MAIRA OKADA DE OLIVEIRA
Projetos de Pesquisa
Unidades Organizacionais
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
34 resultados
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Agora exibindo 1 - 10 de 34
- Classification of Alzheimer's disease and frontotemporal dementia using routine clinical and cognitive measures across multicentric underrepresented samples: A cross sectional observational study(2023) MAITO, Marcelo Adrian; SANTAMARIA-GARCIA, Hernando; MOGUILNER, Sebastian; POSSIN, Katherine L.; GODOY, Maria E.; AVILA-FUNES, Jose Alberto; I, Maria Behrens; BRUSCO, Ignacio L.; BRUNO, Martin A.; CARDONA, Juan F.; CUSTODIO, Nilton; GARCIA, Adolfo M.; JAVANDEL, Shireen; LOPERA, Francisco; MATALLANA, Diana L.; MILLER, Bruce; OLIVEIRA, Maira Okada de; PINA-ESCUDERO, Stefanie D.; SLACHEVSKY, Andrea; ORTIZ, Ana L. Sosa; TAKADA, Leonel T.; TAGLIAZUCHI, Enzo; VALCOUR, Victor; YOKOYAMA, Jennifer S.; IBANEZ, AgustinBackground Global brain health initiatives call for improving methods for the diagnosis of Alzheimer & rsquo;s disease (AD) and frontotemporal dementia (FTD) in underrepresented populations. However, diagnostic procedures in upper -middle-income countries (UMICs) and lower-middle income countries (LMICs), such as Latin American countries (LAC), face multiple challenges. These include the heterogeneity in diagnostic methods, lack of clinical harmonisation, and limited access to biomarkers. Methods This cross-sectional observational study aimed to identify the best combination of predictors to discriminate between AD and FTD using demographic, clinical and cognitive data among 1794 participants [904 diagnosed with AD, 282 diagnosed with FTD, and 606 healthy controls (HCs)] collected in 11 clinical centres across five LAC (ReDLat cohort). Findings A fully automated computational approach included classical statistical methods, support vector machine procedures, and machine learning techniques (random forest and sequential feature selection procedures). Results demonstrated an accurate classification of patients with AD and FTD and HCs. A machine learning model produced the best values to differentiate AD from FTD patients with an accuracy = 0.91. The top features included social cognition, neuropsychiatric symptoms, executive functioning performance, and cognitive screening; with secondary contributions from age, educational attainment, and sex. Interpretation Results demonstrate that data-driven techniques applied in archival clinical datasets could enhance diagnostic procedures in regions with limited resources. These results also suggest specific fine-grained cognitive and behavioural measures may aid in the diagnosis of AD and FTD in LAC. Moreover, our results highlight an opportunity for harmonisation of clinical tools for dementia diagnosis in the region.
- Brain PET amyloid and neurodegeneration biomarkers in the context of the 2018 NIA-AA research framework: an individual approach exploring clinical-biomarker mismatches and sociodemographic parameters (vol 45, pg 616, 2020)(2020) COUTINHO, Artur Martins; BUSATTO, Geraldo F.; PORTO, Fabio Henrique de Gobbi; FARIA, Daniele de Paula; ONO, Carla Rachel; GARCEZ, Alexandre Teles; SQUARZONI, Paula; DURAN, Fabio Luiz de Souza; OLIVEIRA, Maira Okada de; TRES, Eduardo Sturzeneker; BRUCKI, Sonia Maria Dozzi; FORLENZA, Orestes Vicente; NITRINI, Ricardo; BUCHPIGUEL, Carlos Alberto
- Inference comprehension from reading in individuals with mild cognitive impairment(2021) SILAGI, Marcela Lima; ROMERO, Vivian Urbanejo; OLIVEIRA, Maira Okada de; TRES, Eduardo Sturzeneker; BRUCKI, Sonia Maria Dozzi; RADANOVIC, Marcia; MANSUR, Leticia LessaInference comprehension is a complex ability that recruits distinct cognitive domains, such as language, memory, attention, and executive functions. Therefore, it might be sensitive to identify early deficits in subjects with MCI. To compare the performance of subjects with mild cognitive impairment (MCI) in an inference reading comprehension task, and to analyze the correlations between inferential comprehension and other cognitive functions. We studied 100 individuals aged 60 and over, divided into MCI (50) [aMCI (35), naMCI (15)], and cognitively healthy individuals [controls (50)]. The Implicit Management Test (IMT) was used to assess inference in reading comprehension in five categories: explicit, logical, distractor, pragmatic, and ""others"". MCI group performed worse than controls in logical, pragmatic, distractor, and ""others"" questions (p < 0.01). The aMCI and naMCI subgroups presented a similar performance in all types of questions (p > 0.05). We observed significant correlations between the total IMT score and the TMT-A in the naMCI group (r = - 0.562, p = 0.036), and the Rey-Osterrieth Complex Figure and RAVLT tasks in the aMCI group (r = 0.474, p = 0.010 and r = 0.593, p = 0.0001, respectively). The MCI group as a whole performed worse than controls on the logical, pragmatic, other and distractor questions, and consequently on the total score. There were no differences in explicit questions, which impose lower inferential demands. The aMCI group suffered a significant impact from memory on inference comprehension, and difficulties in executive functions impacted naMCI performance. The IMT was useful to differentiate MCI patients from cognitively healthy individuals, but not MCI subgroups among themselves.
