPECT Pattern Capable of Predicting Clinical Features?(2018) PARMERA, Jacy; ARANHA, Mateus; NETO, Adalberto; BUCHPIGUEL, Carlos; BARBOSA, Egberto; BRUCKI, Sonia Dozzi- Brain glucose metabolism and gray matter volume in retired professional soccer players: a cross-sectional [F-18]FDG-PET/MRI study(2023) ARANHA, Mateus Rozalem; COUTINHO, Artur Martins; CARNEIRO, Camila de Godoi; PASTORELLO, Bruno Fraccini; STUDART-NETO, Adalberto; GUARIGLIA, Carla Cristina; TSUNEMI, Miriam Harumi; MOREIRA, Everton Luis Santos; IANOF, Jessica Natuline; ANGHINAH, Renato; NITRINI, Ricardo; CERRI, Giovanni Guido; FORTEA, Juan; BUCHPIGUEL, Carlos Alberto; LEITE, Claudia CostaBackground Professional soccer athletes are exposed to repetitive head impacts and are at risk of developing chronic traumatic encephalopathy. Objective To evaluate regional brain glucose metabolism (rBGM) and gray matter (GM) volume in retired soccer players (RSPs). Methods Male RSPs and age and sex-matched controls prospectively enrolled between 2017 and 2019 underwent neurological and neuropsychological evaluations, brain MRI and [F-18]FDG-PET in a 3.0-Tesla PET/MRI scanner. Visual analysis was performed by a blinded neuroradiologist and a blinded nuclear physician. Regional brain glucose metabolism and GM volume were assessed using SPM8 software. Groups were compared using appropriate statistical tests available at SPM8 and R. Results Nineteen RSPs (median [IQR]: 62 [50-64.5] years old) and 20 controls (60 [48-73] years old) were included. Retired soccer players performed worse on mini-mental state examination, digit span, clock drawing, phonemic and semantic verbal fluency tests, and had reduced rBGM in the left temporal pole (pFDR = 0.008) and the anterior left middle temporal gyrus (pFDR = 0.043). Semantic verbal fluency correlated with rBGM in the right hippocampus, left temporal pole, and posterior left middle temporal gyrus (p <= 0.042). Gray matter volume reduction was observed in similar anatomic regions but was less extensive and did not survive correction for multiple comparisons (pFDR >= 0.085). Individual [18F]FDG-PET visual analysis revealed seven RSPs with overt hypometabolism in the medial and lateral temporal lobes, frontal lobes, and temporoparietal regions. Retired soccer players had a higher prevalence of septum pellucidum abnormalities on MRI. Conclusion Retired soccer players had reduced rBGM and GM volume in the temporal lobes and septum pellucidum abnormalities, findings possibly related to repetitive head impacts.