- Analysis of the posterior cingulate cortex with [ 18 F]FDG-PET and Naa/mI in mild cognitive impairment and Alzheimer's disease: Correlations and differences between the two methods(2015) COUTINHO, Artur M.N.; PORTO, Fábio H.G.; ZAMPIERI, Poliana F.; OTADUY, Maria C.; PERROCO, Tíbor R.; OLIVEIRA, Maira O.; NUNES, Rafael F.; PINHEIRO, Toulouse Leusin; BOTTINO, Cassio M.C.; LEITE, Claudia C.; BUCHPIGUEL, Carlos A.ABSTRACT Reduction of regional brain glucose metabolism (rBGM) measured by [18F]FDG-PET in the posterior cingulate cortex (PCC) has been associated with a higher conversion rate from mild cognitive impairment (MCI) to Alzheimer's disease (AD). Magnetic Resonance Spectroscopy (MRS) is a potential biomarker that has disclosed Naa/mI reductions within the PCC in both MCI and AD. Studies investigating the relationships between the two modalities are scarce. OBJECTIVE To evaluate differences and possible correlations between the findings of rBGM and NAA/mI in the PCC of individuals with AD, MCI and of cognitively normal volunteers. METHODS Patients diagnosed with AD (N=32) or MCI (N=27) and cognitively normal older adults (CG, N=28), were submitted to [18F]FDG-PET and MRS to analyze the PCC. The two methods were compared and possible correlations between the modalities were investigated. RESULTS The AD group exhibited rBGM reduction in the PCC when compared to the CG but not in the MCI group. MRS revealed lower NAA/mI values in the AD group compared to the CG but not in the MCI group. A positive correlation between rBGM and NAA/mI in the PCC was found. NAA/mI reduction in the PCC differentiated AD patients from control subjects with an area under the ROC curve of 0.70, while [18F]FDG-PET yielded a value of 0.93. CONCLUSION rBGM and Naa/mI in the PCC were positively correlated in patients with MCI and AD. [18F]FDG-PET had greater accuracy than MRS for discriminating AD patients from controls.
- Interoception Primes Emotional Processing: Multimodal Evidence from Neurodegeneration(2021) SALAMONE, Paula C.; LEGAZ, Agustina; SEDENO, Lucas; MOGUILNER, Sebastian; FRAILE-VAZQUEZ, Matias; CAMPO, Cecilia Gonzalez; FITTIPALDI, Sol; YORIS, Adrian; MIRANDA, Magdalena; BIRBA, Agustina; GALIANI, Agostina; ABREVAYA, Sofia; NEELY, Alejandra; CARO, Miguel Martorell; ALIFANO, Florencia; VILLAGRA, Roque; ANUNZIATA, Florencia; OLIVEIRA, Maira Okada de; PAUTASSI, Ricardo M.; SLACHEVSKY, Andrea; SERRANO, Cecilia; GARCIA, Adolfo M.; IBANEZ, AgustinRecent frameworks in cognitive neuroscience and behavioral neurology underscore interoceptive priors as core modulators of negative emotions. However, the field lacks experimental designs manipulating the priming of emotions via interoception and exploring their multimodal signatures in neurodegenerative models. Here, we designed a novel task that involves interoceptive and control-exteroceptive priming conditions followed by post-interoception and post-exteroception facial emotion recognition (FER). We recruited 114 participants, including healthy controls (HCs) as well as patients with behavioral variant frontotemporal dementia (bvFTD), Parkinson's disease (PD), and Alzheimer's disease (AD). We measured online EEG modulations of the heart-evoked potential (HEP), and associations with both brain structural and resting-state functional connectivity patterns. Behaviorally, post-interoception negative FER was enhanced in HCs but selectively disrupted in bvFTD and PD, with AD presenting generalized disruptions across emotion types. Only bvFTD presented impaired interoceptive accuracy. Increased HEP modulations during post-interoception negative FER was observed in HCs and AD, but not in bvFTD or PD patients. Across all groups, post-interoception negative FER correlated with the volume of the insula and the ACC. Also, negative FER was associated with functional connectivity along the (a) salience network in the post-interoception condition, and along the (b) executive network in the post-exteroception condition. These patterns were selectively disrupted in bvFTD (a) and PD (b), respectively. Our approach underscores the multidimensional impact of interoception on emotion, while revealing a specific pathophysiological marker of bvFTD. These findings inform a promising theoretical and clinical agenda in the fields of nteroception, emotion, allostasis, and neurodegeneration.
- Prevalence of Cognitive Impairment Without Dementia and Dementia in Tremembe, Brazil(2016) CESAR, Karolina G.; BRUCKI, Sonia M. D.; TAKADA, Leonel T.; NASCIMENTO, Luiz F. C.; GOMES, Camila M. S.; ALMEIDA, Milena C. S.; OLIVEIRA, Maira O.; PORTO, Fabio H. G.; SENAHA, Mirna L. H.; BAHIA, Valeria S.; SILVA, Thais B. L.; IANOF, Jessica N.; SPINDOLA, Livia; SCHMIDT, Magali T.; JORGE, Mario S.; VALE, Patricia H. F.; CECCHINI, Mario A.; CASSIMIRO, Luciana; SOARES, Roger T.; GONCALVES, Marcia R.; MARTINS, Ana C. S.; DARE, Patricia; SMID, Jerusa; PORTO, Claudia S.; CARTHERY-GOULART, Maria T.; YASSUDA, Monica S.; MANSUR, Leticia L.; NITRINI, RicardoBackground:The prevalence of cognitive impairment is insufficiently determined in developing countries. The aim of this study was to ascertain the prevalence of cognitive impairment without dementia and dementia in community-dwelling elderly in Brazil.Methods:This was a single-phase cross-sectional survey of the elderly (aged 60 years and above) living in the municipality of Tremembe, Brazil. Twenty percent of the households with elderly persons were randomly selected from urban and rural areas, to obtain a homogenous representation of all socioeconomic and cultural levels.Results:We assessed 630 individuals [mean age, 71.3 y (7.99); mean years of education, 4.9 (+/- 4.54)] and found prevalence rates of 17.5% (95% confidence interval, 14.6-20.6) for dementia and 19.5% (95% confidence interval, 16.6-22.8) for cognitive impairment without dementia. These prevalence rates were influenced by age (P<0.001) and by educational level (P<0.001). There was no significant sex difference among diagnostic groups (P=0.166). The prevalence of dementia was higher in relatively younger individuals (below 70 y) when compared with other studies. Besides, dementia was associated with low socioeconomic status, stroke, previous psychiatric disorder, alcoholism, and epilepsy.Conclusions:The prevalence of dementia in this study was higher than in other studies, particularly among younger elderly.
- The S-TOFHLA as a Measure of Functional Literacy in Patients with Mild Alzheimer's Disease or Mild Cognitive Impairment(2014) OLIVEIRA, Maira Okada de; NITRINI, Ricardo; BRUCKI, Sonia Maria DozziIn developing countries, education levels vary dramatically, and the number of years of schooling does not always correlate with the true level of educational competency. This study was designed to verify the accuracy of the Short-Test of Functional Health Literacy in Adults (S-TOFHLA) in individuals with mild cognitive impairment (MCI) and mild Alzheimer's disease (AD), when compared with healthy controls (HCs), in order to assess its utility as a measure of functional literacy. One hundred forty-eight subjects were divided into three groups: HC (n = 61), MCI patients (n = 42), and AD patients (n = 45). The S-TOFHLA does not seem to be suitable as an instrument to measure functional literacy for patients with advanced cognitive impairment, but proved to be appropriate in both the HC group and MCI patients in numeracy and prove to be useful as an adjuvant to estimate IQ, reading ability, and premorbid IQ, as an indicator of cognitive reserve.
- Vocabulary Is an Appropriate Measure of Premorbid Intelligence in a Sample with Heterogeneous Educational Level in Brazil(2014) OLIVEIRA, Maira Okada de; NITRINI, Ricardo; YASSUDA, Mnica Sanches; BRUCKI, Sonia Maria DozziCrystallized intelligence refers to one's knowledge base and can be measured by vocabulary tests. Fluid intelligence is related to nonverbal aspects of intelligence, depends very little on previously acquired knowledge, and can be measured by tests such as Block Design (BD) and Raven Colored Matrices (RCM). Premorbid intelligence quotient (IQ) refers to one's intellectual ability level previous to the onset of disorders like mild cognitive impairment (MCI) and Alzheimer's disease (AD) and it is important to estimate disease severity. The objective was to compare performance in tests that measure crystallized and fluid intelligence in healthy subjects and patients with amnestic MCI (aMCI) and AD. One hundred forty-four participants (aMCI (n = 38), AD (n = 45), and healthy controls (n = 61)) were submitted to neuropsychological tests (WAIS-III vocabulary, BD, and RCM). There were significant among groups, except for vocabulary, indicating a relative stability of crystallized intelligence in the continuum from normal to pathological cognitive decline. Vocabulary seems to be stable during the progression of the disease and useful as a measure of premorbid intelligence, that is, to estimate previous function in relation to the level of education and, as a collateral measure of cognition in people with low education.
- Brain metabolism and cerebrospinal fluid biomarkers profile of non-amnestic mild cognitive impairment in comparison to amnestic mild cognitive impairment and normal older subjects(2015) COUTINHO, Artur M. N.; PORTO, Fabio H. G.; DURAN, Fabio L. S.; PRANDO, Silvana; ONO, Carla R.; FEITOSA, Esther A. A. F.; SPINDOLA, Livia; OLIVEIRA, Maira O. de; VALE, Patricia H. F. do; GOMES, Helio R.; NITRINI, Ricardo; BRUCKI, Sonia M. D.; BUCHPIGUEL, Carlos A.Introduction: Mild cognitive impairment (MCI) is classically considered a transitional stage between normal aging and dementia. Non-amnestic MCI (naMCI) patients, however, typically demonstrate cognitive deficits other than memory decline. Furthermore, as a group, naMCI have a lower rate of an eventual dementia diagnosis as compared to amnestic subtypes of MCI (aMCI). Unfortunately, studies investigating biomarker profiles of naMCI are scarce. The study objective was to investigate the regional brain glucose metabolism (rBGM) with [F-18]FDG-PET and cerebrospinal fluid (CSF) biomarkers in subjects with naMCI as compared to a control group (CG) and aMCI subjects. Methods: Ninety-five patients were included in three different groups: naMCI (N = 32), aMCI (N = 33) and CG (N = 30). Patients underwent brain MRI and [F-18]FDG-PET. A subsample (naMCI = 26, aMCI = 28) also had an assessment of amyloid-beta, tau, and phosphorylated tau levels in the CSF. Results: Both MCI groups had lower rBGM in relation to the CG in the precuneus. Subjects with naMCI showed decreased right prefrontal metabolism as well as higher levels of CSF amyloid-beta relative to aMCI subjects. Conclusion: While amnestic MCI subjects showed a biomarker profile classically related to MCI due to Alzheimer's disease, naMCI patients illustrated a decrease in both prefrontal hypometabolism and higher CSF amyloid-beta levels relative to the aMCI group. These biomarker findings indicate that naMCI is probably a heterogeneous group with similar precuneus hypometabolism compared to aMCI, but additional frontal hypometabolism and less amyloid-beta deposition in the brain. Clinical follow-up and reappraisal of biomarkers of the naMCI group is needed to determine the outcome and probable etiological diagnosis.
- The Nairobi Declaration-Reducing the burden of dementia in low- and middle-income countries (LMICs): Declaration of the 2022 Symposium on Dementia and Brain Aging in LMICs(2023) MAESTRE, Gladys; CARRILLO, Maria; KALARIA, Raj; ACOSTA, Daisy; ADAMS, Larry; ADOUKONOU, Thierry; AKINWANDE, Kazeem; AKINYEMI, Joshua; AKINYEMI, Rufus; AKPA, Onoja; ALLADI, Suvarna; OGUNNIYI, Adesola; OLIVEIRA, Maira Okada De; OKUBADEJO, Njideka; ORRELL, Martin; ORUNMUYI, Akintunde; OWOLABI, Mayowa; PADDICK, Stella; PERICAK-VANCE, Margaret A.; PIRTOSEK, Zvezdan; POTOCNIK, Felix; SEPULVEDA-FALLA, Diego; PRESTON, Bill; RAMAN, Rema; RANCHOD, Kirti; RIZIG, Mie; ROSSELLI, Monica; DEEPA, Roy; ROY, Upal; SALOKHIDDINOV, Marufjon; SANO, Mary; SARFO, Fred; SESHADRI, Sudha; SATIZABAL, Claudia L.; SEXTON, Claire; SKOOG, Ingmar; GEORGE-HYSLOP, Peter St; SUEMOTO, Claudia; TANNER, Jeremy; THAPA, Prekshya; TOURE, Kamadore; UCHEAGWU, Valentine; ALLEGRI, Ricardo; UDEH-MOMOH, Chinedu; VALCOUR, Victor; VANCE, Jeffery; VARGHESE, Mathew; VERA, Jaime; WALKER, Richard; WEIDNER, Wendy; SEBASTIAN, Walsh; GAY, Patrice Whitehead; ZETTERBERG, Henrik; ARIZAGA, Raul; ZEWDE, Yared; ARSHAD, Faheem; ARULOGUN, Oyedunni; NDETEI, David; BAIYEWU, Olusegun; ISSAC, Thomas; BELLAJ, Tarek; BOSHE, Judith; BRAYNE, Carol; BRODIE-MENDS, David; BROWN, Richard; CAHN, Jennifer; CYRILLE, Nkouonlack; DAMASCENO, Albertino; SILVA, Ranil de; SILVA, Rohan de; DJIBUTI, Mamuka; DREYER, Anna Jane; ELLAJOSYULA, Ratnavalli; FAROMBI, Temitope; FONGANG, Bernard; FORNER, Stefania; FRIEDLAND, Rob; GARZA, Noe; GBESSEMEHLAN, Antoine; GEORGIOU, Eliza (Eleni- Zacharoula); GOUIDER, Riadh; GOVIA, Ishtar; GRINBERG, Lea; GUERCHET, Maelenn; GUGSSA, Seid; GUMIKIRIZA-ONORIA, Joy Louise; GUSTAFSON, Deborah; HOGERVORST, Eef; HORNBERGER, Michael; IBANEZ, Agustin; IHARA, Masafumi; ISMAIL, Ozama; ISSAC, Thomas; JOENSSON, Linus; KAPUTU, Celestin; KARANJA, Wambui; KARUNGI, Jackline; TSHALA-KATUMBAY, Desire; KUNKLE, Brian; LEE, Joseph H.; LEROI, Iracema; LEWIS, Raphaella; LIVINGSTON, Gill; LOPERA, Francisco; LWERE, Kamada; MANES, Facundo; MBAKILE-MAHLANZA, Lingani; MENA, Pedro; MILLER, Bruce; MILLOGO, Athanase; MOHAMED, Abdul; MUSYIMI, Christine; MUTISO, Victoria; NAKASUJJA, Noeline; NDETEI, David; NIGHTINGALE, Sam; NJAMNSHI, Alfred K.; NOVOTNI, Gabriela; NYAMAYARO, Primrose; NYAME, Solomon; OGENG'O, Julius